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1. 发明申请

US20080183003A1 AMINOADAMANTANE DERIVATIVES AS THERAPEUTIC AGENTS 审中-公开
标题翻译：氨基甲酸衍生物作为治疗剂
公开(公告)号：US20080183003A1
公开(公告)日：2008-07-31
申请号：US12025622
申请日：2008-02-04
申请人： Yuqiang Wang , Wenqing Ye , James W. Larrick , Jonathan S. Stamler , Stuart A. Lipton
发明人： Yuqiang Wang , Wenqing Ye , James W. Larrick , Jonathan S. Stamler , Stuart A. Lipton
IPC分类号： C07C271/06 , C07C211/33 , C07C61/12
CPC分类号： C07C233/23 , C07C219/24 , C07C2603/74
摘要： The present invention provides novel aminoadamantane derivatives, methods of making the derivatives, compositions including the novel aminoadamantane derivatives, and methods for the treatment and prevention of neurological diseases using the derivatives and compositions. There are a variety of neurological disorders that can be treated using the present invention, including, for example, the following: neurological disorders arising from trauma, ischemic or hypoxic conditions that can be treated include stroke, hypoglycemia, cerebral ischemia, cardiac arrest, spinal cord trauma, head trauma, perinatal hypoxia, cardiac arrest and hypoglycemic neuronal damage; neurodegenerative disorders such as epilepsy, Alzheimer's disease, Huntington's disease Parkinsonism, and amyotrophic lateral sclerosis; other diseases or disorders such as convulsion, pain, depression, anxiety, schizophrenia, muscle spasms, migraine headaches, urinary incontinence, nicotine withdrawal, opiate tolerance and withdrawal, emesis, brain edema, tardive dyskinesia, AIDS-induced dementia, ocular damage, retinopathy, cognitive disorders, and neuronal injury associated with HIV-infection such as dysfunction in cognition, movement and sensation.
摘要翻译：本发明提供了新的氨基金刚烷衍生物，制备衍生物的方法，包括新的氨基金刚烷衍生物的组合物，以及使用该衍生物和组合物治疗和预防神经疾病的方法。存在可以使用本发明治疗的各种神经障碍，包括例如以下：由可以治疗的创伤，缺血或缺氧状况引起的神经障碍包括中风，低血糖，脑缺血，心跳停止，脊髓脐带创伤，头部创伤，围产期缺氧，心脏骤停和降血糖神经元损伤; 神经退行性疾病如癫痫，阿尔茨海默病，亨廷顿病帕金森综合征和肌萎缩性侧索硬化; 其他疾病或障碍，如惊厥，疼痛，抑郁，焦虑，精神分裂症，肌肉痉挛，偏头痛，尿失禁，尼古丁戒断，阿片剂耐受和戒断，呕吐，脑水肿，迟发性运动障碍，艾滋病诱导的痴呆，眼部损伤，视网膜病变，认知障碍和与HIV感染相关的神经元损伤，如认知，运动和感觉功能障碍。

2. 发明授权

US06503947B1 Method of treating cytotoxic damage 失效
标题翻译：细胞毒性损伤的治疗方法
公开(公告)号：US06503947B1
公开(公告)日：2003-01-07
申请号：US09239056
申请日：1999-01-27
申请人： Stuart A. Lipton , Dean Le , Marcus Kaul , Jonathan S. Stamler
发明人： Stuart A. Lipton , Dean Le , Marcus Kaul , Jonathan S. Stamler
IPC分类号： A61K3115
CPC分类号： A61K31/195 , A61K31/00 , A61K31/05 , A61K31/15 , A61K31/16 , A61K31/166 , A61K31/19 , A61K31/192 , A61K31/353 , A61K38/166 , A61K38/49 , A61K2300/00
摘要： The invention features methods of treating cytotoxic damage in a subject comprising administering to the subject a substance which is a complement inhibitor, free radical scavenger, or both, to thereby treat cytotoxic damage. The methods of the invention can be used to treat cytotoxic damage associated with a non-thrombotic or thrombotic condition. Methods of treating thrombotic conditions such as stroke and/or ischemia in a subject, comprise administering a thrombolytic agent and a substance which is a complement inhibitor, free radical scavenger or both.
摘要翻译：本发明的特征在于治疗受试者的细胞毒性损伤的方法，其包括向受试者施用作为补体抑制剂的物质，自由基清除剂或二者，从而治疗细胞毒性损伤。本发明的方法可用于治疗与非血栓形成或血栓形成相关的细胞毒性损伤。治疗受试者血栓形成条件如中风和/或局部缺血的方法包括施用血栓溶解剂和作为补体抑制剂的物质，自由基清除剂或两者。

