专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5420126A 3,4-dihydro-2H-1,4-benzoxazine derivatives and pharmaceutical compositions containing the same 失效
标题翻译： 3,4-二氢-2H-1,4-苯并恶嗪衍生物和含有它们的药物组合物
公开(公告)号：US5420126A
公开(公告)日：1995-05-30
申请号：US982034
申请日：1992-11-24
申请人： Yuzo Matsumoto , Ryuji Tsuzuki , Akira Matsuhisa , Kazuhisa Takayama , Wataru Uchida , Masaharu Asano , Isao Yanagisawa , Toru Yoden
发明人： Yuzo Matsumoto , Ryuji Tsuzuki , Akira Matsuhisa , Kazuhisa Takayama , Wataru Uchida , Masaharu Asano , Isao Yanagisawa , Toru Yoden
IPC分类号： C07D265/36 , C07D413/04 , C07D413/06 , C07D273/01 , C07D413/02
CPC分类号： C07D413/04 , C07D265/36 , C07D413/06
摘要： Novel benzoxazine derivatives of the formula (I): ##STR1## are provided as well as their pharmaceutically acceptable salts and a method for their use as potassium channel activating agents 2-(3,4-Dihydro-2, 2-dimethyl-6-phenylsulfonyl-2H-1,4-benzoxazin-4-yl)pyridine N-oxide is illustrative of a benzoxazine derivative of formula (I). Also provided are intermediate compounds such as those of formula (II): ##STR2##
摘要翻译：提供了式（I）：新颖的（I）的苯并恶嗪衍生物：其中药学上可接受的盐及其作为钾通道活化剂的方法2-（3,4-二氢-2,2-二甲基 -6-苯基磺酰基-2H-1,4-苯并恶嗪-4-基）吡啶N-氧化物是式（I）的苯并恶嗪衍生物的说明。还提供了中间体化合物，例如式（II）的那些：（II）

2. 发明授权

US5110820A Dihydropyridine compounds which process both calcium (2+)-antagonistic and beta receptor blocking activities 失效
标题翻译：二钙二氢化合物（2 +） - 拮抗剂和受体阻断活性
公开(公告)号：US5110820A
公开(公告)日：1992-05-05
申请号：US611340
申请日：1990-11-13
申请人： Takashi Fujikura , Noriki Ito , Yuzo Matsumoto , Masaharu Asano , Toichi Takenaka
发明人： Takashi Fujikura , Noriki Ito , Yuzo Matsumoto , Masaharu Asano , Toichi Takenaka
IPC分类号： A61K31/4427 , A61K31/455 , A61P3/00 , A61P3/14 , A61P9/08 , A61P9/10 , A61P9/12 , A61P25/02 , C07D211/90 , C07D401/12
CPC分类号： C07D401/12 , C07D211/90
摘要： Dihydropyridine compounds and salts thereof are provided which exhibit both Ca.sup.2+ -antagonistic and adrenergic beta-receptor blocking activities and therefore are useful for the treatment of ischemic heart diseases and hypertension. The compounds have the formula ##STR1## wherein A represents a straight or branched carbon chain alkylene group having 1 to 10 carbon atoms which may be interrupted by an oxygen atom(s); R.sup.1 and R.sup.4, which may be the same or different, each represents a lower alkyl group; R.sup.2 represents an amino group, ##STR2## R.sup.3 represents a straight or branched carbon chain alkyl group having 1 to 10 carbon atoms which may be interrupted by an oxygen atom(s), or ##STR3## R.sup.5 and R.sup.6, which may be the same or different, each represents a hydrogen atom, a nitro group, a halogen atom, a trifluoromethyl group, a cyano group, a lower alkyl group, a lower alkoxy group or a lower alkenyloxy group; R.sup.7 represents a hydrogen atom, a cyano group, a halogen atom, a lower alkoxy group or a lower alkanoyl group; R.sup.8 and R.sup.9, which may be the same or different, each represents a lower alkyl group or an aralkyl group; and n represents an integer of 1 to 2: these symbols, hereafter, have the same significances.
摘要翻译：提供二氢吡啶化合物及其盐，其表现出Ca 2+ +拮抗性和肾上腺素能β受体阻断活性，因此可用于治疗缺血性心脏病和高血压。化合物具有式（I）的化合物，其中A表示可被氧原子间隔的具有1-10个碳原子的直链或支链碳链亚烷基; R 1和R 4可以相同或不同，各自表示低级烷基; R 2表示氨基，R 3表示可被氧原子间隔的具有1〜10个碳原子的直链或支链碳链烷基，或者R 5和R 6 可以相同或不同，分别表示氢原子，硝基，卤素原子，三氟甲基，氰基，低级烷基，低级烷氧基或低级链烯氧基。 R7表示氢原子，氰基，卤素原子，低级烷氧基或低级烷酰基; R 8和R 9可以相同或不同，各自表示低级烷基或芳烷基; n表示1〜2的整数，以下，符号相同。

