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1. 发明申请

US20110274597A1 USE OF Mg(HCO3)2 AND/OR Ca(HCO3)2 AQUEOUS SOLUTION IN METAL EXTRACTIVE SEPARATION AND PURIFICATION 有权
标题翻译：在金属提取分离和纯化中使用Mg（HCO3）2和/或Ca（HCO3）2水溶液
公开(公告)号：US20110274597A1
公开(公告)日：2011-11-10
申请号：US13143772
申请日：2010-01-14
申请人： Xiaowei Huang , Zhiqi Long , Xinlin Peng , Hongwei Li , Guilin Yang , Dali Cui , Chunmei Wang , Na Zhao , Liangshi Wang , Ying Yu
发明人： Xiaowei Huang , Zhiqi Long , Xinlin Peng , Hongwei Li , Guilin Yang , Dali Cui , Chunmei Wang , Na Zhao , Liangshi Wang , Ying Yu
IPC分类号： C01F17/00 , C01F7/74 , C01F5/24 , C01G3/10 , C01G51/04 , C01F11/18 , C01G51/00 , C01G31/02
CPC分类号： C22B59/00 , C22B3/0005 , C22B3/0043 , C22B3/0067 , C22B3/0068 , Y02P10/234
摘要： The application of aqueous solution of magnesium bicarbonate and/or calcium bicarbonate in the process of extraction separation and purification of metals is disclosed, wherein the aqueous solution of magnesium bicarbonate and/or calcium bicarbonate is used as an acidity balancing agent, in order to adjust the balancing pH value of the extraction separation process which uses an acidic organic extractant, improve the extraction capacity of organic phase, and increase the concentration of metal ions in the loaded organic phase.
摘要翻译：公开了在金属萃取分离和纯化过程中应用碳酸氢镁和/或碳酸氢钙的水溶液，其中将碳酸氢镁和/或碳酸氢钙的水溶液用作酸度平衡剂，以便调节使用酸性有机萃取剂的提取分离过程的平衡pH值，提高有机相的萃取能力，提高负载有机相中金属离子的浓度。

2. 发明授权

US08721998B2 Use of Mg(HCO3)2 and/or Ca(HCO3)2 aqueous solution in metal extractive separation and purification 有权
标题翻译：在金属萃取分离和纯化中使用Mg（HCO3）2和/或Ca（HCO3）2水溶液）
公开(公告)号：US08721998B2
公开(公告)日：2014-05-13
申请号：US13143772
申请日：2010-01-14
申请人： Xiaowei Huang , Zhiqi Long , Xinlin Peng , Hongwei Li , Guilin Yang , Dali Cui , Chunmei Wang , Na Zhao , Liangshi Wang , Ying Yu
发明人： Xiaowei Huang , Zhiqi Long , Xinlin Peng , Hongwei Li , Guilin Yang , Dali Cui , Chunmei Wang , Na Zhao , Liangshi Wang , Ying Yu
IPC分类号： C01F17/00
CPC分类号： C22B59/00 , C22B3/0005 , C22B3/0043 , C22B3/0067 , C22B3/0068 , Y02P10/234
摘要： The application of aqueous solution of magnesium bicarbonate and/or calcium bicarbonate in the process of extraction separation and purification of metals is disclosed, wherein the aqueous solution of magnesium bicarbonate and/or calcium bicarbonate is used as an acidity balancing agent, in order to adjust the balancing pH value of the extraction separation process which uses an acidic organic extractant, improve the extraction capacity of organic phase, and increase the concentration of metal ions in the loaded organic phase.
摘要翻译：公开了在金属萃取分离和纯化过程中应用碳酸氢镁和/或碳酸氢钙的水溶液，其中将碳酸氢镁和/或碳酸氢钙的水溶液用作酸度平衡剂，以便调节使用酸性有机萃取剂的提取分离过程的平衡pH值，提高有机相的萃取能力，提高负载有机相中金属离子的浓度。

