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1. 发明授权

US5445955A Immobilization of lipase on a polymer carrier containing epoxy and tertiary amino groups 失效
标题翻译：在含有环氧基和叔氨基的聚合物载体上固定脂肪酶
公开(公告)号：US5445955A
公开(公告)日：1995-08-29
申请号：US65496
申请日：1993-05-24
申请人： Yuzo Ikuta , Satoshi Tashiro , Yoshiyuki Hatano , Tadasu Fujita , Noboru Andoh , Sachio Asaoka , Haruto Kobayashi , Takeshi Minami
发明人： Yuzo Ikuta , Satoshi Tashiro , Yoshiyuki Hatano , Tadasu Fujita , Noboru Andoh , Sachio Asaoka , Haruto Kobayashi , Takeshi Minami
IPC分类号： C12N9/20 , C12N11/08 , C12P7/64 , C12N11/06
CPC分类号： C12P7/6454 , C12N11/08 , C12N9/20 , C12P7/6481
摘要： An immobilized lipase is prepared for transesterification of oils, fats or phospholipids in a reaction system containing a very small amount of water such as 50 to 2,000 ppm. The lipase may be a phospholipase such as phospholipase A.sub.2. In a first embodiment, lipase from a microorganism of the genus Rhizopus, Mucor, Alcaligenes or Candida is immobilized on the surface of a hydrophobic, insoluble organic polymer carrier having pores of an average diameter of 10 nm or larger. A solution of lipase is contacted with the polymer carrier for 10 minutes to 40 hours to covalently bond the lipase to the carrier. The immobilized lipase is dried under reduced pressure to a water content of 0.5 to 30 wt %. In a second embodiment, lipase is immobilized on the surface of a polymer carrier such as a hydrophobic, insoluble organic polymer carrier having a pore diameter of 5 to 1,000 nm and having a functional group capable of binding lipase in a aqueous solution and an anion-exchange group on the surface. Preferably, the functional group is an epoxy group and the anion-exchange group is a tertiary amino group. The lipase may be obtained from the same microorganism as in the first embodiment or from another lipase-producing microorganism. Immobilization can be carried out as in the first embodiment. It is preferred to contact a solution of lipase with the polymer carrier in the presence of a fatty acid or derivative thereof for 10 minutes to 10 hours to covalently bond the lipase to the polymer carrier.
摘要翻译：制备固定化的脂肪酶用于在含有非常少量的水如50-2000ppm的反应体系中对油，脂肪或磷脂进行酯交换反应。脂肪酶可以是磷脂酶如磷脂酶A2。在第一实施方案中，将来自根霉属，毛毛虫，产碱杆菌或假丝酵母属的微生物的脂肪酶固定在具有平均直径为10nm以上的孔的疏水性不溶性有机聚合物载体的表面。将脂肪酶溶液与聚合物载体接触10分钟至40小时，以将脂肪酶共价键合到载体上。将固定化的脂肪酶在减压下干燥至含水量为0.5〜30重量％。在第二实施方案中，将脂肪酶固定在聚合物载体的表面上，例如孔径为5至1000nm的疏水性不溶性有机聚合物载体，并且具有能够在水溶液中结合脂肪酶的官能团和阴离子交换树脂，交流组在表面上。优选地，官能团是环氧基团，阴离子交换基团是叔氨基。脂肪酶可以从与第一实施方案相同的微生物获得，或从另一种脂肪酶生产微生物获得。固定可以如第一实施例那样进行。优选在脂肪酸或其衍生物的存在下将脂肪酶与聚合物载体接触10分钟至10小时以将脂肪酶共价结合到聚合物载体上。

2. 发明授权

US5569594A Transesterification with lipase immobilized on a polymer containing epoxy and tertiary amino groups 失效
标题翻译：固定在含有环氧基和叔氨基的聚合物上的脂肪酶进行酯交换
公开(公告)号：US5569594A
公开(公告)日：1996-10-29
申请号：US438921
申请日：1995-05-10
申请人： Yuzo Ikuta , Satoshi Tashiro , Yoshiyuki Hatano , Tadasu Fujita , Noboru Andoh , Sachio Asaoka , Haruto Kobayashi , Takeshi Minami
发明人： Yuzo Ikuta , Satoshi Tashiro , Yoshiyuki Hatano , Tadasu Fujita , Noboru Andoh , Sachio Asaoka , Haruto Kobayashi , Takeshi Minami
IPC分类号： C12N9/20 , C12N11/08 , C12P7/64 , C12N11/06 , C12P7/62
CPC分类号： C12P7/6454 , C12N11/08 , C12N9/20 , C12P7/6481
摘要： Transesterification involving a fat, or a fat and fatty acid, or a phospholipid is carried out with a lipase or phospholipase immobilized on a polymer carrier. The transesterification is preferably carried out in a system containing a very small amount of water such as 50 to 2,000 ppm. The phospholipase can be phospholipase A.sub.2. In a first embodiment, lipase from a microorganism of the genus Rhizopus, Mucor, Alcaligenes or Candida is immobilized on the surface of a hydrophobic, insoluble organic polymer carrier having pores of an average diameter of 10 nm or larger and having on the surface epoxy groups capable of covalently binding lipase. The immobilized lipase is dried under reduced pressure. In a second embodiment, lipase is immobilized on the surface of a polymer carrier such as a hydrophobic, insoluble organic polymer carrier having a pore diameter of 5 to 1,000 nm and having on the surface a functional group capable of binding lipase and an anion-exchange group. Preferably, the functional group is an epoxy group and the anion-exchange group is a tertiary amino group. The lipase may be obtained from the same microorganism as in the first embodiment or from another lipase-producing microorganism. Iramobilization can be carried out as in the first embodiment. It is preferred to contact a solution of lipase with the polymer carrier in the presence of a fatty acid or derivative thereof for 10 minutes to 10 hours to covalently bond the lipase to the polymer carrier.
摘要翻译：涉及脂肪或脂肪和脂肪酸或磷脂的酯交换是用固定在聚合物载体上的脂肪酶或磷脂酶进行的。酯交换优选在含有非常少量的水如50-2000ppm的体系中进行。磷脂酶可以是磷脂酶A2。在第一实施方案中，将来自根霉属，毛霉属，产碱杆菌属或假丝酵母属的微生物的脂肪酶固定在具有平均直径为10nm以上的孔的疏水性不溶性有机聚合物载体的表面，并且在表面具有环氧基能够共价结合脂肪酶。将固定的脂肪酶在减压下干燥。在第二实施方案中，将脂肪酶固定在聚合物载体的表面上，例如孔径为5至1000nm的疏水性不溶性有机聚合物载体，并且在表面上具有能够结合脂肪酶和阴离子交换的官能团组。优选地，官能团是环氧基团，阴离子交换基团是叔氨基。脂肪酶可以从与第一实施方案相同的微生物获得，或从另一种脂肪酶生产微生物获得。可以如第一实施方案那样进行消毒。优选在脂肪酸或其衍生物的存在下将脂肪酶与聚合物载体接触10分钟至10小时以将脂肪酶共价结合到聚合物载体上。

