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1. 发明授权

US07794729B2 Methods and compositions for immunotherapy of cancer 有权
标题翻译：癌症免疫治疗的方法和组成
公开(公告)号：US07794729B2
公开(公告)日：2010-09-14
申请号：US10949667
申请日：2004-09-24
申请人： Yvonne Paterson , Reshma Singh
发明人： Yvonne Paterson , Reshma Singh
IPC分类号： A61K39/02 , A61K38/04 , A61K38/16
CPC分类号： C07K14/005 , A61K39/00 , C07K14/34 , C07K14/705 , C07K2319/00 , C12N2760/16122
摘要： The present invention includes compositions, methods and kits for inducing an immune response to a tumor and for treating cancer with a Listeria vaccine strain expressing an antigen fused to a truncated LLO protein.
摘要翻译：本发明包括用表达与截短的LLO蛋白融合的抗原的利斯特氏菌疫苗株诱导对肿瘤的免疫应答和治疗癌症的组合物，方法和试剂盒。

2. 发明申请

US20050129715A1 Methods and compositions for immunotherapy of cancer 有权
标题翻译：癌症免疫治疗的方法和组成
公开(公告)号：US20050129715A1
公开(公告)日：2005-06-16
申请号：US10949667
申请日：2004-09-24
申请人： Yvonne Paterson , Reshma Singh
发明人： Yvonne Paterson , Reshma Singh
IPC分类号： A61K39/00 , C07K14/11 , C07K14/34 , C07K14/705 , A61K39/02
CPC分类号： C07K14/005 , A61K39/00 , C07K14/34 , C07K14/705 , C07K2319/00 , C12N2760/16122
摘要： The present invention includes compositions, methods and kits for inducing an immune response to a tumor and for treating cancer with a Listeria vaccine strain expressing an antigen fused to a truncated LLO protein.
摘要翻译：本发明包括用表达与截短的LLO蛋白融合的抗原的利斯特氏菌疫苗株诱导对肿瘤的免疫应答和治疗癌症的组合物，方法和试剂盒。

3. 发明授权

US09463227B2 Listeria-based adjuvants 有权
标题翻译：基于利斯特氏菌的佐剂
公开(公告)号：US09463227B2
公开(公告)日：2016-10-11
申请号：US14004455
申请日：2012-03-12
申请人： John Rothman , Anu Wallecha , Reshma Singh , Donald A. Harn, Jr. , Yvonne Paterson
发明人： John Rothman , Anu Wallecha , Reshma Singh , Donald A. Harn, Jr. , Yvonne Paterson
IPC分类号： A01N63/00 , A61K39/00 , A61K35/74
CPC分类号： A61K39/0011 , A61K35/74 , A61K2039/522 , A61K2039/523
摘要： This invention provides methods and compositions for using Listeria monocytogenes as an adjuvant for enhancing immune responses in a subject.
摘要翻译：本发明提供了使用单核细胞增生利斯特氏菌作为佐剂以增强受试者的免疫应答的方法和组合物。

4. 发明授权

US07662396B2 Compositions and methods for enhancing the immunogenicity of antigens 有权
标题翻译：用于增强抗原免疫原性的组合物和方法
公开(公告)号：US07662396B2
公开(公告)日：2010-02-16
申请号：US11373528
申请日：2006-03-13
申请人： Yvonne Paterson , Nicholas Souders , Duane Sewell , Zhen-kun Pan , Reshma Singh
发明人： Yvonne Paterson , Nicholas Souders , Duane Sewell , Zhen-kun Pan , Reshma Singh
IPC分类号： A61K39/02 , C12N1/21 , C07H21/04
CPC分类号： A61K39/0011 , A61K38/164 , A61K39/12 , A61K39/385 , A61K2039/523 , A61K2039/5256 , A61K2039/53 , A61K2039/572 , A61K2039/6037 , A61K2039/6068 , C07K14/005 , C07K14/4748 , C07K2319/00 , C07K2319/55 , C12N7/00 , C12N15/74 , C12N2710/20022 , C12N2710/20034
摘要： The present invention provides recombinant polypeptides comprising an N-terminal fragment of an ActA protein or LLO protein fused to an antigen or a fragment thereof, nucleotides encoding same, recombinant vectors comprising same, and immunogenic and therapeutic methods utilizing same.
摘要翻译：本发明提供了包含与抗原或其片段融合的ActA蛋白或LLO蛋白的N末端片段的重组多肽，其编码的核苷酸，包含其的重组载体和使用其的免疫原性和治疗方法。

