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1. 发明申请

US20220111389A1 SAMPLE PREPARATION DEVICE 有权
公开(公告)号：US20220111389A1
公开(公告)日：2022-04-14
申请号：US17515959
申请日：2021-11-01
申请人： ALERE SAN DIEGO, INC. , ALERE SWITZERLAND GMBH
发明人： Daniel Nicholas HAWORTH , John Paul PALMER-FELGATE
IPC分类号： B01L3/00 , F04B9/14 , G01N30/20 , B01J20/281 , F04B53/10 , B01L3/02 , F04B13/00 , G01N1/14 , G01N1/40 , F04B9/12 , G01N30/14 , B01D15/12 , B01D15/34 , C12Q1/6844 , G01N30/02 , G01N30/00
摘要： A manually actuated chromatography device comprising a chamber for receiving a liquid sample, a pump with a metering valve, and a chromatography element, wherein the pump moves a predetermined volume of liquid from the sample chamber to the chromatography element.

2. 发明授权

US10107720B2 Detection device and method of using the same 有权
公开(公告)号：US10107720B2
公开(公告)日：2018-10-23
申请号：US13389433
申请日：2010-08-13
申请人： Christopher Tarpey , Mary Catherine Parsons , Lijian Gou , Haipeng Hu , Fei Gao , Yinfei Wu
发明人： Christopher Tarpey , Mary Catherine Parsons , Lijian Gou , Haipeng Hu , Fei Gao , Yinfei Wu
IPC分类号： G01N21/00 , G01N1/10 , G01N33/493 , G01N1/02 , G01N33/487
摘要： A detection device (100) comprises a detecting chamber (32) containing a detecting element for analyzing whether a specimen containing an analyte, and an indicating element (8) displaying whether the detection is activated. The method for using the detection device (100) is also disclosed.

3. 发明授权

US08617907B2 Determining the presence or amount of a metal-labelled species 有权
标题翻译：确定金属标记物种的存在或数量
公开(公告)号：US08617907B2
公开(公告)日：2013-12-31
申请号：US11570174
申请日：2005-06-07
申请人： Brian Jeffrey Birch , Camilla Sofia Forssten , Alena Kabil , Robert Andrew Porter
发明人： Brian Jeffrey Birch , Camilla Sofia Forssten , Alena Kabil , Robert Andrew Porter
IPC分类号： G01N33/553
CPC分类号： G01N33/5438 , G01N33/54313
摘要： A method for determining the presence or amount of a metal-labelled species in a sample may include causing the metal of the metal-labelled species in the sample to form a soluble electrochemically-active complex which is stable relative to moieties present or potentially present in the sample which will form an insoluble and/or electrochemically-inactive complex with the metal, and electrochemically measuring the formed complex to provide an indication of the presence or amount of the metal-labelled species.
摘要翻译：用于确定样品中金属标记物质的存在或量的方法可以包括使样品中的金属标记物质的金属形成可溶的电化学活性复合物，其相对于存在或可能存在于将与金属形成不溶性和/或电化学非活性复合物的样品，以及电化学测量形成的络合物以提供金属标记物质的存在或量的指示。

4. 发明授权

US08486353B2 Sample collection cup with integrated activatable sample analysis system 有权
标题翻译：样品收集杯具有集成的可激活的样品分析系统
公开(公告)号：US08486353B2
公开(公告)日：2013-07-16
申请号：US11845346
申请日：2007-08-27
申请人： Yuzhang Wu , Lijiang Guo , Jeilin Dai , Hsiaoho Tung
发明人： Yuzhang Wu , Lijiang Guo , Jeilin Dai , Hsiaoho Tung
IPC分类号： B01L3/00
CPC分类号： A61B10/0096 , A61B10/007 , B01L3/502 , B01L3/5023 , B01L2200/141 , B01L2300/042 , B01L2300/047 , B01L2300/048 , B01L2300/0663 , B01L2300/0832 , B01L2300/0864 , B01L2400/0644 , G01N33/49 , G01N33/493
摘要： Medical and environmental diagnostic devices are described and claimed. Preferred embodiments feature cup (1) within cup configurations wherein one cup is dedicated, for the most part, to sample collection and another cup (2) is dedicated, for the most part, to assay performance. Communication between the cups is afforded by what is believed to be a unique valve assembly (3) and lid (7) tandem.
摘要翻译：描述和要求保护医疗和环境诊断装置。优选的实施方案在杯配置中具有杯（1），其中一个杯专用于大部分样品收集，另一个杯（2）主要用于测定性能。杯子之间的通信由被认为是独特的阀组件（3）和盖（7）串联提供。

