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1. 发明授权

US09184040B2 Abridged multipole structure for the transport and selection of ions in a vacuum system 有权
标题翻译：用于在真空系统中运输和选择离子的简化多极结构
公开(公告)号：US09184040B2
公开(公告)日：2015-11-10
申请号：US13152363
申请日：2011-06-03
申请人： Melvin Andrew Park
发明人： Melvin Andrew Park
IPC分类号： H01J49/26 , H01J49/42 , H01J49/06
CPC分类号： H01J49/421 , H01J49/063 , H01J49/4235 , H01J49/4255
摘要： An abridged multipole structure for the transport and selection of ions along a central axis in a vacuum system is constructed from a plurality of rectilinear electrode structures, each having a substantially planar face with a first dimension and a second dimension perpendicular to the first dimension. When a voltage is applied across the second dimension, an electrical potential is produced at the planar face whose amplitude is a linear function of position along the second dimension. Two electrode structures can be arranged parallel to each other with the first dimension extending along the central axis or more electrodes structures can be arranged to form multipole structures with various polygonal cross sections.
摘要翻译：用于在真空系统中沿着中心轴输送和选择离子的简单多极结构由多个直线电极结构构成，每个直线电极结构具有基本平坦的面，其具有垂直于第一维度的第一尺寸和第二尺寸。当跨越第二维度施加电压时，在平面处产生电位，其幅度是沿着第二维度的位置的线性函数。两个电极结构可以彼此平行地布置，其中第一尺寸沿着中心轴延伸，或者更多的电极结构可被布置成形成具有各种多边形横截面的多极结构。

2. 发明授权

US08942943B2 Dynamic range improvement for mass spectrometry 有权
标题翻译：动态范围改进质谱
公开(公告)号：US08942943B2
公开(公告)日：2015-01-27
申请号：US13184399
申请日：2011-07-15
申请人： Shankar Telasang
发明人： Shankar Telasang
IPC分类号： H01J49/26 , H01J49/00
CPC分类号： H01J49/0036
摘要： Embodiments of the present disclosure provide methods of controlling an ion detector to minimize false peaks when utilizing extended dynamic range techniques. In one exemplary example, methods of controlling an ion detector are provided, comprising the steps of: determining an electronic baseline signal of the ion detector; receiving one or more ion input signals at the ion detector; comparing the ion input signal to the electronic baseline signal; and multiplying the ion input signal by a selected compensation factor when the ion input signal exceeds the electronic baseline signal.
摘要翻译：本公开的实施例提供了当利用扩展的动态范围技术时控制离子检测器以最小化假峰的方法。在一个示例性示例中，提供了控制离子检测器的方法，包括以下步骤：确定离子检测器的电子基线信号; 在离子检测器处接收一个或多个离子输入信号; 将离子输入信号与电子基线信号进行比较; 并且当离子输入信号超过电子基线信号时，将离子输入信号乘以选定的补偿因子。

3. 发明授权

US08779353B2 Ion guide and electrode for its assembly 有权
标题翻译：离子导向器和电极组装
公开(公告)号：US08779353B2
公开(公告)日：2014-07-15
申请号：US13347754
申请日：2012-01-11
申请人： Stephen Zanon , Maurizio A. Splendore
发明人： Stephen Zanon , Maurizio A. Splendore
IPC分类号： H01J3/14 , B01D59/44
CPC分类号： H01J49/065 , H01J49/066
摘要： An ion guide that transports ions from an ion source at generally a high-pressure level to a mass analyzer at generally a low-pressure level has a plurality of identical electrodes fabricated with protruding elements that forming an ion tunnel or an ion funnel, when the electrodes are assembled around a common longitudinal axis. The protruding elements allow the generation of the radio frequency field necessary to radially confine ions. Each electrode may be machined from a solid block of conductive material, such as metal. The disclosed arrangement greatly simplifies the manufacturing process, reducing cost, and improving robustness and reliability of the ion guide itself.
摘要翻译：将离子通常以高压水平传输到质量分析器的离子导向器通常在低压水平下具有多个相同的电极，该电极用形成离子通道或离子漏斗的突出元件制成，电极围绕共同的纵向轴线组装。突出元件允许产生径向限制离子所需的射频场。每个电极可以由诸如金属的导电材料的固体块来加工。所公开的装置大大简化了制造过程，降低了成本，提高了离子导向器本身的鲁棒性和可靠性。

