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1. 发明申请

US20110083509A1 Photoacoustic Spectroscopy With Focused Light 审中-公开
标题翻译：光聚焦光学光谱
公开(公告)号：US20110083509A1
公开(公告)日：2011-04-14
申请号：US12576377
申请日：2009-10-09
申请人： Youzhi Li , Edward McKenna , Andy S. Lin
发明人： Youzhi Li , Edward McKenna , Andy S. Lin
IPC分类号： G01N29/00 , G01N21/00
CPC分类号： A61B5/0059 , A61B5/0095 , A61B8/00
摘要： Photoacoustic measurements utilize emitted light to generate an acoustic response in tissue, with the acoustic response being proportional to the presence of an absorber of the light in the tissue. The present disclosure relates the use of focused light to acquire photoacoustic measurements. In one embodiment, the light is modulated, such as spatially modulated, such that the light may be focused within an otherwise scattering medium, such as tissue.
摘要翻译：光声测量利用发射光在组织中产生声响应，声响应与组织中光吸收体的存在成比例。本公开涉及聚焦光的使用以获得光声测量。在一个实施例中，光被调制，例如空间调制，使得光可以聚焦在否则散射介质（例如组织）内。

2. 发明授权

US09282924B2 Medical sensor with temperature control 有权
标题翻译：医疗传感器带温度控制
公开(公告)号：US09282924B2
公开(公告)日：2016-03-15
申请号：US13077164
申请日：2011-03-31
申请人： Andy S. Lin , Youzhi Li , Bo Chen , Daniel Lisogurski , Friso Schlottau
发明人： Andy S. Lin , Youzhi Li , Bo Chen , Daniel Lisogurski , Friso Schlottau
IPC分类号： A61B5/1455 , A61B5/00
CPC分类号： A61B5/14551 , A61B5/6826 , A61B2560/0252 , A61B2560/0266
摘要： Embodiments of the present disclosure relate to techniques for controlling the temperature of light sources within physiological sensors in order to regulate the wavelengths emitted by the light sources. The sensors may include a temperature control element that is designed to provide heating and/or cooling to the light sources. The sensors also may include a temperature sensor designed to detect the temperature of the light sources. Based on the detected temperature, a controller can vary the amount of heating and/or cooling provided by the temperature control element to maintain the temperature of the light sources at a desired temperature or within a desired temperature range.
摘要翻译：本公开的实施例涉及用于控制生理传感器内的光源的温度以便调节由光源发射的波长的技术。传感器可以包括被设计成向光源提供加热和/或冷却的温度控制元件。传感器还可以包括设计用于检测光源的温度的温度传感器。基于检测到的温度，控制器可以改变由温度控制元件提供的加热和/或冷却量，以将光源的温度保持在期望的温度或期望的温度范围内。

3. 发明授权

US08788001B2 Time-division multiplexing in a multi-wavelength photon density wave system 有权
标题翻译：多波长光子密度波系统中的时分复用
公开(公告)号：US08788001B2
公开(公告)日：2014-07-22
申请号：US12563852
申请日：2009-09-21
申请人： Youzhi Li , Andy S. Lin , Edward M. McKenna
发明人： Youzhi Li , Andy S. Lin , Edward M. McKenna
IPC分类号： A61B5/1455 , A61B6/00
CPC分类号： A61B5/14551 , A61B5/0059 , A61B2562/223
摘要： Multi-wavelength photon density wave medical systems, methods, and devices are provided. In one embodiment, a multi-wavelength system may include a sensor, a sensor cable, and a patient monitor. The sensor may have an emitter output and a detector input configured to pass a multi-wavelength photon density wave input signal into a patient and receive a resulting multi-wavelength photon density wave output signal. The sensor cable may couple to the sensor using two optical cables for transmitting and receiving the multi-wavelength photon density wave signals. The patient monitor may couple to the sensor cable and generate several time-division multiplexed single-wavelength input signals by modulating one or more light sources at a frequency sufficient to produce resolvable photon density waves. By combining the several time-division multiplexed single-wavelength input signals into one of the optical cables of the sensor cable, the patient monitor may generate the multi-wavelength photon density wave input signal.
摘要翻译：提供了多波长光子密度波医疗系统，方法和装置。在一个实施例中，多波长系统可以包括传感器，传感器电缆和患者监护仪。传感器可以具有发射器输出和检测器输入，其被配置为将多波长光子密度波输入信号传递到患者体内并且接收所得到的多波长光子密度波输出信号。传感器电缆可以使用两根光缆耦合到传感器，用于发射和接收多波长光子密度波信号。患者监护仪可以耦合到传感器电缆，并通过以足以产生可分辨的光子密度波的频率调制一个或多个光源来产生几个时分多路复用的单波长输入信号。通过将几个时分复用的单波长输入信号组合成传感器电缆的光缆之一，患者监视器可以产生多波长光子密度波输入信号。

