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1. 发明授权

US10308660B2 Compounds and compositions for inhibiting the activity of SHP2 有权
公开(公告)号：US10308660B2
公开(公告)日：2019-06-04
申请号：US15736989
申请日：2016-06-15
申请人： Zhuoliang Chen , Jorge Garcia Fortanet , Matthew J. LaMarche , Martin Sendzik , Victoriano Tamez, Jr. , Bing Yu
发明人： Zhuoliang Chen , Jorge Garcia Fortanet , Matthew J. LaMarche , Martin Sendzik , Victoriano Tamez, Jr. , Bing Yu
IPC分类号： C07D401/04 , C07D491/107 , C07D401/14 , A61P35/00
摘要： The present invention relates to compounds of formula I: in which X1, X2, X3, Y1, Y2, Y3, R1, R2, R3a, R4a, R4b, R5a, R5b, R6a and R6b are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

2. 发明申请

US20180251471A1 COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 审中-公开
公开(公告)号：US20180251471A1
公开(公告)日：2018-09-06
申请号：US15736989
申请日：2016-06-15
申请人： Zhuoliang CHEN , Jorge Garcia FORTANET , Matthew J. LAMARCHE , Martin SENDZIK , Victoriano TAMEZ, JR. , Bing YU
发明人： Zhuoliang Chen , Jorge Garcia Fortanet , Matthew J. LaMarche , Martin Sendzik , Victoriano Tamez, JR. , Bing Yu
IPC分类号： C07D491/107 , C07D401/14 , C07D401/04 , A61P35/00
CPC分类号： C07D491/107 , A61P35/00 , C07D401/04 , C07D401/14
摘要： The present invention relates to compounds of formula I: in which X1, X2, X3, Y1, Y2, Y3, R1, R2, R3a, R4a, R4b, R5a, R5b, R6a and R6b are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

3. 发明申请

US20180186770A1 COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 审中-公开
公开(公告)号：US20180186770A1
公开(公告)日：2018-07-05
申请号：US15736925
申请日：2016-06-15
申请人： Zhuoliang Chen , Jorge Garcia Fortanet , Andriana Jouk , Rajesh Karki , Matthew J. LaMarche , Gang Liu , Mark G. Palermo , Lawrence Blas Perez , Patrick James Sarver , Michael David Shultz , Martin Sendzik , Bakary-Barry Toure , Bing Yu
发明人： Zhuoliang Chen , Jorge Garcia Fortanet , Andriana Jouk , Rajesh Karki , Matthew J. LaMarche , Gang Liu , Mark G. Palermo , Lawrence Blas Perez , Patrick James Sarver , Michael David Shultz , Martin Sendzik , Bakary-Barry Toure , Bing Yu
IPC分类号： C07D401/14 , C07D491/107 , C07D498/10 , C07D471/10 , C07D401/04
CPC分类号： C07D401/14 , C07D401/04 , C07D471/10 , C07D491/107 , C07D498/10
摘要： The present invention relates to compounds of formula I: in which Y1, Y2, Y3, R1, R2, R4a, R5b, R5a, R5b, R6a and R6b are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

4. 发明授权

US10537235B2 Multimodal endoscope apparatus 有权
公开(公告)号：US10537235B2
公开(公告)日：2020-01-21
申请号：US14824535
申请日：2015-08-12
申请人： Bing Yu
发明人： Bing Yu
IPC分类号： A61B1/07 , A61B5/00 , A61B1/04
摘要： A multimodal endoscope apparatus includes optical components (couplers, collimators, mirrors, beam splitters, filters and the like) structured to work together to interact with a multimodal endoscope probe to provide at least two imaging modalities selected from fluorescence imaging, optical coherence tomography, and photoacoustic imaging. The multimodal endoscope probe includes a fiber optic imaging bundle including a multitude of optical fibers. In embodiments employing photoacoustic imaging, the multimodal endoscope probe further includes a polymer-Fabry-Perot interferometer. In some embodiments, a galvo scanner and fiber collimator are included and are together capable of directing light to a single optical fiber of the multitude optical fibers. The system is modular in some embodiments, allowing for switching of some components.

