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1. 发明申请

US20100075965A1 PI3 KINASE INHIBITORS AND METHODS OF THEIR USE 审中-公开
标题翻译： PI3激酶抑制剂及其使用方法
公开(公告)号：US20100075965A1
公开(公告)日：2010-03-25
申请号：US12279148
申请日：2007-02-14
申请人： Zhi-Jie Ni , Sabina Pecchi , Matthew Burger , Wooseok Han , Aaron Smith , Gordana Atallah , Sarah Bartulis , Kelly Frazier , Joelle Verhagen , Yanchen Zhang , Ed Iwanowicz , Tom Hendrickson , Mark Knapp , Hanne Merritt , Charles Voliva , Marion Wiesmann , Darren Mark Legrand , Ian Bruce , James Dale , Jiong Lan , Barry Levine , Abran Costales , Jui Liu , Teresa Pick , Daniel Menezes
发明人： Zhi-Jie Ni , Sabina Pecchi , Matthew Burger , Wooseok Han , Aaron Smith , Gordana Atallah , Sarah Bartulis , Kelly Frazier , Joelle Verhagen , Yanchen Zhang , Ed Iwanowicz , Tom Hendrickson , Mark Knapp , Hanne Merritt , Charles Voliva , Marion Wiesmann , Darren Mark Legrand , Ian Bruce , James Dale , Jiong Lan , Barry Levine , Abran Costales , Jui Liu , Teresa Pick , Daniel Menezes
IPC分类号： A61K31/5377 , C07D471/04 , C07D487/04 , C07D413/14 , A61K31/437 , A61K31/5025 , A61P35/00
CPC分类号： C07D487/04 , C07D417/04 , C07D417/14 , C07D471/04
摘要： Phosphatidylinositol (PI) 3 kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, phospholipid kinases, G-protein coupled receptors, and phosphatases.
摘要翻译：磷脂酰肌醇（PI）3激酶抑制剂化合物，其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂联合使用的新化合物在预防或治疗以生长因子，蛋白丝氨酸/苏氨酸激酶，磷脂激酶，G蛋白偶联的异常活性为特征的增殖性疾病中的用途受体和磷酸酶。

2. 发明申请

US20050192287A1 Substituted benzazoles and methods of their use as inhibitors of Raf kinase 失效
标题翻译：取代的苯并唑及其作为Raf激酶抑制剂的方法
公开(公告)号：US20050192287A1
公开(公告)日：2005-09-01
申请号：US10967089
申请日：2004-10-15
申请人： Abran Costales , Teresa Hansen , Barry Levine , Christopher McBride , Daniel Poon , Savithri Ramurthy , Paul Renhowe , Cynthia Shafer , Sharadha Subramanian , Joelle Verhagen
发明人： Abran Costales , Teresa Hansen , Barry Levine , Christopher McBride , Daniel Poon , Savithri Ramurthy , Paul Renhowe , Cynthia Shafer , Sharadha Subramanian , Joelle Verhagen
IPC分类号： A61K31/4439 , A61K31/4745 , A61K31/496 , A61K31/506 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/12
CPC分类号： C07D401/12 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/551 , A61K45/06 , C04B35/632 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14
摘要： New substituted benzazole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.
摘要翻译：提供了新的取代的苯唑化合物，抑制人或动物受试者中的Raf激酶活性的组合物和方法。新化合物组合物可以单独使用或与至少一种另外的药物组合使用，用于治疗Raf激酶介导的病症，例如癌症。

