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1. 发明授权

US08895512B2 Composition for improving brain function and method for improving brain function 有权
标题翻译：用于改善脑功能的组合物和改善脑功能的方法
公开(公告)号：US08895512B2
公开(公告)日：2014-11-25
申请号：US13233490
申请日：2011-09-15
申请人： Kazuhito Ohsawa , Naoto Uchida , Kohji Ohki
发明人： Kazuhito Ohsawa , Naoto Uchida , Kohji Ohki
IPC分类号： A01N37/18 , A61K38/00 , A61K38/05
CPC分类号： A61K38/05
摘要： The present invention provides a composition which may be ingested orally in a small dose for the purpose of improving brain function, and a method for improving brain function. The present invention is a composition for improving brain function, comprising, as an active ingredient, Phe-Pro.
摘要翻译：本发明提供可以以小剂量口服摄取以改善脑功能的组合物，以及改善脑功能的方法。本发明是一种用于改善脑功能的组合物，其包含Phe-Pro作为活性成分。

2. 发明申请

US20140308733A1 METHOD FOR INDUCING GERMINATION OF SPORE FORMING BACTERIUM 审中-公开
标题翻译：诱导孢子形成细菌发芽的方法
公开(公告)号：US20140308733A1
公开(公告)日：2014-10-16
申请号：US14343506
申请日：2012-09-06
申请人： Toki Nishiyama , Nobuhisa Ashida , Gentaro Yasuda , Yukie Tadano
发明人： Toki Nishiyama , Nobuhisa Ashida , Gentaro Yasuda , Yukie Tadano
IPC分类号： C12N3/00
CPC分类号： C12N3/00 , C12N1/005 , C12N1/20 , C12N1/38 , C12R1/07 , C12R1/10 , C12R1/125
摘要： The present application relates to a method for inducing germination of a spore forming bacterium, specifically, a method for inducing germination of a spore forming bacterium, comprising: using one or more compounds having a phenolic backbone to induce germination of a spore forming bacterium selected from the group consisting of the genus Bacillus, the genus Geobacillus, and the genus Aeribacillus; to a germination inducer for a spore forming bacterium; and to a kit for use in germination of a spore forming bacterium.
摘要翻译：本申请涉及一种诱导孢子形成细菌发芽的方法，具体地，涉及诱导孢子形成细菌发芽的方法，该方法包括：使用一种或多种具有酚骨架的化合物诱导孢子形成细菌的萌发，所述孢子形成细菌选自由芽孢杆菌属，芽孢杆菌属和气丝杆菌属组成的组; 用于孢子形成细菌的发芽诱导物; 以及用于孢子形成细菌发芽的试剂盒。

3. 发明授权

US08580557B2 Casein hydrolyzate, process for producing the same and use thereof 有权
标题翻译：酪蛋白水解物，其制备方法及其用途
公开(公告)号：US08580557B2
公开(公告)日：2013-11-12
申请号：US12873500
申请日：2010-09-01
申请人： Naoyuki Yamamoto , Seiichi Mizuno , Takanobu Gotou , Keiichi Matsuura , Tadashi Shinoda , Hideo Nishimura
发明人： Naoyuki Yamamoto , Seiichi Mizuno , Shingo Nishimura , Takanobu Gotou , Keiichi Matsuura , Tadashi Shinoda
IPC分类号： C12N1/00 , C12N9/62 , A61K38/00 , A61K38/05 , A61K38/06 , C12N9/50 , C12N9/48 , A61K47/00 , A61K38/55 , A23C9/12 , C12P21/06 , A61P9/12
CPC分类号： C07K5/06104 , A23L33/18 , A61K38/00 , C07K5/06034 , C07K5/06095 , C07K5/081
摘要： The present invention relates to a casein hydrolysate containing free amino acids and in vivo indigestible peptides having minimally suppressed in vivo enzymatic digestibility, and expected to express functions, such as hypotensive effect, in living organism, and to a method for preparing such a hydrolysate, and use thereof. The casein hydrolysate of the present invention contains free amino acids and peptides, such as in vivo indigestible peptides including Xaa-Pro and Xaa-Pro-Pro, obtained by hydrolyzing animal milk casein to have an average chain length of not longer than 2.1 in terms of the number of amino acid residues, and has ACE inhibitory activity or hypotensive effect.
摘要翻译：本发明涉及含有游离氨基酸的酪蛋白水解物和体内消化不良的肽，其具有最低限度的体内酶消化率，预期在活生物体中表达功能降低作用，以及制备这种水解产物的方法，及其用途。本发明的酪蛋白水解物含有游离氨基酸和肽，例如通过水解动物乳酪蛋白得到的体内难消化的肽，包括Xaa-Pro和Xaa-Pro-Pro，其平均链长度不超过2.1 的氨基酸残基数，并具有ACE抑制活性或降血压作用。

