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1. 发明申请

US20070231399A1 COATED FINE PARTICLES CONTAINING DRUG FOR INTRABUCCALLY FAST DISINTEGRATING DOSAGE FORMS 失效
标题翻译：含有药物的含有精细颗粒的快速消毒剂型
公开(公告)号：US20070231399A1
公开(公告)日：2007-10-04
申请号：US11458582
申请日：2006-07-19
申请人： Yuki Kasashima , Ippei Kurimoto , Hitoshi Kawai
发明人： Yuki Kasashima , Ippei Kurimoto , Hitoshi Kawai
IPC分类号： A61K9/52
CPC分类号： A61K9/5078 , A61K9/5047
摘要： Regarding an object of sufficient suppression of unpleasant taste in the oral cavity and quick dissolution in the gastrointestinal tract, which is generated when a drug having a strong unpleasant taste such as bitterness, astringency and the like is applied to a quickly disintegrating preparations in the oral cavity, this invention has achieved the aforementioned object for the first time by employing a constitution of coating a coat of a water-soluble polymer and a specified ratio of a pH-independent water-insoluble polymer and hydroxypropylcellulose.
摘要翻译：关于在口腔中充分抑制不愉快味道和快速溶解在胃肠道中的目的，当将具有强烈令人不快的味道（例如苦味，涩味等）的药物施用于口服的快速崩解制剂时产生本发明通过使用涂布水溶性聚合物的涂层和与pH无关的水不溶性聚合物和羟丙基纤维素的规定比例的结构第一次实现了上述目的。

2. 发明申请

US20050175689A1 Coated fine particles containing drug for intrabuccally fast disintegrating tablet 审中-公开
标题翻译：含有药物的包衣微粒含有快速崩解片剂
公开(公告)号：US20050175689A1
公开(公告)日：2005-08-11
申请号：US10975210
申请日：2004-10-27
申请人： Ippei Kurimoto , Yuki Kasashima , Hitoshi Kawai , Yuuki Takaishi , Masataka Katsuma , Hiroshi Ohi , Takayuki Yoshida , Hiroaki Tasaki
发明人： Ippei Kurimoto , Yuki Kasashima , Hitoshi Kawai , Yuuki Takaishi , Masataka Katsuma , Hiroshi Ohi , Takayuki Yoshida , Hiroaki Tasaki
IPC分类号： A61K9/14 , A61K9/20
CPC分类号： A61K9/0056 , A61K9/2081
摘要： The present invention makes it possible to provide drug-containing coated microparticles for quick-disintegrating oral tablets wherein microparticles containing a drug with an unpleasant taste are coated with a film composed of (1) a pH-independent water-insoluble polymer accounting for 60% or more but less than 80% of the film and (2) a pH-independent water-soluble substance accounting for more than 20% to 40% or less of the film, these microparticles being characterized in that the rate of dissolution of the drug from the drug-containing microparticles is 0% to 10% in one minute and 80% to 100% in 30 minutes, and the average particle diameter is 350 μm or less, in order to realize sufficient control of oral drug dissolution and fast gastrointestinal drug dissolution.
摘要翻译：本发明使得可以提供用于快速崩解口服片剂的药物包衣微粒，其中含有具有令人不快的味道的药物的微粒被包被（1）不含pH的水不溶性聚合物占60％或更多但小于80％的膜，（2）占pH超过20％至40％以下的pH不依赖性水溶性物质，这些微粒的特征在于药物的溶解速率含药微粒在1分钟内为0％〜10％，30分钟为80％〜100％，平均粒径为350μm以下，为了实现口服药物溶解和快速胃肠药物的充分控制溶解

