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1. 发明申请

US20060078475A1 Modular microfluidic packaging system 审中-公开
标题翻译：模块化微流体包装系统
公开(公告)号：US20060078475A1
公开(公告)日：2006-04-13
申请号：US11192434
申请日：2005-07-29
申请人： Yu-Chong Tai , Scott Miserendino , Qing He , Siyang Zheng
发明人： Yu-Chong Tai , Scott Miserendino , Qing He , Siyang Zheng
IPC分类号： G01N27/447 , B01L11/00
CPC分类号： B01L9/527 , B01J2219/00286 , B01J2219/00605 , B01L3/502707 , B01L3/502715 , B01L2200/027 , B01L2200/028 , B01L2200/04 , B01L2300/0816 , G01N35/1095
摘要： A packaging system for microfluidics including a microfluidic modular packaging system comprising: a packaging jig comprising a body, at least two module ports for placing microfluidic modules, at least one external fluidic port, and at least one internal fluidic port; at least two die platforms adapted to fit into the module ports and move the microfluidic modules; at least one fluidic control die; at least one circuit board, and at least one cover. HPLC applications are particularly important for proteomics research and commercialization.
摘要翻译：一种用于微流体的包装系统，包括微流体模块化包装系统，包括：包装夹具，包括主体，用于放置微流体模块的至少两个模块端口，至少一个外部流体端口和至少一个内部流体端口; 至少两个模具平台，其适于装配到所述模块端口中并移动所述微流体模块; 至少一个流体控制管芯; 至少一个电路板和至少一个盖。 HPLC应用对蛋白质组学研究和商业化尤其重要。

2. 发明授权

US07846743B2 Uses of parylene membrane filters 有权
标题翻译：聚对二甲苯膜过滤器的使用
公开(公告)号：US07846743B2
公开(公告)日：2010-12-07
申请号：US11408499
申请日：2006-04-20
申请人： Yu-Chong Tai , Siyang Zheng , Henry Lin , Ram Datar , Richard Cote
发明人： Yu-Chong Tai , Siyang Zheng , Henry Lin , Ram Datar , Richard Cote
IPC分类号： G01N1/18
CPC分类号： B01D71/72 , B01D61/14 , B01D61/18 , B01D61/20 , B01D67/0034 , B01D67/0088 , B01D69/02 , B01D71/022 , B01D2325/021 , B01D2325/08 , B01L3/5635 , B01L2300/0681 , B01L2400/0415 , B01L2400/0487 , Y10T436/25375
摘要： The invention provides parylene membrane filters, filter devices and methods of making them and using them in the mechanical separation of cells and particles by size. The provision of parylene membrane filters with high figures of merit and finely controlled hole sizes allows the separation of cells and particles in a variety of biological and other fluids according to sizes.
摘要翻译：本发明提供聚对二甲苯膜过滤器，过滤装置和制造它们的方法，并将其用于通过尺寸机械分离细胞和颗粒。提供具有高品质因数和精细控制的孔尺寸的聚对二甲苯膜过滤器允许根据尺寸分离各种生物和其它流体中的细胞和颗粒。

3. 发明申请

US20110111412A1 Uses of Parylene Membrane Filters 有权
标题翻译：聚对二甲苯膜过滤器的使用
公开(公告)号：US20110111412A1
公开(公告)日：2011-05-12
申请号：US12943891
申请日：2010-11-10
申请人： Yu-Chong Tai , Siyang Zheng , Henry Lin , Ram Datar , Richard Cote
发明人： Yu-Chong Tai , Siyang Zheng , Henry Lin , Ram Datar , Richard Cote
IPC分类号： C12Q1/68 , C12N5/09 , C12Q1/04 , G01N33/53
CPC分类号： B01D69/02 , B01D61/14 , B01D61/18 , B01D61/20 , B01D67/0034 , B01D67/0088 , B01D71/022 , B01D71/72 , B01D2325/021 , Y10T436/25375
摘要： The invention provides parylene membrane filters, filter devices and methods of making them and using them in the mechanical separation of cells and particles by size. The provision of parylene membrane filters with high figures of merit and finely controlled hole sizes allows the separation of cells and particles in a variety of biological and other fluids according to sizes.
摘要翻译：本发明提供聚对二甲苯膜过滤器，过滤装置和制造它们的方法，并将其用于通过尺寸机械分离细胞和颗粒。提供具有高品质因数和精细控制的孔尺寸的聚对二甲苯膜过滤器允许根据尺寸分离各种生物和其它流体中的细胞和颗粒。