5. 发明申请

US20110082281A1 CASEIN HYDROLYZATE, PROCESS FOR PRODUCING THE SAME AND USE THEREOF 有权
标题翻译： CASEIN水解产物，其生产方法和用途
公开(公告)号：US20110082281A1
公开(公告)日：2011-04-07
申请号：US12873500
申请日：2010-09-01
申请人： Naoyuki Yamamoto , Seiichi Mizuno , Shingo Nishimura , Hideo Nishimura , Takanobu Gotou , Keiichi Matsuura , Tadashi Shinoda
发明人： Naoyuki Yamamoto , Seiichi Mizuno , Shingo Nishimura , Hideo Nishimura , Takanobu Gotou , Keiichi Matsuura , Tadashi Shinoda
IPC分类号： C07K5/08 , C07K5/06 , C12P21/00
CPC分类号： C07K5/06104 , A23L33/18 , A61K38/00 , C07K5/06034 , C07K5/06095 , C07K5/081
摘要： The present invention relates to a casein hydrolysate containing free amino acids and in vivo indigestible peptides having minimally suppressed in vivo enzymatic digestibility, and expected to express functions, such as hypotensive effect, in living organism, and to a method for preparing such a hydrolysate, and use thereof. The casein hydrolysate of the present invention contains free amino acids and peptides, such as in vivo indigestible peptides including Xaa-Pro and Xaa-Pro-Pro, obtained by hydrolyzing animal milk casein to have an average chain length of not longer than 2.1 in terms of the number of amino acid residues, and has ACE inhibitory activity or hypotensive effect.
摘要翻译：本发明涉及含有游离氨基酸的酪蛋白水解物和体内消化不良的肽，其具有最低限度的体内酶消化率，预期在活生物体中表达功能降低作用，以及制备这种水解产物的方法，及其用途。本发明的酪蛋白水解物含有游离氨基酸和肽，例如通过水解动物乳酪蛋白得到的体内难消化的肽，包括Xaa-Pro和Xaa-Pro-Pro，其平均链长度不超过2.1 的氨基酸残基数，并具有ACE抑制活性或降血压作用。

6. 发明授权

US07846231B2 Method of treating organic waste, agent for treating organic waste and microorganisms to be used therein 有权
标题翻译：处理有机废物的方法，用于处理有机废物的试剂和其中使用的微生物
公开(公告)号：US07846231B2
公开(公告)日：2010-12-07
申请号：US10543900
申请日：2004-01-29
申请人： Hiroshi Miyazaki , Kiyoshi Maruta , Tomohiro Hamaoka
发明人： Hiroshi Miyazaki , Kiyoshi Maruta , Tomohiro Hamaoka
IPC分类号： C05F11/08 , C05F11/00 , C05F3/00 , C05F9/00 , C05F1/00 , C05F7/00 , C05D9/02 , C12N9/52 , C12N9/54 , C12N9/56 , A62D3/30
CPC分类号： C12R1/07 , C02F3/34
摘要： There are provided a method of treating organic waste, which is excellent in the smooth temperature elevation in the early stage of the treatment and satisfactory in temperature-maintenance in a high temperature range, and by which the stable treatment of organic waste is achieved and the evaporation of moisture is promoted, thereby a stable effect of treating organic waste and an increased treatment scale being achieved; an agent for treating organic waste; and microorganisms to be used therein. The method is characterized by the use of a mesophilic bacterium showing its activity at 15 to 50° C. and a thermophilic bacterium showing its activity at 50 to 70° C. in the organic waste. As the mesophilic bacteria, bacteria which have an exothermic action and form spores under a temperature of 50° C. or higher are preferable and Bacillus subtilis is more preferable. Among these bacteria, a C-3102 strain (FERM BP-1096) is especially preferable. As the thermophilic bacteria, Bacillus pallidus is preferable and, among these bacteria, a TK6004 strain (FERM BP-08597) is more preferable.
摘要翻译：提供了一种处理有机废弃物的方法，其在处理的早期阶段的平稳的温度上升是优异的，并且在高温范围内的温度维持是令人满意的，并且通过其有机废物的稳定处理和促进水分蒸发，从而达到治疗有机废物的稳定效果，提高处理规模; 一种处理有机废物的药剂; 和其中使用的微生物。该方法的特征在于使用在15至50℃下显示其活性的嗜温细菌，以及在有机废物中在50至70℃显示出其活性的嗜热细菌。作为嗜温菌，优选在50℃以上的温度下具有放热作用并形成孢子的细菌，更优选枯草芽孢杆菌。在这些细菌中，特别优选C-3102菌株（FERM BP-1096）。作为嗜热菌，优选芽孢杆菌，其中更优选TK6004菌株（FERM BP-08597）。