3. 发明申请

US20070027150A1 2-Amino-quinazolin-5-ones 审中-公开
标题翻译： 2-氨基 - 喹唑啉-5-酮
公开(公告)号：US20070027150A1
公开(公告)日：2007-02-01
申请号：US11404372
申请日：2006-04-14
申请人： Cornelia Bellamacina , Abran Costales , Brandon Doughan , Susan Fong , Zhenhai Gao , Thomas Hendrickson , Barry Levine , Xiaodong Lin , Timothy Machajewski , Christopher McBride , William Antonios-McCrea , Maureen McKenna , Kris Mendenhall , Alice Rico , Cynthia Shafer , X. Wang , Yi Xia , Yasheen Zhou
发明人： Cornelia Bellamacina , Abran Costales , Brandon Doughan , Susan Fong , Zhenhai Gao , Thomas Hendrickson , Barry Levine , Xiaodong Lin , Timothy Machajewski , Christopher McBride , William Antonios-McCrea , Maureen McKenna , Kris Mendenhall , Alice Rico , Cynthia Shafer , X. Wang , Yi Xia , Yasheen Zhou
IPC分类号： A61K31/5377 , A61K31/517 , C07D413/02 , C07D403/02
CPC分类号： C07D401/14 , C07D239/84 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D409/10 , C07D413/10 , C07D417/10 , C07D417/12 , C07D417/14
摘要： 2-Amino-quinazolin-5-one compounds, stereoisomers, tautomers, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the 2-amino-quinazolin-5-one compounds, either alone or in combination with at least one additional therapeutic agent. Methods of using the 2-amino-quinazolin-5-one compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cell proliferative diseases.
摘要翻译： 2-氨基 - 喹唑啉-5-酮化合物，立体异构体，互变异构体，药用盐和前药; 包括药学上可接受的载体和一种或多种2-氨基 - 喹唑啉-5-酮化合物的组合物，单独或与至少一种另外的治疗剂组合。将2-氨基 - 喹唑啉-5-酮化合物单独使用或与至少一种另外的治疗剂组合使用的方法用于预防或治疗细胞增殖性疾病。

4. 发明申请

US20070161680A1 Substituted benzimidazoles and methods of their use 有权
标题翻译：取代的苯并咪唑及其使用方法
公开(公告)号：US20070161680A1
公开(公告)日：2007-07-12
申请号：US11513959
申请日：2006-08-30
申请人： Mina Alkawa , Payman Amiri , Jeffrey Dove , Barry Levine , Christopher McBride , Teresa Pick , Daniel Poon , Savithri Ramurthy , Paul Renhowe , Cynthia Shafer , Darrin Stuart , Sharadha Subramanian
发明人： Mina Alkawa , Payman Amiri , Jeffrey Dove , Barry Levine , Christopher McBride , Teresa Pick , Daniel Poon , Savithri Ramurthy , Paul Renhowe , Cynthia Shafer , Darrin Stuart , Sharadha Subramanian
IPC分类号： A61K31/4439 , C07D403/14
CPC分类号： C07D401/14 , Y02P20/55
摘要： New substituted benzimidazole compounds, compositions, and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.
摘要翻译：提供了新的取代的苯并咪唑化合物，组合物和抑制与人或动物受试者的肿瘤发生相关的激酶活性的方法。在某些实施方案中，化合物和组合物有效地抑制至少一种丝氨酸/苏氨酸激酶或受体酪氨酸激酶的活性。新化合物和组合物可以单独使用或与至少一种另外的药剂组合使用，用于治疗丝氨酸/苏氨酸激酶或受体酪氨酸激酶介导的病症，例如癌症。

