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1. 发明申请

US20080138290A1 Fluoro-Carbon Emulsion Enhancement Agent for High Intensity Focused Ultrasound Treatment and Use thereof 审中-公开
标题翻译：用于高强度聚焦超声治疗及其应用的氟碳乳液增强剂
公开(公告)号：US20080138290A1
公开(公告)日：2008-06-12
申请号：US11794932
申请日：2005-09-02
申请人： Zhibiao Wang , Faqi Li , Ziwen Xiao , Yanbing Xiao , Liping Liu , Zhilong Wang
发明人： Zhibiao Wang , Faqi Li , Ziwen Xiao , Yanbing Xiao , Liping Liu , Zhilong Wang
IPC分类号： A61K49/22
CPC分类号： A61K41/0033 , A61K9/0009 , A61K9/0019 , A61K9/107 , A61K9/1075 , A61K31/685 , A61K49/226
摘要： The present invention discloses a fluorocarbon emulsion enhancement agent for HIFU treatment, which can increase acoustic energy deposition at the target location during HIFU treatment. The enhancement agent comprises a discontinuous phase comprising of a core material encapsulated by a membrane-forming material and a continuous phase comprised of aqueous medium; the discontinuous phase is uniformly dispersed in the continuous phase and the particle size of the discontinuous phase ranges from 0.1-2 μm; the amount of the membrane-forming material in the enhancement agent is 0.1-100 g/L; the core material is comprised of a liquid that undergoes a liquid-gas phase transition at 38-100° C., and the amount of the core material in the enhancement agent is 5-200 ml/L. The fluorocarbon emulsion enhancement agent for HIFU treatment of the present invention can significantly change the acoustic environment of the target location and can increase acoustic energy deposition at the target location during HIFU treatment.
摘要翻译：本发明公开了一种用于HIFU处理的碳氟化合物乳液增强剂，其可以在HIFU处理期间增加目标位置处的声能沉积。增强剂包括由膜形成材料包封的芯材料和由水性介质组成的连续相的不连续相; 不连续相均匀分散在连续相中，不连续相的粒径为0.1-2μm; 增塑剂中的成膜材料的量为0.1-100g / L; 核心材料由在38-100℃下经历液相 - 气相转变的液体组成，增强剂中核心材料的量为5-200ml / L。本发明的用于HIFU处理的碳氟化合物乳液增强剂可以显着改变目标位置的声学环境，并且可以在HIFU处理期间增加目标位置处的声能沉积。

2. 发明申请

US20080139973A1 Particle Enhancement Agent For High Intensity Focused Ultrasound Treatment And Use Thereof 审中-公开
标题翻译：用于高强度聚焦超声治疗和使用的粒子增强剂
公开(公告)号：US20080139973A1
公开(公告)日：2008-06-12
申请号：US11794931
申请日：2005-09-02
申请人： Zhibiao Wang , Faqi Li , Yanbing Xiao , Ziwen Xiao , Liping Liu , Zhilong Wang
发明人： Zhibiao Wang , Faqi Li , Yanbing Xiao , Ziwen Xiao , Liping Liu , Zhilong Wang
IPC分类号： A61N7/02
CPC分类号： A61K41/0033 , A61K9/0019 , A61K9/107 , A61K9/127 , A61K31/685
摘要： The present invention discloses a particle enhancement agent for high intensity focused ultrasound (HIFU) treatment, which can increase acoustic energy deposition at the target location during HIFU treatment. The enhancement agent comprises a discontinuous phase comprised of a core material encapsulated by a membrane-forming material and a continuous phase comprising of aqueous medium. The discontinuous phase is uniformly dispersed in the continuous phase and the particle size of the discontinuous phase ranges from 0.1-8 μm; the amount of the membrane-forming material in the enhancement agent is 0.1-100 g/L; the core material is comprised of a liquid that does not undergo a liquid-gas phase transition at 38-100° C., and the amount of core material in the enhancement agent is 5-200 g/L.
摘要翻译：本发明公开了一种用于高强度聚焦超声（HIFU）处理的颗粒增强剂，其可以在HIFU处理期间增加目标位置处的声能沉积。增强剂包括由膜形成材料包封的芯材料和包含水性介质的连续相组成的不连续相。不连续相均匀分散在连续相中，不连续相的粒径为0.1-8μm; 增塑剂中的成膜材料的量为0.1-100g / L; 核心材料由在38-100℃不经历液 - 气相变的液体组成，增强剂中芯材的量为5-200g / L。

