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1. 发明申请

US20120018912A1 METHOD OF PREPARING NANO-DISPERSED HIGH-ALL-TRANS-CAROTENOID MICROCAPSULES 有权
标题翻译：制备纳米分散高转移CAROTENOID微球的方法
公开(公告)号：US20120018912A1
公开(公告)日：2012-01-26
申请号：US13259291
申请日：2010-03-18
申请人： Zhirong Chen , Jianfeng Chen , Hong Yin , Hong Zhao , Dan Qiu , Lifang Shi , Jiandong Li , Guangwen Chu , Lei Shao
发明人： Zhirong Chen , Jianfeng Chen , Hong Yin , Hong Zhao , Dan Qiu , Lifang Shi , Jiandong Li , Guangwen Chu , Lei Shao
IPC分类号： B29B9/12
CPC分类号： B01J13/043 , A23K20/179 , A23L5/44 , A23L33/10 , A23L33/105 , A23P10/30 , A23V2002/00 , A61K8/0241 , A61K8/11 , A61K8/31 , A61K8/35 , A61K31/01 , A61K31/122 , A61K2800/412 , A61Q19/00 , C09B61/00 , C09B67/0097 , A23V2250/211 , A23V2200/224
摘要： A method of preparing nano-dispersed high-all-trans-carotenoid microcapsules is provided, comprising: preparing 10-20% carotenoid suspension by milling the high-all trans-carotenoid crystals with dichloromethane until the particle size thereof is in the range of 2-5 μm, then supplying the suspension together with preheated dichloromethane of another pass into a dissolving tank to obtain a solution of 0.5-2%; delivering the solution together with ethanol or isopropanol into a crystallization device having high gravity rotating packed bed simultaneously and continuously, and then into a wiped-film evaporator for desolvation until the solid content is 10-20%, then a transparent alcohol dispersion of carotenoid is obtained; mashing the alcohol dispersion together with an aqueous solution containing an antioxidant and protective colloid and spray drying to obtain nano-dispersed high-all-trans-carotenoid microcapsules. As the crystals are nano-dispersed and the content of trans-isomer is more than 90%, the carotenoid microcapsules of present inventions exhibit high bioavailability.
摘要翻译：提供了一种制备纳米分散高全反式类胡萝卜素微胶囊的方法，包括：通过用二氯甲烷研磨高全反式类胡萝卜素晶体制备10-20％的类胡萝卜素悬浮液，直到其粒径在2 -5μm，然后将悬浮液与另一道次的预热二氯甲烷一起供入溶解槽中，得到0.5-2％的溶液; 将溶液与乙醇或异丙醇一起输送到具有高重力旋转填充床的结晶装置中，同时且连续地进行，然后进入擦膜蒸发器进行去溶剂化直到固体含量为10-20％，然后将类胡萝卜素的透明醇分散体获得; 将醇分散体与含有抗氧化剂和保护胶体的水溶液一起糖化并喷雾干燥，得到纳米分散的高全反式类胡萝卜素微胶囊。由于晶体是纳米分散的并且反式异构体的含量大于90％，本发明的类胡萝卜素微胶囊显示出高的生物利用度。