5. 发明申请

US20070123546A1 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-ones 有权
标题翻译： 2-氨基-7,8-二氢-6H-吡啶并[4,3-d]嘧啶-5-酮
公开(公告)号：US20070123546A1
公开(公告)日：2007-05-31
申请号：US11541462
申请日：2006-09-28
申请人： Timothy Machajewski , Cynthia Shafer , Christopher McBride , William Antonios-McCrea , Brandon Doughan , Barry Levine , Yi Xia , Maureen McKeena , X. Wang , Kris Mendenhall , Yasheen Zhou , Baoquing Gong , Dan Gu , John Dolan , John Tulinsky , Kristin Brinner , Zhenhai Gao
发明人： Timothy Machajewski , Cynthia Shafer , Christopher McBride , William Antonios-McCrea , Brandon Doughan , Barry Levine , Yi Xia , Maureen McKeena , X. Wang , Kris Mendenhall , Yasheen Zhou , Baoquing Gong , Dan Gu , John Dolan , John Tulinsky , Kristin Brinner , Zhenhai Gao
IPC分类号： A61K31/519 , C07D487/02 , C07D211/54
CPC分类号： C07D211/86 , C07D471/04
摘要： Disclosed are 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, their stereoisomers, tautomers, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent. Disclosed also are methods of using the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cellular proliferative, viral, autoimmune, cardiovascular, and central nervous system diseases.
摘要翻译：公开了2-氨基-7,8-二氢-6H-吡啶并[4,3-d]嘧啶-5-酮化合物，其立体异构体，互变异构体，其药学上可接受的盐和前药; 包括药学上可接受的载体和一种或多种2-氨基-7,8-二氢-6H-吡啶并[4,3-d]嘧啶-5-酮化合物的组合物，单独或与至少一种额外的治疗剂。还公开了将2-氨基-7,8-二氢-6H-吡啶并[4,3-d]嘧啶-5-酮化合物单独使用或与至少一种另外的治疗剂组合使用的方法，用于预防或治疗细胞增殖，病毒，自身免疫，心血管和中枢神经系统疾病。

6. 发明授权

US07348608B2 Planar avalanche photodiode 有权
标题翻译：平面雪崩光电二极管
公开(公告)号：US07348608B2
公开(公告)日：2008-03-25
申请号：US10836878
申请日：2004-04-30
申请人： Cheng C. Ko , Barry Levine
发明人： Cheng C. Ko , Barry Levine
IPC分类号： H01L29/732
CPC分类号： H01L31/1075 , H01L31/035281 , Y02E10/50
摘要： A planar avalanche photodiode includes a small localized contact layer on the top of the device produced by either a diffusion or etching process and a semiconductor layer defining a lower contact area. A semiconductor multiplication layer is positioned between the two contact areas and a semiconductor absorption layer is positioned between the multiplication layer and the upper contact layer. The photodiode has a low capacitance and a low field near the edges of the semiconductor multiplication and absorption layers.
摘要翻译：平面雪崩光电二极管包括通过扩散或蚀刻工艺产生的器件的顶部上的小的局部接触层和限定较低接触面积的半导体层。半导体倍增层位于两个接触区域之间，半导体吸收层位于倍增层和上接触层之间。光电二极管在半导体乘法吸收层的边缘附近具有低电容和低电场。

7. 发明授权

US07348607B2 Planar avalanche photodiode 有权
标题翻译：平面雪崩光电二极管
公开(公告)号：US07348607B2
公开(公告)日：2008-03-25
申请号：US10502110
申请日：2003-02-03
申请人： Cheng C. Ko , Barry Levine
发明人： Cheng C. Ko , Barry Levine
IPC分类号： H01L29/732
CPC分类号： H01L31/1075 , H01L31/035281 , Y02E10/50
摘要： The present invention includes a planar avalanche photodiode having a first n-type semiconductor layer defining a planar contact area, and a second n-type semiconductor layer having a p-type diffusion region. Further features of the structure includes an n-type semiconductor multiplication layer, an n-type semiconductor absorption layer, and a p-type contact layer. Further embodiments include a planar avalanche photodiode having a first n-type semiconductor layer defining a planar contact area, an n-type semiconductor multiplication layer, an n-type semiconductor absorption layer and a p-type semiconductor layer electrically coupled to a p-type contact layer.
摘要翻译：本发明包括具有限定平面接触面积的第一n型半导体层的平面雪崩光电二极管和具有p型扩散区域的第二n型半导体层。该结构的其它特征包括n型半导体倍增层，n型半导体吸收层和p型接触层。另外的实施例包括具有限定平面接触面积的第一n型半导体层的平面雪崩光电二极管，n型半导体倍增层，n型半导体吸收层和与p型电耦合的p型半导体层接触层。