5. 发明授权

US09091637B2 Smart fiber optic sensors systems and methods for quantitative optical spectroscopy 有权
标题翻译：智能光纤传感器系统和定量光谱法的方法
公开(公告)号：US09091637B2
公开(公告)日：2015-07-28
申请号：US13513458
申请日：2010-12-06
申请人： Bing Yu , Nirmala Ramanujam
发明人： Bing Yu , Nirmala Ramanujam
IPC分类号： G01N21/00 , G01N21/25 , G01N21/27 , G01J3/28 , G01J3/42 , G01J3/02 , A61B5/00 , G01L9/00 , G01N21/64
CPC分类号： G01N21/255 , A61B5/0075 , A61B5/0084 , A61B5/4331 , A61B5/4552 , A61B5/6885 , A61B2560/0228 , G01J3/0218 , G01J3/28 , G01J3/42 , G01L9/0079 , G01N21/274 , G01N21/645 , G01N2201/0627 , G01N2201/08
摘要： Smart fiber optic sensors, systems, and methods for performing quantitative optical spectroscopy are disclosed. In one embodiment, smart fiber optic sensor can include a sensing channel, a calibration channel, and a pressure sensing channel. External force or pressure can be calculated at pressure sensing channel for monitoring and controlling pressure at a sensor-specimen interface thereby ensuring more accurate specimen spectral data is collected. Contact pressure can be adjusted to remain within a specified range. A calibration light of the calibration channel and an illumination light of the sensing channel can be generated simultaneously from a shared light source. Pressure sensing channel can transmit light from a second light source and collect pressure spectral data.
摘要翻译：公开了用于执行定量光谱的智能光纤传感器，系统和方法。在一个实施例中，智能光纤传感器可以包括感测通道，校准通道和压力感测通道。可以在压力感测通道处计算外部力或压力，用于监测和控制传感器 - 样本接口处的压力，从而确保收集更准确的样本光谱数据。接触压力可以调整到一定范围内。可以从共享光源同时生成校准通道的校准光和感测通道的照明光。压力感测通道可以传输来自第二光源的光并收集压力光谱数据。

6. 发明申请

US20150141768A1 Smart Fiber-Optic Sensor System and Method for Optical Spectroscopy in Robotic Surgical Systems 审中-公开
标题翻译：智能光纤传感器系统和机器人手术系统中光学光谱的方法
公开(公告)号：US20150141768A1
公开(公告)日：2015-05-21
申请号：US14523520
申请日：2014-10-24
申请人： Bing Yu , Erik D. Engeberg
发明人： Bing Yu , Erik D. Engeberg
IPC分类号： A61B1/07 , A61B5/107 , A61B19/00 , A61B1/313 , A61B5/00 , A61B5/01
CPC分类号： A61B5/1076 , A61B5/0075 , A61B5/0084 , A61B5/015 , A61B5/4836 , A61B5/6843 , A61B5/7203 , A61B18/12 , A61B34/30 , A61B2017/00061 , A61B2017/00084 , A61B2018/00791 , A61B2090/064 , A61B2560/0252
摘要： A smart fiber-optic sensor system for use with robotic surgical systems performs optical spectroscopy using a diffuse reflectance spectroscopy (DRS) sensing channel, a self-calibration (SC) channel, a pressure-sensing channel, and a temperature sensing channel. During use of the fiber-optic sensor during a laparoscopic procedure, the pressure-sensing channel ensures that the fiber-optic sensor is maintained in suitable contact with the target tissue being treated. In addition, the temperature sensor is used to ensure that the target tissue does not exceed a desired temperature from the use of an electrosurgical cutting device during the laparoscopic procedure, so as to prevent burning or charring damage at the target tissue.
摘要翻译：用于机器人手术系统的智能光纤传感器系统使用漫反射光谱（DRS）感测通道，自校准（SC）通道，压力感测通道和温度感测通道执行光学光谱。在腹腔镜手术期间使用光纤传感器期间，压力感测通道确保光纤传感器保持与被治疗的靶组织适当的接触。此外，温度传感器用于确保在腹腔镜手术期间使用电外科切割装置时目标组织不超过所需温度，以防止靶组织上的烧伤或烧伤。