3. 发明申请

US20130196342A1 Compositions And Methods For Modulating S-Nitrosogluthione Reductase 审中-公开
标题翻译：用于调节S-硝基葡萄糖还原酶的组合物和方法
公开(公告)号：US20130196342A1
公开(公告)日：2013-08-01
申请号：US13094091
申请日：2011-04-26
申请人： Jonathan S. Stamler , Limin Liu
发明人： Jonathan S. Stamler , Limin Liu
IPC分类号： G01N33/573
CPC分类号： G01N33/573 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/035 , A61K31/155 , A61K31/41 , A61K38/44 , C12N9/0008 , C12N15/8509 , C12Q1/26 , C12Y102/01046 , G01N2333/90212 , G01N2800/00 , A61K2300/00
摘要： Disclosed herein are methods and compositions for modulating the levels and/or activity of S-nitrosoglutathione reductase (GSNOR) in vivo or in vitro. Specifically disclosed are GSNOR deletion constructs, host cells and non-human mammals comprising GSNOR deletions, and methods of screening employing GSNOR deletion mutants. Also specifically disclosed are reagents and procedures for measuring, monitoring, or altering GSNOR levels or activity (as well as nitric oxide and S-nitrosothiol levels) in connection with various medical conditions.
摘要翻译：本文公开了用于在体内或体外调节S-亚硝基谷胱甘肽还原酶（GSNOR）的水平和/或活性的方法和组合物。具体公开的是GSNOR缺失构建体，宿主细胞和包含GSNOR缺失的非人哺乳动物，以及使用GSNOR缺失突变体进行筛选的方法。还具体公开了用于测量，监测或改变与各种医学状况有关的GSNOR水平或活性（以及一氧化氮和S-亚硝基硫醇水平）的试剂和程序。

4. 发明申请

US20120245116A1 Inhibiting GS-FDH to Modulate No Bioactivity 审中-公开
标题翻译：抑制GS-FDH调节无生物活性
公开(公告)号：US20120245116A1
公开(公告)日：2012-09-27
申请号：US13491752
申请日：2012-06-08
申请人： Jonathan S. Stamler , Limin Liu , Alfred Hausladen , Raphael Nudelman
发明人： Jonathan S. Stamler , Limin Liu , Alfred Hausladen , Raphael Nudelman
IPC分类号： A61K31/7056 , A61K31/197 , A61K31/343
CPC分类号： A61K38/063 , A61K31/365 , A61K31/7056 , Y10S514/824
摘要： Patients needing NO donor therapy or inhibition of pathologically proliferating cells or increased NO bioactivity are treated with a therapeutically effective amount of an inhibitor of glutathione-dependent formaldehyde dehydrogenase.
摘要翻译：需要NO供体治疗或抑制病理增殖细胞或增加NO生物活性的患者用治疗有效量的谷胱甘肽依赖性甲醛脱氢酶抑制剂治疗。

5. 发明申请

US20120225133A1 USE OF AN AGENT THAT RESTORES TISSUE PERFUSION AND OXYGENATION 有权
标题翻译：使用恢复组织灌注和氧化的药剂
公开(公告)号：US20120225133A1
公开(公告)日：2012-09-06
申请号：US13449932
申请日：2012-04-18
申请人： Mark W. Dewhirst , Jonathan S. Stamler , Timothy J. McMahon , Pierre Sonveaux
发明人： Mark W. Dewhirst , Jonathan S. Stamler , Timothy J. McMahon , Pierre Sonveaux
IPC分类号： A61K33/00 , A61P3/10 , A61P9/10 , A61P29/00 , A61P25/00 , A61P35/00 , A61P1/16
CPC分类号： A61K38/1709 , A61K31/21 , A61K33/00 , A61K35/18 , A61K38/00 , A61K38/42 , A61K45/06 , A61K47/08 , A61K47/16 , A61K47/6445 , A61K2300/00
摘要： The presently disclosed subject matter provides methods for increasing perfusion in hypoxic regions of tissues in subjects. Also provided are methods for treating diseases and/or disorders associated with hypoxia in subjects, methods for increasing sensitivity of tumors to radiation and/or chemotherapy treatments, methods for delaying tumor growth in subjects, and methods for inhibiting tumor blood vessel growth in subjects. In some embodiments, the presently disclosed methods involve administering to subjects in need thereof a first composition selected from the group consisting of a nitrosylated hemoglobin and an agent that induces nitrosylation of endogenous hemoglobin in the subject and a second composition comprising a hyperoxic gas. In some embodiments, the presently disclosed methods also include treating a tumor with radiation therapy, chemotherapy, photodynamic therapy, immunotherapy, or combinations thereof. Also provided are inhalable gases that can be employed in the presently disclosed methods.
摘要翻译：目前公开的主题提供了在受试者的组织的缺氧区域中增加灌注的方法。还提供了用于治疗受试者与缺氧相关的疾病和/或病症的方法，用于增加肿瘤对放射和/或化疗治疗的敏感性的方法，用于延迟受试者的肿瘤生长的方法，以及用于抑制受试者的肿瘤血管生长的方法。在一些实施方案中，本发明公开的方法包括向有需要的受试者施用选自亚硝基化血红蛋白和诱导受试者内源性血红蛋白亚硝基化的试剂的第一组合物和包含高氧气体的第二组合物。在一些实施方案中，本发明公开的方法还包括用放射治疗，化疗，光动力疗法，免疫治疗或其组合治疗肿瘤。还提供了可在本公开的方法中使用的可吸入气体。

