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1. 发明授权

US07679748B2 Coupled waveguide-surface plasmon resonance biosensor 有权
标题翻译：耦合波导表面等离子体共振生物传感器
公开(公告)号：US07679748B2
公开(公告)日：2010-03-16
申请号：US11448098
申请日：2006-06-07
申请人： Shean-Jen Chen , Yen-Chieh Mao , Jeng-Nan Yih , Fan-Ching Chien , Chun-Yu Lin , Yi-Ming Chu , Lai-Sheng Chen , Wei-Han Wang , Chao-Chi Wu , Yen-Chun Lin
发明人： Shean-Jen Chen , Yen-Chieh Mao , Jeng-Nan Yih , Fan-Ching Chien , Chun-Yu Lin , Yi-Ming Chu , Lai-Sheng Chen , Wei-Han Wang , Chao-Chi Wu , Yen-Chun Lin
IPC分类号： G01N21/55
CPC分类号： G01N21/7703 , G01N21/7743
摘要： The present invention discloses a coupled waveguide-surface plasmon resonance biosensor, comprising: a grating layer formed of a transparent material, the grating layer comprising a first periodic grating structure; a waveguide layer formed on the first periodic grating structure, the refractive index of the waveguide layer being larger than the refractive index of the grating layer; a plasmon resonance layer formed on the waveguide layer, capable of being optically excited to cause a plasmon resonance wave; and a ligand layer formed on the plasmon resonance layer; capable of being bound to react with receptors of a sample to be tested.
摘要翻译：本发明公开了一种耦合的波导表面等离子体共振生物传感器，包括：由透明材料形成的光栅层，所述光栅层包括第一周期性光栅结构; 形成在所述第一周期性光栅结构上的波导层，所述波导层的折射率大于所述光栅层的折射率; 形成在波导层上的等离子体共振层，能够被光学激发以产生等离子体共振波; 和形成在等离子体共振层上的配体层; 能够与待测样品的受体反应。

2. 发明申请

US20060238767A1 Coupled waveguide-surface plasmon resonance biosensor 有权
标题翻译：耦合波导表面等离子体共振生物传感器
公开(公告)号：US20060238767A1
公开(公告)日：2006-10-26
申请号：US11448098
申请日：2006-06-07
申请人： Shean-Jen Chen , Yen-Chieh Mao , Jenq-Nan Yih , Fan-Ching Chien , Chun-Yu Lin , Yi-Ming Chu , Lai-Sheng Chen , Wei-Han Wang , Chao-Chi Wu , Yen-Chun Lin
发明人： Shean-Jen Chen , Yen-Chieh Mao , Jenq-Nan Yih , Fan-Ching Chien , Chun-Yu Lin , Yi-Ming Chu , Lai-Sheng Chen , Wei-Han Wang , Chao-Chi Wu , Yen-Chun Lin
IPC分类号： G01N21/55
CPC分类号： G01N21/7703 , G01N21/7743
摘要： The present invention discloses a coupled waveguide-surface plasmon resonance biosensor, comprising: a grating layer formed of a transparent material, the grating layer comprising a first periodic grating structure; a waveguide layer formed on the first periodic grating structure, the refractive index of the waveguide layer being larger than the refractive index of the grating layer; a plasmon resonance layer formed on the waveguide layer, capable of being optically excited to cause a plasmon resonance wave; and a ligand layer formed on the plasmon resonance layer; capable of being bound to react with receptors of a sample to be tested.
摘要翻译：本发明公开了一种耦合的波导表面等离子体共振生物传感器，包括：由透明材料形成的光栅层，所述光栅层包括第一周期性光栅结构; 形成在所述第一周期性光栅结构上的波导层，所述波导层的折射率大于所述光栅层的折射率; 形成在波导层上的等离子体共振层，能够被光学激发以产生等离子体共振波; 和形成在等离子体共振层上的配体层; 能够与待测样品的受体反应。