2. 发明授权

US08540908B2 Method of preparing nano-dispersed high-all-trans-carotenoid microcapsules 有权
标题翻译：制备纳米分散高全反式类胡萝卜素微胶囊的方法
公开(公告)号：US08540908B2
公开(公告)日：2013-09-24
申请号：US13259291
申请日：2010-03-18
申请人： Zhirong Chen , Jianfeng Chen , Hong Yin , Hong Zhao , Dan Qiu , Lifang Shi , Jiandong Li , Guangwen Chu , Lei Shao
发明人： Zhirong Chen , Jianfeng Chen , Hong Yin , Hong Zhao , Dan Qiu , Lifang Shi , Jiandong Li , Guangwen Chu , Lei Shao
IPC分类号： B01J13/04
CPC分类号： B01J13/043 , A23K20/179 , A23L5/44 , A23L33/10 , A23L33/105 , A23P10/30 , A23V2002/00 , A61K8/0241 , A61K8/11 , A61K8/31 , A61K8/35 , A61K31/01 , A61K31/122 , A61K2800/412 , A61Q19/00 , C09B61/00 , C09B67/0097 , A23V2250/211 , A23V2200/224
摘要： A method of preparing nano-dispersed high-all-trans-carotenoid microcapsules is provided, comprising: preparing 10-20% carotenoid suspension by milling the high-all trans-carotenoid crystals with dichloromethane until the particle size thereof is in the range of 2-5 μm, then supplying the suspension together with preheated dichloromethane of another pass into a dissolving tank to obtain a solution of 0.5-2%; delivering the solution together with ethanol or isopropanol into a crystallization device having high gravity rotating packed bed simultaneously and continuously, and then into a wiped-film evaporator for desolvation until the solid content is 10-20%, then a transparent alcohol dispersion of carotenoid is obtained; mashing the alcohol dispersion together with an aqueous solution containing an antioxidant and protective colloid and spray drying to obtain nano-dispersed high-all-trans-carotenoid microcapsules. As the crystals are nano-dispersed and the content of trans-isomer is more than 90%, the carotenoid microcapsules of present inventions exhibit high bioavailability.
摘要翻译：提供了一种制备纳米分散高全反式类胡萝卜素微胶囊的方法，包括：通过用二氯甲烷研磨高全反式类胡萝卜素晶体制备10-20％的类胡萝卜素悬浮液，直到其粒径在2 -5μm，然后将悬浮液与另一道次的预热二氯甲烷一起供入溶解槽中，得到0.5-2％的溶液; 将溶液与乙醇或异丙醇一起输送到具有高重力旋转填充床的结晶装置中，同时且连续地进行，然后进入擦膜蒸发器进行去溶剂化直到固体含量为10-20％，然后将类胡萝卜素的透明醇分散体获得; 将醇分散体与含有抗氧化剂和保护胶体的水溶液一起糖化并喷雾干燥，得到纳米分散的高全反式类胡萝卜素微胶囊。由于晶体是纳米分散的并且反式异构体的含量大于90％，本发明的类胡萝卜素微胶囊显示出高的生物利用度。

3. 发明申请

US20140001662A1 METHOD FOR PREPARING STABLE-TYPE VITAMIN A MICROCAPSULES CONTINUOUSLY 有权
标题翻译：连续制备稳定型维生素一微生物的方法
公开(公告)号：US20140001662A1
公开(公告)日：2014-01-02
申请号：US13980126
申请日：2011-03-25
申请人： Hong Yin , Jianfeng Chen , Zhirong Chen , Jiexin Wang , Yong Qi , Hong Zhao , Lifang Shi , Dan Qiu
发明人： Hong Yin , Jianfeng Chen , Zhirong Chen , Jiexin Wang , Yong Qi , Hong Zhao , Lifang Shi , Dan Qiu
IPC分类号： A61J3/07
CPC分类号： A61J3/07 , A61K9/1652 , A61K9/1694 , A61K9/5036 , A61K9/5089 , A61K9/5161 , A61K31/07
摘要： A method for continuously preparing stable-type vitamin A microcapsules is disclosed. The method comprises the following steps: adding vitamin A crystals and an antioxidant into a crystal melter continuously according to a certain ratio under the protection of nitrogen to prepare vitamin A melting oil containing the antioxidant; pumping the above melting oil into a high gravity rotary packed bed emulsifier with a liquid distributor by a pump, and pumping aqueous solution containing gellable modified starch into the above high gravity rotary packed bed emulsifier after deoxidation treatment to obtain vitamin A emulsion at the outlet of the high gravity rotary packed bed emulsifier; and atomizing and spraying the emulsion continuously in a cooled starch bed for granulating, and performing fluidization drying and gelation treatment in a fluidized bed by taking nitrogen as a drying medium to obtain the stable-type vitamin A microcapsules. Above method has the advantage of capability of continuous production, and has good embedding effect due to adopting the gellable modified starch, granulating and gelation treatment, thus the product has good storage stability.
摘要翻译：公开了连续制备稳定型维生素A微胶囊的方法。该方法包括以下步骤：在氮保护下，以一定的比例将维生素A晶体和抗氧化剂连续添加到晶体熔化器中，制备含有抗氧化剂的维生素A熔融油; 通过泵将上述熔融油泵送到具有液体分配器的高重力旋转填充床乳化剂中，并且在脱氧处理之后将含有可凝胶改性淀粉的水溶液泵送到上述高重力旋转填充床乳化剂中以在出口处获得维生素A乳液高重力旋转填充床乳化剂; 并在冷却的淀粉床中连续雾化和喷雾乳液进行造粒，并通过以氮气作为干燥介质在流化床中进行流化干燥和凝胶化处理，得到稳定型维生素A微胶囊。上述方法具有连续生产能力的优点，由于采用可凝胶改性淀粉，造粒和凝胶化处理，具有良好的包埋效果，因此产品具有良好的储存稳定性。

