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1. 发明授权

US6036974A Method and apparatus for preparation of molded tablet and thereby prepared molded tablet 失效
标题翻译：用于制备模塑片剂的方法和设备，从而制备模塑片剂
公开(公告)号：US6036974A
公开(公告)日：2000-03-14
申请号：US127555
申请日：1993-09-28
申请人： Yuki Tsushima , Kazuhide Ashizawa , Sumio Watanabe
发明人： Yuki Tsushima , Kazuhide Ashizawa , Sumio Watanabe
IPC分类号： A61J3/10 , A61K9/20 , B30B11/02
CPC分类号： A61K9/2095 , B30B11/02 , B30B11/027
摘要： Active ingredients such as medicines are mixed with excipient and then kneaded together with binder and solvent such as alcohol or water to prepare a wetted paste. A mold is filled with this paste. Top and bottom surfaces of the paste within the mold are coated with powder such as lubricant in order to avoid possible sticking of the paste to the apparatus during a subsequent compression step. Then a compressive pressure is exerted on the surface of the paste. Thereafter, the tablet is taken from the mold. The molded tablet can contain water-soluble or fat-soluble medicine.
摘要翻译：将有效成分如药物与赋形剂混合，然后与粘合剂和溶剂如醇或水一起捏合以制备湿润糊剂。一个模子里装满了这种糊状物。模具内的糊料的顶部和底部表面涂覆有诸如润滑剂的粉末，以避免在随后的压缩步骤期间膏体可能粘附到装置上。然后在浆料的表面施加压缩压力。此后，从模具中取出片剂。成型片剂可含有水溶性或脂溶性药物。

2. 发明申请

US20080085309A1 Rapidly disintegrating tablets in buccal cavity and manufacturing method thereof 审中-公开
标题翻译：颊腔快速崩解片及其制造方法
公开(公告)号：US20080085309A1
公开(公告)日：2008-04-10
申请号：US11898610
申请日：2007-09-13
申请人： Yuki Tsushima , Soichiro Nakamura
发明人： Yuki Tsushima , Soichiro Nakamura
IPC分类号： A61K9/20 , A61K47/26
CPC分类号： A61K9/0056
摘要： A rapidly disintegrating tablet in the buccal cavity, comprising a drug, a treated starch having a degree of gelatinization of 30% to 60%, and a saccharide, and a process for manufacturing the same comprising the steps of mixing a drug, a treated starch having a degree of gelatinization of 30% to 60%, and a saccharide, and tabletting the mixture, are disclosed. The rapidly disintegrating tablet in the buccal cavity has a rapid disintegrability and solubility in the buccal cavity, and an appropriate hardness, without using special fillers, an apparatus, or the like.
摘要翻译：包含药物，糊化度为30％〜60％的处理淀粉和糖类的颊腔中的快速崩解片剂及其制造方法，包括以下步骤：将药物，经处理的淀粉具有30％至60％的糊化度和糖，并且对该混合物进行压片。颊腔中的快速崩解片剂在颊腔中具有快速的崩解性和溶解性，并且具有适当的硬度，而不使用特殊的填充剂，装置等。

