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    • 10. 发明授权
    • Synthetic insecticidal proteins active against corn rootworm
    • 对玉米根虫有活性的合成杀虫蛋白
    • US09109231B2
    • 2015-08-18
    • US13370408
    • 2012-02-10
    • Ericka BermudezRuth CongJingtong HouTakashi Yamamoto
    • Ericka BermudezRuth CongJingtong HouTakashi Yamamoto
    • C12N15/82C07K14/325A01N37/46A01N63/02
    • C12N15/8286A01N37/46A01N63/02C07K14/325Y02A40/162
    • Traditionally, the primary method for impacting insect pest populations is the application of broad-spectrum chemical insecticides. However, there is increasing concern about the environmental hazards associated with the production and use of synthetic chemical pesticides. Thus, there is substantial interest in developing alternative pesticides, including biological control of insect pests of agricultural significance using a microbial agent or another species of insect. The present invention provides compositions and methods for such biological control. Modified Cry3 pesticidal polypeptides, polynucleotides encoding such polypeptides, and methods of use are disclosed. The modified polynucleotides provided herein can be used to transform organisms and cells of hosts comprising plant, insects, and microorganisms. The expression of modified polypeptides can provide the host with improved insecticidal activity against one or more insect pathogens.
    • 传统上,影响昆虫害虫种群的主要方法是应用广谱化学杀虫剂。 然而,对生产和使用合成化学农药的环境危害越来越受到关注。 因此,使用微生物剂或其他昆虫种类开发替代农药,包括对具有农业意义的害虫的生物防治具有重大意义。 本发明提供了用于这种生物学控制的组合物和方法。 公开了修饰的Cry3杀虫多肽,编码这些多肽的多核苷酸和使用方法。 本文提供的修饰的多核苷酸可用于转化包含植物,昆虫和微生物的宿主的生物体和细胞。 修饰的多肽的表达可以为宿主提供对一种或多种昆虫病原体的改善的杀虫活性。