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1. 发明授权

US08361500B2 Tablet formulations containing 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one salts and tablets made therefrom 有权
标题翻译：含有8 - [{1-（3,5-双 - （三氟甲基）苯基） - 乙氧基} - 甲基] -8-苯基-1,7-二氮杂 - 螺[4.5]癸-2-酮盐和片剂由此制成
公开(公告)号：US08361500B2
公开(公告)日：2013-01-29
申请号：US12531966
申请日：2008-03-20
申请人： Zhihui Qiu , Wing-Kee Philip Cho , Na Zhao , Victor Ming-she Wong
发明人： Zhihui Qiu , Wing-Kee Philip Cho , Na Zhao , Victor Ming-she Wong
IPC分类号： A61K9/20 , A61K9/28 , A61K31/44 , A01N43/42 , C07D491/00 , C07D495/00 , C07D491/10 , C07D497/20 , C07D215/00 , C07D219/00
CPC分类号： A61K31/435 , A61K9/1652 , A61K9/1682 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2077 , A61K9/2095 , A61K9/28 , A61K31/438
摘要： Pharmaceutical formulations containing a salt of (5S,8S)-8-[{(1R)-1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diazaspiro[4.5]decan-2-one, represented by Formula I, which are suitable for forming into a tablet dosage form, as well as tablet dosage forms are disclosed. Disclosed also are methods of treatment utilizing such dosage forms.
摘要翻译：含有（5S，8S）-8 - [{（1R）-1-（3,5-双 - （三氟甲基）苯基） - 乙氧基} - 甲基] -8-苯基-1,7-二氮杂螺公开了由式I代表的适合形成片剂剂型的[4.5]癸-2-酮以及片剂剂型。还公开了利用这种剂型的治疗方法。

2. 发明申请

US20100104637A1 TABLET FORMULATIONS CONTAINING 8-[-METHYL]-8-PHENYL-1,7-DIAZA-SPIRO[4.5]DECAN-2-ONE SALTS AND TABLETS MADE THEREFROM 有权
标题翻译：含有8 - [ - 甲基] -8-苯基-1,7-二氮杂螺[4.5]癸烷-2-酮的片剂配方及其制备的片剂
公开(公告)号：US20100104637A1
公开(公告)日：2010-04-29
申请号：US12531966
申请日：2008-03-20
申请人： Zhihui Qiu , Wing-Kee Philip Cho , Na Zhao , Victor Ming-She Wong
发明人： Zhihui Qiu , Wing-Kee Philip Cho , Na Zhao , Victor Ming-She Wong
IPC分类号： A61K9/20 , A61K9/14 , A61K31/438 , A61K9/28 , A61P1/08
CPC分类号： A61K31/435 , A61K9/1652 , A61K9/1682 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2077 , A61K9/2095 , A61K9/28 , A61K31/438
摘要： Pharmaceutical formulations containing a salt of (5S,8S)-8-[{(1R)-1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diazaspiro[4.5]decan-2-one, represented by Formula I, which are suitable for forming into a tablet dosage form, as well as tablet dosage forms are disclosed. Disclosed also are methods of treatment utilizing such dosage forms.
摘要翻译：含有（5S，8S）-8 - [{（1R）-1-（3,5-双 - （三氟甲基）苯基） - 乙氧基} - 甲基] -8-苯基-1,7-二氮杂螺公开了由式I代表的适合形成片剂剂型的[4.5]癸-2-酮以及片剂剂型。还公开了利用这种剂型的治疗方法。

