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1. 发明授权

US07521047B2 Human polypeptides causing or leading to the killing of cells including lymphoid tumor cells 失效
标题翻译：引起或导致包括淋巴样肿瘤细胞杀死细胞的人多肽
公开(公告)号：US07521047B2
公开(公告)日：2009-04-21
申请号：US10001934
申请日：2001-11-15
申请人： Zoltan Nagy , Christoph Brunner , Michael Tesar , Elisabeth Thomassen-Wolf , Robert Rauchenberger
发明人： Zoltan Nagy , Christoph Brunner , Michael Tesar , Elisabeth Thomassen-Wolf , Robert Rauchenberger
IPC分类号： A31K39/395 , C07K16/00 , C07K16/28 , C07K16/30 , C07K16/46
CPC分类号： C07K16/2833 , A61K2039/505 , C07K2317/21 , C07K2317/31 , C07K2317/55 , C07K2317/565 , C07K2317/622
摘要： The present invention relates to polypeptide compositions which bind to cell surface epitopes and, in multivalent forms, cause or lead to the killing of cells including lymphoid tumor cells, and in the case of monovalent forms, cause immunosuppression or otherwise inhibit activation of lymphocytes. The invention further relates to nucleic acids encoding the polypeptides, methods for the production of the polypeptides, methods for killing cells, methods for immunosuppressing a patient, pharmaceutical, diagnostic and multivalent compositions and kits comprising the polypeptides and uses of the polypeptides.
摘要翻译：本发明涉及结合细胞表面表位并以多价形式引起或导致包括淋巴样肿瘤细胞在内的细胞杀伤的多肽组合物，并且在单价形式的情况下，引起免疫抑制或以其它方式抑制淋巴细胞的活化。本发明还涉及编码多肽的核酸，多肽的制备方法，杀死细胞的方法，用于免疫抑制患者的方法，药物，诊断和多价组合物以及包含该多肽的多肽和多肽用途的试剂盒。

2. 发明申请

US20090325290A1 Human polypeptides causing or leading to the killing of cells including lymphoid tumor cells 审中-公开
公开(公告)号：US20090325290A1
公开(公告)日：2009-12-31
申请号：US12386568
申请日：2009-04-20
申请人： Zoltan Nagy , Christoph Brunner , Michael Tesar , Elisabeth Thomassen Wolf , Robert Rauchenberger
发明人： Zoltan Nagy , Christoph Brunner , Michael Tesar , Elisabeth Thomassen Wolf , Robert Rauchenberger
IPC分类号： C07H21/04 , C12N15/63 , C12N5/10
CPC分类号： C07K16/2833 , A61K2039/505 , C07K2317/21 , C07K2317/31 , C07K2317/55 , C07K2317/565 , C07K2317/622
摘要： The present invention relates to polypeptide compositions which bind to cell surface epitopes and, in multivalent forms, cause or lead to the killing of cells including lymphoid tumor cells, and in the case of monovalent forms, cause immunosuppression or otherwise inhibit activation of lymphocytes. The invention further relates to nucleic acids encoding the polypeptides, methods for the production of the polypeptides, methods for killing cells, methods for immunosuppressing a patient, pharmaceutical, diagnostic and multivalent compositions and kits comprising the polypeptides and uses of the polypeptides.