8. 发明申请

US20070299039A1 Substituted benz-azoles and methods of their use as inhibitors of Raf kinase 失效
标题翻译：取代的苯并唑及其用作Raf激酶抑制剂的方法
公开(公告)号：US20070299039A1
公开(公告)日：2007-12-27
申请号：US11282939
申请日：2005-11-18
申请人： Payman Amiri , Wendy Fantl , Teresa Hansen , Barry Levine , Christopher McBride , Daniel Poon , Savithri Ramurthy , Paul Renhowe , Cynthia Shafer , Sharadha Subramanian , Leonard Sung
发明人： Payman Amiri , Wendy Fantl , Teresa Hansen , Barry Levine , Christopher McBride , Daniel Poon , Savithri Ramurthy , Paul Renhowe , Cynthia Shafer , Sharadha Subramanian , Leonard Sung
IPC分类号： A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/5377 , A61K31/55 , A61K31/665 , A61P35/00 , C07D401/10 , C07D401/14 , C07D413/10 , C07D413/14 , C07D417/10
CPC分类号： C07D401/14 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/12 , C07D417/14 , C07D453/02
摘要： New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.
摘要翻译：提供了新的取代的苯并唑化合物，抑制人或动物受试者中Raf激酶活性的组合物和方法。新化合物组合物可以单独使用或与至少一种另外的药物组合使用，用于治疗Raf激酶介导的病症，例如癌症。

9. 发明授权

US07468503B2 Pin photodetector with mini-mesa contact layer 有权
标题翻译：带微型台面接触层的针式光电探测器
公开(公告)号：US07468503B2
公开(公告)日：2008-12-23
申请号：US10555144
申请日：2004-04-30
申请人： Cheng C. Ko , Barry Levine
发明人： Cheng C. Ko , Barry Levine
IPC分类号： H01L31/00
CPC分类号： H01L31/105 , H01L31/02161 , H01L31/03046 , Y02E10/544
摘要： A PIN photodetector includes a first semiconductor contact layer, a semiconductor absorption layer having a larger area than the first semiconductor contact layer, a semiconductor passivation layer positioned between the first semiconductor contact layer and absorption layer, and a second semiconductor contact layer. The semiconductor absorption layer and passivation layers are positioned between the first and second semiconductor contact layers.
摘要翻译： PIN光检测器包括第一半导体接触层，具有比第一半导体接触层更大的面积的半导体吸收层，位于第一半导体接触层和吸收层之间的半导体钝化层和第二半导体接触层。半导体吸收层和钝化层位于第一和第二半导体接触层之间。

10. 发明授权

US07078741B2 Enhanced photodetector 有权
标题翻译：增强型光电探测器
公开(公告)号：US07078741B2
公开(公告)日：2006-07-18
申请号：US10502109
申请日：2003-02-03
申请人： Cheng C. Ko , Barry Levine
发明人： Cheng C. Ko , Barry Levine
IPC分类号： H01L31/109
CPC分类号： H01L31/105 , H01L31/03042 , H01L31/102 , Y02E10/544
摘要： The present invention includes a photodiode having a first p-type semiconductor layer and an n-type semiconductor layer coupled by a second p-type semiconductor layer. The second p-type semiconductor layer has graded doping along the path of the carriers. In particular, the doping is concentration graded from a high value near the anode to a lower p concentration towards the cathode. By grading the doping in this way, an increase in absorption is achieved, improving the responsivity of the device. Although this doping increases the capacitance relative to an intrinsic semiconductor of the same thickness, the pseudo electric field that is created by the graded doping gives the electrons a very high velocity which more than compensates for this increased capacitance.
摘要翻译：本发明包括具有第一p型半导体层和通过第二p型半导体层耦合的n型半导体层的光电二极管。第二p型半导体层沿载流子的路径分级掺杂。特别地，掺杂是从阳极附近的高值到朝向阴极的较低p浓度的浓度。通过以这种方式对掺杂进行分级，实现了吸收的增加，提高了器件的响应度。虽然这种掺杂相对于相同厚度的本征半导体增加了电容，但是由渐变掺杂产生的伪电场给予电子非常高的速度，这大大地补偿了这种增加的电容。

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