3. 发明申请

US20080014262A1 Rapidly disintegrating tablet containing polyvinyl alcohol 失效
标题翻译：含聚乙烯醇快速崩解片
公开(公告)号：US20080014262A1
公开(公告)日：2008-01-17
申请号：US11778504
申请日：2007-07-16
申请人： Yutaka MORITA , Masanobu Yasui , Takayuki Ohwaki , Yuki Tsushima
发明人： Yutaka MORITA , Masanobu Yasui , Takayuki Ohwaki , Yuki Tsushima
IPC分类号： A61K9/20 , A61K31/167 , A61K31/426 , A61P1/04 , A61P43/00 , A61P9/02 , A61P25/28 , A61K31/445 , A61K31/551
CPC分类号： A61K31/551 , A61K9/0056 , A61K9/2018 , A61K9/2027 , A61K9/2077 , A61K31/165 , A61K31/426
摘要： The present invention provides a quickly disintegrating tablet which has quick disintegrability and solubility in an oral cavity, and does not have uncomfortable tastes such as bitterness, has a small variation of a tablet physical property even in storage under a humidifying condition, and has substantially no change in a medicine content in the tablet and tablet appearance and which is superior in stability; and a manufacturing method of the tablet. That is, it provides: a quickly disintegrating tablet which is prepared by blending a medicine with a saccharide and polyvinyl alcohol, which has small variations of tablet weight, tablet hardness, tablet diameter and tablet thickness, and which is superior in medicine stability in the tablet; and a manufacturing method of the tablet.
摘要翻译：本发明提供一种快速崩解片剂，其在口腔内具有快速的崩解性和溶解性，并且不具有不适感的味道，例如苦味，即使在加湿条件下储存时片剂物理性质的变化也小，并且基本上没有改变片剂和片剂外观中的药物含量，其稳定性优异; 和片剂的制造方法。也就是说，它提供：通过将药物与糖和聚乙烯醇混合制备的快速崩解片剂，其片剂重量，片剂硬度，片剂直径和片剂厚度的变化小，并且在药物稳定性方面优异片剂; 和片剂的制造方法。

4. 发明申请

US20130115291A1 ENTERIC TABLET 有权
公开(公告)号：US20130115291A1
公开(公告)日：2013-05-09
申请号：US13695220
申请日：2011-04-28
申请人： Masafumi Misaki , Yuki Tsushima , Masahiro Niwa
发明人： Masafumi Misaki , Yuki Tsushima , Masahiro Niwa
IPC分类号： A61K9/28
CPC分类号： A61K9/2077 , A61K9/2813 , A61K9/2846 , A61K9/2886 , A61K31/4465
摘要： The present invention relates to an enteric tablet with improved bioavailability, which is rapidly disintegrated after reaching the intestine to allow dissolution of the active ingredient, and which characteristically reduces the amount of talc to be used and is free of an alkali component.

5. 发明申请

US20130115292A1 ENTERIC TABLET 审中-公开
公开(公告)号：US20130115292A1
公开(公告)日：2013-05-09
申请号：US13695366
申请日：2011-04-28
申请人： Masafumi Misaki , Yuki Tsushima , Masahiro Niwa
发明人： Masafumi Misaki , Yuki Tsushima , Masahiro Niwa
IPC分类号： A61K9/28
CPC分类号： A61K9/2027 , A61K9/2018 , A61K9/2813 , A61K9/2846 , A61K9/2866 , A61K9/2886 , A61K31/495
摘要： The present invention relates to an enteric tablet with improved bioavailability, which is rapidly disintegrated after reaching the intestine to allow dissolution of the active ingredient, and which characteristically reduces the amount of talc to be used and is free of an alkali component.

6. 发明授权

US5672364A Apparatus for manufacturing tablets 失效
标题翻译：片剂制造装置
公开(公告)号：US5672364A
公开(公告)日：1997-09-30
申请号：US494924
申请日：1995-06-26
申请人： Heizaburo Kato , Yuki Tsushima , Takayuki Ohwaki , Masaharu Nakajima , Yutaka Morita
发明人： Heizaburo Kato , Yuki Tsushima , Takayuki Ohwaki , Masaharu Nakajima , Yutaka Morita
IPC分类号： A61J1/10 , A61J3/10 , B30B11/10
CPC分类号： A61J3/10 , B30B11/027 , B30B11/10 , B30B15/302
摘要： A method and an apparatus for manufacturing tablets of moist powder which is produced by adding an additive agent such as an excipient or a binder to medical ingredients, further adding a solvent such as water, ethanol or the like, and kneading the mixture. The tablet manufacturing method comprises the steps of: preparing a first table and a second table which are intermittently rotated and driven relatively with respect to each other; supplying moist powder from a hopper into filling holes of the first table; filling the supplied moist powder into mold cavities of the second table under a pressurized condition by means of filling pins of a filling and pressurizing device at a location where the first table overlaps with the second table; relatively moving the first and second tables with respect to each other so as to level the surface of the moist powder in the mold cavities by removing the excessive powder; chamfering the surface of the moist powder by a finish-forming device; drying the moist powder by a dryer; and releasing the moist powder out of the mold cavities by a release device.
摘要翻译：通过向医药成分添加赋形剂或粘合剂等添加剂而进一步添加水，乙醇等溶剂，捏合该混合物而制造的湿粉状片剂的制造方法和装置。片剂制造方法包括以下步骤：制备相对于彼此间歇地旋转和驱动的第一工作台和第二工作台; 将料斗中的潮湿粉末装入第一台的填充孔; 在第一台与第二台重叠的位置处，通过填充和加压装置的填充销填充所供应的潮湿粉末到加压状态下的第二台的模腔中; 相对于彼此相对移动第一和第二台，以通过去除过量的粉末来平衡模具腔中的湿粉末的表面; 通过精整成形装置对潮湿粉末的表面进行倒角; 用干燥机干燥湿粉; 并通过释放装置将湿粉释放出模腔。

