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1. 发明授权

US11782058B2 Diagnostic test system using measurement obtained from reference feature to modify operational parameter of reader 有权
公开(公告)号：US11782058B2
公开(公告)日：2023-10-10
申请号：US16257537
申请日：2019-01-25
申请人： Alverix, Inc.
发明人： Patrick T. Petruno , John Francis Petrilla , Michael J. Brosnan , Rong Zhou , Daniel B. Roitman , Bo U. Curry
IPC分类号： G01N33/53 , G01N33/558 , G01N21/62 , G01N21/63 , G01N21/64 , G01N21/84 , G01N21/17 , G01N21/27 , G01N33/543 , G01N33/58
CPC分类号： G01N33/54388 , G01N21/17 , G01N21/274 , G01N21/6428 , G01N21/8483 , G01N33/54393 , G01N33/558 , G01N33/58 , G01N2021/6439 , G01N2201/062 , G01N2201/067 , Y10S435/805 , Y10S435/823 , Y10S436/807 , Y10S436/809 , Y10S436/81 , Y10S436/823 , Y10T436/25125
摘要： A diagnostic test system includes a housing, a reader, and a data analyzer. The housing includes a port constructed and arranged to receive a test strip that includes a flow path for a fluid sample, a sample receiving zone couple to the flow path, a label that specifically binds a target analyte, a detection zone coupled to the flow path and comprising a test region exposed for optical inspection and having an immobilized test reagent that specifically binds the target analyte, and at least one reference feature. The reader is operable to obtain light intensity measurements from exposed regions of the test strip when the test strip is loaded in the port. The data analyzer is operable to perform operations including at least one of (a) identifying ones of the light intensity measurements obtained from the test region based on at least one measurement obtained from the at least one reference feature, and (b) generating a control signal modifying at least one operational parameter of the reader based on at least one measurement obtained from the at least one reference feature.

2. 发明授权

US11243209B2 Method of using differential measurement in two or more channels to improve sensitivity 有权
公开(公告)号：US11243209B2
公开(公告)日：2022-02-08
申请号：US16008891
申请日：2018-06-14
申请人： Alverix, Inc.
发明人： Bo U. Curry , Rene B. Helbing
IPC分类号： G01N33/58 , G01N35/00 , G01N21/00 , G01N21/76 , G01N33/558
摘要： A method to calibrate measurements of a test analyte in a test sample including measuring at least one test-light level responsive to reactions of at least one reagent group and at least one reactive test analyte in the test sample and measuring at least one control-light level responsive to reactions of at least one reagent group and at least one control analyte in a control sample. Each control analyte is a known amount of at least one reactive test analyte. The method further includes determining a presence of the reactive test analyte in the test sample based on the measured test-light levels and control-light levels. The reagent group and the reactive test analyte react by attaching to each other.

3. 发明授权

US10041941B2 Assay test strips with multiple labels and reading same 有权
公开(公告)号：US10041941B2
公开(公告)日：2018-08-07
申请号：US12410178
申请日：2009-03-24
申请人： Patrick T. Petruno , John F. Petrilla , Michael J. Brosnan , Rong Zhou , Daniel B. Roitman
发明人： Patrick T. Petruno , John F. Petrilla , Michael J. Brosnan , Rong Zhou , Daniel B. Roitman
IPC分类号： G01N33/558 , G01N33/58 , G01N21/77 , G01N35/00
摘要： In one aspect, an assay test strip includes a test label that specifically binds a target analyte and a control label that is free of any specific binding affinity for the target analyte and has a different optical characteristic than the test label. In another aspect, an assay test strip includes a test label that specifically binds a target analyte and at least one non-specific-binding label that is free of any specific binding affinity for the target analyte. Systems and methods of reading assay test strips also are described.