5. 发明申请

US20080124354A1 Methods for administering tumor vaccines 审中-公开
标题翻译：肿瘤疫苗的使用方法
公开(公告)号：US20080124354A1
公开(公告)日：2008-05-29
申请号：US11822870
申请日：2007-07-10
申请人： Yvonne Paterson , Reshma Singh , Paulo Maciag
发明人： Yvonne Paterson , Reshma Singh , Paulo Maciag
IPC分类号： A61K39/00 , A61K39/02 , A61K38/02 , C07K7/06 , C07H21/04 , A61K31/711 , A61P35/00
CPC分类号： A61K39/0011 , A61K2039/523 , A61K2039/6068 , C07K14/4748 , C07K14/71
摘要： The present invention provides methods of inducing an immune response in a subject against a protein of interest and treating and suppressing a formation of a tumor comprising a tumor-associated protein, comprising sequential administration of fragments of the protein. The present invention also provides Her-2 protein fragments, recombinant peptides comprising same, nucleotide molecules encoding same, recombinant vaccine vectors and immunogenic compositions comprising same, and methods for inducing immune response and treating cancer, comprising same.
摘要翻译：本发明提供了针对目的蛋白质诱导受试者的免疫应答的方法，并且治疗和抑制包含肿瘤相关蛋白的肿瘤的形成，包括顺序施用蛋白质的片段。本发明还提供了Her-2蛋白片段，包含其的重组肽，编码它们的核苷酸分子，重组疫苗载体和包含其的免疫原性组合物，以及诱导免疫应答和治疗癌症的方法。

6. 发明申请

US20160051651A1 TREATMENT OF CANCER USING A CLL-1 CHIMERIC ANTIGEN RECEPTOR 审中-公开
标题翻译：使用CLL-1 CHIMERIC抗原受体治疗癌症
公开(公告)号：US20160051651A1
公开(公告)日：2016-02-25
申请号：US14805075
申请日：2015-07-21
申请人： Jennifer Brogdon , Hilmar Erhard Ebersbach , Saar Gill , David Glass , Julia Jascur , Saad Kenderian , Joan Mannick , Michael C. Milone , Leon Murphy , Celeste Richardson , Reshma Singh , Lai Wei , Qilong Wu , Qiumei Yang , Jiquan Zhang
发明人： Jennifer Brogdon , Hilmar Erhard Ebersbach , Saar Gill , David Glass , Julia Jascur , Saad Kenderian , Joan Mannick , Michael C. Milone , Leon Murphy , Celeste Richardson , Reshma Singh , Lai Wei , Qilong Wu , Qiumei Yang , Jiquan Zhang
IPC分类号： A61K39/00 , A61K31/7068 , C07K14/705 , A61K45/06 , C07K16/28 , C07K14/725
CPC分类号： A61K39/0011 , A61K31/7068 , A61K35/17 , A61K45/06 , A61K2039/5156 , C07K14/7051 , C07K14/70578 , C07K16/2851 , C07K2317/622 , C07K2319/02 , C07K2319/03
摘要： The invention provides compositions and methods for treating diseases associated with expression of CLL-1. The invention also relates to chimeric antigen receptor (CAR) specific to CLL-1, vectors encoding the same, and recombinant cells comprising the CLL-1 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CLL-1 binding domain.
摘要翻译：本发明提供了治疗与CLL-1表达相关的疾病的组合物和方法。本发明还涉及对CLL-1特异性的嵌合抗原受体（CAR），编码它的载体和包含CLL-1 CAR的重组细胞。本发明还包括施用基因修饰的表达包含CLL-1结合结构域的CAR的细胞的方法。

7. 发明申请

US20160046724A1 TREATMENT OF CANCER USING HUMANIZED ANTI-BCMA CHIMERIC ANTIGEN RECEPTOR 审中-公开
标题翻译：使用人类抗体BCMA CHIMERIC抗原受体治疗癌症
公开(公告)号：US20160046724A1
公开(公告)日：2016-02-18
申请号：US14805193
申请日：2015-07-21
申请人： Jennifer Brogdon , Eugene Choi , Hilmar Erhard Ebersbach , David Glass , Heather Huet , Carl H. June , Joan Mannick , Michael C. Milone , Leon Murphy , Gabriela Plesa , Celeste Richardson , Marco Ruella , Reshma Singh , Yongqiang Wang , Qilong Wu
发明人： Jennifer Brogdon , Eugene Choi , Hilmar Erhard Ebersbach , David Glass , Heather Huet , Carl H. June , Joan Mannick , Michael C. Milone , Leon Murphy , Gabriela Plesa , Celeste Richardson , Marco Ruella , Reshma Singh , Yongqiang Wang , Qilong Wu
IPC分类号： C07K16/30 , C07K14/705 , A61K38/17 , A61K35/12 , A61K39/395
CPC分类号： C07K14/705 , A61K35/12 , A61K38/177 , A61K39/395 , A61P35/00 , C07H21/04 , C07K14/7151 , C07K16/28 , C07K16/2878 , C07K19/00 , C07K2317/24 , C07K2317/565 , C07K2317/622 , C07K2317/92 , C07K2319/00 , C07K2319/30 , C12N5/00 , C12N15/63
摘要： The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.
摘要翻译：本发明提供用于治疗与BCMA表达相关的疾病的组合物和方法。本发明还涉及对编码其的BCMA载体特异的嵌合抗原受体（CAR）和包含BCMA CAR的重组T细胞。本发明还包括施用表达包含BCMA结合结构域的CAR的经遗传修饰的T细胞的方法。