3. 发明申请

US20120189622A1 ANTI-CD38 HUMAN ANTIBODIES AND USES THEREOF 审中-公开
标题翻译：抗CD38人类抗体及其用途
公开(公告)号：US20120189622A1
公开(公告)日：2012-07-26
申请号：US13427305
申请日：2012-03-22
申请人： Michael Tesar , Ute Jager
发明人： Michael Tesar , Ute Jager
IPC分类号： A61K39/395 , C12N15/13 , C12N15/63 , A61P19/02 , C12N1/19 , C12N1/21 , A61P35/02 , A61P29/00 , C07K16/28 , C12N5/10
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/005 , C07K16/3061 , C07K16/40 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/732 , C07K2317/734 , C07K2317/74 , C07K2317/92 , C07K2319/30 , C12N9/2497 , C12Y302/02024
摘要： The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for CD38, which plays an integral role in various disorders or conditions. These antibodies, accordingly, can be used to treat, for example, hematological malignancies such as multiple myeloma. Antibodies of the invention also can be used in the diagnostics field, as well as for investigating the role of CD38 in the progression of disorders associated with malignancies. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use. The invention also provides isolated novel epitopes of CD38 and methods of use therefore.
摘要翻译：本发明提供重组抗原结合区和抗体以及含有CD38特异性抗原结合区的功能片段，其在各种病症或病症中起积分作用。因此，这些抗体可用于治疗例如血液恶性肿瘤例如多发性骨髓瘤。本发明的抗体也可用于诊断领域，以及用于研究CD38在恶性肿瘤相关疾病进展中的作用。本发明还提供了编码前述抗体的核酸序列，含有该抗体的载体，药物组合物和具有使用说明书的试剂盒。本发明还提供CD38的分离的新型表位和因此使用的方法。

4. 发明申请

US20090123950A1 Generation And Profiling Of Fully Human Hucal Gold®-Derived Therapeutic Antibodies Specific For Human CD38 审中-公开
标题翻译：全人类Hucal Gold（R） - 针对人类CD38特异性的治疗性抗体的生成和分析
公开(公告)号：US20090123950A1
公开(公告)日：2009-05-14
申请号：US11920830
申请日：2006-05-24
申请人： Michael Tesar
发明人： Michael Tesar
IPC分类号： G01N33/574 , C12Q1/02
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/55
摘要： The present invention provides novel methods for using recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for CD38, which plays an integral role in various disorders or conditions. These methods take advantage of newly discovered antibodies and surprising properties of such antibodies, such as the ability to bind CD38 of minipig origin and the ability to induce, by cross-linking, specific killing of cells that express CD38. These antibodies as well as the novel methods for using those antibodies can be used to treat, for example, hematological malignancies such as multiple myeloma.
摘要翻译：本发明提供了使用重组抗原结合区和抗体的新方法和含有对CD38特异性的这种抗原结合区的功能片段，其在各种病症或病症中起积体作用。这些方法利用新发现的抗体和这些抗体的令人惊奇的性质，例如结合小型猪来源的CD38的能力和通过交联诱导特异性杀死表达CD38的细胞的能力。这些抗体以及使用这些抗体的新方法可用于治疗例如血液恶性肿瘤例如多发性骨髓瘤。

5. 发明授权

US08486394B2 Generation and Profiling of fully human hucal gold-derived therapeutic antibodies specific for human CD38 有权
标题翻译：对人CD38特异性的完全人类hucal金衍生治疗性抗体的产生和分析
公开(公告)号：US08486394B2
公开(公告)日：2013-07-16
申请号：US13291473
申请日：2011-11-08
申请人： Michael Tesar , Ute Jäger
发明人： Michael Tesar , Ute Jäger
IPC分类号： A61K39/395 , C07K16/00 , C12P21/08
CPC分类号： C07K16/3061 , C07K16/2896 , C07K16/40 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/732
摘要： The present invention provides novel antibodies and functional fragments thereof specific for CD38, and methods of using the same for the treatment of diseases associated with CD38 expression, including hematological malignancies such as multiple myeloma.
摘要翻译：本发明提供了对CD38特异性的新型抗体及其功能片段，及其用于治疗与CD38表达相关疾病（包括血液恶性肿瘤例如多发性骨髓瘤）的方法。