3. 发明授权

US08206940B2 Methods for diagnosis of Clostridium difficile and methods and vectors for recombinant toxin expression 失效
标题翻译：艰难梭菌诊断方法及重组毒素表达的方法和载体
公开(公告)号：US08206940B2
公开(公告)日：2012-06-26
申请号：US12992330
申请日：2009-05-15
申请人： Hanping Feng , Saul Tzipori , Guilin Yang
发明人： Hanping Feng , Saul Tzipori , Guilin Yang
IPC分类号： G01N33/53
CPC分类号： G01N33/56911 , G01N33/5014 , G01N33/5055 , G01N2333/33
摘要： Cell-based methods for rapid real time assay of a presence of Clostridium difficile toxin and/or cells are provided, using an assay having a toxin-enhancing antibody and a sensitive cell line carrying FcyR receptors, and kits for this assay. An ultrasensitive cell based immunocytotoxicity assay for detecting less then 1 pg/ml of C. difficile toxins in clinical samples. A TcdA-specific monoclonal antibody, AIH3, was found to significantly enhance the cytotoxicity of TcdA to macrophages and monocytes. The AIH3-dependent enhancement of glucosyltransferase activity, cytoskeleton disruption, and TNF-a production induced by TcdA was demonstrated also in RAW 264.7 cells. Methods for high level recombinant expression of C. difficile toxins in Bacillus cells, and vectors for expression, strains of Bacillus carrying the vectors are provided.
摘要翻译：使用具有毒素增强抗体和携带FcyR受体的敏感细胞系的测定法和用于该测定的试剂盒，提供了用于快速实时测定艰难梭菌毒素和/或细胞存在的基于细胞的方法。用于在临床样品中检测少于1pg / ml的艰难梭菌毒素的基于超敏感的基于细胞的免疫细胞毒性测定。发现TcdA特异性单克隆抗体AIH3显着增强TcdA对巨噬细胞和单核细胞的细胞毒性。在RAW 264.7细胞中也证明了由TcdA诱导的葡萄糖基转移酶活性，细胞骨架破坏和TNF-α产生的AIH3依赖性增强。提供了在芽孢杆菌细胞中高水平重组表达艰难梭菌毒素的方法和用于表达载体的载体载体的芽孢杆菌菌株。

4. 发明申请

US20100003176A1 PROCESS FOR PRETREATING ORGANIC EXTRACTANTS AND ITS PRODUCT AND APPLICATION 审中-公开
标题翻译：预处理有机提取物及其产品和应用的方法
公开(公告)号：US20100003176A1
公开(公告)日：2010-01-07
申请号：US12526436
申请日：2008-02-02
申请人： Xiaowei Huang , Hongwei Li , Zhiqi Long , Xinlin Peng , Dali Cui , Guilin Yang , Xinghua Luo , Na Zhao , Yongqi Zhang
发明人： Xiaowei Huang , Hongwei Li , Zhiqi Long , Xinlin Peng , Dali Cui , Guilin Yang , Xinghua Luo , Na Zhao , Yongqi Zhang
IPC分类号： C01F17/00
CPC分类号： C22B3/0067 , B01D11/0288 , B01D11/0492 , C01F17/0006 , C22B3/0005 , C22B3/0044 , C22B59/00 , Y02P10/234
摘要： A process for pretreating organic extractants and its product and application in SX separation of rare earth. The pretreating method is that extractant and rare earth solution are mixed with powder or slurry of alkaline earth metal compound containing magnesium and/or calcium to realize pre-extraction, or the organic extractant are mixed with rare earth carbonate slurry to realize pre-extraction. When rare earth ion in aqueous phase is extracted into organic phase, the exchanged hydrogen ions enter into aqueous phase and dissolve the alkaline earth metal compound or the rare earth carbonate which helps to keep the acidity equilibrium of the system. The obtained organic extractant loaded with rare earth is used for unsaponificated SX separation of rare earth.With this method, there is no need to saponificate organic extractant with liquid ammonia or alkali, and there is no ammonia-nitrogen wastewater produced. So separation cost decrease at a large scale and a lot of the cost to treat the three wastes is cut. This method is applicable to SX separation for all rare earth elements in chloride, sulphate and nitrate system and has advantages of low investment and high profit.
摘要翻译：一种用于预处理有机萃取剂及其产品和在稀土SX分离中的应用的方法。预处理方法是将萃取剂和稀土溶液与含有镁和/或钙的碱土金属化合物的粉末或浆料混合以实现预萃取，或者将有机萃取剂与稀土碳酸盐浆料混合以实现预萃取。当水相中的稀土离子萃取到有机相中时，交换的氢离子进入水相并溶解碱土金属化合物或稀土碳酸盐，有助于保持体系的酸度平衡。将所得到的装有稀土的有机萃取剂用于稀土的未分配的SX分离。通过这种方法，不需要用液体氨或碱对有机萃取剂进行皂化，不产生氨氮废水。因此，分离成本大幅度地下降，处理三种废物的成本大幅度下降。该方法适用于氯化物，硫酸盐和硝酸盐体系中所有稀土元素的SX分离，具有投资低，利润高的优点。