4. 发明申请

US20060057597A1 Method and system for processing nanoparticles using a self assembly mechanism to form combined species 审中-公开
标题翻译：使用自组装机构处理纳米颗粒以形成组合物种的方法和系统
公开(公告)号：US20060057597A1
公开(公告)日：2006-03-16
申请号：US10985841
申请日：2004-11-09
申请人： Yu-Chong Tai , Chi-Yuan Shih , Siyang Zheng
发明人： Yu-Chong Tai , Chi-Yuan Shih , Siyang Zheng
IPC分类号： C40B40/08 , C40B40/10
CPC分类号： B01L3/502707 , B01L3/00 , B01L3/502753 , B01L3/502776 , B01L2300/0663
摘要： A method for processing nanoparticles using a self assembly mechanism. The method includes flowing a first reactant species through a first channel region, which has a predetermined dimension including a first width and a first depth. The method includes flowing a second reactant species through a second channel region, which also has a predetermined dimension including a second width and a second depth. The method includes outputting the first reactant species through a first orifice exiting the first channel region and outputting the second reactant species through a second orifice exiting the second channel region. Additionally, the method forms an interface region along a first predetermined length in a third channel, which couples the first orifice to the second orifice at the interface region. The method contacts one or more of the first reactant species with one or more of the second reactant species at the interface region to form a combined species of the one or more first reactant species and the one or more second reactant species. The method also transfers the combined species of the one or more first reactant and the one or more second reactant species from the first predetermined length to a second predetermined length of the third channel region.
摘要翻译：使用自组装机构处理纳米颗粒的方法。该方法包括使第一反应物种流过第一通道区，第一通道区具有包括第一宽度和第一深度的预定尺寸。该方法包括使第二反应物种流过第二通道区，第二通道区也具有包括第二宽度和第二深度的预定尺寸。该方法包括通过离开第一通道区域的第一孔输出第一反应物种，并通过离开第二通道区的第二孔输出第二反应物种。此外，该方法在第三通道中形成沿着第一预定长度的界面区域，其在接口区域处将第一孔口耦合到第二孔口。该方法在界面区域将一种或多种第一反应物种与一种或多种第二反应物种接触，以形成一种或多种第一反应物种和一种或多种第二种反应物种的组合物种。该方法还将一种或多种第一反应物和一种或多种第二反应物种类的组合物质从第一预定长度转移到第三通道区域的第二预定长度。

5. 发明授权

US07846393B2 Membrane filter for capturing circulating tumor cells 有权
标题翻译：用于捕获循环肿瘤细胞的膜过滤器
公开(公告)号：US07846393B2
公开(公告)日：2010-12-07
申请号：US11408501
申请日：2006-04-20
申请人： Yu-Chong Tai , Siyang Zheng , Henry Lin , Ram Datar , Richard Cote
发明人： Yu-Chong Tai , Siyang Zheng , Henry Lin , Ram Datar , Richard Cote
IPC分类号： B01L99/00
CPC分类号： B01D69/02 , B01D61/14 , B01D61/18 , B01D61/20 , B01D67/0034 , B01D67/0088 , B01D71/022 , B01D71/72 , B01D2325/021 , Y10T436/25375
摘要： The present invention provides a parylene-based membrane filter device for capturing of circulating tumor cells (CTC). The membrane filter has an array of holes having a predetermined geometric design with precisely controlled size, shape and density. In one aspect, the device has a stack of substantially parallel membrane filters with uniformly-spaced and/or monodispersed holes.
摘要翻译：本发明提供了一种用于捕获循环肿瘤细胞（CTC）的聚对二甲苯基膜过滤装置。膜过滤器具有具有预定几何设计并具有精确控制的尺寸，形状和密度的孔阵列。在一个方面，该装置具有基本上平行的具有均匀间隔和/或单分散孔的膜过滤器的堆叠。