4. 发明申请

US20140061500A1 ATMOSPHERIC PRESSURE ION SOURCE WITH EXHAUST SYSTEM 有权
标题翻译：大气压离子源与排气系统
公开(公告)号：US20140061500A1
公开(公告)日：2014-03-06
申请号：US13602249
申请日：2012-09-03
申请人： Zicheng YANG , Roy P. MOELLER , Stephen ZANON
发明人： Zicheng YANG , Roy P. MOELLER , Stephen ZANON
IPC分类号： H01J27/02 , H01J27/24
CPC分类号： H01J49/044 , H01J49/165 , H01J49/168 , H01J49/24
摘要： An atmospheric pressure ion source, employing the principle of electrospray ionization, chemical ionization, or photo-ionization, comprises a spray probe for spraying a liquid into an ionization chamber and has an exhaust port through which residual spray mist and waste gas, such as evaporated solvent, are extracted. The ion source further comprises an exhaust system comprising a conduit which is connected to the exhaust port. The conduit has a transition from a first cross-section to a second cross section at a point downstream of the exhaust port wherein the second cross section is reduced in relation to the first cross section. Gas is injected via a gas injector into the conduit in a region of the transition to create a low pressure region that removes unwanted material from the chamber.
摘要翻译：使用电喷雾电离，化学电离或光电离原理的大气压离子源包括用于将液体喷射到电离室中的喷射探针，并具有排气口，残留的喷雾和废气如蒸发溶剂，萃取。离子源还包括排气系统，其包括连接到排气口的导管。导管在排气口下游的点处具有从第一横截面到第二横截面的过渡，其中第二横截面相对于第一横截面减小。气体通过气体注入器在过渡区域中被注入导管，以产生从腔室去除不需要的材料的低压区域。

5. 发明授权

US08399830B2 Means and method for field asymmetric ion mobility spectrometry combined with mass spectrometry 有权
标题翻译：用于场非对称离子迁移光谱法与质谱联用的方法和方法
公开(公告)号：US08399830B2
公开(公告)日：2013-03-19
申请号：US13115424
申请日：2011-05-25
申请人： Melvin Andrew Park , Desmond Allen Kaplan , Mark Ridgeway , Gary L. Glish
发明人： Melvin Andrew Park , Desmond Allen Kaplan , Mark Ridgeway , Gary L. Glish
IPC分类号： H01J3/14 , B01D59/44
CPC分类号： G01N27/624 , H01J49/0404 , Y10T29/49826
摘要： Analyte ions are analyzed first by field asymmetric ion mobility spectrometry (FAIMS) before being analyzed by a mass analyzer. Analyte ions are produced at near atmospheric pressure and transferred via a dielectric capillary into the vacuum system of the mass analyzer. While passing through the capillary, the ions are analyzed by FAIMS via electrodes on the interior wall of the capillary. Improved ion transmission is achieved by providing smooth geometric transitions between the channel in FAIMS analyzer and the channel in the remainder of the capillary.
摘要翻译：首先通过场不对称离子迁移谱（FAIMS）分析分析离子，然后通过质谱仪进行分析。分析离子在接近大气压下产生，并通过介电毛细管转移到质量分析仪的真空系统中。当通过毛细管时，通过FAIMS通过毛细管内壁上的电极分析离子。通过在FAIMS分析仪中的通道和毛细管剩余部分中的通道之间提供平滑的几何过渡来实现改进的离子透过。

6. 发明申请

US20130018621A1 Dynamic Range Improvement For Mass Spectrometry 有权
标题翻译：动态范围改进质谱法
公开(公告)号：US20130018621A1
公开(公告)日：2013-01-17
申请号：US13184399
申请日：2011-07-15
申请人： Shankar Telasang
发明人： Shankar Telasang
IPC分类号： G06F19/00 , H01J49/26
CPC分类号： H01J49/0036
摘要： Embodiments of the present disclosure provide methods of controlling an ion detector to minimize false peaks when utilizing extended dynamic range techniques. In one exemplary example, methods of controlling an ion detector are provided, comprising the steps of: determining an electronic baseline signal of the ion detector; receiving one or more ion input signals at the ion detector; comparing the ion input signal to the electronic baseline signal; and multiplying the ion input signal by a selected compensation factor when the ion input signal exceeds the electronic baseline signal.
摘要翻译：本公开的实施例提供了当利用扩展的动态范围技术时控制离子检测器以最小化假峰的方法。在一个示例性示例中，提供了控制离子检测器的方法，包括以下步骤：确定离子检测器的电子基线信号; 在离子检测器处接收一个或多个离子输入信号; 将离子输入信号与电子基线信号进行比较; 并且当离子输入信号超过电子基线信号时，将离子输入信号乘以选定的补偿因子。