7. 发明授权

US08263123B2 Rapidly disintegrating tablet containing polyvinyl alcohol 失效
标题翻译：含聚乙烯醇快速崩解片
公开(公告)号：US08263123B2
公开(公告)日：2012-09-11
申请号：US11778504
申请日：2007-07-16
申请人： Yutaka Morita , Masanobu Yasui , Takayuki Ohwaki , Yuki Tsushima
发明人： Yutaka Morita , Masanobu Yasui , Takayuki Ohwaki , Yuki Tsushima
IPC分类号： A61Q9/20
CPC分类号： A61K31/551 , A61K9/0056 , A61K9/2018 , A61K9/2027 , A61K9/2077 , A61K31/165 , A61K31/426
摘要： The present invention provides a quickly disintegrating tablet which has quick disintegrability and solubility in an oral cavity, and does not have uncomfortable tastes such as bitterness, has a small variation of a tablet physical property even in storage under a humidifying condition, and has substantially no change in a medicine content in the tablet and tablet appearance and which is superior in stability; and a manufacturing method of the tablet. That is, it provides: a quickly disintegrating tablet which is prepared by blending a medicine with a saccharide and polyvinyl alcohol, which has small variations of tablet weight, tablet hardness, tablet diameter and tablet thickness, and which is superior in medicine stability in the tablet; and a manufacturing method of the tablet.
摘要翻译：本发明提供一种快速崩解片剂，其在口腔内具有快速的崩解性和溶解性，并且不具有不适感的味道，例如苦味，即使在加湿条件下储存时片剂物理性质的变化也小，并且基本上没有改变片剂和片剂外观中的药物含量，其稳定性优异; 和片剂的制造方法。也就是说，它提供：通过将药物与糖和聚乙烯醇混合制备的快速崩解片剂，其片剂重量，片剂硬度，片剂直径和片剂厚度的变化小，并且在药物稳定性方面优异片剂; 和片剂的制造方法。

8. 发明授权

US07727548B2 Rapidly disintegrable tablet containing polyvinyl alcohol 失效
标题翻译：含聚乙烯醇的快速崩解片
公开(公告)号：US07727548B2
公开(公告)日：2010-06-01
申请号：US10203687
申请日：2001-03-01
申请人： Yutaka Morita , Masanobu Yasui , Takayuki Ohwaki , Yuki Tsushima
发明人： Yutaka Morita , Masanobu Yasui , Takayuki Ohwaki , Yuki Tsushima
IPC分类号： A61Q9/20
CPC分类号： A61K31/551 , A61K9/0056 , A61K9/2018 , A61K9/2027 , A61K9/2077 , A61K31/165 , A61K31/426
摘要： The present invention provides a quickly disintegrating tablet which has quick disintegrability and solubility in an oral cavity, and does not have uncomfortable tastes such as bitterness, has a small variation of a tablet physical property even in storage under a humidifying condition, and has substantially no change in a medicine content in the tablet and tablet appearance and which is superior in stability; and a manufacturing method of the tablet. That is, it provides: a quickly disintegrating tablet which is prepared by blending a medicine with a saccharide and polyvinyl alcohol, which has small variations of tablet weight, tablet hardness, tablet diameter and tablet thickness, and which is superior in medicine stability in the tablet; and a manufacturing method of the tablet.
摘要翻译：本发明提供一种快速崩解片剂，其在口腔内具有快速的崩解性和溶解性，并且不具有不适感的味道，例如苦味，即使在加湿条件下储存时片剂物理性质的变化也小，并且基本上没有改变片剂和片剂外观中的药物含量，其稳定性优异; 和片剂的制造方法。也就是说，它提供：通过将药物与糖和聚乙烯醇混合制备的快速崩解片剂，其片剂重量，片剂硬度，片剂直径和片剂厚度的变化小，并且在药物稳定性方面优异片剂; 和片剂的制造方法。