5. 发明申请

US20130029350A1 BI-STABLE OSCILLATOR 有权
标题翻译：双稳态振荡器
公开(公告)号：US20130029350A1
公开(公告)日：2013-01-31
申请号：US13574135
申请日：2011-01-19
申请人： Matthew Cooper , Alexander Sleptsov , Richard John Hammond
发明人： Matthew Cooper , Alexander Sleptsov , Richard John Hammond
IPC分类号： G01N27/00 , G01N33/48
CPC分类号： H03B5/32 , G01N29/022 , G01N2291/02466
摘要： In accordance with the present invention there is provided a bi-stable oscillator circuit for detecting a load imparted to a surface. The bi-stable oscillator comprises an electrical amplifier, at least one resonator comprising an electrical transducer having a resonant frequency, a surface of the resonator forming the surface on which the load is to be detected and an impedance network having a resonant frequency. The resonator is arranged to be exposed to an environment under test, and the resonator and the impedance network are connected in parallel with the electrical amplifier such that when a load imparted to the surface exceeds a pre-determined threshold value the oscillator circuit oscillates at the resonant frequency of the impedance network and when a load imparted to the surface is less than the threshold value the oscillator circuit oscillates at the resonant frequency of the resonator, switching of the circuit oscillation frequency being indicative of the load crossing the predetermined threshold value.
摘要翻译：根据本发明，提供一种用于检测施加到表面的负载的双稳态振荡器电路。所述双稳态振荡器包括电放大器，至少一个谐振器包括具有谐振频率的电变换器，谐振器的形成要在其上检测负载的表面的表面和具有谐振频率的阻抗网络。谐振器被布置为暴露于被测环境，并且谐振器和阻抗网络与电放大器并联连接，使得当施加到表面的负载超过预定阈值时，振荡器电路在阻抗网络的谐振频率和施加到表面的负载小于阈值时，振荡器电路以共振器的谐振频率振荡，电路振荡频率的切换指示负载超过预定阈值的负载。

6. 发明授权

US08193002B2 Lateral flow immunoassay controls 有权
标题翻译：侧流免疫测定对照
公开(公告)号：US08193002B2
公开(公告)日：2012-06-05
申请号：US12262079
申请日：2008-10-30
申请人： Huiyan Guo , Min Wang , Tao Shang , Hui-Kang Chen , Fei Gao
发明人： Huiyan Guo , Min Wang , Tao Shang , Hui-Kang Chen , Fei Gao
IPC分类号： G01N33/53
CPC分类号： G01N33/521 , Y10S436/808 , Y10S436/81
摘要： Rapid lateral flow immunoassays have an extensive history of use in both the clinical and home settings. These devices are used to test for a variety of analytes, such as drugs of abuse, hormones, proteins, urine or plasma components and the like. The present invention provides an improved procedural control that indicates to the test user that at least a portion of the applied sample has passed through the test result zone of the test strip, and optionally that the test is complete and the test results may be read.
摘要翻译：快速侧流免疫测定在临床和家庭环境中具有广泛的应用历史。这些装置用于测试各种分析物，例如滥用药物，激素，蛋白质，尿液或血浆成分等。本发明提供了一种改进的程序控制，其向测试用户指示所应用样品的至少一部分已经通过测试条的测试结果区域，并且可选地，测试完成并且可以读取测试结果。