3. 发明授权

US5591757A Dihydropyridine composition 失效
标题翻译：二氢吡啶组成
公开(公告)号：US5591757A
公开(公告)日：1997-01-07
申请号：US418262
申请日：1995-04-06
申请人： Takashi Fujikura , Noriki Ito , Yuzo Matsumoto , Masaharu Asano , Toichi Takenaka
发明人： Takashi Fujikura , Noriki Ito , Yuzo Matsumoto , Masaharu Asano , Toichi Takenaka
IPC分类号： A61K31/4427 , A61K31/455 , A61P3/00 , A61P3/14 , A61P9/08 , A61P9/10 , A61P9/12 , A61P25/02 , C07D211/90 , C07D401/12
CPC分类号： C07D401/12 , C07D211/90
摘要： Pharmaceutical composition of certain dihydropyridine compounds and salts thereof are provided which exhibit both Ca.sup.2+ -antagonistic and adrenergic beta-receptor blocking activities and therefore are useful for the treatment of ischemic heart diseases and hypertension. The pharmaceutical compositions contains either 4-(2-hydroxy-3-phenoxy-propylamino)-butyl methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate or 6-(2-hydroxy-3-phenoxypropylamino) hexyl methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate or their pharmaceutically acceptable salts.
摘要翻译：提供某些二氢吡啶化合物及其盐的药物组合物，其表现出Ca 2+拮抗剂和肾上腺素能β受体阻断活性，因此可用于治疗缺血性心脏病和高血压。药物组合物含有4-（2-羟基-3-苯氧基 - 丙基氨基） - 丁基甲基2,6-二甲基-4-（间硝基苯基）-1,4-二氢吡啶-3,5-二羧酸酯或6-（ 2-羟基-3-苯氧基丙基氨基）己基甲基2,6-二甲基-4-（间硝基苯基）-1,4-二氢吡啶-3,5-二羧酸酯或其药学上可接受的盐。

4. 发明授权

US4727082A Dihydropyridine compounds and pharmaceutical compositions containing them 失效
标题翻译：二氢吡啶化合物和含有它们的药物组合物
公开(公告)号：US4727082A
公开(公告)日：1988-02-23
申请号：US908350
申请日：1986-09-17
申请人： Takashi Fujikura , Noriki Ito , Yuzo Matsumoto , Yasuo Isomura , Masaharu Asano , Toichi Takenaka
发明人： Takashi Fujikura , Noriki Ito , Yuzo Matsumoto , Yasuo Isomura , Masaharu Asano , Toichi Takenaka
IPC分类号： C07D211/82 , A61K31/44 , A61K31/455 , A61P9/00 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , A61P25/02 , A61P25/28 , C07D211/90 , C07D401/12
CPC分类号： C07D401/12 , C07C317/00 , C07C323/00 , C07D211/90
摘要： A dihydropyridine compound of the following general formula (I) or a salt thereof: ##STR1## wherein R.sup.1 and R.sup.2, which are the same or different, each represents a C.sub.1 to C.sub.10 alkyl group, a lower alkyl group which is interrupted by oxygen atom(s), or a lower alkyl group substituted by C.sub.3 to C.sub.6 alicyclic group(s); R.sup.3 and R.sup.4, which are the same or different, each represents a lower alkyl group; R.sup.5 and R.sup.6, which are the same or different, each represents a hydrogen atom, a nitro group, a halogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a lower alkylsulfonyl group, or a lower alkylsulfinyl group; R.sup.7 and R.sup.8, which are the same or different, each represents a hydrogen atom, a halogen atom, a cyano group, a lower alkoxy group, or a lower alkanoylamino group, or R.sup.7 may combine with R.sup.8 to form a naphthyl group together with the adjacent phenyl group; A represents a single bond, a vinylene group (--CH.dbd.CH--), or a ethynylene group (--C.dbd.C--); B represents a single bond or --CH.sub. 2 O--; and m and n, which are the same or different, each represents 0 or an integer of 1 to 5.The compounds are useful for the treatment of various cardiovascular disorders, since they possess both Ca.sup.2+ -antagonistic and adrenergic beta-receptor blocking activities.
摘要翻译：下列通式（I）的二氢吡啶化合物或其盐：其中R 1和R 2相同或不同，各自表示C1至C10烷基，低级烷基其被氧原子或被C3-C6脂环族基团取代的低级烷基取代; R 3和R 4相同或不同，各自表示低级烷基; R 5和R 6相同或不同，分别表示氢原子，硝基，卤素原子，低级烷基，低级烷氧基，低级烷硫基，低级烷基磺酰基或低级烷基亚磺酰基 ; R 7和R 8相同或不同，各自表示氢原子，卤素原子，氰基，低级烷氧基或低级烷酰氨基，或者可以与R 8结合形成萘基，相邻苯基; A表示单键，亚乙烯基（-CH = CH-）或亚乙炔基（-C = C-）; B表示单键或-CH 2 O-; 和m和n相同或不同，各自表示0或1至5的整数。该化合物可用于治疗各种心血管疾病，因为它们具有Ca 2+拮抗剂和肾上腺素能β受体阻断活性。

