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1. 发明授权

US07127298B1 Switched-matrix output for multi-channel implantable stimulator 有权
标题翻译：多通道植入式刺激器的开关矩阵输出
公开(公告)号：US07127298B1
公开(公告)日：2006-10-24
申请号：US10686219
申请日：2003-10-15
申请人： Yuping He , David K. L. Peterson , Jordi Parramon
发明人： Yuping He , David K. L. Peterson , Jordi Parramon
IPC分类号： A61N1/08
CPC分类号： A61N1/08 , A61N1/32 , A61N1/36071
摘要： The invention is a switched-matrix output for a multi-channel stimulator. The switch-matrix output system uses groups of switches connectively placed between N number of digital-to-analog convertors (DACs) and M electrode contacts to permit fewer, space-consuming DACs to be used in an implantable stimulator, thereby saving internal stimulator space. One embodiment of the switched matrix output uses switches to activate only one active-electrode subset of M electrode contacts at any one time, so that the total number of DACs contained in the stimulator can be less than the M total number of electrode contacts.
摘要翻译：本发明是用于多通道刺激器的开关矩阵输出。开关矩阵输出系统使用连接放置在N个数模转换器（DAC）和M个电极触点之间的开关组，以允许在可植入的刺激器中使用更少的占用空间的DAC，从而节省内部刺激器空间。开关矩阵输出的一个实施例使用开关在任何一个时间仅激活M个电极触点的一个有源电极子集，使得包含在刺激器中的DAC的总数可以小于M个电极触点的总数。

2. 发明授权

US08620436B2 Current generation architecture for an implantable stimulator device having coarse and fine current control 有权
标题翻译：具有粗细和精细电流控制的植入式刺激器装置的当前一代架构
公开(公告)号：US08620436B2
公开(公告)日：2013-12-31
申请号：US11550763
申请日：2006-10-18
申请人： Jordi Parramon , David K. L. Peterson , Paul J. Griffith
发明人： Jordi Parramon , David K. L. Peterson , Paul J. Griffith
IPC分类号： A61N1/02
CPC分类号： A61N1/36125 , A61N1/0531 , A61N1/0534 , A61N1/0541 , A61N1/0543 , A61N1/0551 , A61N1/36071
摘要： Disclosed herein is a current generation architecture for an implantable stimulator device such as an Implantable Pulse Generator (IPG). Current source and sink circuitry are both divided into coarse and fine portions, which respectively can provide a coarse and fine current resolution to a specified electrode on the IPG. The coarse portion is distributed across all of the electrodes and so can source or sink current to any of the electrodes. The coarse portion is divided into a plurality of stages, each of which is capable via an associated switch bank of sourcing or sinking a coarse amount of current to or from any one of the electrodes on the device. The fine portion of the current generation circuit preferably includes source and sink circuitry dedicated to each of the electrode on the device, which can comprise digital-to-analog current converters (DACs). The DACs also receives the above-noted reference current, which is amplified by the DACs in fine increments by appropriate selection of fine current control signals. When the coarse and fine current control circuitry are used in tandem, ample current with a fine current resolution can be achieved at any electrode and in a space- and power-efficient manner.
摘要翻译：本文公开了用于植入式脉冲发生器（IPG）的植入式刺激器装置的当前一代架构。电流源和接收电路都分为粗细部分，分别可以为IPG上的指定电极提供粗细和精细的电流分辨率。粗糙部分分布在所有电极上，因此可以将电流吸收或吸收到任何电极。粗略部分被分成多个级，每个级能够经由相关联的开关组，该器件对设备上的任何一个电极进行粗电流的吸收或吸收。电流产生电路的优良部分优选地包括专用于器件上每个电极的源极和漏极电路，其可以包括数模转换器（DAC）。 DAC还接收上述参考电流，其通过适当选择精细电流控制信号以细微增量由DAC放大。当粗调和精细电流控制电路串联使用时，可以在任何电极上以空间和功率有效的方式实现具有精细电流分辨率的充足电流。