5. 发明授权

US08808660B2 Method of precipitation of metal ions 有权
标题翻译：金属离子析出方法
公开(公告)号：US08808660B2
公开(公告)日：2014-08-19
申请号：US13145632
申请日：2010-02-09
申请人： Xiaowei Huang , Zhiqi Long , Hongwei Li , Dali Cui , Xinlin Peng , Guilin Yang , Yongke Hou , Chunmei Wang , Shunli Zhang
发明人： Xiaowei Huang , Zhiqi Long , Hongwei Li , Dali Cui , Xinlin Peng , Guilin Yang , Yongke Hou , Chunmei Wang , Shunli Zhang
IPC分类号： C01B31/24
CPC分类号： C22B3/44 , C04B22/064 , C04B22/066 , C22B59/00 , Y02P10/234
摘要： The present invention relates to a method of precipitation of metal ions. Mineral(s), oxide(s), hydroxide(s) of magnesium and/or calcium are adopted as raw materials, and the raw material(s) is processed through at least one step of calcination, slaking, or carbonization to produce aqueous solution(s) of magnesium bicarbonate and/or calcium bicarbonate, and then the solution(s) is used as precipitant(s) to deposit rare earth, such as nickel, cobalt, iron, aluminum, gallium, indium, manganese, cadmium, zirconium, hafnium, strontium, barium, copper and zinc ions. And at least one of metal carbonates, hydroxides or basic carbonates is obtained, or furthermore the obtained products are calcined to produce metal oxides. The invention takes the cheap calcium and/or magnesium minerals or their oxides, hydroxides with low purity as raw materials to instead common precipitants such as ammonium bicarbonate and sodium carbonate etc. The calcium, magnesium, carbon dioxide etc are efficiently and circularly used, and the environment pollution by ammonium-nitrogen wastewater, high concentration salts wastewater is avoided, and both of the discharge of greenhouse gas carbon dioxide and the production cost of metal are decreased.
摘要翻译：本发明涉及一种沉淀金属离子的方法。采用矿物，氧化物，镁和/或钙的氢氧化物作为原料，通过至少一个煅烧，去渣或碳化步骤处理原料以产生水溶液碳酸氢钙和/或碳酸氢钙的溶液，然后使用该溶液作为沉淀剂沉积稀土，例如镍，钴，铁，铝，镓，铟，锰，镉，锆，铪，锶，钡，铜和锌离子。并且获得金属碳酸盐，氢氧化物或碱性碳酸盐中的至少一种，或者进一步将所得产物煅烧以产生金属氧化物。本发明以廉价的钙和/或镁矿物或其氧化物，低纯度的氢氧化物为原料，代替普通的沉淀剂如碳酸氢铵和碳酸钠等。钙，镁，二氧化碳等有效和循环使用，避免了氮铵废水，高浓度盐水等环境污染，温室气体二氧化碳的排放和金属的生产成本均下降。

6. 发明申请

US20120262259A1 LINEAR-ROTARY ELECTROMAGNETIC ACTUATOR 审中-公开
标题翻译：线性旋转电磁致动器
公开(公告)号：US20120262259A1
公开(公告)日：2012-10-18
申请号：US13502091
申请日：2010-10-14
申请人： Tat Joo Teo , Guilin Yang
发明人： Tat Joo Teo , Guilin Yang
IPC分类号： H01F7/06 , H01F7/02
CPC分类号： H02K16/00 , H02K7/08 , H02K11/20 , H02K26/00 , H02K41/03 , H02K2201/18
摘要： A linear-rotary electromagnetic actuator with a rotation module having an output shaft and a rotary encoder configured to sense rotary motion of the output shaft; and a translation module having a linear encoder configured to sense translational motion of the intermediate component; and an intermediate translator coupled between the rotation module and the translation module.
摘要翻译：一种具有旋转模块的线性旋转电磁致动器，具有输出轴和被配置为感测输出轴的旋转运动的旋转编码器; 以及翻译模块，其具有被配置为感测中间组件的平移运动的线性编码器; 以及耦合在所述旋转模块和所述平移模块之间的中间翻译器。