4. 发明授权

US10001486B2 Method of using differential measurement in two or more channels to improve sensitivity 有权
公开(公告)号：US10001486B2
公开(公告)日：2018-06-19
申请号：US11500626
申请日：2006-08-08
申请人： Bo U. Curry , Rene P. Helbing
发明人： Bo U. Curry , Rene P. Helbing
IPC分类号： C12Q1/00 , C12Q1/68 , G06F19/00 , G01N33/58 , G01N33/558
CPC分类号： G01N33/582 , G01N33/558
摘要： A method to calibrate measurements of a test analyte in a test sample including measuring at least one test-light level responsive to reactions of at least one reagent group and at least one reactive test analyte in the test sample and measuring at least one control-light level responsive to reactions of at least one reagent group and at least one control analyte in a control sample. Each control analyte is a known amount of at least one reactive test analyte. The method further includes determining a presence of the reactive test analyte in the test sample based on the measured test-light levels and control-light levels. The reagent group and the reactive test analyte react by attaching to each other.

5. 发明授权

US09165357B2 Methods for determining a wavefront position on a test strip 有权
标题翻译：确定测试条上波前位置的方法
公开(公告)号：US09165357B2
公开(公告)日：2015-10-20
申请号：US13804248
申请日：2013-03-14
申请人： Alverix, Inc.
发明人： Scott Dylewski
IPC分类号： G01F1/708 , G06T7/00 , G01N21/84 , G01N21/78
CPC分类号： G06T7/0012 , G01F1/7086 , G01N21/78 , G01N21/8483
摘要： The present disclosure relates to methods for determining a wavefront position of a liquid on a surface of an assay test strip placing a liquid on the surface of the test strip; and acquiring one or more signals from the surface of the test strip at one or more times, comparing the one or more acquired signals to a threshold, wherein the wavefront position is a position on the surface of the test strip where a signal is greater than or less than a threshold (e.g., fixed or dynamic threshold). Such methods may be used to determine the wavefront velocity of a liquid on a surface of an assay test strip and the transit time of a liquid sample to traverse the one or more positions on the surface of the assay test strip.
摘要翻译：本公开涉及用于确定在测试条的表面上放置液体的测定试纸的表面上的液体的波前位置的方法; 以及一次或多次从所述测试条的表面获取一个或多个信号，将所述一个或多个获取的信号与阈值进行比较，其中所述波前位置是所述测试条的表面上的位置，其中信号大于或小于阈值（例如，固定或动态阈值）。这样的方法可以用于确定测定试纸的表面上的液体的波前速度和液体样品穿过测定测试条的表面上的一个或多个位置的通过时间。

6. 发明授权

US08692873B2 Video-frame data receiver with low frame capture rate 有权
标题翻译：具有低帧捕获率的视频帧数据接收机
公开(公告)号：US08692873B2
公开(公告)日：2014-04-08
申请号：US12354134
申请日：2009-01-15
申请人： Stephan Hengstler
发明人： Stephan Hengstler
IPC分类号： H04N7/18
CPC分类号： H04N5/04 , G06F19/00 , G06F19/36 , G16H10/20 , H04N5/225 , H04N5/2353 , H04N5/2625 , H04N17/002
摘要： The present disclosure relates generally to a video frame data receiver that is capable of image acquisition at low frame rates. Such video frame data receivers may be used to capture images from diagnostic tests or assays in which lower frame capture rates are sufficient including, for example, lateral flow test strips.
摘要翻译：本公开一般涉及能够以低帧速率进行图像采集的视频帧数据接收机。这样的视频帧数据接收器可用于从诊断测试或测定中捕获图像，其中较低帧捕获速率是足够的，包括例如横向流测试条。

7. 发明申请

US20130196345A1 METHODS FOR DETERMINING A WAVEFRONT POSITION ON A TEST STRIP 审中-公开
公开(公告)号：US20130196345A1
公开(公告)日：2013-08-01
申请号：US13804284
申请日：2013-03-14
申请人： Alverix, Inc.
发明人： Scott Dylewski
IPC分类号： G01N21/78
CPC分类号： G06T7/0012 , G01F1/7086 , G01N21/78 , G01N21/8483
摘要： The present disclosure relates to methods for determining a wavefront position of a liquid on a surface of an assay test strip placing a liquid on the surface of the test strip; and acquiring one or more signals from the surface of the test strip at one or more times, comparing the one or more acquired signals to a threshold, wherein the wavefront position is a position on the surface of the test strip where a signal is greater than or less than a threshold (e.g., fixed or dynamic threshold). Such methods may be used to determine the wavefront velocity of a liquid on a surface of an assay test strip and the transit time of a liquid sample to traverse the one or more positions on the surface of the assay test strip.