3. 发明授权

US07815939B2 Coated fine particles containing drug for intrabuccally fast disintegrating dosage forms 失效
标题翻译：含有药物的包被的细颗粒用于脂肪内快速崩解剂型
公开(公告)号：US07815939B2
公开(公告)日：2010-10-19
申请号：US11458582
申请日：2006-07-19
申请人： Yuki Kasashima , Ippei Kurimoto , Hitoshi Kawai
发明人： Yuki Kasashima , Ippei Kurimoto , Hitoshi Kawai
IPC分类号： A61K9/24 , A61K9/16
CPC分类号： A61K9/5078 , A61K9/5047
摘要： Regarding an object of sufficient suppression of unpleasant taste in the oral cavity and quick dissolution in the gastrointestinal tract, which is generated when a drug having a strong unpleasant taste such as bitterness, astringency and the like is applied to a quickly disintegrating preparations in the oral cavity, this invention has achieved the aforementioned object for the first time by employing a constitution of coating a coat of a water-soluble polymer and a specified ratio of a pH-independent water-insoluble polymer and hydroxypropylcellulose.
摘要翻译：关于在口腔中充分抑制不愉快味道和快速溶解在胃肠道中的目的，当将具有强烈令人不快的味道（例如苦味，涩味等）的药物施用于口服的快速崩解制剂时产生本发明通过使用涂布水溶性聚合物的涂层和与pH无关的水不溶性聚合物和羟丙基纤维素的规定比例的结构第一次实现了上述目的。

4. 发明申请

US20070193984A1 Laser welding apparatus and method 有权
标题翻译：激光焊接设备及方法
公开(公告)号：US20070193984A1
公开(公告)日：2007-08-23
申请号：US11348552
申请日：2006-02-07
申请人： Hitoshi Kawai , Yuji Hamaguchi , Tatsuya Sakurai
发明人： Hitoshi Kawai , Yuji Hamaguchi , Tatsuya Sakurai
IPC分类号： B23K26/20 , B23K26/06 , B23K26/08
CPC分类号： B23K26/0884 , B23K26/046 , B23K26/073 , B23K26/082
摘要： A laser welding apparatus includes a laser welding unit including a first lens adapted to focus a laser beam; a second lens adapted to diffuse the laser beam to the first lens; and a third lens adapted to guide the laser beam to the second lens. The relative positions of the first lens, the second lens, and the third lens, are adjusted to adjust a diffusion angle and a beam width of the laser beam entering the first lens. The laser welding apparatus performs: actuating the laser welding unit to travel at a predetermined speed along a predetermined trajectory; directing the laser beam at a first welding spot; adjusting the focal length to focus the laser beam at the first welding spot; holding the laser focal spot size substantially constant; and directing the laser beam at a second welding spot after completion of welding for the first welding spot.
摘要翻译：激光焊接装置包括激光焊接单元，其包括适于聚焦激光束的第一透镜; 第二透镜，适于将激光束扩散到第一透镜; 以及适于将激光束引导到第二透镜的第三透镜。调整第一透镜，第二透镜和第三透镜的相对位置，以调节进入第一透镜的激光束的扩散角和光束宽度。该激光焊接装置执行以下步骤：致动激光焊接单元沿预定轨迹以预定速度行进; 将激光束引导到第一焊接点; 调整焦距以将激光束聚焦在第一焊接点处; 保持激光焦点尺寸基本恒定; 以及在第一焊接点的焊接完成之后将激光束引导到第二焊接点。

5. 发明授权

US08465010B2 Vibration damping rubber bushing 有权
标题翻译：减震橡胶衬套
公开(公告)号：US08465010B2
公开(公告)日：2013-06-18
申请号：US12821409
申请日：2010-06-23
申请人： Norimasa Kuki , Yoshikane Akiyama , Mitiharu Hikosaka , Kazuhiko Kato , Hitoshi Kawai , Mie Miyauchi
发明人： Norimasa Kuki , Yoshikane Akiyama , Mitiharu Hikosaka , Kazuhiko Kato , Hitoshi Kawai , Mie Miyauchi
IPC分类号： F16F1/44
CPC分类号： F16F1/3863 , F16F2230/02
摘要： A vibration damping rubber bushing including: an inner cylindrical member; a main rubber elastic body bonded to an outer circumferential face of the inner cylindrical member; a plurality of anti-slip projections provided on at least one of axial end faces of the inner cylindrical member that project axially outward from the axial end face and extend with ribbed shape in a diametrical direction on the axial end face to produce a spokewise pattern overall; and an annular water barrier projection provided on a diametrical medial section of the at least one of the axial end faces of the inner cylindrical member, projecting axially outwardly and extending circumferentially, with the anti-slip projections being disposed to both radially inner side and radially outer side of the annular water barrier projection.
摘要翻译： 1.一种减振橡胶衬套，包括：内圆柱形构件; 主橡胶弹性体，其与所述内筒状构件的外周面接合; 所述多个防滑突起设置在所述内圆柱形构件的轴向端面中的至少一个轴向端面上，所述多个防滑突起从所述轴向端面轴向向外突出，并且在所述轴向端面上沿直径方向延伸成肋状以产生总体上的轴向图案 ; 以及环形防水突起，其设置在所述内圆柱形构件的所述至少一个轴向端面的直径中间部分上，所述中空部分轴向向外突出并且沿周向延伸，所述防滑突起设置在径向内侧和径向环形防水突起的外侧。