6. 发明授权

US08815092B2 Method and apparatus for microfiltration to perform cell separation 有权
标题翻译：微滤法进行细胞分离的方法和装置
公开(公告)号：US08815092B2
公开(公告)日：2014-08-26
申请号：US13340516
申请日：2011-12-29
申请人： Siyang Zheng , Richard Cote , Henry Lin , Bo Lu , Yu-Chong Tai
发明人： Siyang Zheng , Richard Cote , Henry Lin , Bo Lu , Yu-Chong Tai
IPC分类号： B01D63/00 , B01D61/00
CPC分类号： B01D69/12 , B01D61/18 , B01D63/082 , B01D67/0034 , B01D71/28 , B01D2325/021
摘要： A microfiltration apparatus and method for separating cells, such as circulating tumor cells, from a sample using a microfiltration device having a top porous membrane and a bottom porous membrane. The porous membranes are formed from parylene and assembled using microfabrication techniques. The porous membranes are arranged so that the pores in the top membrane are offset from the pores in the bottom membrane.
摘要翻译：一种使用具有顶部多孔膜和底部多孔膜的微量过滤装置从样品中分离诸如循环肿瘤细胞的细胞的微滤装置和方法。多孔膜由聚对二甲苯形成并使用微细加工技术组装。多孔膜被布置成使得顶部膜中的孔与底部膜中的孔偏离。

7. 发明申请

US20070247173A1 RESONANCE-INDUCED SENSITIVITY ENHANCEMENT METHOD FOR CONDUCTIVITY SENSORS 失效
标题翻译：用于电导率传感器的谐振感应灵敏度增强方法
公开(公告)号：US20070247173A1
公开(公告)日：2007-10-25
申请号：US11697060
申请日：2007-04-05
申请人： Yu-Chong Tai , Chi-yuan Shih , Wei Li , Siyang Zheng
发明人： Yu-Chong Tai , Chi-yuan Shih , Wei Li , Siyang Zheng
IPC分类号： G01R27/08
CPC分类号： G01N27/023 , G01N15/1056 , G01N15/12 , G01N27/4473 , G01N2030/645 , G01R27/22
摘要： Methods and systems for improving the sensitivity of a variety of conductivity sensing devices, in particular capacitively-coupled contactless conductivity detectors. A parallel inductor is added to the conductivity sensor. The sensor with the parallel inductor is operated at a resonant frequency of the equivalent circuit model. At the resonant frequency, parasitic capacitances that are either in series or in parallel with the conductance (and possibly a series resistance) is substantially removed from the equivalent circuit, leaving a purely resistive impedance. An appreciably higher sensor sensitivity results. Experimental verification shows that sensitivity improvements of the order of 10,000-fold are possible. Examples of detecting particulates with high precision by application of the apparatus and methods of operation are described.
摘要翻译：用于提高各种电导率传感装置的灵敏度的方法和系统，特别是电容耦合的非接触电导检测器。并联电感器被添加到电导率传感器。具有并联电感器的传感器以等效电路模型的谐振频率工作。在谐振频率下，与电导串联或并联的寄生电容（和可能的串联电阻）基本上从等效电路中去除，留下纯电阻阻抗。传感器敏感度会更高。实验验证表明灵敏度提高可达10,000倍。描述了通过应用该装置和操作方法检测高精度的微粒的实例。