6. 发明授权

US08088896B2 Generation and profiling of fully human gold-derived therapeutic antibodies specific for human CD38 有权
标题翻译：对人CD38特异性的完全人类金衍生治疗性抗体的产生和分析
公开(公告)号：US08088896B2
公开(公告)日：2012-01-03
申请号：US12089806
申请日：2006-10-12
申请人： Michael Tesar , Ute Jäger
发明人： Michael Tesar , Ute Jäger
IPC分类号： C07K16/00 , C12P21/08
CPC分类号： C07K16/3061 , C07K16/2896 , C07K16/40 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/732
摘要： The present invention provides novel antibodies and functional fragments thereof specific for CD38, and methods for using the same. These antibodies as well as the novel methods for using those antibodies can be used to treat, for example, hematological malignancies such as multiple myeloma.
摘要翻译：本发明提供了对CD38特异性的新型抗体及其功能片段及其使用方法。这些抗体以及使用这些抗体的新方法可用于治疗例如血液恶性肿瘤例如多发性骨髓瘤。

7. 发明申请

US20050260103A1 Determination of supplemental fuel requirement and instantaneous control thereof involving regenerative thermal oxidation 有权
标题翻译：补充燃料需求的确定及其再生热氧化的瞬时控制
公开(公告)号：US20050260103A1
公开(公告)日：2005-11-24
申请号：US10416929
申请日：2001-12-07
申请人： Michael Tesar , Andreas Ruhl , Steven Zagar
发明人： Michael Tesar , Andreas Ruhl , Steven Zagar
IPC分类号： F01N3/10 , F23G5/50 , F23G7/06 , F28D17/02 , G05D23/00
CPC分类号： F26B23/022 , F23G5/50 , F23G7/068 , F23G2207/101 , F23G2207/40 , F28D17/02 , Y02P70/40
摘要： A control system for a regenerative thermal oxidizer in which contaminated air is first passed through a hot heat-exchange bed and into a communicating high temperature oxidation (combustion) chamber, and then through a relatively cool second heat exchange bed. The apparatus includes a number of internally insulated, ceramic filled heat recovery columns topped by an internally insulated combustion chamber. Contaminated air is directed into heat exchange media in one of said columns, and oxidation is completed as the flow passes through the combustion chamber. From the combustion chamber, the now clean air flows through another column containing heat exchange media, thereby storing heat in the media for use in a subsequent inlet cycle when the flow control valves reverse. The resulting clean air is directed via an outlet valve through an outlet manifold and released to atmosphere or is recirculated back to the oxidizer inlet. A combustible fuel such as natural gas is added to the inlet-contaminated air prior to its entry into the hot heat exchange column when the contaminant concentration in the contaminated air falls below a predetermined level. The oxidizer is preferably integrated with a web dryer, such that hot aire from the combustion chamber is supplied to the dryer.
摘要翻译：一种用于再生式热氧化剂的控制系统，其中污染的空气首先通过热的热交换床并进入连通的高温氧化（燃烧）室，然后通过相对冷却的第二热交换床。该装置包括多个内部绝缘的陶瓷填充的热回收塔，其由内部绝缘的燃烧室顶起。受污染的空气被引导到所述塔中的一个中的热交换介质中，并且当流动通过燃烧室时氧化完成。从燃烧室起，现在清洁的空气流过另一个含有热交换介质的塔，从而将热量存储在介质中，以便在流量控制阀反向时用于随后的进口循环。所得到的清洁空气通过出口阀通过出口歧管引导并释放到大气中或被再循环回到氧化剂入口。当污染空气中的污染物浓度低于预定水平时，诸如天然气的可燃燃料在进入热交换塔之前被加入入口污染的空气中。氧化剂优选与卷筒式干燥器一体化，使得来自燃烧室的热气供应到干燥器。