5. 发明授权

US4968671A Therapeutic agents for ischemic heart diseases 失效
标题翻译：缺血性心脏病的治疗剂
公开(公告)号：US4968671A
公开(公告)日：1990-11-06
申请号：US275217
申请日：1988-11-23
申请人： Masaharu Asano , Wataru Uchida , Kumiko Shibasaki
发明人： Masaharu Asano , Wataru Uchida , Kumiko Shibasaki
IPC分类号： A61K38/06
CPC分类号： A61K38/063
摘要： Therapeutic agents for ischemic heart diseases are provided and contain as an effective component a glutathione monoalkyl ester. The invention is also directed to the use of such therapeutic agents for the treatment of ischemic heart diseases.

6. 发明授权

US08329766B2 Functional membrane and production method thereof, and electrolyte membrane for use in fuel cell and production method thereof 失效
标题翻译：功能膜及其制造方法以及燃料电池用电解质膜及其制造方法
公开(公告)号：US08329766B2
公开(公告)日：2012-12-11
申请号：US11884786
申请日：2006-02-23
申请人： Shigeharu Takagi , Toshiya Saito , Misaki Kobayashi , Masaru Yoshida , Tetsuya Yamaki , Masaharu Asano
发明人： Shigeharu Takagi , Toshiya Saito , Misaki Kobayashi , Masaru Yoshida , Tetsuya Yamaki , Masaharu Asano
IPC分类号： C08J5/20 , C08J7/18 , B01J47/00 , B01J47/12 , B01J41/00
CPC分类号： H01M8/1088 , B01D67/0032 , B01D67/0093 , B01D2323/34 , B01D2323/385 , C08J5/2293 , C08J7/123 , C08J7/18 , C08J2327/18 , H01M8/1023 , H01M8/1039 , H01M8/106 , H01M8/1072 , H01M2300/0082 , H01M2300/0088 , Y02P70/56 , Y10T428/249992
摘要： A functional membrane and a production method thereof including: an ion irradiation step in which a polymer film substrate is irradiated with high energy heavy ions at 104 to 1014 ions/cm2, to generate active species in the film substrate; and a graft polymerization step in which after the ion irradiation step, the film substrate is added with one or more monomers selected from a group A consisting of monomers each having a functional group and 1 to 80 mol % of a monomer including a group B consisting of a crosslinking agent(s) for the group A monomer(s), and the film substrate and the monomer(s) are graft-polymerized. There is obtained a functional membrane having high functionality in conjunction with the gas barrier property intrinsically possessed by a polymer film substrate, in particular, a polymer electrolyte membrane optimal as a polymer electrolyte membrane for use in fuel cells, high in proton conductivity and excellent in gas barrier property.
摘要翻译：一种功能膜及其制造方法，其特征在于，包括：离子照射工序，其中以104〜1014个离子/ cm 2的高能重离子照射聚合物膜基材，以在所述膜基材中生成活性物质; 以及接枝聚合步骤，其中在离子照射步骤之后，向基材添加一种或多种选自由各自具有官能团的单体组成的单体A和1至80mol％的包含B组的单体，的用于A族单体的交联剂，并且膜基材和单体被接枝聚合。结合聚合物膜基材本身具有的气体阻隔性能，特别是优选作为燃料电池用高分子电解质膜的高分子电解质膜，具有高官能度的功能膜，质子传导性高，优异的阻气性。