7. 发明申请

US20130015343A1 Radio Frequency Voltage Temperature Stabilization 有权
标题翻译：射频电压温度稳定
公开(公告)号：US20130015343A1
公开(公告)日：2013-01-17
申请号：US13184278
申请日：2011-07-15
申请人： Urs Steiner , Lawrence B. Jones
发明人： Urs Steiner , Lawrence B. Jones
IPC分类号： H01J49/36
CPC分类号： H01J49/022 , G01R19/0084
摘要： A temperature-regulated radio frequency management system for use in a mass spectrometer is described. The temperature-regulated radio frequency management system having one or more radio frequency components disposed in a vacuum environment. The temperature-regulated radio frequency management system including a radio frequency detection circuit configured to provide feedback indicative of a radio frequency signal in one or more of the radio frequency components. In addition, the temperature-regulated radio frequency management system includes a temperature regulation circuit disposed in the vacuum environment and configured to reduce temperature-induced variations in the detection circuit.
摘要翻译：描述了用于质谱仪的温度调节射频管理系统。具有设置在真空环境中的一个或多个射频分量的温度调节射频管理系统。该温度调节射频管理系统包括射频检测电路，该射频检测电路被配置为提供一个或多个射频分量中指示射频信号的反馈。此外，温度调节射频管理系统包括设置在真空环境中并被配置为降低检测电路中的温度引起的变化的温度调节电路。

8. 发明申请

US20120298860A1 MEANS AND METHOD FOR FIELD ASYMMETRIC ION MOBILITY SPECTROMETRY COMBINED WITH MASS SPECTROMETRY 有权
标题翻译：用于质谱分析的场非对称离子电离光谱的方法和方法
公开(公告)号：US20120298860A1
公开(公告)日：2012-11-29
申请号：US13115424
申请日：2011-05-25
申请人： Melvin Andrew PARK , Desmond Allen KAPLAN , Mark RIDGEWAY , Gary L. GLISH
发明人： Melvin Andrew PARK , Desmond Allen KAPLAN , Mark RIDGEWAY , Gary L. GLISH
IPC分类号： H01J49/26 , B23P11/00
CPC分类号： G01N27/624 , H01J49/0404 , Y10T29/49826
摘要： Analyte ions are analyzed first by field asymmetric ion mobility spectrometry (FAIMS) before being analyzed by a mass analyzer. Analyte ions are produced at near atmospheric pressure and transferred via a dielectric capillary into the vacuum system of the mass analyzer. While passing through the capillary, the ions are analyzed by FAIMS via electrodes on the interior wall of the capillary. Improved ion transmission is achieved by providing smooth geometric transitions between the channel in FAIMS analyzer and the channel in the remainder of the capillary.
摘要翻译：首先通过场不对称离子迁移谱（FAIMS）分析分析离子，然后通过质谱仪进行分析。分析离子在接近大气压下产生，并通过介电毛细管转移到质量分析仪的真空系统中。当通过毛细管时，通过FAIMS通过毛细管内壁上的电极分析离子。通过在FAIMS分析仪中的通道和毛细管剩余部分中的通道之间提供平滑的几何过渡来实现改进的离子透过。

9. 发明授权

US07277799B2 Isotope correlation filter for mass spectrometry 有权
标题翻译：用于质谱的同位素相关滤波器
公开(公告)号：US07277799B2
公开(公告)日：2007-10-02
申请号：US11055530
申请日：2005-02-09
申请人： Melvin A. Park
发明人： Melvin A. Park
IPC分类号： G06F19/00 , H01J49/26
CPC分类号： H01J49/0036
摘要： The present invention relates generally to mass spectrometry and the analysis of chemical samples, and more particularly to methods for processing data obtained therefrom. Disclosed is an improved method for filtering low intensity mass spectral data. More specifically, the invention provides a method for use with digitized mass spectra that facilitates the distinction between low level signals and noise using the correlation of signals therein based on their mass differences.
摘要翻译：本发明一般涉及质谱和化学样品的分析，更具体地涉及用于处理从其获得的数据的方法。公开了一种用于过滤低强度质谱数据的改进方法。更具体地，本发明提供一种使用数字化质谱的方法，其有助于根据其质量差使用其中的信号的相关性来区分低电平信号和噪声。

10. 发明授权

US07126118B2 Method and apparatus for multiple frequency multipole 有权
公开(公告)号：US07126118B2
公开(公告)日：2006-10-24
申请号：US11166038
申请日：2005-06-24
申请人： Melvin A. Park
发明人： Melvin A. Park
IPC分类号： B01D59/44
CPC分类号： H01J49/4225 , H01J49/063 , H01J49/065 , H01J49/4255
摘要： The invention relates to a means and a method for the manipulation of ions. Specifically, the invention teaches a multipole device consisting of a multitude of electrodes which are of such a geometry that the proper application of RF and DC potentials between the electrodes will result in the transmission of a broad range of m/z ions through the device. The electrodes may be arranged in such a way that it also can be operated so as to select a narrow range of m/z ions for transmission through the device.

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