3. 发明授权

US08706238B2 Current generation architecture for an implantable stimulator device having coarse and fine current control 有权
标题翻译：具有粗细和精细电流控制的植入式刺激器装置的当前一代架构
公开(公告)号：US08706238B2
公开(公告)日：2014-04-22
申请号：US12838260
申请日：2010-07-16
申请人： Jordi Parramon , David K. L. Peterson , Paul J. Griffith
发明人： Jordi Parramon , David K. L. Peterson , Paul J. Griffith
IPC分类号： A61N1/02
CPC分类号： A61N1/36125 , A61N1/0531 , A61N1/0534 , A61N1/0541 , A61N1/0543 , A61N1/0551 , A61N1/36071
摘要： Disclosed herein is a current generation architecture for an implantable stimulator device such as an Implantable Pulse Generator (IPG). Current source and sink circuitry are both divided into coarse and fine portions, which respectively can provide a coarse and fine current resolution to a specified electrode on the IPG. The coarse portion is distributed across all of the electrodes and so can source or sink current to any of the electrodes. The coarse portion is divided into a plurality of stages, each of which is capable via an associated switch bank of sourcing or sinking a coarse amount of current to or from any one of the electrodes on the device. The fine portion of the current generation circuit preferably includes source and sink circuitry dedicated to each of the electrode on the device, which can comprise digital-to-analog current converters (DACs). The DACs also receives the above-noted reference current, which is amplified by the DACs in fine increments by appropriate selection of fine current control signals. When the coarse and fine current control circuitry are used in tandem, ample current with a fine current resolution can be achieved at any electrode and in a space- and power-efficient manner.
摘要翻译：本文公开了用于植入式脉冲发生器（IPG）的植入式刺激器装置的当前一代架构。电流源和接收电路都分为粗细部分，分别可以为IPG上的指定电极提供粗细和精细的电流分辨率。粗糙部分分布在所有电极上，因此可以将电流吸收或吸收到任何电极。粗略部分被分成多个级，每个级能够经由相关联的开关组，该器件对设备上的任何一个电极进行粗电流的吸收或吸收。电流产生电路的优良部分优选地包括专用于器件上每个电极的源极和漏极电路，其可以包括数模转换器（DAC）。 DAC还接收上述参考电流，其通过适当选择精细电流控制信号以细微增量由DAC放大。当粗调和精细电流控制电路串联使用时，可以在任何电极上以空间和功率有效的方式实现具有精细电流分辨率的充足电流。

4. 发明授权

US08583262B2 Implantable medical device that uses electrical current steering by means of output impedance modulation 有权
标题翻译：通过输出阻抗调制使用电流转向的可植入医疗器械
公开(公告)号：US08583262B2
公开(公告)日：2013-11-12
申请号：US12606065
申请日：2009-10-26
申请人： Jordi Parramon , David K. L. Peterson , Kerry Bradley , Rafael Carbunaru , Andrew DiGiore
发明人： Jordi Parramon , David K. L. Peterson , Kerry Bradley , Rafael Carbunaru , Andrew DiGiore
IPC分类号： A61N1/08
CPC分类号： A61N1/36125 , A61N1/0551 , A61N1/36157 , A61N1/36185
摘要： A method and system of providing therapy to a patient implanted with an array of electrodes is provided. Electrical stimulation current is conveyed from at least two of the electrodes to at least one of the electrodes along at least two electrical paths through tissue of the patient, and the electrical stimulation current is shifted between the electrical paths by actively adjusting one or more finite resistances respectively associated with one or more of the electrical paths.
摘要翻译：提供了向植入电极阵列的患者提供治疗的方法和系统。电刺激电流沿着沿着患者组织的至少两条电路径从至少两个电极传送到至少一个电极，并且电刺激电流通过主动调节一个或多个有限电阻而在电路径之间移动分别与一个或多个电路径相关联。

