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    • 8. 发明申请
    • Optical waveguide bio-sensing device
    • 光波导生物传感器
    • US20070147727A1
    • 2007-06-28
    • US11540972
    • 2006-10-02
    • Yen-Chieh MaoJian-Shian LinLai-Sheng ChenWei-Han Wang
    • Yen-Chieh MaoJian-Shian LinLai-Sheng ChenWei-Han Wang
    • G02B6/00
    • G01N21/7703G01N21/553G01N2021/7773
    • An optical waveguide bio-sensing device, comprising: a monochromatic light source, a beam splitter, a grating chip with a sub-wavelength grating structure and a sensor. Moreover, in order to enhance the sensitivity of the system using the optical waveguide bio-sensing device, a light concentrating element or a quarter waveplate (¼λ) is arranged in the optical path during detection. When the grating chip is not coated with a layer of biochemical substance corresponding to a monochrome light emitted from the monochromatic light source, a reflected light of a specific narrow wavelength is reflected by a specific angle as a surface plasmon resonant effect caused by waveguide coupling is excited by the incidence of the monochrome light to the grating chip through the beam splitter; otherwise, there will be little or no reflection. Accordingly, the optical waveguide bio-sensing device can detect bio-molecular interactions, reaction rate and/or molecular dynamics without any labeling in real time. Optical systems using the present invention are simplified and capable of being portable. Thus a high sensitivity detection technique is achieved.
    • 一种光波导生物感测装置,包括:单色光源,分束器,具有亚波长光栅结构的光栅芯片和传感器。 此外,为了提高使用光波导生物感测装置的系统的灵敏度,在检测期间在光路中布置光聚集元件或四分之一波片(λ=λ)。 当光栅芯片没有涂覆与从单色光源发射的单色光相对应的生物化学物质层时,由于波导耦合引起的表面等离子体共振效应,特定窄波长的反射光被反射特定角度 由单色光通过分束器激发到光栅芯片; 否则,会有很少或没有反映。 因此,光波导生物传感装置可以实时检测生物分子相互作用,反应速率和/或分子动力学,而无需任何标记。 使用本发明的光学系统被简化并能够便携。 因此实现了高灵敏度检测技术。
    • 9. 发明授权
    • Optical waveguide bio-sensing device
    • 光波导生物传感器
    • US07636502B2
    • 2009-12-22
    • US11540972
    • 2006-10-02
    • Yen-Chieh MaoJian-Shian LinLai-Sheng ChenWei-Han Wang
    • Yen-Chieh MaoJian-Shian LinLai-Sheng ChenWei-Han Wang
    • G02B6/00G02B6/34
    • G01N21/7703G01N21/553G01N2021/7773
    • An optical waveguide bio-sensing device, comprising: a monochromatic light source, a beam splitter, a grating chip with a sub-wavelength grating structure and a sensor. Moreover, in order to enhance the sensitivity of the system using the optical waveguide bio-sensing device, a light concentrating element or a quarter waveplate (¼λ) is arranged in the optical path during detection. When the grating chip is not coated with a layer of biochemical substance corresponding to a monochrome light emitted from the monochromatic light source, a reflected light of a specific narrow wavelength is reflected by a specific angle as a surface plasmon resonant effect caused by waveguide coupling is excited by the incidence of the monochrome light to the grating chip through the beam splitter; otherwise, there will be little or no reflection. Accordingly, the optical waveguide bio-sensing device can detect bio-molecular interactions, reaction rate and/or molecular dynamics without any labeling in real time. Optical systems using the present invention are simplified and capable of being portable. Thus a high sensitivity detection technique is achieved.
    • 一种光波导生物感测装置,包括:单色光源,分束器,具有亚波长光栅结构的光栅芯片和传感器。 此外,为了提高使用光波导生物感测装置的系统的灵敏度,在检测期间在光路中布置光聚集元件或四分之一波片(λ-λ)。 当光栅芯片没有涂覆与从单色光源发射的单色光相对应的生物化学物质层时,由于波导耦合引起的表面等离子体共振效应,特定窄波长的反射光被反射特定角度 由单色光通过分束器激发到光栅芯片; 否则,会有很少或没有反映。 因此,光波导生物传感装置可以实时检测生物分子相互作用,反应速率和/或分子动力学,而无需任何标记。 使用本发明的光学系统被简化并能够便携。 因此实现了高灵敏度检测技术。