4. 发明授权

US09173818B2 Method for preparing stable-type vitamin A microcapsules continuously 有权
标题翻译：连续制备稳定型维生素A微胶囊的方法
公开(公告)号：US09173818B2
公开(公告)日：2015-11-03
申请号：US13980126
申请日：2011-03-25
申请人： Hong Yin , Jianfeng Chen , Zhirong Chen , Jiexin Wang , Yong Qi , Hong Zhao , Lifang Shi , Dan Qiu
发明人： Hong Yin , Jianfeng Chen , Zhirong Chen , Jiexin Wang , Yong Qi , Hong Zhao , Lifang Shi , Dan Qiu
IPC分类号： A61J3/07 , A61K9/00 , B29B9/12 , A61K9/16 , A61K9/50 , A61K31/07 , A61K9/51
CPC分类号： A61J3/07 , A61K9/1652 , A61K9/1694 , A61K9/5036 , A61K9/5089 , A61K9/5161 , A61K31/07
摘要： A method for continuously preparing stable-type vitamin A microcapsules is disclosed. The method comprises the following steps: adding vitamin A crystals and an antioxidant into a crystal melter continuously according to a certain ratio under the protection of nitrogen to prepare vitamin A melting oil containing the antioxidant; pumping the above melting oil into a high gravity rotary packed bed emulsifier with a liquid distributor by a pump, and pumping aqueous solution containing gellable modified starch into the above high gravity rotary packed bed emulsifier after deoxidation treatment to obtain vitamin A emulsion at the outlet of the high gravity rotary packed bed emulsifier; and atomizing and spraying the emulsion continuously in a cooled starch bed for granulating, and performing fluidization drying and gelation treatment in a fluidized bed by taking nitrogen as a drying medium to obtain the stable-type vitamin A microcapsules. Above method has the advantage of capability of continuous production, and has good embedding effect due to adopting the gellable modified starch, granulating and gelation treatment, thus the product has good storage stability.
摘要翻译：公开了连续制备稳定型维生素A微胶囊的方法。该方法包括以下步骤：在氮保护下，以一定的比例将维生素A晶体和抗氧化剂连续添加到晶体熔化器中，制备含有抗氧化剂的维生素A熔融油; 通过泵将上述熔融油泵送到具有液体分配器的高重力旋转填充床乳化剂中，并且在脱氧处理之后将含有可凝胶改性淀粉的水溶液泵送到上述高重力旋转填充床乳化剂中以在出口处获得维生素A乳液高重力旋转填充床乳化剂; 并在冷却的淀粉床中连续雾化和喷雾乳液进行造粒，并通过以氮气作为干燥介质在流化床中进行流化干燥和凝胶化处理，得到稳定型维生素A微胶囊。上述方法具有连续生产能力的优点，由于采用可凝胶改性淀粉，造粒和凝胶化处理，具有良好的包埋效果，因此产品具有良好的储存稳定性。