8. 发明申请

US20070025883A1 Uses of parylene membrane filters 有权
标题翻译：聚对二甲苯膜过滤器的使用
公开(公告)号：US20070025883A1
公开(公告)日：2007-02-01
申请号：US11408499
申请日：2006-04-20
申请人： Yu-Chong Tai , Siyang Zheng , Henry Lin , Ram Datar , Richard Cote
发明人： Yu-Chong Tai , Siyang Zheng , Henry Lin , Ram Datar , Richard Cote
IPC分类号： B01L11/00
CPC分类号： B01D71/72 , B01D61/14 , B01D61/18 , B01D61/20 , B01D67/0034 , B01D67/0088 , B01D69/02 , B01D71/022 , B01D2325/021 , B01D2325/08 , B01L3/5635 , B01L2300/0681 , B01L2400/0415 , B01L2400/0487 , Y10T436/25375
摘要： The invention provides parylene membrane filters, filter devices and methods of making them and using them in the mechanical separation of cells and particles by size. The provision of parylene membrane filters with high figures of merit and finely controlled hole sizes allows the separation of cells and particles in a variety of biological and other fluids according to sizes.
摘要翻译：本发明提供聚对二甲苯膜过滤器，过滤装置和制造它们的方法，并将其用于通过尺寸机械分离细胞和颗粒。提供具有高品质因数和精细控制的孔尺寸的聚对二甲苯膜过滤器允许根据尺寸分离各种生物和其它流体中的细胞和颗粒。

9. 发明授权

US08354075B1 Streamline-based microfluidic device 有权
标题翻译：流线型微流控器件
公开(公告)号：US08354075B1
公开(公告)日：2013-01-15
申请号：US11408514
申请日：2006-04-20
申请人： Yu-Chong Tai , Siyang Zheng , Harvey Kasdan
发明人： Yu-Chong Tai , Siyang Zheng , Harvey Kasdan
IPC分类号： B01L3/00 , G01N1/00
CPC分类号： B01L3/502761 , B01L3/502746 , B01L2200/0636 , B01L2200/0652 , B01L2400/0487 , B01L2400/0688 , Y10T436/2575
摘要： The present invention provides a streamline-based device and a method for using the device for continuous separation of particles including cells in biological fluids. The device includes a main microchannel and an array of side microchannels disposed on a substrate. The main microchannel has a plurality of stagnation points with a predetermined geometric design, for example, each of the stagnation points has a predetermined distance from the upstream edge of each of the side microchannels. The particles are separated and collected in the side microchannels.
摘要翻译：本发明提供了一种基于流线的装置和使用该装置用于连续分离包括生物流体中的细胞的颗粒的方法。该器件包括主微通道和设置在衬底上的侧面微通道阵列。主微通道具有多个具有预定几何设计的停滞点，例如，每个停滞点距离每个侧面微通道的上游边缘具有预定距离。将颗粒分离并收集在侧面微通道中。

10. 发明授权

US08288170B2 Uses of parylene membrane filters 有权
标题翻译：聚对二甲苯膜过滤器的使用
公开(公告)号：US08288170B2
公开(公告)日：2012-10-16
申请号：US12943891
申请日：2010-11-10
申请人： Yu-Chong Tai , Siyang Zheng , Henry Lin , Ram Datar , Richard Cote
发明人： Yu-Chong Tai , Siyang Zheng , Henry Lin , Ram Datar , Richard Cote
IPC分类号： G01N1/18
CPC分类号： B01D69/02 , B01D61/14 , B01D61/18 , B01D61/20 , B01D67/0034 , B01D67/0088 , B01D71/022 , B01D71/72 , B01D2325/021 , Y10T436/25375
摘要： The invention provides parylene membrane filters, filter devices and methods of making them and using them in the mechanical separation of cells and particles by size. The provision of parylene membrane filters with high figures of merit and finely controlled hole sizes allows the separation of cells and particles in a variety of biological and other fluids according to sizes.
摘要翻译：本发明提供聚对二甲苯膜过滤器，过滤装置和制造它们的方法，并将其用于通过尺寸机械分离细胞和颗粒。提供具有高品质因数和精细控制的孔尺寸的聚对二甲苯膜过滤器允许根据尺寸分离各种生物和其它流体中的细胞和颗粒。

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