3. 发明授权

US5183675A Process for producing salad oil 失效
标题翻译：生产沙拉油的方法
公开(公告)号：US5183675A
公开(公告)日：1993-02-02
申请号：US727445
申请日：1991-07-09
申请人： Koichi Tamura , Nobuo Taguchi , Satoshi Tashiro
发明人： Koichi Tamura , Nobuo Taguchi , Satoshi Tashiro
IPC分类号： C12P7/64 , A23D9/00 , C11C3/10
CPC分类号： A23D9/00 , C11C3/10
摘要： A process for producing a salad oil comprises transesterifying a mixture of (A) an oil or fat produced from palm oil and having the following characteristics:______________________________________ iodine value: 55 to 75 constituent fatty acids: palmitic acid: 30 to 42% by weight oleic acid: 42 to 48% by weight linoleic acid: 11 to 20% by weight tripalmitin: 2% by weight or less open-tube melting point: 5 to 25.degree. C. ______________________________________ and (B) a liquid edible oil other than the component (A) in a weight ratio of 5:95 to 95:5 with immobilized lipase having 1,3-specificity in the absence of solvent and then fractionating the product in the absence of solvent. Thereby, the salad oil can be efficiently derived from palm oil which is a solid oil and the relative amount of the starting material obtained from palm oil in the salad oil can be increased. The thus-produced salad oil has a satisfactory cooling resistance.
摘要翻译：一种生产色拉油的方法包括将（A）由棕榈油产生的油或脂肪的混合物酯交换，具有以下特征： - 碘值：55至75-取代脂肪酸： - 棕榈酸：30-42％重量 - 油酸：42〜48重量％亚油酸：11〜20重量％ - 三棕榈精：2重量％以下 - 开管熔点：5〜25℃ - 和（B）液体不含组分（A）的食用油的重量比为5:95至95:5，在不存在溶剂的情况下具有1,3-特异性的固定化脂肪酶，然后在不存在溶剂的情况下对产物进行分级。因此，可以从作为固体油的棕榈油中有效地获得色拉油，并且能够提高从色拉油中的棕榈油得到的起始原料的相对量。这样生产的色拉油具有令人满意的耐冷却性。

4. 发明申请

US20060281789A1 Protein kinase inhibitors 审中-公开
标题翻译：蛋白激酶抑制剂
公开(公告)号：US20060281789A1
公开(公告)日：2006-12-14
申请号：US10548592
申请日：2004-07-30
申请人： Yukimasa Shiotsu , Hiroshi Umehara , Fumihiko Kanai , Shinji Nara , Yoshihisa Ohta , Yutaka Kanda , Shiro Akinaga , Tomoki Naoe , Hitoshi Kiyoi , Tomoyuki Nakazato , Satoshi Tashiro
发明人： Yukimasa Shiotsu , Hiroshi Umehara , Fumihiko Kanai , Shinji Nara , Yoshihisa Ohta , Yutaka Kanda , Shiro Akinaga , Tomoki Naoe , Hitoshi Kiyoi , Tomoyuki Nakazato , Satoshi Tashiro
IPC分类号： A61K31/4439 , C07D403/02
CPC分类号： C07D231/56
摘要： The present invention provides a protein kinase inhibitor (excluding c-Jun N-terminal kinase inhibitor) which comprises, as an active ingredient, an indazole derivative represented by Formula (I) (wherein R1 represents substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclic group) or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供一种蛋白激酶抑制剂（不包括c-Jun N-末端激酶抑制剂），其包含作为活性成分的由式（I）表示的吲唑衍生物（其中R 1表示取代或未取代的芳基或取代或未取代的杂环基）或其药学上可接受的盐。

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