3. 发明申请

US20090117052A1 Enhancement agent for high intensity focused ultrasound treatment and method for screening the same 审中-公开
标题翻译：高强度聚焦超声治疗增强剂及其筛选方法
公开(公告)号：US20090117052A1
公开(公告)日：2009-05-07
申请号：US11794928
申请日：2005-08-30
申请人： Zhibiao Wang , Faqi Li , Yanbing Xiao , Ziwen Xiao , Liping Liu , Zhilong Wang
发明人： Zhibiao Wang , Faqi Li , Yanbing Xiao , Ziwen Xiao , Liping Liu , Zhilong Wang
IPC分类号： A61B8/00 , A61N7/00
CPC分类号： A61K41/0052 , A61K41/0028
摘要： The present invention discloses an enhancement agent for high intensity focused ultrasound (HIFU) treatment, which is administered to a patient before HIFU treatment and can reduce the level of EEF at the target location to be treated with HIFU. EEF is presented by the expression: EEF=ηPt/V (unit: J/mm3), and refers to the HIFU energy needed to effectively treat a tumor per unit volume of the tumor, wherein, η=0.7; P refers to the total acoustic power of HIFU source (unit: W); t refers to the total time of HIFU treatment (unit: s); V refers to the volume of HIFU-induced lesions (unit: mm3). If the amount of EEF at the target location before administration of the enhancement agent is defined as EEF(base) and the amount of EEF at the target location after administration of the enhancement agent is defined as EEF(measurement), the ratio between EEF(base) and EEF(measurement) is more than 1, preferably more than 2, and more preferably over 4. The use of the enhancement agent for HIFU treatment of the present invention makes it possible to treat deep-seated tumors. In addition, patients with hepatic tumors can be effectively treated without removal of ribs. Accordingly, the present invention discloses methods for increasing acoustic energy deposition at target location during HIFU treatment and screening the enhancement agents for HIFU treatment.
摘要翻译：本发明公开了一种用于高强度聚焦超声（HIFU）治疗的增强剂，其在HIFU治疗之前施用于患者，并且可以降低用HIFU治疗的目标位置处的EEF水平。 EEF由以下表达式表示：EEF = etaPt / V（单位：J / mm 3），并且是指每单位体积肿瘤有效治疗肿瘤所需的HIFU能量，其中eta = 0.7; P指HIFU源的总声功率（单位：W）; t指HIFU治疗的总时间（单位：s）; V指HIFU诱导的病变体积（单位：mm3）。如果将增强剂施用前的目标位置处的EEF量定义为EEF（碱基），并且将施用增效剂后的目标位置处的EEF的量定义为EEF（测定），则EEF 碱）和EEF（测量）大于1，优选大于2，更优选超过4.使用本发明的HIFU治疗用增强剂可以治疗深层肿瘤。此外，肝脏肿瘤患者可以有效地治疗，无需排除肋骨。因此，本发明公开了在HIFU处理期间增加目标位置处的声能沉积并筛选用于HIFU处理的增强剂的方法。

4. 发明申请

US20080260790A1 Plasmid Enhancement Agent for High Intensity Focused Ultrasound Treatment and Use Thereof 审中-公开
标题翻译：用于高强度聚焦超声治疗和使用的质粒增强剂
公开(公告)号：US20080260790A1
公开(公告)日：2008-10-23
申请号：US11794927
申请日：2005-08-30
申请人： Zhibiao Wang , Faqi Li , Liping Liu , Yanbing Xiao , Ziwen Xiao , Zhilong Wang
发明人： Zhibiao Wang , Faqi Li , Liping Liu , Yanbing Xiao , Ziwen Xiao , Zhilong Wang
IPC分类号： A61K9/50 , A61K33/42 , A61K33/10 , A61P35/00
CPC分类号： A61K33/10 , A61K31/575 , A61K31/66 , A61K33/42 , A61K41/0028 , A61K41/0052 , A61K45/06 , A61N7/02 , A61K2300/00
摘要： The present invention discloses a plasmid enhancement agent for high intensity focused ultrasound (HIFU) treatment, which can increase acoustic energy deposition at the target location during HIFU treatment. The enhancement agent comprises a nanometer-sized biocompatible solid. The present invention also discloses another plasmid enhancement agent for HIFU treatment, wherein, the enhancement agent comprises a discontinuous phase is comprised of a core material encapsulated by a membrane-forming material, and a continuous phase comprised of aqueous medium; the discontinuous phase is uniformly dispersed in the continuous phase and has a particle size ranging from 10-1000 nm; the amount of the membrane-forming material in the enhancement agent is 0.1-100g/L; and the core material comprises nanometer-sized biocompatible solid selected from the group consisting of magnetic biomaterials, hydroxylapatite, and calcium carbonate, and the amount of the core material in the enhancement agent is 0.1-150 g/L.
摘要翻译：本发明公开了一种用于高强度聚焦超声（HIFU）处理的质粒增强剂，其可以在HIFU处理期间增加目标位置处的声能沉积。增强剂包括纳米尺寸的生物相容性固体。本发明还公开了另一种用于HIFU处理的质粒增强剂，其中增强剂包括不连续相，其包含由成膜材料包封的芯材料和由水性介质组成的连续相; 不连续相均匀分散在连续相中，粒径范围为10-1000nm; 增塑剂中的成膜材料的量为0.1-100g / L; 并且核心材料包括选自磁性生物材料，羟基磷灰石和碳酸钙的纳米尺寸的生物相容性固体，并且增强剂中的芯材料的量为0.1-150g / L。

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