专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US11707437B2 Topical formulations with resiniferatoxin nanoparticles and methods 有权
公开(公告)号：US11707437B2
公开(公告)日：2023-07-25
申请号：US16925551
申请日：2020-07-10
申请人： Board of Trustees of Southern Illinois University , University of Wyoming
发明人： Louis Premkumar , Baskaran Thyagarajan
IPC分类号： A61K9/51 , A61K31/35 , A61K9/00 , A61K9/06 , A61K47/36 , A61K47/10 , A61K47/22 , A61P25/02 , A61K9/70 , A61K47/44
CPC分类号： A61K9/5153 , A61K9/0014 , A61K9/06 , A61K9/7015 , A61K31/35 , A61K47/10 , A61K47/22 , A61K47/36 , A61K47/44 , A61P25/02
摘要： Nanoparticles comprising resiniferatoxin (RTX) encapsulated in a poly(lactic-co-glycolic acid) (PLGA) polymer and compositions, especially topical compositions, comprising the nanoparticles. The compositions can be used as topical formulations for ameliorating pain, including for diabetic patients with peripheral neuropathy.

2. 发明公开

US20230150943A1 CLEAVABLE AGENTS 审中-公开
公开(公告)号：US20230150943A1
公开(公告)日：2023-05-18
申请号：US18149740
申请日：2023-01-04
申请人： Board of Trustees of Southern Illinois University , Vanderbilt University
发明人： Boyd M. Goodson , Eduard Y. Chekmenev , Bryce E. Kidd , Jamil A. Mashni , Miranda Limbach , Yuqing Hou , Fan Shi
IPC分类号： C07D233/60 , G01R33/28 , C07D401/06 , C07D241/12 , C07D213/63 , C07F9/6506 , B01J31/12 , C07D213/46
CPC分类号： C07D233/60 , G01R33/282 , C07D401/06 , C07D241/12 , C07D213/63 , C07F9/6506 , B01J31/12 , C07D213/46 , B01J2531/827 , G01R33/46
摘要： The present disclosure is directed to a cleavable agent for enhanced magnetic resonance generally corresponding to the formula Y-L-R, wherein Y represents a catalyst-binding moiety having at least one isotopically labeled heteroatom, L represents a cleavable bond, and R represents a hyperpolarized payload having at least one isotopically labeled carbon. Also disclosed herein is a method of cleaving the cleavable agent for enhanced magnetic resonance.

3. 发明申请

US20220370033A1 THREE-DIMENSIONAL MODELING AND ASSESSMENT OF CARDIAC TISSUE 有权
公开(公告)号：US20220370033A1
公开(公告)日：2022-11-24
申请号：US17730380
申请日：2022-04-27
申请人： Board of Trustees of Southern Illinois University
发明人： Jon Klingensmith , Colin Gibbons , Michaela Kulasekara
IPC分类号： A61B8/08 , G06T7/00 , A61B5/00 , A61B34/10
摘要： A system for patient cardiac imaging and tissue modeling. The system includes a patient imaging device that can acquire patient cardiac imaging data. A processor is configured to receive the cardiac imaging data. A user interface and display allow a user to interact with the cardiac imaging data. The processor includes fat identification software conducting operations to interact with a trained learning network to identify fat tissue in the cardiac imaging data and to map fat tissue onto a three-dimensional model of the heart. A preferred system uses an ultrasound imaging device as the patient imaging device. Another preferred system uses an MRI or CT image device as the patient imaging device.

