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    • 6. 发明申请
    • Listeria-based and LLO-based vaccines
    • 基于李斯特菌和基于LLO的疫苗
    • US20060093582A1
    • 2006-05-04
    • US11223945
    • 2005-09-13
    • Yvonne PatersonReshma Singh
    • Yvonne PatersonReshma Singh
    • A61K48/00A61K39/02
    • A61K39/0011A61K2039/522A61K2039/523A61K2039/6068
    • This invention provides methods of treating and vaccinating against an antigen-expressing tumor and inducing an immune response against a sub-dominant epitope of antigen, comprising a fusion of an LLO fragment to the antigen or a recombinant Listeria strain expressing the antigen. The present invention also provides recombinant peptides comprising a listeriolysin (LLO) protein fragment fused to a Her-2 protein or fragment thereof, recombinant Listeria strains expressing a Her-2 protein, vaccines and immunogenic compositions comprising same, and methods of inducing an anti-Her-2 immune response and treating and vaccinating against a Her-2-expressing tumor, comprising same.
    • 本发明提供了针对抗原表达的肿瘤治疗和接种疫苗并针对抗原的亚优势表位诱导免疫应答的方法,其包括LLO片段与抗原或表达抗原的重组利斯特氏菌属菌株的融合物。 本发明还提供了包含与Her-2蛋白或其片段融合的李斯特里菌素(LLO)蛋白片段,表达Her-2蛋白的重组利斯特氏菌菌株,疫苗和包含其的免疫原性组合物的重组肽, Her-2免疫应答,并针对Her-2表达的肿瘤进行治疗和接种疫苗,包括其。
    • 7. 发明授权
    • Listeria-based and LLO-based vaccines
    • 基于李斯特菌和基于LLO的疫苗
    • US07820180B2
    • 2010-10-26
    • US11223945
    • 2005-09-13
    • Reshma SinghYvonne Paterson
    • Reshma SinghYvonne Paterson
    • A61K39/02A61K38/04A61K38/16
    • A61K39/0011A61K2039/522A61K2039/523A61K2039/6068
    • This invention provides methods of treating and vaccinating against an antigen-expressing tumor and inducing an immune response against a sub-dominant epitope of antigen, comprising a fusion of an LLO fragment to the antigen or a recombinant Listeria strain expressing the antigen. The present invention also provides recombinant peptides comprising a listeriolysin (LLO) protein fragment fused to a Her-2 protein or fragment thereof, recombinant Listeria strains expressing a Her-2 protein, vaccines and immunogenic compositions comprising same, and methods of inducing an anti-Her-2 immune response and treating and vaccinating against a Her-2-expressing tumor, comprising same.
    • 本发明提供了针对抗原表达的肿瘤治疗和接种疫苗并针对抗原的亚优势表位诱导免疫应答的方法,其包括LLO片段与抗原或表达抗原的重组利斯特氏菌属菌株的融合物。 本发明还提供了包含与Her-2蛋白或其片段融合的李斯特里菌素(LLO)蛋白片段,表达Her-2蛋白的重组利斯特氏菌菌株,疫苗和包含其的免疫原性组合物的重组肽, Her-2免疫应答,并针对Her-2表达的肿瘤进行治疗和接种疫苗,包括其。