7. 发明申请

US20100151039A1 SKIN MOISTURIZING AGENT FOR ORAL INTAKE AND FUNCTIONAL FOODS AND DRINKS 审中-公开
标题翻译：用于口腔摄取和功能食品和饮料的皮肤保湿剂
公开(公告)号：US20100151039A1
公开(公告)日：2010-06-17
申请号：US12711451
申请日：2010-02-24
申请人： Chiaki Yoshimura , Akihiro Masuyama
发明人： Chiaki Yoshimura , Akihiro Masuyama
IPC分类号： A61K35/20
CPC分类号： A61K35/20 , A23C21/026 , A23L33/19 , A23V2002/00 , A23Y2220/39 , A61K8/986 , A61K2800/85 , A61K2800/92 , A61Q19/00 , A23V2200/318 , A23V2250/54252
摘要： The present invention provides functional food and beverage that produce a skin moisturizing effect through oral intake, that is excellently safe, and that may be taken regularly. The invention also provides a skin moisturizer for oral intake to be used in the functional food and beverage, as well as use thereof. The present skin moisturizer for oral intake contains as an active component fermented milk whey obtained by fermentation of milk with Lactobacillus helveticus, and the present functional food and beverage contains the skin moisturizer and has a skin moisturizing effect.
摘要翻译：本发明提供通过口服摄取产生皮肤保湿效果的功能性食品和饮料，其是非常安全的，并且可以定期服用。本发明还提供了用于口腔摄取的皮肤保湿剂以用于功能性食品和饮料，以及其用途。目前用于口服的皮肤保湿剂含有通过用瑞利乳杆菌发酵乳获得的发酵乳清乳作为活性成分，本发明的功能性食品和饮料含有皮肤保湿剂并具有皮肤保湿作用。

8. 发明申请

US20080085321A1 AGENT FOR PREVENTING OR SUPPRESSING HEPATOPATHY AND FUNCTIONAL FOOD FOR PREVENTING OR SUPPRESSING HEPATOPATHY 有权
标题翻译：用于预防或抑制HEPATOPATHY和功能食品用于预防或抑制HEPATOPATHY的代理
公开(公告)号：US20080085321A1
公开(公告)日：2008-04-10
申请号：US11952822
申请日：2007-12-07
申请人： Yoshinori MORIYAMA , Seiji Tsuboi , Akihiro Masuyama , Toshiaki Takano , Teppei Nakamura
发明人： Yoshinori MORIYAMA , Seiji Tsuboi , Akihiro Masuyama , Toshiaki Takano , Teppei Nakamura
IPC分类号： A61K35/20
CPC分类号： A61K35/20 , A23L33/10 , A61K35/744 , A61K35/747 , A61K2300/00
摘要： The present invention provides an agent for preventing or suppressing hepatic dysfunction which may be taken daily and continuously, has excellent safety, and is capable of effectively preventing and/or suppressing hepatic dysfunction, such as hepatocellular necrosis, and functional food, such as foods for specified health uses, for preventing or suppressing hepatic dysfunction containing this agent. The agent for preventing or suppressing hepatic dysfunction of the present invention contains whey as the active component, and the functional food for preventing or suppressing hepatic dysfunction contains the agent for preventing or suppressing hepatic dysfunction.
摘要翻译：本发明提供一种可以每天持续服用的肝功能障碍的预防或抑制剂，具有优异的安全性，能够有效地预防和/或抑制肝功能障碍如肝细胞坏死和功能性食物，例如食物中的食物指定的健康用途，用于预防或抑制含有该药物的肝功能障碍。本发明的肝功能障碍的预防或抑制剂含有乳清作为活性成分，作为预防或抑制肝功能障碍的功能性食品含有预防或抑制肝功能障碍的药剂。