5. 发明授权

US07881803B2 Multi-electrode implantable stimulator device with a single current path decoupling capacitor 有权
标题翻译：具有单电流路径去耦电容器的多电极可植入刺激装置
公开(公告)号：US07881803B2
公开(公告)日：2011-02-01
申请号：US11550655
申请日：2006-10-18
申请人： Jordi Parramon , Kiran Nimmagadda , Emanuel Feldman , Yuping He
发明人： Jordi Parramon , Kiran Nimmagadda , Emanuel Feldman , Yuping He
IPC分类号： A61N1/40
CPC分类号： A61N1/36125 , A61N1/025 , A61N1/08 , A61N1/372 , A61N1/37205 , A61N1/3756
摘要： Disclosed herein are circuits and methods for a multi-electrode implantable stimulator device incorporating one decoupling capacitor in the current path established via at least one cathode electrode and at least one anode electrode. In one embodiment, the decoupling capacitor may be hard-wired to a dedicated anode on the device. The cathodes are selectively activatable via stimulation switches. In another embodiment, any of the electrodes on the devices can be selectively activatable as an anode or cathode. In this embodiment, the decoupling capacitor is placed into the current path via selectable anode and cathode stimulation switches. Regardless of the implementation, the techniques allow for the benefits of capacitive decoupling without the need to associate decoupling capacitors with every electrode on the multi-electrode device, which saves space in the body of the device. Although of particular benefit when applied to microstimulators, the disclosed technique can be used with space-saving benefits in any stimulator device.
摘要翻译：本文公开了用于在经由至少一个阴极电极和至少一个阳极电极建立的电流路径中并入一个去耦电容器的多电极可植入刺激器装置的电路和方法。在一个实施例中，去耦电容器可以硬连接到器件上的专用阳极。阴极可以通过刺激开关选择性地激活。在另一个实施例中，器件上的任何电极可以选择性地激活为阳极或阴极。在该实施例中，去耦电容通过可选择的阳极和阴极刺激开关放置在电流路径中。不管实施方案如何，这些技术允许电容去耦的优点，而不需要将去耦电容器与多电极器件上的每个电极相关联，这节省了器件体内的空间。虽然在应用于微型激励器时特别有益，但是所公开的技术可以在任何刺激器装置中具有节省空间的优点。

6. 发明授权

US07539538B2 Low power loss current digital-to-analog converter used in an implantable pulse generator 有权
标题翻译：用于可植入脉冲发生器的低功耗电流数模转换器
公开(公告)号：US07539538B2
公开(公告)日：2009-05-26
申请号：US11138632
申请日：2005-05-26
申请人： Jordi Parramon , Yuping He , Kiran Nimmagadda
发明人： Jordi Parramon , Yuping He , Kiran Nimmagadda
IPC分类号： A61N1/00
CPC分类号： A61N1/36071 , A61N1/025 , A61N1/36125 , A61N1/378
摘要： In one embodiment, the present invention provides an implantable stimulation device that includes output current sources and/or sinks configured to provide an output current for a load (i.e., tissue). The output path of the output current source or sink comprises a transistor which operates in a linear mode instead of a saturation mode. Because operation in a linear mode results in smaller drain-to-source voltage drops, power consumption in the output current source or sink (and hence in the implantable stimulator) is reduced, reducing battery or other power source requirements. Operation in the linear mode is facilitated in useful embodiments by a load in an input path (into which a reference current is sent) and a load in the output path (which bears the output current). The loads can be active transistors or passive resistors. A feedback circuit (e.g., an operational amplifier) receives voltages that build up across these loads, and sends a control signal to the gate of the transistor to ensure its linear operation.
摘要翻译：在一个实施例中，本发明提供了一种植入式刺激装置，其包括被配置为提供负载（即组织）的输出电流的输出电流源和/或接收器。输出电流源或吸收器的输出路径包括以线性模式而不是饱和模式操作的晶体管。因为在线性模式下的操作会导致较小的漏极 - 源极电压降，所以输出电流源或接收器（以及因此在可植入的刺激器中）的功耗降低，从而减少电池或其他电源要求。在有用的实施例中，通过输入路径（发送参考电流）中的负载和输出路径（承担输出电流）中的负载来促进线性模式的操作。负载可以是有源晶体管或无源电阻。反馈电路（例如，运算放大器）接收跨越这些负载的电压，并将控制信号发送到晶体管的栅极，以确保其线性运行。