7. 发明授权

US08283088B2 Silane crosslinked structure-introduced fuel-cell polymer electrolyte membrane and fuel-cell electrode assembly having the same 失效
标题翻译：硅烷交联结构引入的燃料电池聚合物电解质膜和具有该电解质膜的燃料电池电极组件
公开(公告)号：US08283088B2
公开(公告)日：2012-10-09
申请号：US12311570
申请日：2007-09-05
申请人： Masaru Yoshida , Masaharu Asano , Jinhua Chen , Yasunari Maekawa , Toshimitsu Tachibana , Yozo Nagai , Soji Nishiyama
发明人： Masaru Yoshida , Masaharu Asano , Jinhua Chen , Yasunari Maekawa , Toshimitsu Tachibana , Yozo Nagai , Soji Nishiyama
IPC分类号： H01M8/10
CPC分类号： C08F255/00 , C08F8/00 , C08F8/12 , C08F8/36 , C08F259/08 , C08J5/2293 , C08J7/18 , C08J2323/06 , C08J2327/18 , H01B1/122 , H01M8/1027 , H01M8/1037 , H01M8/1039 , H01M8/1044 , H01M8/106 , H01M8/1072 , H01M8/1088 , H01M2300/0082 , Y02P70/56 , C08F230/08
摘要： An object is to provide an electrolyte membrane that maintains excellent cell characteristics for a long time under high temperature and low water retention, as this is the most important point in fuel cells.A process for producing a polymer electrolyte membrane for fuel cells is provided, which process comprises in sequence: forming graft molecular chains by graft-polymerization of a vinyl silane coupling agent on a polymer film substrate that has phenyl groups capable of holding sulfonic acid groups; introducing sulfonic acid groups into phenyl groups contained in the graft molecular chains; and hydrolyzing and condensing alkoxy groups contained in the graft molecular chains so that a silane crosslinked structure is introduced between the graft molecular chains. A polymer electrolyte membrane produced by the process is also provided.
摘要翻译：目的是提供一种电解质膜，其在高温和低保水性下长时间保持优异的电池特性，因为这是燃料电池中最重要的一点。本发明提供一种燃料电池用高分子电解质膜的制造方法，该方法依次包括：在具有能够保持磺酸基的苯基的聚合物膜基材上接枝聚合乙烯基硅烷偶联剂而形成接枝分子链; 将磺酸基团引入到接枝分子链中所含的苯基中; 并且使包含在接枝分子链中的烷氧基水解和缩合，使得在接枝分子链之间引入硅烷交联结构。还提供了通过该方法制备的聚合物电解质膜。

8. 发明授权

US07919537B2 Methods for producing a polymer electrolyte membrane having improved oxidation resistance 失效
标题翻译：具有改善的抗氧化性的聚合物电解质膜的制造方法
公开(公告)号：US07919537B2
公开(公告)日：2011-04-05
申请号：US11267160
申请日：2005-11-07
申请人： Yozo Nagai , Toshimitsu Tachibana , Soji Nishiyama , Tetsuya Yamaki , Masaharu Asano , Masaru Yoshida
发明人： Yozo Nagai , Toshimitsu Tachibana , Soji Nishiyama , Tetsuya Yamaki , Masaharu Asano , Masaru Yoshida
IPC分类号： C08J5/22 , H01M8/10
CPC分类号： C08J5/2243 , C08J2325/00 , H01M8/1004 , H01M8/1023 , H01M8/106 , H01M8/1072 , H01M8/1088 , H01M2300/0082 , Y02P70/56
摘要： A method for producing a polymer electrolyte membrane for electrolyte fuel cells includes: irradiating gamma rays onto a polymer substrate to obtain a crosslinked polytetrafluoroetylene substrate, grafting a styrenic monomer and bis(vinylphenyl)ethane as monomers to the crosslinked polymer substrate, and introducing sulfonic acid groups into graft side chains formed by grafting. Fluoro polymer substrates such as polytetrafluoroethylene and ethylene tetrafluoroethylene copolymer may be used.
摘要翻译：一种电解质燃料电池用聚合物电解质膜的制造方法，其特征在于，将γ射线照射在聚合物基材上，得到交联聚四氟乙烯基材，将苯乙烯类单体和双（乙烯基苯基）乙烷作为单体接枝到交联聚合物基材上，通过接枝形成接枝侧链。可以使用氟聚合物基材如聚四氟乙烯和乙烯四氟乙烯共聚物。