7. 发明申请

US20110280778A1 METHOD OF PRECIPITATION OF METAL IONS 有权
标题翻译：降低金属离子的方法
公开(公告)号：US20110280778A1
公开(公告)日：2011-11-17
申请号：US13145632
申请日：2010-02-09
申请人： Xiaowei Huang , Zhiqi Long , Hongwei Li , Dali Cui , Xinlin Peng , Guilin Yang , Yongke Hou , Chunmei Wang , Shunli Zhang
发明人： Xiaowei Huang , Zhiqi Long , Hongwei Li , Dali Cui , Xinlin Peng , Guilin Yang , Yongke Hou , Chunmei Wang , Shunli Zhang
IPC分类号： C01F17/00 , C01G49/02 , C01F7/34 , C01G51/06 , C01G53/06 , C01G27/00 , C01G45/00 , C01G15/00 , C01G3/00 , C01G9/00 , C01G11/00 , C01G45/02 , C01F11/02 , C01G3/02 , C01G9/02 , C01F5/24 , C01F11/18
CPC分类号： C22B3/44 , C04B22/064 , C04B22/066 , C22B59/00 , Y02P10/234
摘要： The present invention relates to a method of precipitation of metal ions. Mineral(s), oxide(s), hydroxide(s) of magnesium and/or calcium are adopted as raw materials, and the raw material(s) is processed through at least one step of calcination, slaking, or carbonization to produce aqueous solution(s) of magnesium bicarbonate and/or calcium bicarbonate, and then the solution(s) is used as precipitant(s) to deposit rare earth, such as nickel, cobalt, iron, aluminum, gallium, indium, manganese, cadmium, zirconium, hafnium, strontium, barium, copper and zinc ions. And at least one of metal carbonates, hydroxides or basic carbonates is obtained, or furthermore the obtained products are calcined to produce metal oxides. The invention takes the cheap calcium and/or magnesium minerals or their oxides, hydroxides with low purity as raw materials to instead common precipitants such as ammonium bicarbonate and sodium carbonate etc. The calcium, magnesium, carbon dioxide etc are efficiently and circularly used, and the environment pollution by ammonium-nitrogen wastewater, high concentration salts wastewater is avoided, and both of the discharge of greenhouse gas carbon dioxide and the production cost of metal are decreased.
摘要翻译：本发明涉及一种沉淀金属离子的方法。采用矿物，氧化物，镁和/或钙的氢氧化物作为原料，通过至少一个煅烧，去渣或碳化步骤处理原料以产生水溶液碳酸氢钙和/或碳酸氢钙的溶液，然后使用该溶液作为沉淀剂沉积稀土，例如镍，钴，铁，铝，镓，铟，锰，镉，锆，铪，锶，钡，铜和锌离子。并且获得金属碳酸盐，氢氧化物或碱性碳酸盐中的至少一种，或者进一步将所得产物煅烧以产生金属氧化物。本发明以廉价的钙和/或镁矿物或其氧化物，低纯度的氢氧化物为原料，代替普通的沉淀剂如碳酸氢铵和碳酸钠等。钙，镁，二氧化碳等有效和循环使用，避免了氮铵废水，高浓度盐水等环境污染，温室气体二氧化碳的排放和金属的生产成本均下降。