4. 发明授权

US08494604B2 Wavelength-division multiplexing in a multi-wavelength photon density wave system 失效
标题翻译：多波长光子密度波系统中的波分复用
公开(公告)号：US08494604B2
公开(公告)日：2013-07-23
申请号：US12563848
申请日：2009-09-21
申请人： Youzhi Li , Andy S. Lin , Edward M. McKenna
发明人： Youzhi Li , Andy S. Lin , Edward M. McKenna
IPC分类号： A61B5/1455 , A61B6/00
CPC分类号： A61B5/14551 , A61B5/0059 , A61B2562/223
摘要： Multi-wavelength photon density wave medical systems, methods, and devices are provided. In one embodiment, a multi-wavelength photon density wave patient monitor includes multiple light sources, a driving circuit, a fiber coupler, a sensor cable connector, a wavelength demultiplexer, detectors, and data processing circuitry. The driving circuit may modulate the light sources to produce several single-wavelength input photon density wave signals, which the fiber coupler may join into a multi-wavelength input signal. The sensor cable connector may provide this multi-wavelength input signal to a sensor attached to the patient and receive a multi-wavelength output signal. The wavelength demultiplexer may separate the multi-wavelength output signal into single-wavelength output signals for detection by the detectors. Based on a comparison of one of the single-wavelength output signals to a corresponding one of the single-wavelength input signals, the data processing circuitry may determine a physiological parameter of the patient.
摘要翻译：提供了多波长光子密度波医疗系统，方法和装置。在一个实施例中，多波长光子密度波病人监视器包括多个光源，驱动电路，光纤耦合器，传感器电缆连接器，波长解复用器，检测器和数据处理电路。驱动电路可以调制光源以产生几个单波长输入光子密度波信号，光纤耦合器可以连接到多波长输入信号中。传感器电缆连接器可以将这种多波长输入信号提供给附接到患者的传感器并且接收多波长输出信号。波长解复用器可以将多波长输出信号分离成单波长输出信号，以便由检测器检测。基于单波长输出信号之一与单波长输入信号中的相应一个的比较，数据处理电路可以确定患者的生理参数。

5. 发明申请

US20120248985A1 MEDICAL SENSOR WITH TEMPERATURE CONTROL 有权
标题翻译：医疗传感器温度控制
公开(公告)号：US20120248985A1
公开(公告)日：2012-10-04
申请号：US13077164
申请日：2011-03-31
申请人： Andy S. Lin , Youzhi Li , Bo Chen , Daniel Lisogurski , Friso Schlottau
发明人： Andy S. Lin , Youzhi Li , Bo Chen , Daniel Lisogurski , Friso Schlottau
IPC分类号： H01J7/24
CPC分类号： A61B5/14551 , A61B5/6826 , A61B2560/0252 , A61B2560/0266
摘要： Embodiments of the present disclosure relate to techniques for controlling the temperature of light sources within physiological sensors in order to regulate the wavelengths emitted by the light sources. The sensors may include a temperature control element that is designed to provide heating and/or cooling to the light sources. The sensors also may include a temperature sensor designed to detect the temperature of the light sources. Based on the detected temperature, a controller can vary the amount of heating and/or cooling provided by the temperature control element to maintain the temperature of the light sources at a desired temperature or within a desired temperature range.
摘要翻译：本公开的实施例涉及用于控制生理传感器内的光源的温度以便调节由光源发射的波长的技术。传感器可以包括被设计成向光源提供加热和/或冷却的温度控制元件。传感器还可以包括设计用于检测光源的温度的温度传感器。基于检测到的温度，控制器可以改变由温度控制元件提供的加热和/或冷却量，以将光源的温度保持在期望的温度或期望的温度范围内。