7. 发明申请

US20080097529A1 Multi-Electrode Implantable Stimulator Device with a Single Current Path Decoupling Capacitor 有权
标题翻译：具有单电流路径去耦电容器的多电极植入式刺激器装置
公开(公告)号：US20080097529A1
公开(公告)日：2008-04-24
申请号：US11550655
申请日：2006-10-18
申请人： Jordi Parramon , Kiran Nimmagadda , Emanuel Feldman , Yuping He
发明人： Jordi Parramon , Kiran Nimmagadda , Emanuel Feldman , Yuping He
IPC分类号： A61N1/00
CPC分类号： A61N1/36125 , A61N1/025 , A61N1/08 , A61N1/372 , A61N1/37205 , A61N1/3756
摘要： Disclosed herein are circuits and methods for a multi-electrode implantable stimulator device incorporating one decoupling capacitor in the current path established via at least one cathode electrode and at least one anode electrode. In one embodiment, the decoupling capacitor may be hard-wired to a dedicated anode on the device. The cathodes are selectively activatable via stimulation switches. In another embodiment, any of the electrodes on the devices can be selectively activatable as an anode or cathode. In this embodiment, the decoupling capacitor is placed into the current path via selectable anode and cathode stimulation switches. Regardless of the implementation, the techniques allow for the benefits of capacitive decoupling without the need to associate decoupling capacitors with every electrode on the multi-electrode device, which saves space in the body of the device. Although of particular benefit when applied to microstimulators, the disclosed technique can be used with space-saving benefits in any stimulator device.
摘要翻译：本文公开了用于在经由至少一个阴极电极和至少一个阳极电极建立的电流路径中并入一个去耦电容器的多电极可植入刺激器装置的电路和方法。在一个实施例中，去耦电容器可以硬连接到器件上的专用阳极。阴极可以通过刺激开关选择性地激活。在另一个实施例中，器件上的任何电极可以选择性地激活为阳极或阴极。在该实施例中，去耦电容通过可选择的阳极和阴极刺激开关放置在电流路径中。不管实施方案如何，这些技术允许电容去耦的优点，而不需要将去耦电容器与多电极器件上的每个电极相关联，这节省了器件体内的空间。虽然在应用于微型激励器时特别有益，但是所公开的技术可以在任何刺激器装置中具有节省空间的优点。

8. 发明申请

US20110118797A1 Multi-Electrode Implantable Stimulator Device with a Single Current Path Decoupling Capacitor 有权
标题翻译：具有单电流路径去耦电容器的多电极植入式刺激器装置
公开(公告)号：US20110118797A1
公开(公告)日：2011-05-19
申请号：US13012279
申请日：2011-01-24
申请人： Jordi Parramon , Kiran Nimmagadda , Emanuel Feldman , Yuping He
发明人： Jordi Parramon , Kiran Nimmagadda , Emanuel Feldman , Yuping He
IPC分类号： A61N1/36
CPC分类号： A61N1/36125 , A61N1/025 , A61N1/08 , A61N1/372 , A61N1/37205 , A61N1/3756
摘要： Disclosed herein are circuits and methods for a multi-electrode implantable stimulator device incorporating one decoupling capacitor in the current path established via at least one cathode electrode and at least one anode electrode. In one embodiment, the decoupling capacitor may be hard-wired to a dedicated anode on the device. The cathodes are selectively activatable via stimulation switches. In another embodiment, any of the electrodes on the devices can be selectively activatable as an anode or cathode. In this embodiment, the decoupling capacitor is placed into the current path via selectable anode and cathode stimulation switches. Regardless of the implementation, the techniques allow for the benefits of capacitive decoupling without the need to associate decoupling capacitors with every electrode on the multi-electrode device, which saves space in the body of the device. Although of particular benefit when applied to microstimulators, the disclosed technique can be used with space-saving benefits in any stimulator device.
摘要翻译：本文公开了用于在经由至少一个阴极电极和至少一个阳极电极建立的电流路径中并入一个去耦电容器的多电极可植入刺激器装置的电路和方法。在一个实施例中，去耦电容器可以硬连接到器件上的专用阳极。阴极可以通过刺激开关选择性地激活。在另一个实施例中，器件上的任何电极可以选择性地激活为阳极或阴极。在该实施例中，去耦电容通过可选择的阳极和阴极刺激开关放置在电流路径中。不管实施方案如何，这些技术允许电容去耦的优点，而不需要将去耦电容器与多电极器件上的每个电极相关联，这节省了器件体内的空间。虽然在应用于微型激励器时特别有益，但是所公开的技术可以在任何刺激器装置中具有节省空间的优点。