5. 发明申请

US20220093915A1 SILICON MONOXIDE COMPOSITE MATERIAL, METHOD FOR PREPARING SAME, AND LITHIUM ION BATTERY 有权
公开(公告)号：US20220093915A1
公开(公告)日：2022-03-24
申请号：US17120209
申请日：2020-12-13
申请人： Hong Zhao
发明人： Hong Zhao
IPC分类号： H01M4/36 , C23C16/02 , C23C16/26 , H01M10/0525 , H01M4/587 , H01M4/48 , H01M4/04
摘要： A method for preparing a silicon monoxide composite material includes: a first stage: introducing a protective gas into a vapor deposition oven, and pre-heating a silicon monoxide raw material, such that a part of the silicon monoxide raw material is subjected to a disproportionation reaction; a second stage: continuously introducing the protective gas and introducing a carbon source gas, and subjecting the pre-heated silicon monoxide raw material to a chemical vapor deposition to form carbon nanotubes on a surface of silicon monoxide; and a third stage: after a predetermined time period, stopping introducing the carbon source gas, and stopping introducing the protective gas until the vapor deposition oven is cooled to room temperature, to prepare the silicon monoxide composite material. During the preparation process, no extra catalyst needs to be added, a product of the previous disproportionation reaction may act as a catalyst for the growth of the carbon nanotubes.

6. 发明授权

US11237283B2 Visco-pseudo-elastic TTI FWI/RTM formulation and implementation 有权
公开(公告)号：US11237283B2
公开(公告)日：2022-02-01
申请号：US16000960
申请日：2018-06-06
申请人： Praveen Nakshatrala , Anoop A. Mullur , Hong Zhao , Valeriy V. Brytik
发明人： Praveen Nakshatrala , Anoop A. Mullur , Hong Zhao , Valeriy V. Brytik
IPC分类号： G01V1/28 , G01V1/30
摘要： A method, including: obtaining, with a computer, an initial geophysical model; modeling, with a computer, a forward wavefield based on the initial geophysical model with wave equations including a second order z-derivative in a rotated coordinate system that accounts for a tilted transverse isotropic (TTI) medium; modeling, with a computer, an adjoint wavefield with adjoint wave equations including a second order z-derivative in a rotated coordinate system that accounts for a tilted transverse isotropic (TTI) medium, wherein the wave equations and the adjoint wave equations include relaxation terms accounting for anelasticity of earth in an update of a primary variable and an evolution relationship for the relaxation terms; and obtaining, with a computer, a gradient of a cost function based on a combination of a model of the forward wavefield and a model of the adjoint wavefield.

7. 发明授权

US09146624B2 Method for managing screen orientation of a portable electronic device 有权
标题翻译：用于管理便携式电子设备的屏幕方向的方法
公开(公告)号：US09146624B2
公开(公告)日：2015-09-29
申请号：US13368853
申请日：2012-02-08
申请人： Hong Zhao , LieJun Tao , Dean E. Thorson
发明人： Hong Zhao , LieJun Tao , Dean E. Thorson
IPC分类号： G06F3/0346 , G06F3/01 , G06F1/16
CPC分类号： G06F3/0346 , G06F1/1686 , G06F1/1694 , G06F3/012 , G06F3/013 , G06F2200/1614 , G06F2200/1637
摘要： There is described a portable electronic device capable of managing screen orientation. The portable electronic device comprises a display, a motion sensor, an image sensor and a processor. The display provides an image at a first orientation. The motion sensor attempts to detect a rotation of the portable electronic device. The image sensor attempts to detect one or more body features. The processor determines a second orientation of the image at the display based on the rotation detected at the motion sensor and/or the body feature or features detected at the image sensor. The portable electronic device may determine an orientation of the image at the display in response to detecting the rotation at the motion sensor and/or the body feature or features at the image sensor.
摘要翻译：描述了能够管理屏幕取向的便携式电子设备。便携式电子设备包括显示器，运动传感器，图像传感器和处理器。显示器以第一方向提供图像。运动传感器尝试检测便携式电子设备的旋转。图像传感器尝试检测一个或多个身体特征。处理器基于在运动传感器处检测到的旋转和/或在图像传感器处检测到的身体特征或特征来确定图像在显示器处的第二取向。响应于检测到运动传感器处的旋转和/或图像传感器处的身体特征或特征，便携式电子设备可以确定显示器处的图像的取向。

8. 发明授权

US09110519B2 Method for managing screen orientation of a portable electronic device 有权
公开(公告)号：US09110519B2
公开(公告)日：2015-08-18
申请号：US13368853
申请日：2012-02-08
申请人： Hong Zhao , LieJun Tao , Dean E Thorson
发明人： Hong Zhao , LieJun Tao , Dean E Thorson
IPC分类号： G06F3/0346 , G06F3/01 , G06F1/16
摘要： There is described a portable electronic device capable of managing screen orientation. The portable electronic device comprises a display, a motion sensor, an image sensor and a processor. The display provides an image at a first orientation. The motion sensor attempts to detect a rotation of the portable electronic device. The image sensor attempts to detect one or more body features. The processor determines a second orientation of the image at the display based on the rotation detected at the motion sensor and/or the body feature or features detected at the image sensor. The portable electronic device may determine an orientation of the image at the display in response to detecting the rotation at the motion sensor and/or the body feature or features at the image sensor.