8. 发明授权

US07820180B2 Listeria-based and LLO-based vaccines 有权
标题翻译：基于李斯特菌和基于LLO的疫苗
公开(公告)号：US07820180B2
公开(公告)日：2010-10-26
申请号：US11223945
申请日：2005-09-13
申请人： Reshma Singh , Yvonne Paterson
发明人： Reshma Singh , Yvonne Paterson
IPC分类号： A61K39/02 , A61K38/04 , A61K38/16
CPC分类号： A61K39/0011 , A61K2039/522 , A61K2039/523 , A61K2039/6068
摘要： This invention provides methods of treating and vaccinating against an antigen-expressing tumor and inducing an immune response against a sub-dominant epitope of antigen, comprising a fusion of an LLO fragment to the antigen or a recombinant Listeria strain expressing the antigen. The present invention also provides recombinant peptides comprising a listeriolysin (LLO) protein fragment fused to a Her-2 protein or fragment thereof, recombinant Listeria strains expressing a Her-2 protein, vaccines and immunogenic compositions comprising same, and methods of inducing an anti-Her-2 immune response and treating and vaccinating against a Her-2-expressing tumor, comprising same.
摘要翻译：本发明提供了针对抗原表达的肿瘤治疗和接种疫苗并针对抗原的亚优势表位诱导免疫应答的方法，其包括LLO片段与抗原或表达抗原的重组利斯特氏菌属菌株的融合物。本发明还提供了包含与Her-2蛋白或其片段融合的李斯特里菌素（LLO）蛋白片段，表达Her-2蛋白的重组利斯特氏菌菌株，疫苗和包含其的免疫原性组合物的重组肽， Her-2免疫应答，并针对Her-2表达的肿瘤进行治疗和接种疫苗，包括其。

9. 发明申请

US20060210540A1 Compositions and methods for enhancing the immunogenicity of antigens 有权
标题翻译：用于增强抗原免疫原性的组合物和方法
公开(公告)号：US20060210540A1
公开(公告)日：2006-09-21
申请号：US11373528
申请日：2006-03-13
申请人： Yvonne Paterson , Nicholas Souders , Duane Sewell , Zhen-kun Pan , Reshma Singh
发明人： Yvonne Paterson , Nicholas Souders , Duane Sewell , Zhen-kun Pan , Reshma Singh
IPC分类号： A61K48/00 , A61K39/12 , A61K39/00 , C12N1/21
CPC分类号： A61K39/0011 , A61K38/164 , A61K39/12 , A61K39/385 , A61K2039/523 , A61K2039/5256 , A61K2039/53 , A61K2039/572 , A61K2039/6037 , A61K2039/6068 , C07K14/005 , C07K14/4748 , C07K2319/00 , C07K2319/55 , C12N7/00 , C12N15/74 , C12N2710/20022 , C12N2710/20034
摘要： The present invention provides recombinant polypeptides comprising an N-terminal fragment of an ActA protein or LLO protein fused to an antigen or a fragment thereof, nucleotides encoding same, recombinant vectors comprising same, and immunogenic and therapeutic methods utilizing same.
摘要翻译：本发明提供了包含与抗原或其片段融合的ActA蛋白或LLO蛋白的N末端片段的重组多肽，其编码的核苷酸，包含其的重组载体和使用其的免疫原性和治疗方法。

10. 发明申请

US20190000944A1 MESOTHELIN CHIMERIC ANTIGEN RECEPTOR (CAR) AND ANTIBODY AGAINST PD-L1 INHIBITOR FOR COMBINED USE IN ANTICANCER THERAPY 审中-公开
公开(公告)号：US20190000944A1
公开(公告)日：2019-01-03
申请号：US16065387
申请日：2016-12-21
申请人： Jennifer Brogdon , Hwai Wen Chang , Boris Engels , Gordon James Freeman , Gerhard Johann Frey , Jennifer Marie Mataraza , Reshma Singh , Arlene Helen Sharpe , Novartis AG , The Trustees of the University of Pennsylvania , DANA-FARBER CANCER INSTITUTE, INC. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： Jennifer Brogdon , Hwai Wen Chang , Boris Engels , Gordon James Freeman , Gerhard Johann Frey , Jennifer Marie Mataraza , Reshma Singh , Arlene Helen Sharpe
IPC分类号： A61K39/00 , A61K39/395 , A61P35/00 , A61K45/06
摘要： Provided are compositions for use in methods for treating diseases associated with expression of mesothelin comprising administering a cell that expresses a chimeric antigen receptor (CAR) specific to mesothelin in combination with a PD-L1 inhibitor.

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