6. 发明授权

US06656492B2 Quick disintegrating tablet in buccal cavity and manufacturing method thereof 失效
公开(公告)号：US06656492B2
公开(公告)日：2003-12-02
申请号：US09896820
申请日：2001-06-28
申请人： Atushi Kajiyama , Tetsuya Tamura , Takao Mizumoto , Hitoshi Kawai , Tatsuya Takahashi
发明人： Atushi Kajiyama , Tetsuya Tamura , Takao Mizumoto , Hitoshi Kawai , Tatsuya Takahashi
IPC分类号： A61F1300
CPC分类号： A61K9/2077 , A61K9/0056 , A61K9/1635 , A61K9/1652
摘要： The present invention pertains to a quick disintegrating tablet in buccal cavity, characterized in that drug-containing particles with a mean particle diameter of approximately 50˜approximately 250 &mgr;m and an apparent specific gravity of approximately 0.5˜approximately 1.2 consisting of a bitter tasting drug and/or drug of inferior fluidity and a pharmaceutical preparation carrier and obtained by spray drying are added to a quick disintegrating tablet in buccal cavity comprising a drug and saccharide. Moreover, the present invention pertains to a method for manufacturing drug-containing particles having a specific mean particle diameter and specific apparent gravity by dissolving and suspending a bitter tasting drug and/or drug of inferior fluidity and a pharmaceutical preparation carrier (preferably containing water-insoluble polymer, particularly at least aqueous ethyl cellulose suspension (preferably containing plasticizer)) to a high concentration in terms of solid concentration in a solvent that is pharmaceutically acceptable and then spray drying this liquid using a rotating disk-type spray dryer, with the disk operating at low speed, and a method for manufacturing a quick disintegrating tablet in buccal cavity comprising said particles.

7. 发明授权

US08796582B2 Laser welding apparatus and method 有权
标题翻译：激光焊接设备及方法
公开(公告)号：US08796582B2
公开(公告)日：2014-08-05
申请号：US11348552
申请日：2006-02-07
申请人： Hitoshi Kawai , Yuji Hamaguchi , Tatsuya Sakurai
发明人： Hitoshi Kawai , Yuji Hamaguchi , Tatsuya Sakurai
IPC分类号： B23K26/00 , G02B7/02
CPC分类号： B23K26/0884 , B23K26/046 , B23K26/073 , B23K26/082
摘要： A laser welding apparatus includes a laser welding unit including a first lens adapted to focus a laser beam; a second lens adapted to diffuse the laser beam to the first lens; and a third lens adapted to guide the laser beam to the second lens. The relative positions of the first lens, the second lens, and the third lens, are adjusted to adjust a diffusion angle and a beam width of the laser beam entering the first lens. The laser welding apparatus performs: actuating the laser welding unit to travel at a predetermined speed along a predetermined trajectory; directing the laser beam at a first welding spot; adjusting the focal length to focus the laser beam at the first welding spot; holding the laser focal spot size substantially constant; and directing the laser beam at a second welding spot after completion of welding for the first welding spot.
摘要翻译：激光焊接装置包括激光焊接单元，其包括适于聚焦激光束的第一透镜; 第二透镜，适于将激光束扩散到第一透镜; 以及适于将激光束引导到第二透镜的第三透镜。调整第一透镜，第二透镜和第三透镜的相对位置，以调节进入第一透镜的激光束的扩散角和光束宽度。该激光焊接装置执行以下步骤：致动激光焊接单元沿预定轨迹以预定速度行进; 将激光束引导到第一焊接点; 调整焦距以将激光束聚焦在第一焊接点处; 保持激光焦点尺寸基本恒定; 以及在第一焊接点的焊接完成之后将激光束引导到第二焊接点。