7. 发明申请

US20110165024A1 DEVICES AND METHODS FOR DETECTING ANALYTES IN FLUID SAMPLES 审中-公开
标题翻译：用于检测流体样品中分析物的装置和方法
公开(公告)号：US20110165024A1
公开(公告)日：2011-07-07
申请号：US13050671
申请日：2011-03-17
申请人： Yuzhang Wu , Yun Ling , Jielin Dai
发明人： Yuzhang Wu , Yun Ling , Jielin Dai
IPC分类号： G01N33/487
CPC分类号： B01L3/5023 , B01L3/5029 , B01L2200/027 , B01L2300/0663 , G01N2035/00108
摘要： A device for detecting the presence or amount of an analyte in a fluid sample and method thereof, comprises a sample collector and a receiving cup for receiving and holding the sample collector within the receiving cup. The sample collector contains a compressible absorbent member for collecting the fluid sample, and has a first position and a second, locked position within the receiving cup. The absorbent member is uncompressed in the first position and is compressed in the second, locked position. The sample collector or the receiving cup has at least one test element having reagents for detecting the presence or amount of the analyte in the fluid sample.
摘要翻译：用于检测流体样品中分析物的存在或量的装置及其方法包括样品收集器和接收杯，用于将样品收集器接收并保持在接收杯内。样品收集器包含用于收集流体样品的可压缩吸收件，并且在接收杯内具有第一位置和第二锁定位置。吸收体在第一位置未被压缩并在第二锁定位置被压缩。样品收集器或接收杯具有至少一个具有用于检测流体样品中分析物的存在或量的试剂的测试元件。

8. 发明授权

US07879624B2 Assay device with shared zones 有权
标题翻译：具有共享区域的分析设备
公开(公告)号：US07879624B2
公开(公告)日：2011-02-01
申请号：US12199284
申请日：2008-08-27
申请人： Stephen Paul Sharrock
发明人： Stephen Paul Sharrock
IPC分类号： G01N33/53
CPC分类号： G01N33/558 , G01N21/6428 , G01N21/76 , G01N21/8483 , G01N33/54366 , G01N33/545 , G01N33/76 , G01N2021/6439 , G01N2201/062 , G01N2201/12 , G01N2458/00 , Y10S435/808 , Y10S436/805
摘要： Disclosed is an assay device for determining the presence and/or extent of one or more analytes in liquid sample containing a) first and second assays each comprising a flow-path having a detection zone for immobilising a labelled binding reagent, wherein detection of a labelled binding reagent at one or both detection zones is indicative of the presence and/or extent of one or more analytes; b) a shared reference zone; c) one or more light sources to illuminate the detection zones and the reference zone; d) one or more photodetectors to detect light from the detection zones and the reference zone, which photodetector/s generate a signal, the magnitude of which signal is related to the amount of light detected; and e) signal processing means for processing signals from the photodetector/s.
摘要翻译：公开了一种用于确定液体样品中一种或多种分析物的存在和/或程度的测定装置，其包含a）第一和第二测定，每个测定包括具有用于固定标记的结合试剂的检测区的流路，其中检测标记在一个或两个检测区域的结合试剂指示一种或多种分析物的存在和/或程度; b）共享参考区; c）一个或多个光源照射检测区域和参考区域; d）一个或多个光电检测器，用于检测来自检测区域和参考区域的光，该光电检测器产生信号，该信号的大小与检测到的光量有关; 以及e）用于处理来自光电检测器的信号的信号处理装置。