3. 发明授权

US08380328B2 Method and system for monitoring and controlling a multi-variable process throughout a plurality of distinct phases of the process 有权
标题翻译：用于在整个过程的多个不同阶段中监测和控制多变量过程的方法和系统
公开(公告)号：US08380328B2
公开(公告)日：2013-02-19
申请号：US12678202
申请日：2008-09-15
申请人： Robin William Brooks , John Gavin Wilson , Na Zhao
发明人： Robin William Brooks , John Gavin Wilson , Na Zhao
IPC分类号： G05B13/02
CPC分类号： G05B23/024 , G05B19/41875 , G05B2219/1112 , G05B2219/35507 , G05B2223/02 , Y02P90/22
摘要： A control of a multi-variable process throughout a plurality of successive, distinct operational phases of the process involves accumulation of sets of values of the process and quality variables (a-j) from previous multiple operations of the process through all its phases, as respective datasets of a historical record. Each dataset includes an identifier (p) of the phase to which it relates. The current values of the applicable process variables (Qa-Qh) during each phase and the phase identifier (p) are indicated on respective axes (Xp,Xa-Xh) of a multi-dimensional display in relation to an operational envelope which defines bounds (UL,LL) for the values of the individual process and quality variables (a-j) relevant to that phase and which is derived from the datasets of the historical record identified with that phase. Changes in the current process variables (Qa-Qh) result in changes of the bounds (UL,LL), and alarm is given when a current value departs from within them. Either manually or automatically correction of an alarm condition is made in accordance with calculation of required change of value of one or more manipulatable process variables (a-c).
摘要翻译：在整个过程的多个连续的，不同的操作阶段中的多变量过程的控制包括从过程的所有阶段的先前的多个操作中累积过程值和质量变量（aj）的集合作为相应的数据集的历史记录。每个数据集包括与其相关的阶段的标识符（p）。相对于定义边界的操作包络，在多维显示器的各个轴（Xp，Xa-Xh）上指示每个阶段期间适用的过程变量（Qa-Qh）和相位标识符（p）的当前值（UL，LL）用于与该阶段相关的单个过程和质量变量（aj）的值，并且从根据该阶段确定的历史记录的数据集导出。当前过程变量（Qa-Qh）的变化导致边界（UL，LL）的变化，并且当当前值从其中偏离时给出报警。根据一个或多个可操作的过程变量（a-c）的所需要求的变化的计算，进行手动或自动校正报警条件。

4. 发明申请

US20110274597A1 USE OF Mg(HCO3)2 AND/OR Ca(HCO3)2 AQUEOUS SOLUTION IN METAL EXTRACTIVE SEPARATION AND PURIFICATION 有权
标题翻译：在金属提取分离和纯化中使用Mg（HCO3）2和/或Ca（HCO3）2水溶液
公开(公告)号：US20110274597A1
公开(公告)日：2011-11-10
申请号：US13143772
申请日：2010-01-14
申请人： Xiaowei Huang , Zhiqi Long , Xinlin Peng , Hongwei Li , Guilin Yang , Dali Cui , Chunmei Wang , Na Zhao , Liangshi Wang , Ying Yu
发明人： Xiaowei Huang , Zhiqi Long , Xinlin Peng , Hongwei Li , Guilin Yang , Dali Cui , Chunmei Wang , Na Zhao , Liangshi Wang , Ying Yu
IPC分类号： C01F17/00 , C01F7/74 , C01F5/24 , C01G3/10 , C01G51/04 , C01F11/18 , C01G51/00 , C01G31/02
CPC分类号： C22B59/00 , C22B3/0005 , C22B3/0043 , C22B3/0067 , C22B3/0068 , Y02P10/234
摘要： The application of aqueous solution of magnesium bicarbonate and/or calcium bicarbonate in the process of extraction separation and purification of metals is disclosed, wherein the aqueous solution of magnesium bicarbonate and/or calcium bicarbonate is used as an acidity balancing agent, in order to adjust the balancing pH value of the extraction separation process which uses an acidic organic extractant, improve the extraction capacity of organic phase, and increase the concentration of metal ions in the loaded organic phase.
摘要翻译：公开了在金属萃取分离和纯化过程中应用碳酸氢镁和/或碳酸氢钙的水溶液，其中将碳酸氢镁和/或碳酸氢钙的水溶液用作酸度平衡剂，以便调节使用酸性有机萃取剂的提取分离过程的平衡pH值，提高有机相的萃取能力，提高负载有机相中金属离子的浓度。

5. 发明授权

US11065291B2 Traditional Chinese medicine composition for treating tumours, preparation method therefor and use thereof 有权
公开(公告)号：US11065291B2
公开(公告)日：2021-07-20
申请号：US16462073
申请日：2017-09-11
申请人： Angang Zuo , Shixu Zuo , Na Zhao
发明人： Angang Zuo , Shixu Zuo , Na Zhao
IPC分类号： A61K36/481 , A61P35/00 , A61K36/074 , A61K36/236 , A61K36/284 , A61K36/285 , A61K36/287 , A61K36/355 , A61K36/484 , A61K36/534 , A61K36/54 , A61K36/61
摘要： Disclosed are a traditional Chinese medicine composition for treating tumours and a preparation method therefor, wherein the composition is prepared from Sophora flavescens, wild Chrysanthemum flower, honeysuckle, mint, Poria cocos, Atractylodes lancea, cinnamon, clove, Astragalus, Ganoderma lucidum, Ligusticum striatum, Aucklandia root and Radix glycyrrhizae. The traditional Chinese medicine composition has an anti-tumour effect.