6. 发明授权

US08198241B2 Use of an agent that restores tissue perfusion and oxygenation 有权
标题翻译：使用恢复组织灌注和氧合的药物
公开(公告)号：US08198241B2
公开(公告)日：2012-06-12
申请号：US12847330
申请日：2010-07-30
申请人： Mark W. Dewhirst , Jonathan S. Stamler , Timothy J. McMahon , Pierre Sonveaux
发明人： Mark W. Dewhirst , Jonathan S. Stamler , Timothy J. McMahon , Pierre Sonveaux
IPC分类号： A61K38/00 , A61K33/00
CPC分类号： A61K38/1709 , A61K31/21 , A61K33/00 , A61K35/18 , A61K38/00 , A61K38/42 , A61K45/06 , A61K47/08 , A61K47/16 , A61K47/6445 , A61K2300/00
摘要： The presently disclosed subject matter provides methods for increasing perfusion in hypoxic regions of tissues in subjects. Also provided are methods for treating diseases and/or disorders associated with hypoxia in subjects, methods for increasing sensitivity of tumors to radiation and/or chemotherapy treatments, methods for delaying tumor growth in subjects, and methods for inhibiting tumor blood vessel growth in subjects. In some embodiments, the presently disclosed methods involve administering to subjects in need thereof a first composition selected from the group consisting of a nitrosylated hemoglobin and an agent that induces nitrosylation of endogenous hemoglobin in the subject and a second composition comprising a hyperoxic gas. In some embodiments, the presently disclosed methods also include treating a tumor with radiation therapy, chemotherapy, photodynamic therapy, immunotherapy, or combinations thereof. Also provided are inhalable gases that can be employed in the presently disclosed methods.
摘要翻译：目前公开的主题提供了在受试者的组织的缺氧区域中增加灌注的方法。还提供了用于治疗受试者与缺氧相关的疾病和/或病症的方法，用于增加肿瘤对放射和/或化疗治疗的敏感性的方法，用于延迟受试者的肿瘤生长的方法，以及用于抑制受试者的肿瘤血管生长的方法。在一些实施方案中，本发明公开的方法包括向有需要的受试者施用选自亚硝基化血红蛋白和诱导受试者内源性血红蛋白亚硝基化的试剂的第一组合物和包含高氧气体的第二组合物。在一些实施方案中，本发明公开的方法还包括用放射治疗，化疗，光动力疗法，免疫治疗或其组合治疗肿瘤。还提供了可在本公开的方法中使用的可吸入气体。

7. 发明授权

US08039217B2 Proteomic interaction and genomic action determinations in the presence of associated redox state conditions 有权
标题翻译：蛋白质组学相互作用和相关氧化还原状态条件下的基因组作用测定
公开(公告)号：US08039217B2
公开(公告)日：2011-10-18
申请号：US12037411
申请日：2008-02-26
申请人： Jonathan S. Stamler
发明人： Jonathan S. Stamler
IPC分类号： C12Q1/68 , G01N33/569 , C12N15/09
CPC分类号： C12Q1/6809 , G01N33/5091 , G01N33/6803 , Y10S977/924
摘要： Genomic actions and/or proteomic interactions for pathophysiological processes and for physiological processes are determined at associated redox state conditions. Protein interactions are correlated with oxygen tensions. Identification of markers for disease including epitopes is effected in the presence of simulated redox state perturbations. Screening for previously unknown receptors and activating ligands is carried out in the presence of alteration of redox state.
摘要翻译：在相关的氧化还原状态下测定病理生理过程和生理过程的基因组作用和/或蛋白质组学相互作用。蛋白质相互作用与氧气张力相关。在模拟氧化还原状态扰动的情况下，鉴定包括表位的疾病的标志物。在先前未知的受体和活化配体的筛选在氧化还原状态改变的情况下进行。