7. 发明申请

US20130103157A1 Polymeric adhesive for anchoring compliant materials to another surface 审中-公开
标题翻译：用于将柔性材料固定到另一表面的聚合物粘合剂
公开(公告)号：US20130103157A1
公开(公告)日：2013-04-25
申请号：US13573788
申请日：2012-10-03
申请人： Lampros Kourtis , David Myung , Daniel Chang , Bing Yu , Timothy Sun , Michael J. Jaasma , Vernon Hartdegen
发明人： Lampros Kourtis , David Myung , Daniel Chang , Bing Yu , Timothy Sun , Michael J. Jaasma , Vernon Hartdegen
IPC分类号： C09J133/14 , A61F2/30 , A61M5/19 , A61K47/32 , B65D85/00
CPC分类号： C08G18/6229 , A61B17/56 , A61F2/30 , A61K47/32 , A61L24/001 , A61L24/0015 , A61L24/043 , A61L24/06 , A61L2300/406 , A61L2430/24 , A61M5/19 , B65D85/70 , C08G18/3206 , C08G18/4854 , C08G18/6511 , C08G18/6705 , C08G18/728 , C08G81/024 , C08L33/08 , C08L33/12 , C09J4/06 , C09J133/14 , C09J135/02 , F01D5/082 , F01D11/001 , F01D11/025 , F05D2240/57 , F05D2260/14 , C08F2220/343 , C08F220/14
摘要： Methods, compositions, and kits for adhering polymers and other materials to another material, and in particular to bone or bone-like structures or surfaces. A composition of matter includes a urethane dimethacrylate-methyl methacrylate copolymer with a plurality of first polymer regions based on urethane dimethacrylate and a plurality of second polymer regions based on methyl methacrylate. The method includes placing an orthopedic joint implant having an attachment surface in a joint space, applying a first non-urethane-containing precursor, a second urethane-containing precursor, and a initiator to the attachment surface; contacting the first and second precursors and the initiator with the joint surface; and copolymerizing the first and second precursors and forming an adhesive copolymer and attaching the implant to the joint.
摘要翻译：用于将聚合物和其它材料粘附到另一种材料，特别是骨或骨样结构或表面上的方法，组合物和试剂盒。物质组合物包括具有多个基于氨基甲酸酯二甲基丙烯酸酯的多个第一聚合物区域的氨基甲酸酯二甲基丙烯酸酯 - 甲基丙烯酸甲酯共聚物和基于甲基丙烯酸甲酯的多个第二聚合物区域。该方法包括将具有附接表面的整形外科关节植入物放置在关节空间中，将第一非氨基甲酸酯的前体，第二含氨基甲酸酯的前体和引发剂施加到所述附着表面; 使第一和第二前体和引发剂与接合表面接触; 并共聚第一和第二前体并形成粘合剂共聚物并将植入物附着到接头上。

8. 发明授权

US09458163B2 Heterocyclic derivatives 有权
标题翻译：杂环衍生物
公开(公告)号：US09458163B2
公开(公告)日：2016-10-04
申请号：US14644953
申请日：2015-03-11
申请人： Branko Radetich , Bing Yu , Yanyi Zhu
发明人： Branko Radetich , Bing Yu , Yanyi Zhu
IPC分类号： A61K31/5377 , C07D487/04 , C07D519/00
CPC分类号： C07D487/04 , A61K31/5377 , C07D519/00
摘要： The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, to their preparation, to their medical use, in particular to their use in the treatment of cancer and neurodegenerative disorders, and to medicaments comprising them.