8. 发明授权

US07623557B2 Wavelength converting optical system, laser light source, exposure apparatus, mask examining apparatus, and macromolecular crystal lens machining device 有权
标题翻译：波长转换光学系统，激光光源，曝光装置，掩模检查装置和大分子水晶透镜加工装置
公开(公告)号：US07623557B2
公开(公告)日：2009-11-24
申请号：US11602366
申请日：2006-11-20
申请人： Akira Tokuhisa , Hitoshi Kawai , Yoshinori Oshita
发明人： Akira Tokuhisa , Hitoshi Kawai , Yoshinori Oshita
IPC分类号： H01S3/10
CPC分类号： G03F7/70025 , G02F1/353 , G02F1/3534 , G02F2001/354 , G03F1/84 , G03F7/70575 , H01S3/005
摘要： A fifth harmonic wave is formed from a fundamental wave of p-polarized light via a second harmonic wave forming optical element 3, a third harmonic wave forming optical element 4, and a fifth harmonic wave forming optical element 6 and a second harmonic wave of p-polarized light is formed from a fundamental wave of s-polarized light by a second harmonic wave forming optical element 9. The fifth harmonic wave of p-polarized light that is subjected to beam shaping by cylindrical lenses 7 and 8, the fundamental wave of s-polarized light, and the second harmonic wave of p-polarized light are combined by a dichroic mirror 10, and are incident on a seventh harmonic wave forming optical element 11. Furthermore, a seventh harmonic wave of s-polarized light is formed from the second harmonic wave and fifth harmonic wave of p-polarized light, and this seventh harmonic wave is mixed with the fundamental wave of s-polarized light in an eighth harmonic wave forming optical element 12, so that an eighth harmonic wave of p-polarized light is formed. As a result, an eighth harmonic wave can be formed in a simpler optical system than a conventional optical system.
摘要翻译：五次谐波由p偏振光的基波经由二次谐波形成光学元件3，三次谐波形成光学元件4和五次谐波形成光学元件6和二次谐波p形成通过二次谐波形成光学元件9由S偏振光的基波形成偏振光。通过柱面透镜7和8进行光束成形的p偏振光的五次谐波，基波 s偏振光，并且p偏振光的二次谐波通过分色镜10组合，并且入射到第七谐波形成光学元件11.此外，s偏振光的七次谐波由第二谐波和第五谐波的p偏振光，第七谐波与第八谐波成形光学元件12中的s偏振光的基波混合，使得ei 形成p偏振光的第g次谐波。结果，与传统的光学系统相比，可以在更简单的光学系统中形成八次谐波。