8. 发明授权

US07968533B2 Ethyl nitrite as a gastrointestinal smooth muscle relaxant and diagnostic and therapeutic uses thereof 有权
标题翻译：亚硝酸亚乙酯作为胃肠道平滑肌松弛剂及其诊断和治疗用途
公开(公告)号：US07968533B2
公开(公告)日：2011-06-28
申请号：US11715594
申请日：2007-03-07
申请人： Kevin P. Hurley , Jonathan S. Stamler , John Baillie , James D. Reynolds , Stephen O. Vaughan
发明人： Kevin P. Hurley , Jonathan S. Stamler , John Baillie , James D. Reynolds , Stephen O. Vaughan
IPC分类号： A01N43/00 , A61K31/33
CPC分类号： A61K9/12 , A61K9/0073
摘要： The present invention provides compositions comprising a gas and a gastrointestinal smooth muscle relaxing agent comprising ethyl nitrite in a therapeutically effective amount. The present invention also provides methods of relaxing gastrointestinal smooth muscle, alleviating contraction or spasm of gastrointestinal smooth muscle to facilitate a diagnostic medical procedure and treating or preventing a gastrointestinal disorder using the compositions of the invention.
摘要翻译：本发明提供了包含气体和包含治疗有效量的亚硝酸乙酯的胃肠平滑肌松弛剂的组合物。本发明还提供了使用本发明的组合物缓和胃肠平滑肌，减轻胃肠平滑肌的收缩或痉挛以促进诊断医学过程和治疗或预防胃肠道疾病的方法。

9. 发明申请

US20110008815A1 MEASURING AMOUNT OF BOUND AND COMBINED NITRIC OXIDE IN BLOOD 有权
标题翻译：测量血液中结合和组合的氮氧化物
公开(公告)号：US20110008815A1
公开(公告)日：2011-01-13
申请号：US12668211
申请日：2008-07-15
申请人： Jonathan S. Stamler , Michael Angelo
发明人： Jonathan S. Stamler , Michael Angelo
IPC分类号： C12Q1/02 , C12N13/00
CPC分类号： G01N33/84 , A61B5/0059 , A61B5/1405 , A61B5/14546 , A61B5/150022 , A61B5/150251 , A61B5/150343 , A61B5/412 , G01N27/416 , Y10T436/177692
摘要： Amount of combined nitric oxide or nitric oxide present as iron nitrosyls in a blood sample is determined by directing a low power electromagnetic radiation beam at a blood sample to liberate nitric oxide gas, dissolving the liberated nitric oxide gas and electrochemically detecting amount of dissolved nitric oxide gas.
摘要翻译：通过在血液样品上引导低功率电磁辐射束以释放一氧化氮气体，溶解释放的一氧化氮气体和电化学检测溶解的一氧化氮的量来确定血液样品中作为亚硝酰亚胺存在的组合的一氧化氮或一氧化氮的量加油站。

10. 发明申请

US20090253615A1 No-modified hemoglobins and uses therefor 审中-公开
标题翻译：无改性血红蛋白及其用途
公开(公告)号：US20090253615A1
公开(公告)日：2009-10-08
申请号：US12386674
申请日：2009-04-21
申请人： Jonathan S. Stamler
发明人： Jonathan S. Stamler
IPC分类号： A61K38/42
CPC分类号： A61K31/00 , A61K31/04 , A61K31/095 , A61K31/195 , A61K35/18 , A61K38/00 , A61K38/44 , A61K47/6445 , A61K47/6901 , C07K14/00 , C07K14/805 , G01N21/631 , G01N21/76 , G01N33/721 , Y10T436/105831
摘要： Nitrosylhemoglobin can be produced by introducing gaseous NO into an aqueous solution of hemoglobin. It has been demonstrated that nitrosylhemoglobin in aqueous solution can be converted to SNO-hemoglobin upon introduction of oxygen to the solution, as is postulated to occur in the lungs. Nitrosylhemoglobin can be used in methods to produce the physiological effects of NO, for example, to reduce vasoconstriction and to inhibit platelet aggregation.
摘要翻译：可以通过将气态NO引入血红蛋白水溶液中来产生亚硝基血红蛋白。已经证明，如将假定在肺中发生的那样将氧气引入溶液中，则可将水溶液中的亚硝基血红蛋白转化为SNO-血红蛋白。硝基血红蛋白可用于产生NO的生理作用的方法，例如减少血管收缩和抑制血小板聚集。

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