8. 发明授权

US09200061B2 Generation and profiling of fully human HuCAL gold®-derived therapeutic antibodies specific for human CD3i 有权
标题翻译：完全人类HuCALgold®衍生的人类CD3i特异性治疗性抗体的生成和分析
公开(公告)号：US09200061B2
公开(公告)日：2015-12-01
申请号：US13302195
申请日：2011-11-22
申请人： Michael Tesar , Ute Jaeger
发明人： Michael Tesar , Ute Jaeger
IPC分类号： A61K39/395 , C07K16/00 , C07K16/28 , C12N9/24 , A61K39/00
CPC分类号： C07K16/005 , A61K2039/505 , C07K16/2896 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/74 , C07K2317/75 , C07K2317/92 , C07K2319/30 , C12N9/2497 , C12Y302/02005
摘要： The present invention provides methods for using recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for CD38, which plays an integral role in various disorders or conditions. These methods take advantage of newly discovered antibodies and surprising properties of such antibodies, such as the ability to bind CD38 of minipig origin and the ability to induce, by cross-linking, specific killing of cells that express CD38. These antibodies as well as the methods for using those antibodies can be used to treat, for example, hematological malignancies such as multiple myeloma.
摘要翻译：本发明提供了使用重组抗原结合区和抗体的方法以及含有CD38特异性的抗原结合区的功能片段，其在各种病症或病症中起积体作用。这些方法利用新发现的抗体和这些抗体的令人惊奇的性质，例如结合小型猪来源的CD38的能力和通过交联诱导特异性杀死表达CD38的细胞的能力。这些抗体以及使用这些抗体的方法可用于治疗例如血液恶性肿瘤例如多发性骨髓瘤。

9. 发明申请

US20120052078A1 GENERATION AND PROFILING OF FULLY HUMAN HUCAL GOLD-DERIVED THERAPEUTIC ANTIBODIES SPECIFIC FOR HUMAN CD38 有权
标题翻译：人类CD38的完整人类黄金衍生治疗性抗体的产生和分类
公开(公告)号：US20120052078A1
公开(公告)日：2012-03-01
申请号：US13291473
申请日：2011-11-08
申请人： Michael Tesar , Ute Jäger
发明人： Michael Tesar , Ute Jäger
IPC分类号： A61K39/395 , A61P19/02 , A61P35/02 , A61P29/00 , C07H21/04 , A61P35/00
CPC分类号： C07K16/3061 , C07K16/2896 , C07K16/40 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/732
摘要： The present invention provides novel antibodies and functional fragments thereof specific for CD38, and methods of using the same for the treatment of diseases associated with CD38 expression, including hematological malignancies such as multiple myeloma.
摘要翻译：本发明提供了对CD38特异性的新型抗体及其功能片段，及其用于治疗与CD38表达相关疾病（包括血液恶性肿瘤例如多发性骨髓瘤）的方法。

10. 发明申请

US20110268726A9 Anti-CD38 human antibodies and uses thereof 有权
标题翻译：抗CD38人抗体及其用途
公开(公告)号：US20110268726A9
公开(公告)日：2011-11-03
申请号：US10588568
申请日：2005-02-07
申请人： Michael Tesar , Ute Jager
发明人： Michael Tesar , Ute Jager
IPC分类号： A61K39/395 , C07K16/18 , C07H21/04 , C07K14/705 , C07K7/08 , C40B20/00 , A61P29/00 , A61P7/00 , C12N15/63 , C12N1/21 , C12N5/10 , C07K16/46 , A61P35/04
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/005 , C07K16/3061 , C07K16/40 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/732 , C07K2317/734 , C07K2317/74 , C07K2317/92 , C07K2319/30 , C12N9/2497 , C12Y302/02024
摘要： The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for CD38, which plays an integral role in various disorders or conditions. These antibodies, accordingly, can be used to treat, for example, hematological malignancies such as multiple myeloma. Antibodies of the invention also can be used in the diagnostics field, as well as for investigating the role of CD38 in the progression of disorders associated with malignancies. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use. The invention also provides isolated novel epitopes of CD38 and methods of use therefore
摘要翻译：本发明提供重组抗原结合区和抗体以及含有CD38特异性抗原结合区的功能片段，其在各种病症或病症中起积分作用。因此，这些抗体可用于治疗例如血液恶性肿瘤例如多发性骨髓瘤。本发明的抗体也可用于诊断领域，以及用于研究CD38在恶性肿瘤相关疾病进展中的作用。本发明还提供了编码前述抗体的核酸序列，含有该抗体的载体，药物组合物和具有使用说明书的试剂盒。本发明还提供CD38的分离的新型表位和因此使用的方法

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