9. 发明授权

US08367821B2 Preparation of eslicarbazepine and related compounds by asymmetric hydrogenation 有权
标题翻译：通过不对称氢化制备eslicarbazepine和相关化合物
公开(公告)号：US08367821B2
公开(公告)日：2013-02-05
申请号：US12294855
申请日：2007-04-11
申请人： Bing Yu , Wenge Li , David Alexander Learmonth
发明人： Bing Yu , Wenge Li , David Alexander Learmonth
IPC分类号： C07D223/22
CPC分类号： C07D223/22
摘要： A process for preparing a compound of the formula IA or IB: wherein R is alkyl, aminoalkyl, halogenalkyl, aralkyl, cycloalkyl, cycloalkylalkyl, alkoxy, phenyl or substituted phenyl or pyridyl group; the term alkyl means carbon chain, straight or branched, containing from 1 to 18 carbon atoms; the term halogen represents fluorine, chlorine, bromine or iodine; the term cycloalkyl represents a saturated alicyclic group with 3 to 6 carbon atoms; the term aryl represents unsubstituted phenyl group or phenyl substituted by alkoxy, halogen or nitro group, the process comprising asymmetric hydrogenation of a compound of the formula II: wherein R has the same meanings as above, using a chiral catalyst and a source of hydrogen.
摘要翻译：制备式IA或IB化合物的方法：其中R是烷基，氨基烷基，卤代烷基，芳烷基，环烷基，环烷基烷基，烷氧基，苯基或取代的苯基或吡啶基; 术语烷基是指含有1至18个碳原子的直链或支链的碳链; 术语卤素表示氟，氯，溴或碘; 术语环烷基表示具有3至6个碳原子的饱和脂环基; 术语芳基表示未取代的苯基或被烷氧基，卤素或硝基取代的苯基，该方法包括使用手性催化剂和氢源的式II化合物的不对称氢化：其中R具有与上述相同的含义。

10. 发明申请

US20110112435A1 SYSTEMS AND METHODS FOR SPECTRAL ANALYSIS OF A TISSUE MASS USING AN INSTRUMENT, AN OPTICAL PROBE, AND A MONTE CARLO OR A DIFFUSION ALGORITHM 有权
标题翻译：使用仪器，光学探头和蒙特卡罗或扩散算法对组织质量进行光谱分析的系统和方法
公开(公告)号：US20110112435A1
公开(公告)日：2011-05-12
申请号：US12680305
申请日：2008-09-29
申请人： Nirmala Ramanujam , Bing Yu , Jonathon Quincy Brown
发明人： Nirmala Ramanujam , Bing Yu , Jonathon Quincy Brown
IPC分类号： A61B10/02
CPC分类号： A61B5/0091 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/413 , A61B5/4312
摘要： Systems and methods for spectral analysis of a tissue mass using an instrument, an optical probe, and a Monte Carlo algorithm or a diffusion algorithm are provided. According to one method, an instrument is inserted into a tissue mass. A fiber optic probe is applied via the instrument into the tissue mass. Turbid spectral data of the tissue mass is measured using the fiber probe. The turbid spectral data is converted to absorption, scattering, and/or intrinsic fluorescence spectral data via a Monte Carlo algorithm or diffusion algorithm. Biomarker concentrations in the tissue mass are quantified using the absorption, scattering, and/or intrinsic fluorescence spectral data.
摘要翻译：提供了使用仪器，光学探针和蒙特卡洛算法或扩散算法对组织块进行光谱分析的系统和方法。根据一种方法，将器械插入组织块中。通过仪器将光纤探头施加到组织块中。使用光纤探针测量组织块的浊度光谱数据。通过蒙特卡罗算法或扩散算法将浊度光谱数据转换为吸收，散射和/或固有荧光光谱数据。使用吸收，散射和/或固有的荧光光谱数据来量化组织块中的生物标志物浓度。

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