9. 发明申请

US20070177639A1 Wavelength converting optical system, laser light source, exposure apparatus, mask examining apparatus, and macromolecular crystal lens machining device 有权
标题翻译：波长转换光学系统，激光光源，曝光装置，掩模检查装置和大分子水晶透镜加工装置
公开(公告)号：US20070177639A1
公开(公告)日：2007-08-02
申请号：US11602366
申请日：2006-11-20
申请人： Akira Tokuhisa , Hitoshi Kawai , Yoshinori Oshita
发明人： Akira Tokuhisa , Hitoshi Kawai , Yoshinori Oshita
IPC分类号： H01S3/10
CPC分类号： G03F7/70025 , G02F1/353 , G02F1/3534 , G02F2001/354 , G03F1/84 , G03F7/70575 , H01S3/005
摘要： A fifth harmonic wave is formed from a fundamental wave of p-polarized light via a second harmonic wave forming optical element 3, a third harmonic wave forming optical element 4, and a fifth harmonic wave forming optical element 6 and a second harmonic wave of p-polarized light is formed from a fundamental wave of s-polarized light by a second harmonic wave forming optical element 9. The fifth harmonic wave of p-polarized light that is subjected to beam shaping by cylindrical lenses 7 and 8, the fundamental wave of s-polarized light, and the second harmonic wave of p-polarized light are combined by a dichroic mirror 10, and are incident on a seventh harmonic wave forming optical element 11. Furthermore, a seventh harmonic wave of s-polarized light is formed from the second harmonic wave and fifth harmonic wave of p-polarized light, and this seventh harmonic wave is mixed with the fundamental wave of s-polarized light in an eighth harmonic wave forming optical element 12, so that an eighth harmonic wave of p-polarized light is formed. As a result, an eighth harmonic wave can be formed in a simpler optical system than a conventional optical system.
摘要翻译：五次谐波由p偏振光的基波经由二次谐波形成光学元件3，三次谐波形成光学元件4和五次谐波形成光学元件6和二次谐波p形成由二次谐波形成光学元件9由S偏振光的基波形成偏振光。通过柱面透镜7和8进行光束整形的p偏振光的五次谐波，s偏振光的基波和p偏振光的二次谐波通过分色镜10组合，并且入射到第七谐波成形光学元件11上。此外，由p偏振光的二次谐波和五次谐波形成s偏振光的七次谐波，将该七次谐波与第八谐波成形中的s偏振光的基波混合光学元件12，从而形成p偏振光的八次谐波。结果，与传统的光学系统相比，可以在更简单的光学系统中形成八次谐波。

10. 发明申请

US20060291862A1 Laser light source device, exposure device, and mask inspection device using this laser light source device 有权
标题翻译：激光光源装置，曝光装置和使用该激光光源装置的掩模检查装置
公开(公告)号：US20060291862A1
公开(公告)日：2006-12-28
申请号：US11514256
申请日：2006-09-01
申请人： Hitoshi Kawai
发明人： Hitoshi Kawai
IPC分类号： H04J14/02
CPC分类号： G03F1/84 , G03F7/70025 , G03F7/7005 , H01S3/2383 , H01S3/2391 , H04J14/02 , H04J14/08
摘要： A laser light source device 1, comprising M number of laser light sources, of which frequency is shifted from a fundamental frequency by (m−1)·a·Δω, a first laser light source section 2 and a first fiber amplifier section 4 for amplifying these laser lights, a first optical multiplexer 6 for approximately coaxially superimposing the laser lights emitted from the first fiber amplifier section 4 and emitting the laser lights, a first wavelength conversion device 9 for multiplying the frequency of the laser lights emitted from the first optical multiplexer 6 by A, M number of laser light sources, of which frequency is shifted from the fundamental frequency by (m−1)·b·Δω, a second laser light source section 3 and a second fiber amplifier section 5 for amplifying these laser lights, a second optical multiplexer 7 for approximately coaxially superimposing the laser lights emitted from the second fiber amplifier section 5 and emitting the laser lights, a second wavelength conversion device 10 for multiplying the frequency of the laser lights emitted from the second optical multiplexer 7 by B, and a third wavelength conversion device 11 for simultaneously receiving the laser lights emitted from the first and second wavelength conversion devices 9 and 10 and converting the laser lights into laser lights, of which frequency is (A+B) times the fundamental frequency, the laser light source device 1 being characterized in that the expression A·a+B·b=0 is satisfied.
摘要翻译：一种激光光源装置1，包括M个激光源，其频率从基频（m-1）移位.Deltaomega，第一激光光源部分2和第一光纤放大器部分4，用于放大这些激光，第一光复用器6用于大致同轴地叠加从第一光纤放大器部分4发射的激光并发射激光;第一波长转换装置9，用于将从第一光学放大器部分4发射的激光的频率相乘多路复用器6由A，M个激光源组成，其频率从基本频率偏移（m-1）.b.Deltaomega，第二激光光源部分3和用于放大这些激光器的第二光纤放大器部分5 第二光复用器7，用于大致同轴地叠加从第二光纤放大器部分5发出的激光并发射激光，第二波长con 版本装置10，用于将从第二光复用器7发射的激光的频率乘以B;以及第三波长转换装置11，用于同时接收从第一和第二波长转换装置9和10发射的激光，并转换激光照射到激光，其频率为（A + B）倍于基频，激光光源装置1的特征在于表达式A.a + Bb = 0。

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