9. 发明授权

US08849276B2 Intelligent network selection based on quality of service and applications over different wireless networks 有权
标题翻译：基于不同无线网络的服务质量和应用的智能网络选择
公开(公告)号：US08849276B2
公开(公告)日：2014-09-30
申请号：US12197830
申请日：2008-08-25
申请人： Ann C. Guilford , Mike Verstegen , Hong Zhao
发明人： Ann C. Guilford , Mike Verstegen , Hong Zhao
IPC分类号： H04W4/00 , H04W36/00 , H04W48/18 , H04W28/24 , H04W28/08
CPC分类号： H04W48/18 , H04M15/8038 , H04M2215/34 , H04W28/0247 , H04W28/08 , H04W28/24
摘要： A system and method for selecting a wireless network is disclosed. The method relates to selecting a wireless network from a plurality of wireless networks. A variation of the invention includes selecting a new platform from a plurality of platforms offered by the current service provider according to a service request from the wireless device. The method comprises determining a requested service associated with the wireless device, determining whether one of the plurality of wireless networks can provide the requested service, and, if one of the plurality of wireless networks can provide the requested service, choosing the one wireless network of the plurality of wireless networks. The method further involves using a variety of parameters in determining which wireless network to choose for servicing the requested service from the wireless device. These parameters include quality of services, application supported, or other business factors such as roaming agreements, traffic load and cost of services. The system comprises at least one wireless network node, a wireless device, and a plurality of wireless networks communicating with each other. Either the wireless device or network node may operate to decide based on the services the wireless device user requires on which network the user will receive service from. The network assignment is accomplished to maximize the speed, cost and efficiency of transmission.
摘要翻译：公开了一种用于选择无线网络的系统和方法。该方法涉及从多个无线网络中选择无线网络。本发明的变型包括根据来自无线设备的服务请求从当前服务提供商提供的多个平台中选择新平台。该方法包括确定与无线设备相关联的所请求的服务，确定所述多个无线网络中的一个是否能够提供所请求的服务;以及如果所述多个无线网络中的一个可以提供所请求的服务，则选择所述一个无线网络多个无线网络。该方法还涉及使用各种参数来确定从无线设备为哪个无线网络选择用于服务所请求的服务。这些参数包括服务质量，支持的应用程序或其他业务因素，如漫游协议，流量负载和服务成本。该系统包括彼此通信的至少一个无线网络节点，无线设备和多个无线网络。无线设备或网络节点可以基于无线设备用户在用户将从哪个网络接收服务所需的服务来进行操作。实现网络分配以最大限度地提高传输的速度，成本和效率。

10. 发明授权

US08748573B2 Formulations comprising linaclotide 有权
标题翻译：包含利那洛肽的制剂
公开(公告)号：US08748573B2
公开(公告)日：2014-06-10
申请号：US12851330
申请日：2010-08-05
申请人： Angelika Fretzen , Steven Witowski , Alfredo Grossi , Hong Zhao , Mahendra Dedhiya , Yun Mo
发明人： Angelika Fretzen , Steven Witowski , Alfredo Grossi , Hong Zhao , Mahendra Dedhiya , Yun Mo
IPC分类号： C07K7/08 , C07K7/06
CPC分类号： A61K9/50 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/205 , A61K9/2054 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K9/5078 , A61K38/10 , A61K38/12 , A61K47/02 , A61K47/183 , A61K47/36 , B65D81/26 , G01N30/02 , G01N2030/027
摘要： The present invention relates to stable compositions comprising linaclotide, as well as to various methods and processes for the preparation and use of the compositions.
摘要翻译：本发明涉及包含利那洛肽的稳定组合物，以及用于制备和使用组合物的各种方法和方法。

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