4. 发明申请

US20210346437A1 NOVEL TREATMENT OF DYSPHAGIA 有权
公开(公告)号：US20210346437A1
公开(公告)日：2021-11-11
申请号：US17313277
申请日：2021-05-06
申请人： Board of Trustees of Southern Illinois University
发明人： Sandra Ettema
IPC分类号： A61K35/50 , A61K9/00 , A61P1/00 , A61M29/02
摘要： This disclosure provides methods for treating dysphagia in a patient in need of esophageal dilation of his/her esophageal stricture. The methods according to this disclosure comprise: i. injecting circumferentially into the esophageal stricture area a sterile pharmaceutical composition comprising a pharmaceutically acceptable fluid carrier and tissue matrix allograft particles composed of human amnion and chorion membranes, wherein the amnion membrane is de-epithelized; and ii. performing pneumatic dilation of the esophageal stricture with a balloon dilator. The methods of this disclosure are particularly suitable for treating a complex and scarred cervical esophageal stricture, including reoccurring cervical esophageal strictures. The present methods may be particularly beneficial for cancer patients, including head and neck cancer patients, who were previously treated with external beam radiation and/or chemotherapy and/or a surgery for his/her cancer.

5. 发明授权

US11136312B2 3,4,5-trisubstituted-1,2,4-triazoles and 3,4,5-trisubstituted-3-thio-1,2,4-triazoles and uses thereof 有权
公开(公告)号：US11136312B2
公开(公告)日：2021-10-05
申请号：US16613086
申请日：2018-05-11
申请人： Board of Trustees of Southern Illinois University
发明人： Kenneth A. Witt , Albert M. Crider , William Neumann , Audrey Hospital , Karin Sandoval , Maria Kontoyianni
IPC分类号： C07D403/14 , C07D233/64 , C07D401/12 , C07D401/14 , C07D403/12
摘要： The present disclosure describes novel compounds that are somatostatin receptor type 4 agonists.

6. 发明申请

US20210253689A1 REGIMENS, COMPOSITIONS AND METHODS WITH CAPSAICIN AND TNF-alpha INHIBITOR 有权
公开(公告)号：US20210253689A1
公开(公告)日：2021-08-19
申请号：US17169950
申请日：2021-02-08
申请人： Board of Trustees of Southern Illinois University
发明人： Debashree Mukherjea , Vickram Ramkumar , Leonard Rybak
IPC分类号： C07K16/24 , A61K31/165 , A61P27/16
摘要： Compositions and treatment regimen that includes the compositions, suitable for preventing, treating and restoring hearing acuity in a subject are provided. The treatment regimen includes an amount of capsaicin and an amount of a TNF-α inhibitor (such as etanercept) that are delivered relatively simultaneously to a subject. Methods of providing a pretreatment to a subject suitable for preventing hearing loss are also provided. The capsaicin and TNFα inhibitor may be provided in different delivery forms to the subject. Methods of providing a treatment for hearing loss with a TNFα inhibitor alone, such as entanercept, or with capsaicin alone, are also provided.

7. 发明申请

US20200172493A1 CLEAVABLE AGENTS 审中-公开
公开(公告)号：US20200172493A1
公开(公告)日：2020-06-04
申请号：US16698332
申请日：2019-11-27
申请人： Board of Trustees of Southern Illinois University , Vanderbilt University
发明人： Boyd M. Goodson , Eduard Y. Chekmenev , Bryce E. Kidd , Jamil A. Mashni , Miranda Limbach , Yuqing Hou , Fan Shi
IPC分类号： C07D233/60 , G01R33/28 , C07D401/06 , C07D241/12 , C07D213/46 , C07D213/63 , C07F9/6506 , B01J31/12
摘要： The present disclosure is directed to a cleavable agent for enhanced magnetic resonance generally corresponding to the formula Y-L-R, wherein Y represents a catalyst-binding moiety having at least one isotopically labeled heteroatom, L represents a cleavable bond, and R represents a hyperpolarized payload having at least one isotopically labeled carbon. Also disclosed herein is a method of cleaving the cleavable agent for enhanced magnetic resonance.

