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    • 10. 发明申请
    • Indazole derivatives
    • 吲唑衍生物
    • US20070117856A1
    • 2007-05-24
    • US10548475
    • 2004-07-30
    • Yoshihisa OhtaFumihiko KanaiShinji NaraYutaka KandaHiroshi UmeharaYukimasa ShiotsuTomoki NaoeHitoshi KiyoiKeiko KawashimaHiromi AndoMotoki Miyama
    • Yoshihisa OhtaFumihiko KanaiShinji NaraYutaka KandaHiroshi UmeharaYukimasa ShiotsuTomoki NaoeHitoshi KiyoiKeiko KawashimaHiromi AndoMotoki Miyama
    • A61K31/416C07D231/56
    • C07D231/56
    • The present invention provides a compound represented by Formula (I): [wherein R1 represents CONR1aR1b (wherein R1a and R1b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R1a and R1b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group) or the like, R2 represents a hydrogen atom, CONR2aR2b (wherein R2a and R2b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R2a and R2b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group), NR2cR2d (wherein R2c and R2d may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkanoyl, substituted or unsubstituted aroyl, substituted or unsubstituted heteroaroyl, substituted or unsubstituted ararkyl, substituted or unsubstituted lower alkylsulfonyl or substituted or unsubstituted lower arylsulfonyl) or the like].
    • 本发明提供由式(I)表示的化合物:[其中R 1表示CONR 1a 1b 1b(其中R 1a) R 1b和R 1b可以相同或不同,各自表示氢原子,取代或未取代的低级烷基,取代或未取代的芳基,取代或未取代的芳烷基或取代或未取代的杂环基, 或R 1a和R 1b与相邻的氮原子一起形成取代或未取代的杂环基)等,R 2 O, >表示氢原子,其中R 2a,R 2b和R 2b可以相同或不同, 各自表示氢原子,取代或未取代的低级烷基,取代或未取代的芳基,取代或未取代的芳烷基或取代或未取代的杂环基,或R 2b和R 2b >与t结合在一起 它与氮原子相邻以形成取代或未取代的杂环基),NR 2c R 2d(其中R 2c和R 2d) 取代或未取代的低级烷酰基,取代或未取代的芳酰基,取代或未取代的杂芳酰基,取代或未取代的芳烷基,取代或未取代的低级烷基磺酰基或 取代或未取代的低级芳基磺酰基等)。