6. 发明授权

US08721998B2 Use of Mg(HCO3)2 and/or Ca(HCO3)2 aqueous solution in metal extractive separation and purification 有权
标题翻译：在金属萃取分离和纯化中使用Mg（HCO3）2和/或Ca（HCO3）2水溶液）
公开(公告)号：US08721998B2
公开(公告)日：2014-05-13
申请号：US13143772
申请日：2010-01-14
申请人： Xiaowei Huang , Zhiqi Long , Xinlin Peng , Hongwei Li , Guilin Yang , Dali Cui , Chunmei Wang , Na Zhao , Liangshi Wang , Ying Yu
发明人： Xiaowei Huang , Zhiqi Long , Xinlin Peng , Hongwei Li , Guilin Yang , Dali Cui , Chunmei Wang , Na Zhao , Liangshi Wang , Ying Yu
IPC分类号： C01F17/00
CPC分类号： C22B59/00 , C22B3/0005 , C22B3/0043 , C22B3/0067 , C22B3/0068 , Y02P10/234
摘要： The application of aqueous solution of magnesium bicarbonate and/or calcium bicarbonate in the process of extraction separation and purification of metals is disclosed, wherein the aqueous solution of magnesium bicarbonate and/or calcium bicarbonate is used as an acidity balancing agent, in order to adjust the balancing pH value of the extraction separation process which uses an acidic organic extractant, improve the extraction capacity of organic phase, and increase the concentration of metal ions in the loaded organic phase.
摘要翻译：公开了在金属萃取分离和纯化过程中应用碳酸氢镁和/或碳酸氢钙的水溶液，其中将碳酸氢镁和/或碳酸氢钙的水溶液用作酸度平衡剂，以便调节使用酸性有机萃取剂的提取分离过程的平衡pH值，提高有机相的萃取能力，提高负载有机相中金属离子的浓度。

7. 发明申请

US20100003176A1 PROCESS FOR PRETREATING ORGANIC EXTRACTANTS AND ITS PRODUCT AND APPLICATION 审中-公开
标题翻译：预处理有机提取物及其产品和应用的方法
公开(公告)号：US20100003176A1
公开(公告)日：2010-01-07
申请号：US12526436
申请日：2008-02-02
申请人： Xiaowei Huang , Hongwei Li , Zhiqi Long , Xinlin Peng , Dali Cui , Guilin Yang , Xinghua Luo , Na Zhao , Yongqi Zhang
发明人： Xiaowei Huang , Hongwei Li , Zhiqi Long , Xinlin Peng , Dali Cui , Guilin Yang , Xinghua Luo , Na Zhao , Yongqi Zhang
IPC分类号： C01F17/00
CPC分类号： C22B3/0067 , B01D11/0288 , B01D11/0492 , C01F17/0006 , C22B3/0005 , C22B3/0044 , C22B59/00 , Y02P10/234
摘要： A process for pretreating organic extractants and its product and application in SX separation of rare earth. The pretreating method is that extractant and rare earth solution are mixed with powder or slurry of alkaline earth metal compound containing magnesium and/or calcium to realize pre-extraction, or the organic extractant are mixed with rare earth carbonate slurry to realize pre-extraction. When rare earth ion in aqueous phase is extracted into organic phase, the exchanged hydrogen ions enter into aqueous phase and dissolve the alkaline earth metal compound or the rare earth carbonate which helps to keep the acidity equilibrium of the system. The obtained organic extractant loaded with rare earth is used for unsaponificated SX separation of rare earth.With this method, there is no need to saponificate organic extractant with liquid ammonia or alkali, and there is no ammonia-nitrogen wastewater produced. So separation cost decrease at a large scale and a lot of the cost to treat the three wastes is cut. This method is applicable to SX separation for all rare earth elements in chloride, sulphate and nitrate system and has advantages of low investment and high profit.
摘要翻译：一种用于预处理有机萃取剂及其产品和在稀土SX分离中的应用的方法。预处理方法是将萃取剂和稀土溶液与含有镁和/或钙的碱土金属化合物的粉末或浆料混合以实现预萃取，或者将有机萃取剂与稀土碳酸盐浆料混合以实现预萃取。当水相中的稀土离子萃取到有机相中时，交换的氢离子进入水相并溶解碱土金属化合物或稀土碳酸盐，有助于保持体系的酸度平衡。将所得到的装有稀土的有机萃取剂用于稀土的未分配的SX分离。通过这种方法，不需要用液体氨或碱对有机萃取剂进行皂化，不产生氨氮废水。因此，分离成本大幅度地下降，处理三种废物的成本大幅度下降。该方法适用于氯化物，硫酸盐和硝酸盐体系中所有稀土元素的SX分离，具有投资低，利润高的优点。