3. 发明申请

US20060197952A1 Surface plasmon resonance sensor with high sensitivity 审中-公开
标题翻译：表面等离子体共振传感器具有高灵敏度
公开(公告)号：US20060197952A1
公开(公告)日：2006-09-07
申请号：US10660833
申请日：2003-09-12
申请人： Shean-Jen Chen , Chun-Yu Lin , Fan-Ching Chien , K.T. Huang , W.P. Hu , Wen-Yih Chen , Kuan-Ching Lee , Wen-Hsien Li
发明人： Shean-Jen Chen , Chun-Yu Lin , Fan-Ching Chien , K.T. Huang , W.P. Hu , Wen-Yih Chen , Kuan-Ching Lee , Wen-Hsien Li
IPC分类号： G01N21/55
CPC分类号： G01N21/658 , G01N21/554
摘要： A high-sensitivity SPR (surface plasmon resonance) sensor includes at least a prism having a first surface on which a metallic layer and a metallic nanoparticle layer are sequentially formed. A light source projects an incident light into the prism through a second surface of the prism. The light is reflected by the metallic layer and the metallic nanoparticle layer and leaves the prism through a third surface of the prism. A light detector detects the reflected light. The SPR sensor has an extensive detection range as compared with the conventional ones and is applicable in the detection of gas, chemical substance, and biomolecule. Moreover, the SPR sensor is advantageous in arranging fabrication process consistently, controlling film thickness, improving product quality, and decreasing fabrication cost.
摘要翻译：高灵敏度SPR（表面等离子体共振）传感器至少包括具有顺序地形成有金属层和金属纳米粒子层的第一表面的棱镜。光源通过棱镜的第二表面将入射光投影到棱镜中。光被金属层和金属纳米颗粒层反射，并通过棱镜的第三表面离开棱镜。光检测器检测反射光。 SPR传感器与传统传感器相比具有广泛的检测范围，适用于气体，化学物质和生物分子的检测。此外，SPR传感器有利于一致地布置制造工艺，控制膜厚度，提高产品质量和降低制造成本。

4. 发明授权

US07339681B2 Surface plasmon resonance microscope using common-path phase-shift interferometry 有权
标题翻译：表面等离子体共振显微镜使用共轨相移干涉测量
公开(公告)号：US07339681B2
公开(公告)日：2008-03-04
申请号：US11288274
申请日：2005-11-29
申请人： Yuan Deng Su , Shean Jen Chen
发明人： Yuan Deng Su , Shean Jen Chen
IPC分类号： G01B11/02
CPC分类号： G01N21/553 , B82Y20/00 , G01N21/21 , G01N21/45 , G02B5/008 , G02B21/00
摘要： The present invention integrates the surface plasmon resonance and common-path phase-shift interferometry techniques to develop a microscope for measuring the two-dimensional spatial phase variation caused by biomolecular interactions on a sensing chip without the need for additional labeling. The common-path phase-shift interferometry technique has the advantage of long-term stability, even when subjected to external disturbances. Hence, the developed microscope meets the requirements of the real-time kinetic studies involved in biomolecular interaction analysis. The surface plasmon resonance microscope of the present invention using common-path phase-shift interferometry demonstrates a detection limit of 2×10−7 refractive index change, a long-term phase stability of 2.5×10−4π rms over four hours, and a spatial phase resolution of 10−3 π with a lateral resolution of 100 μm.
摘要翻译：本发明集成了表面等离子体共振和共轨相移干涉测量技术，以开发用于测量由感测芯片上的生物分子相互作用引起的二维空间相位变化的显微镜，而不需要额外的标记。共轨相移干涉测量技术具有长期稳定的优点，即使在受到外部干扰的情况下也是如此。因此，研制的显微镜符合生物分子相互作用分析涉及的实时动力学研究的要求。使用共路相位干涉测量法的本发明的表面等离子体共振显微镜显示了2×10 -7折射率变化的检测极限，2.5×10 -4的长期相位稳定性 4小时以上，并且横向分辨率为100um的空间相位分辨率为10 -3像素。

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