8. 发明申请

US20090180928A1 ASSAY TEST STRIPS WITH MULTIPLE LABELS AND READING SAME 审中-公开
标题翻译：具有多个标签和阅读的测试条
公开(公告)号：US20090180928A1
公开(公告)日：2009-07-16
申请号：US12410178
申请日：2009-03-24
申请人： Patrick T. Petruno , John F. Petrilla , Michael J. Brosnan , Rong Zhou , Daniel B. Roitman
发明人： Patrick T. Petruno , John F. Petrilla , Michael J. Brosnan , Rong Zhou , Daniel B. Roitman
IPC分类号： G01N31/22 , B82B1/00
CPC分类号： G01N33/558 , G01N33/582 , G01N2021/7786 , G01N2035/00108
摘要： In one aspect, an assay test strip includes a test label that specifically binds a target analyte and a control label that is free of any specific binding affinity for the target analyte and has a different optical characteristic than the test label. In another aspect, an assay test strip includes a test label that specifically binds a target analyte and at least one non-specific-binding label that is free of any specific binding affinity for the target analyte. Systems and methods of reading assay test strips also are described.
摘要翻译：在一个方面，分析测试条包括特异性结合目标分析物的测试标签和对目标分析物没有任何特异性结合亲和力并且具有与测试标记不同的光学特性的对照标记。在另一方面，测定试片包括特异性结合目标分析物和至少一种对目标分析物没有任何特异性结合亲和力的非特异性结合标记的测试标记。还描述了读取测定条带的系统和方法。

9. 发明授权

US07459317B2 Method for detecting an analyte in a sample 有权
标题翻译：检测样品中分析物的方法
公开(公告)号：US07459317B2
公开(公告)日：2008-12-02
申请号：US11734317
申请日：2007-04-12
申请人： Daniel B. Roitman
发明人： Daniel B. Roitman
IPC分类号： G01N33/543
CPC分类号： G01N33/54306 , G01N33/581 , G01N33/582 , G01N2458/30
摘要： Methods for detecting the presence of an analyte in a sample are provided. Aspects of the methods include mixing a sample with an indirectly-detectable labeled binding member that includes a label moiety. The mixing produces a first composition. Unbound labeled binding member is then separated from any resultant binding complexes to produce a second composition that includes the binding complexes. A second light emitted by a light wavelength converter that is excited by a first light generated by the labeled binding member of the binding complexes of the second composition is then detected to detect the presence of the analyte in the sample. Embodiments also include kits and systems that find use in practicing the subject methods.
摘要翻译：提供了用于检测样品中分析物的存在的方法。方法的方面包括将样品与包含标记部分的间接可检测的标记结合成员混合。混合产生第一组合物。然后将未结合的标记结合成员与任何所得的结合复合物分离，以产生包含结合复合物的第二组合物。然后检测由光波长转换器发射的由第二组合物的结合复合物的标记结合成员产生的第一光激发的第二光，以检测样品中分析物的存在。实施例还包括用于实践主题方法的套件和系统。

10. 发明授权

US12025617B2 Method of using differential measurement in two or more channels to improve sensitivity 有权
公开(公告)号：US12025617B2
公开(公告)日：2024-07-02
申请号：US17592946
申请日：2022-02-04
申请人： Alverix, Inc.
发明人： Bo U. Curry , Rene B. Helbing
IPC分类号： G01N33/58
CPC分类号： G01N33/582
摘要： A method to calibrate measurements of a test analyte in a test sample including measuring at least one test-light level responsive to reactions of at least one reagent group and at least one reactive test analyte in the test sample and measuring at least one control-light level responsive to reactions of at least one reagent group and at least one control analyte in a control sample. Each control analyte is a known amount of at least one reactive test analyte. The method further includes determining a presence of the reactive test analyte in the test sample based on the measured test-light levels and control-light levels. The reagent group and the reactive test analyte react by attaching to each other.

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