8. 发明申请

US20070071837A1 Treatment of aspirin resistance with radix salviae mitiorhizae, its extract and composition 审中-公开
标题翻译：用丹参丹参治疗阿司匹林抵抗，其提取物和组成
公开(公告)号：US20070071837A1
公开(公告)日：2007-03-29
申请号：US10564661
申请日：2004-08-26
申请人： Xijun Yan , Naifeng Wu , Zhengliang Ye , Xu Li , Zhixin Guo , Na Zhao
发明人： Xijun Yan , Naifeng Wu , Zhengliang Ye , Xu Li , Zhixin Guo , Na Zhao
IPC分类号： A61K36/254 , A61K36/258
CPC分类号： A61K36/537 , A61K36/185 , A61K36/258 , A61K45/06 , A61K2300/00
摘要： The present invention relates to the treatment of aspirin resistant cardio-cerebrovascular diseases using RSM (RSM), its extract and composition comprising any or both of them, especially the formulation Dan Shen Drop Pills (Drop Pills of RSM).
摘要翻译：本发明涉及使用RSM（RSM）治疗阿司匹林抗心律失常性心脑血管疾病，其提取物和组合物包含任何或两者，特别是制剂丹申滴丸（RSM滴剂）。

9. 发明申请

US20100198369A1 METHOD AND SYSTEM FOR MONITORING AND CONTROLLNG A MULTI-VARIABLE PROCESS THROUGHOUT A PLURALITY OF DISTINCT PHASES OF THE PROCESS 有权
标题翻译：用于监测和控制多变量过程的方法和系统通过过程的多个不同阶段
公开(公告)号：US20100198369A1
公开(公告)日：2010-08-05
申请号：US12678202
申请日：2008-09-15
申请人： Robin William Brooks , John Gavin Wilson , Na Zhao
发明人： Robin William Brooks , John Gavin Wilson , Na Zhao
IPC分类号： G05B13/02
CPC分类号： G05B23/024 , G05B19/41875 , G05B2219/1112 , G05B2219/35507 , G05B2223/02 , Y02P90/22
摘要： A control of a multi-variable process throughout a plurality of successive, distinct operational phases of the process involves accumulation of sets of values of the process and quality variables (a-j) from previous multiple operations of the process through all its phases, as respective datasets of a historical record. Each dataset includes an identifier (p) of the phase to which it relates. The current values of the applicable process variables (Qa-Qh) during each phase and the phase identifier (p) are indicated on respective axes (Xp,Xa-Xh) of a multi-dimensional display in relation to an operational envelope which defines bounds (UL,LL) for the values of the individual process and quality variables (a-j) relevant to that phase and which is derived from the datasets of the historical record identified with that phase. Changes in the current process variables (Qa-Qh) result in changes of the bounds (UL,LL), and alarm is given when a current value departs from within them. Either manually or automatically correction of an alarm condition is made in accordance with calculation of required change of value of one or more manipulatable process variables (a-c).
摘要翻译：在整个过程的多个连续的，不同的操作阶段中的多变量过程的控制包括从过程的所有阶段的先前的多个操作中累积过程值和质量变量（aj）的集合作为相应的数据集的历史记录。每个数据集包括与其相关的阶段的标识符（p）。相对于定义边界的操作包络，在多维显示器的各个轴（Xp，Xa-Xh）上指示每个阶段期间适用的过程变量（Qa-Qh）和相位标识符（p）的当前值（UL，LL）用于与该阶段相关的单个过程和质量变量（aj）的值，并且从根据该阶段确定的历史记录的数据集导出。当前过程变量（Qa-Qh）的变化导致边界（UL，LL）的变化，并且当当前值从其中偏离时给出报警。根据一个或多个可操作的过程变量（a-c）的所需要求的变化的计算，进行手动或自动校正报警条件。

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