9. 发明申请

US20100040927A1 Silane crosslinked structure-introduced fuel-cell polymer electrolyte membrane and fuel-cell electrode assembly having the same 失效
标题翻译：硅烷交联结构引入的燃料电池聚合物电解质膜和具有该电解质膜的燃料电池电极组件
公开(公告)号：US20100040927A1
公开(公告)日：2010-02-18
申请号：US12311570
申请日：2007-09-05
申请人： Masaru Yoshida , Masaharu Asano , Jinhua Chen , Yasunari Maekawa , Toshimitsu Tachibana , Yozo Nagai , Soji Nishiyama
发明人： Masaru Yoshida , Masaharu Asano , Jinhua Chen , Yasunari Maekawa , Toshimitsu Tachibana , Yozo Nagai , Soji Nishiyama
IPC分类号： H01M8/10 , C08J9/00
CPC分类号： C08F255/00 , C08F8/00 , C08F8/12 , C08F8/36 , C08F259/08 , C08J5/2293 , C08J7/18 , C08J2323/06 , C08J2327/18 , H01B1/122 , H01M8/1027 , H01M8/1037 , H01M8/1039 , H01M8/1044 , H01M8/106 , H01M8/1072 , H01M8/1088 , H01M2300/0082 , Y02P70/56 , C08F230/08
摘要： An object is to provide an electrolyte membrane that maintains excellent cell characteristics for a long time under high temperature and low water retention, as this is the most important point in fuel cells.A process for producing a polymer electrolyte membrane for fuel cells is provided, which process comprises in sequence: forming graft molecular chains by graft-polymerization of a vinyl silane coupling agent on a polymer film substrate that has phenyl groups capable of holding sulfonic acid groups; introducing sulfonic acid groups into phenyl groups contained in the graft molecular chains; and hydrolyzing and condensing alkoxy groups contained in the graft molecular chains so that a silane crosslinked structure is introduced between the graft molecular chains. A polymer electrolyte membrane produced by the process is also provided.
摘要翻译：目的是提供一种电解质膜，其在高温和低保水性下长时间保持优异的电池特性，因为这是燃料电池中最重要的一点。本发明提供一种燃料电池用高分子电解质膜的制造方法，该方法依次包括：在具有能够保持磺酸基的苯基的聚合物膜基材上接枝聚合乙烯基硅烷偶联剂而形成接枝分子链; 将磺酸基团引入到接枝分子链中所含的苯基中; 并且使包含在接枝分子链中的烷氧基水解和缩合，使得在接枝分子链之间引入硅烷交联结构。还提供了通过该方法制备的聚合物电解质膜。

10. 发明申请

US20080171251A1 Functional Membrane and Production Method Thereof, and Electrolyte Membrane for Use in Fuel Cell and Production Method Thereof 失效
标题翻译：功能膜及其制备方法以及用于燃料电池的电解质膜及其制备方法
公开(公告)号：US20080171251A1
公开(公告)日：2008-07-17
申请号：US11884786
申请日：2006-02-23
申请人： Shigeharu Takagi , Toshiya Saito , Misaki Kobayashi , Masaru Yoshida , Tetsuya Yamaki , Masaharu Asano
发明人： Shigeharu Takagi , Toshiya Saito , Misaki Kobayashi , Masaru Yoshida , Tetsuya Yamaki , Masaharu Asano
IPC分类号： H01M8/10 , C08J5/22
CPC分类号： H01M8/1088 , B01D67/0032 , B01D67/0093 , B01D2323/34 , B01D2323/385 , C08J5/2293 , C08J7/123 , C08J7/18 , C08J2327/18 , H01M8/1023 , H01M8/1039 , H01M8/106 , H01M8/1072 , H01M2300/0082 , H01M2300/0088 , Y02P70/56 , Y10T428/249992
摘要： A functional membrane and a production method thereof including: an ion irradiation step in which a polymer film substrate is irradiated with high energy heavy ions at 10 4 to 10 14 ions/cm2, to generate active species in the film substrate; and a graft polymerization step in which after the ion irradiation step, the film substrate is added with one or more monomers selected from a group A consisting of monomers each having a functional group and 1 to 80 mol % of a monomer including a group B consisting of a crosslinking agent(s) for the group A monomer(s), and the film substrate and the monomer(s) are graft-polymerized. There is obtained a functional membrane having high functionality in conjunction with the gas barrier property intrinsically possessed by a polymer film substrate, in particular, a polymer electrolyte membrane optimal as a polymer electrolyte membrane for use in fuel cells, high in proton conductivity and excellent in gas barrier property.
摘要翻译：一种功能膜及其制造方法，其特征在于，包括：以10 4〜10 14个/ cm 2以高能重离子照射高分子膜基板的离子照射工序，生成活性物质薄膜基材; 以及接枝聚合步骤，其中在离子照射步骤之后，向基材添加一种或多种选自由各自具有官能团的单体组成的单体A和1至80mol％的包含B组的单体，的用于A族单体的交联剂，并且膜基材和单体被接枝聚合。结合聚合物膜基材本身具有的气体阻隔性能，特别是优选作为燃料电池用高分子电解质膜的高分子电解质膜，具有高官能度的功能膜，质子传导性高，优异的阻气性。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式