8. 发明申请

US20130328431A1 CYLINDRICAL ELECTROMAGNETIC ACTUATOR 审中-公开
标题翻译：圆柱电磁致动器
公开(公告)号：US20130328431A1
公开(公告)日：2013-12-12
申请号：US13990219
申请日：2010-11-29
申请人： Tat Joo Teo , Guilin Yang
发明人： Tat Joo Teo , Guilin Yang
IPC分类号： H02K1/06
CPC分类号： H02K1/06 , H02K41/0356
摘要： A cylindrical-shape electromagnetic actuator comprising a plurality of pairs of magnets, the magnets of each pair being held at a distance from each other with an effective air gap formed therebetween for accommodating a coil structure; and a substantially cylindrical frame structure for supporting the pairs of magnets, the frame structure being configured such that substantially separate closed loop magnetic paths are provided for the respective pairs of magnets.
摘要翻译：一种圆柱形电磁致动器，包括多对磁体，每对磁体彼此保持一段距离，在其间形成有效的气隙，用于容纳线圈结构; 以及用于支撑所述成对的磁体的大致圆柱形的框架结构，所述框架结构被配置成使得为相应的磁体对提供基本分离的闭环磁路。

9. 发明申请

US20110065123A1 Methods for diagnosis of Clostridium difficile and methods and vectors for recombinant toxin expression 失效
标题翻译：艰难梭菌诊断方法及重组毒素表达的方法和载体
公开(公告)号：US20110065123A1
公开(公告)日：2011-03-17
申请号：US12992330
申请日：2009-05-15
申请人： Hanping Feng , Saul Tzipori , Guilin Yang
发明人： Hanping Feng , Saul Tzipori , Guilin Yang
IPC分类号： G01N33/53 , C12Q1/04 , C12P1/04 , C12N15/63 , C12N5/07
CPC分类号： G01N33/56911 , G01N33/5014 , G01N33/5055 , G01N2333/33
摘要： Cell-based methods for rapid real time assay of a presence of Clostridium difficile toxin and/or cells are provided, using an assay having a toxin-enhancing antibody and a sensitive cell line carrying FcyR receptors, and kits for this assay. An ultrasensitive cell based immunocytotoxicity assay for detecting less then 1 pg/ml of C. difficile toxins in clinical samples. A TcdA-specific monoclonal antibody, AIH3, was found to significantly enhance the cytotoxicity of TcdA to macrophages and monocytes. The AIH3-dependent enhancement of glucosyltransferase activity, cytoskeleton disruption, and TNF-a production induced by TcdA was demonstrated also in RAW 264.7 cells. Methods for high level recombinant expression of C. difficile toxins in Bacillus cells, and vectors for expression, strains of Bacillus carrying the vectors are provided.
摘要翻译：使用具有毒素增强抗体和携带FcyR受体的敏感细胞系的测定法和用于该测定的试剂盒，提供了用于快速实时测定艰难梭菌毒素和/或细胞存在的基于细胞的方法。用于在临床样品中检测少于1pg / ml的艰难梭菌毒素的基于超敏感的基于细胞的免疫细胞毒性测定。发现TcdA特异性单克隆抗体AIH3显着增强TcdA对巨噬细胞和单核细胞的细胞毒性。在RAW 264.7细胞中也证明了由TcdA诱导的葡萄糖基转移酶活性，细胞骨架破坏和TNF-α产生的AIH3依赖性增强。提供了在芽孢杆菌细胞中高水平重组表达艰难梭菌毒素的方法和用于表达载体的载体载体的芽孢杆菌菌株。

10. 发明申请

US20100060088A1 Nano-Positioning Electromagnetic Linear Actuator 有权
标题翻译：纳米定位电磁线性执行器
公开(公告)号：US20100060088A1
公开(公告)日：2010-03-11
申请号：US12084948
申请日：2006-10-23
申请人： Tat Joo Teo , Guilin Yang
发明人： Tat Joo Teo , Guilin Yang
IPC分类号： H02K41/035
CPC分类号： H02K33/18 , F16F15/046 , F16F2238/022 , H02K41/0356 , H02K2213/03
摘要： A flexure for an electromagnetic nano-positioning linear actuator having a support and an actuating body, the flexure comprising: a first resilient end for attaching to the support; a second resilient end for attaching to the actuating body; and a substantially rigid intermediate portion located between the first resilient end and the second resilient end.
摘要翻译：用于具有支撑件和致动体的电磁纳米定位线性致动器的挠曲件，所述挠曲件包括：用于附接到所述支撑件的第一弹性端; 用于附接到致动体的第二弹性端; 以及位于第一弹性端和第二弹性端之间的基本上刚性的中间部分。

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