9. 发明申请

US20070224285A1 Agent for Preventing or Suppressing Hepatopathy and Functional Food for Preventing or Suppressing Hepatopathy 审中-公开
标题翻译：用于预防或抑制肝病和功能性食物预防或抑制肝病的药剂
公开(公告)号：US20070224285A1
公开(公告)日：2007-09-27
申请号：US10599447
申请日：2005-03-31
申请人： Yoshinori Moriyama , Seiji Tsuboi , Akihiro Masuyama , Toshiaki Takano , Teppei Nakamura
发明人： Yoshinori Moriyama , Seiji Tsuboi , Akihiro Masuyama , Toshiaki Takano , Teppei Nakamura
IPC分类号： A61K35/20 , A23L1/30 , A61K35/74 , A61P1/16
CPC分类号： A61K35/20 , A23L33/10 , A61K35/744 , A61K35/747 , A61K2300/00
摘要： The present invention provides an agent for preventing or suppressing hepatic dysfunction which may be taken daily and continuously, has excellent safety, and is capable of effectively preventing and/or suppressing hepatic dysfunction, such as hepatocellular necrosis, and functional food, such as foods for specified health uses, for preventing or suppressing hepatic dysfunction containing this agent. The agent for preventing or suppressing hepatic dysfunction of the present invention contains whey as the active component, and the functional food for preventing or suppressing hepatic dysfunction contains the agent for preventing or suppressing hepatic dysfunction.
摘要翻译：本发明提供一种可以每天持续服用的预防或抑制肝功能障碍的药剂，具有优异的安全性，能够有效地预防和/或抑制肝功能障碍如肝细胞坏死，功能性食品，例如指定的健康用途，用于预防或抑制含有该药物的肝功能障碍。本发明的肝功能障碍的预防或抑制剂含有乳清作为活性成分，作为预防或抑制肝功能障碍的功能性食品含有预防或抑制肝功能障碍的药剂。

10. 发明申请

US20160120919A1 PREVENTIVE OR THERAPEUTIC AGENT FOR RUMINANT ANIMAL MASTITIS 审中-公开
标题翻译：预防或治疗动物代谢动物
公开(公告)号：US20160120919A1
公开(公告)日：2016-05-05
申请号：US14891533
申请日：2014-05-16
申请人： CALPIS CO., LTD.
发明人： Nobuhisa ASHIDA , Tomokazu IMABAYASHI , Hisashi ASO
IPC分类号： A61K35/742
CPC分类号： A61K35/742 , A23K10/18 , A23K50/10
摘要： The present invention relates to a substance or method for preventing or treating mastitis in ruminant animals, particularly in dairy cows. Specifically provided are: a preventive or therapeutic agent, a feed additive, a feed, and a pharmaceutical composition for ruminant animal mastitis, characterized by comprising, as an active ingredient, a Bacillus genus bacterium having the property of being capable of increasing or maintaining CD11c+ CD172a+ blood dendritic cell gate 2 in cows.
摘要翻译：本发明涉及用于预防或治疗反刍动物，特别是奶牛中的乳房炎的物质或方法。具体提供的是：预防或治疗剂，饲料添加剂，饲料和用于反刍动物乳腺炎的药物组合物，其特征在于包含作为活性成分的芽孢杆菌属属，其具有能够增加或维持CD11c + CD172a +血树突状细胞门2在牛。

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