9. 发明授权

US09352312B2 System and apparatus for reactions 有权
标题翻译：系统和反应装置
公开(公告)号：US09352312B2
公开(公告)日：2016-05-31
申请号：US13242999
申请日：2011-09-23
申请人： Simon Roderick Grover , Paul Graham Wilkins , Nick David Rollings , Peter Laurence Mayne , Wai Ting Chan , Natalie Frances Scott , Olivier Fernand Flick , Henry Charles Innes , Martyn Gray Darnbrough Beedham , Nicholas David Long , Richard John Hammond
发明人： Simon Roderick Grover , Paul Graham Wilkins , Nick David Rollings , Peter Laurence Mayne , Wai Ting Chan , Natalie Frances Scott , Olivier Fernand Flick , Henry Charles Innes , Martyn Gray Darnbrough Beedham , Nicholas David Long , Richard John Hammond
IPC分类号： G01N1/28 , B01L3/02 , B01L3/00 , A61J1/20
CPC分类号： B01L3/0217 , A61J1/2096 , B01L3/502 , B01L2200/025 , B01L2200/026 , B01L2200/16 , B01L2300/025 , B01L2400/0478 , Y10T436/2575
摘要： This disclosure provides systems, apparatuses, and methods for liquid transfer and performing reactions. In one aspect, a system includes a liquid transfer device having a housing having a pipette tip and a plunger assembly; and a reaction chamber, wherein the housing of the liquid transfer device is configured to sealably engage with the reaction chamber. In another aspect, a liquid transfer device including a housing having a pipette tip; and a plunger assembly disposed within the housing and the pipette tip, wherein a portion of the plunger assembly is configured to engage a fluid reservoir such that the plunger assembly remains stationary relative to the fluid reservoir and the housing moves relative to the plunger assembly.
摘要翻译：本公开提供了用于液体转移和执行反应的系统，装置和方法。在一个方面，一种系统包括具有具有移液管末端和柱塞组件的壳体的液体转移装置; 以及反应室，其中液体输送装置的壳体构造成与反应室密封地接合。在另一方面，一种液体转移装置，包括具有移液管尖端的壳体; 以及设置在所述壳体和所述移液管尖端内的柱塞组件，其中所述柱塞组件的一部分被配置成接合流体容器，使得所述柱塞组件相对于所述流体容器保持静止并且所述壳体相对于所述柱塞组件移动。

10. 发明授权

US09151749B2 Assay device comprising bubble-forming means 有权
标题翻译：包含气泡形成装置的测定装置
公开(公告)号：US09151749B2
公开(公告)日：2015-10-06
申请号：US12937465
申请日：2009-04-09
申请人： Balbir Raj
发明人： Balbir Raj , David Tolley
IPC分类号： C12Q1/00 , G01N33/543 , B01L3/00 , G01N33/58
CPC分类号： G01N33/54366 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2300/025 , B01L2300/0816 , B01L2400/0406 , B01L2400/046 , B01L2400/0622 , G01N33/581 , G01N2333/59 , G01N2333/908
摘要： Disclosed is a method for determining the presence and/or amount Oran analyte of interest in a liquid sample comprising the steps of: contacting the liquid sample suspected of containing analyte with a gas generating means (eg. catalase and peracid or peroxygen compound), which gas generating means forms a gas dependent upon the presence, absence or amount of analyte, which gas creates one or more bubbles in the liquid sample which act to alter the flow of liquid along a flow path; and determining an alteration of flow in the liquid wherein the alteration of flow of liquid along the flow path is indicative of the presence and/or amount of analyte in the liquid sample.
摘要翻译：公开了一种用于确定液体样品中目标的存在和/或量Oran分析物的方法，包括以下步骤：将怀疑含有分析物的液体样品与气体产生装置（例如过氧化氢酶和过酸或过氧化合物）接触，气体发生装置根据分析物的存在，不存在或数量形成气体，该气体在液体样品中产生一个或多个气泡，其用于改变液体沿着流动路径的流动; 以及确定液体中的流动的改变，其中沿着流动路径的液体流动的改变指示液体样品中分析物的存在和/或量。

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