9. 发明申请

US20050267546A1 Low power loss current digital-to-analog converter used in an implantable pulse generator 有权
标题翻译：用于可植入脉冲发生器的低功耗电流数模转换器
公开(公告)号：US20050267546A1
公开(公告)日：2005-12-01
申请号：US11138632
申请日：2005-05-26
申请人： Jordi Parramon , Yuping He , Kiran Nimmagadda
发明人： Jordi Parramon , Yuping He , Kiran Nimmagadda
IPC分类号： A61N1/18 , A61N1/36
CPC分类号： A61N1/36071 , A61N1/025 , A61N1/36125 , A61N1/378
摘要： In one embodiment, the present invention provides an implantable stimulation device that includes output current sources and/or sinks configured to provide an output current for a load (i.e., tissue). The output path of the output current source or sink comprises a transistor which operates in a linear mode instead of a saturation mode. Because operation in a linear mode results in smaller drain-to-source voltage drops, power consumption in the output current source or sink (and hence in the implantable stimulator) is reduced, reducing battery or other power source requirements. Operation in the linear mode is facilitated in useful embodiments by a load in an input path (into which a reference current is sent) and a load in the output path (which bears the output current). The loads can be active transistors or passive resistors. A feedback circuit (e.g., an operational amplifier) receives voltages that build up across these loads, and sends a control signal to the gate of the transistor to ensure its linear operation.
摘要翻译：在一个实施例中，本发明提供了一种植入式刺激装置，其包括被配置为提供负载（即组织）的输出电流的输出电流源和/或接收器。输出电流源或吸收器的输出路径包括以线性模式而不是饱和模式操作的晶体管。因为在线性模式下的操作会导致较小的漏极 - 源极电压降，所以输出电流源或接收器（以及因此在可植入的刺激器中）的功耗降低，从而减少电池或其他电源要求。在有用的实施例中，通过输入路径（发送参考电流）中的负载和输出路径（承担输出电流）中的负载来促进线性模式的操作。负载可以是有源晶体管或无源电阻。反馈电路（例如，运算放大器）接收跨越这些负载的电压，并将控制信号发送到晶体管的栅极，以确保其线性运行。

10. 发明授权

US08750985B2 Low power loss current digital-to-analog converter used in an implantable pulse generator 有权
标题翻译：用于可植入脉冲发生器的低功耗电流数模转换器
公开(公告)号：US08750985B2
公开(公告)日：2014-06-10
申请号：US12424916
申请日：2009-04-16
申请人： Jordi Parramon , Yuping He , Kiran Nimmagadda
发明人： Jordi Parramon , Yuping He , Kiran Nimmagadda
IPC分类号： A61N1/36
CPC分类号： A61N1/36071 , A61N1/025 , A61N1/36125 , A61N1/378
摘要： In one embodiment, the present invention provides an implantable stimulation device that includes output current sources and/or sinks configured to provide an output current for a load (i.e., tissue). The output path of the output current source or sink comprises a transistor which operates in a linear mode instead of a saturation mode. Because operation in a linear mode results in smaller drain-to-source voltage drops, power consumption in the output current source or sink (and hence in the implantable stimulator) is reduced, reducing battery or other power source requirements. Operation in the linear mode is facilitated in useful embodiments by a load in an input path (into which a reference current is sent) and a load in the output path (which bears the output current). The loads can be active transistors or passive resistors. A feedback circuit (e.g., an operational amplifier) receives voltages that build up across these loads, and sends a control signal to the gate of the transistor to ensure its linear operation.
摘要翻译：在一个实施例中，本发明提供了一种植入式刺激装置，其包括被配置为提供负载（即组织）的输出电流的输出电流源和/或接收器。输出电流源或吸收器的输出路径包括以线性模式而不是饱和模式操作的晶体管。因为在线性模式下的操作会导致较小的漏极 - 源极电压降，所以输出电流源或接收器（以及因此在可植入的刺激器中）的功耗降低，从而减少了电池或其他电源的要求。在有用的实施例中，通过输入路径（发送参考电流）中的负载和输出路径（承担输出电流）中的负载来促进线性模式的操作。负载可以是有源晶体管或无源电阻。反馈电路（例如，运算放大器）接收跨越这些负载的电压，并将控制信号发送到晶体管的栅极，以确保其线性运行。

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