8. 发明申请

US20180010086A1 NOVEL SYRINGE SYSTEM FOR FLUID SEPARATION 审中-公开
公开(公告)号：US20180010086A1
公开(公告)日：2018-01-11
申请号：US15645657
申请日：2017-07-10
申请人： Board of Trustees of Southern Illinois University
发明人： Ashim Gupta , Michael W. Neumeister , Sohyung Cho
IPC分类号： C12M1/00 , B01D17/02 , A61M5/315 , A61M5/34
摘要： A syringe device for separating liquids of different densities is provided with a hollow syringe barrel, a perforated plunger seal with a seal hole, and a hollow plunging tube with a closed bottom with at least one tube hole. The perforated plunger seal has an outer perimeter that resides flush against an interior surface of the hollow syringe barrel. The tube hole is in operational relationship with the seal hole. Optionally, a relief hole is provided on a top portion of the hollow plunging tube to allow a user to create vacuum pressure as necessary.

9. 发明授权

US08979212B2 Water sprays for dust control on mining machines 有权
标题翻译：喷水器用于矿山机械的粉尘控制
公开(公告)号：US08979212B2
公开(公告)日：2015-03-17
申请号：US14024924
申请日：2013-09-12
申请人： Board of Trustees of Southern Illinois University
发明人： Yoginder P Chugh
IPC分类号： E21C35/22 , E21C35/23 , E21C27/24
CPC分类号： E21C35/23 , E21C27/24 , E21C35/22
摘要： This invention refers to innovative water sprays applications to significantly improve coal and quartz dust control around a continuous miner. Significant dust control is achieved through utilizing different types of sprays at locations on the top and sides of the miner chassis to create water curtains or shrouds of water around zones of high dust concentration and zones of high concentration dust transport. This is called “multiple lines of defense” spray system (MLD.) This invention also provides a method of reducing dust around a continuous miner by configuring a spray system, located at the top or sides of the cutter boom, thereby improving control of respirable dust.
摘要翻译：本发明涉及创新的喷水应用，以显着改善连续采矿机周围的煤和石英粉尘控制。通过在矿用底盘顶部和侧面的位置处使用不同类型的喷雾，在高灰尘浓度区域和高浓度粉尘输送区域周围创建水幕或水箱，可以实现显着的灰尘控制。这被称为“多防线”喷雾系统（MLD）。本发明还提供了一种通过配置位于切割臂顶部或侧面的喷雾系统来减少连续采矿机周围的灰尘的方法，从而改善可呼吸的控制灰尘。

10. 发明授权

US08888712B2 Tinnitus testing device and method 有权
标题翻译：耳鸣测试装置及方法
公开(公告)号：US08888712B2
公开(公告)日：2014-11-18
申请号：US13741085
申请日：2013-01-14
申请人： Board of Trustees Of Southern Illinois University
发明人： Jeremy Turner , James Michael Kinder
IPC分类号： A61B5/00 , A61B5/12 , A61B5/0484 , A61B5/04 , A61F11/00
CPC分类号： A61B5/128 , A61B5/04001 , A61B5/04845 , A61B5/121 , A61F11/00
摘要： Objectively identifying an acoustic characteristic of tinnitus of a subject. The subject is exposed to a sound pattern having a background acoustic signal preceding an audible silence. The background acoustic signal has a selected acoustic characteristic. An electrical response of the subject's central nervous system to the exposure to the sound pattern is measured. The measured electrical response has a first portion representing the electrical response of the subject's central nervous system to the background acoustic signal, and a second portion representing the electrical response of the subject's central nervous system to the audible silence in the sound pattern. The first portion of the measured electrical response is compared to the second portion of the measured electrical response and a determination is made as to whether the subject has tinnitus with an acoustic characteristic similar to the selected acoustic characteristic based on the comparison.
摘要翻译：客观地识别受试者的耳鸣的声学特征。受试者暴露于具有在可听见沉默之前的背景声信号的声音图案。背景声信号具有选定的声学特征。测量受试者的中枢神经系统对声音模式的暴露的电响应。测量的电响应具有表示受试者的中枢神经系统对背景声信号的电响应的第一部分，以及表示受试者的中枢神经系统对声音模式中的可听静音的电响应的第二部分。将测量的电响应的第一部分与测量的电响应的第二部分进行比较，并且基于该比较确定对象是否具有与所选择的声学特性相似的声学特征的耳鸣。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式