9. 发明授权

US06074586A Method for manufacturing tablets 失效
标题翻译：制造片剂的方法
公开(公告)号：US06074586A
公开(公告)日：2000-06-13
申请号：US833244
申请日：1997-04-17
申请人： Heizaburo Kato , Yuki Tsushima , Takayuki Ohwaki , Masaharu Nakajima , Yutaka Morita
发明人： Heizaburo Kato , Yuki Tsushima , Takayuki Ohwaki , Masaharu Nakajima , Yutaka Morita
IPC分类号： A61J1/10 , A61J3/10 , B30B11/10 , B29C43/06
CPC分类号： A61J3/10 , B30B11/027 , B30B11/10 , B30B15/302
摘要： A method and an apparatus for manufacturing tablets of moist powder which is produced by adding an additive agent such as an excipient or a binder to medical ingredients, further adding a solvent such as water, ethanol or the like, and kneading the mixture. The tablet manufacturing method comprises the steps of: preparing a first table and a second table which are intermittently rotated and driven relatively with respect to each other; supplying moist powder from a hopper into filling holes of the first table; filling the supplied moist powder into mold cavities of the second table under a pressurized condition by means of filling pins of a filling and pressurizing device at a location where the first table overlaps with the second table; relatively moving the first and second tables with respect to each other so as to level the surface of the moist powder in the mold cavities by removing the excessive powder; chamfering the surface of the moist powder by a finish-forming device; drying the moist powder by a dryer; and releasing the moist powder out of the mold cavities by a release device.
摘要翻译：通过向医药成分添加赋形剂或粘合剂等添加剂而进一步添加水，乙醇等溶剂，捏合该混合物而制造的湿粉状片剂的制造方法和装置。片剂制造方法包括以下步骤：制备相对于彼此间歇地旋转和驱动的第一工作台和第二工作台; 将料斗中的潮湿粉末装入第一台的填充孔; 在第一台与第二台重叠的位置处，通过填充和加压装置的填充销填充所供应的潮湿粉末到加压状态下的第二台的模腔中; 相对于彼此相对移动第一和第二台，以通过去除过量的粉末来平衡模具腔中的湿粉末的表面; 通过精整成形装置对潮湿粉末的表面进行倒角; 用干燥机干燥湿粉; 并通过释放装置将湿粉释放出模腔。

10. 发明授权

US08920840B2 Enteric tablet 有权
标题翻译：肠溶片
公开(公告)号：US08920840B2
公开(公告)日：2014-12-30
申请号：US13695220
申请日：2011-04-28
申请人： Masafumi Misaki , Yuki Tsushima , Masahiro Niwa
发明人： Masafumi Misaki , Yuki Tsushima , Masahiro Niwa
IPC分类号： A61K9/28 , A61K31/451 , A61K31/4465 , A61K9/20
CPC分类号： A61K9/2077 , A61K9/2813 , A61K9/2846 , A61K9/2886 , A61K31/4465
摘要： The present invention relates to an enteric tablet with improved bioavailability, which is rapidly disintegrated after reaching the intestine to allow dissolution of the active ingredient, and which characteristically reduces the amount of talc to be used and is free of an alkali component.
摘要翻译：本发明涉及具有改善的生物利用度的肠溶片剂，其在到达肠后快速崩解以允许活性成分溶解，并且其特征在于减少使用的滑石并且不含碱组分。

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