6. 发明申请

US20110245636A1 Multi-Wavelength Photon Density Wave System Using An Optical Switch 有权
标题翻译：使用光开关的多波长光子密度波系统
公开(公告)号：US20110245636A1
公开(公告)日：2011-10-06
申请号：US12751264
申请日：2010-03-31
申请人： Youzhi Li , Andy S. Lin , Edward M. McKenna
发明人： Youzhi Li , Andy S. Lin , Edward M. McKenna
IPC分类号： A61B5/1455
CPC分类号： A61B5/14551 , A61B5/02416 , A61B5/1455 , A61B2562/0242 , A61B2562/223 , G01N21/3151 , G01N21/49
摘要： Multi-wavelength photon density wave (PDW) medical systems, methods, and devices are provided. In one embodiment, a multi-wavelength system may include a sensor, a sensor cable, and a patient monitor. The sensor may have an emitter and a detector configured to pass a multi-wavelength PDW input signal into a patient and receive a resulting multi-wavelength PDW output signal. The sensor cable may couple to the sensor and include two optical cables for transmitting and receiving the multi-wavelength PDW signals. The patient monitor may couple to the sensor cable and generate several single-wavelength PDW input signals by modulating a plurality of light sources. The monitor may include an optical switch configured to time-division multiplex the several single-wavelength PDW wave input signals by selecting one of the single-wavelength PDW signals at one time to produce a multi-wavelength PDW signal which is output from the monitor to the sensor via the sensor cable.
摘要翻译：提供了多波长光子密度波（PDW）医疗系统，方法和设备。在一个实施例中，多波长系统可以包括传感器，传感器电缆和患者监护仪。传感器可以具有发射器和检测器，其被配置为将多波长PDW输入信号传递到患者体内并且接收所得到的多波长PDW输出信号。传感器电缆可以耦合到传感器并且包括用于发射和接收多波长PDW信号的两条光缆。患者监视器可以耦合到传感器电缆并且通过调制多个光源来生成多个单波长PDW输入信号。监视器可以包括配置成通过一次选择一个单波长PDW信号来对多个单波长PDW波输入信号进行时分复用以产生从监视器输出的多波长PDW信号的光开关传感器通过传感器电缆。

7. 发明授权

US08886290B2 Method and system for determining placement of a tracheal tube in a subject 有权
标题翻译：用于确定受试者气管插管位置的方法和系统
公开(公告)号：US08886290B2
公开(公告)日：2014-11-11
申请号：US13608585
申请日：2012-09-10
申请人： Youzhi Li , Edward M. McKenna , Andy S. Lin , Sarah Hayman
发明人： Youzhi Li , Edward M. McKenna , Andy S. Lin , Sarah Hayman
IPC分类号： A61B5/00 , G01B11/02 , A61B5/107 , A61M25/01 , A61M16/04 , A61M25/00
CPC分类号： A61M16/0488 , A61B5/0084 , A61B5/0086 , A61B5/1076 , A61B2562/223 , A61M16/04 , A61M16/0434 , A61M16/0443 , A61M25/0043 , A61M25/01 , A61M2025/0166 , A61M2205/3306 , G01B11/026
摘要： According to various embodiments, a tracheal tube may employ optical sensing techniques for determining a distance between the inserted tube and an anatomical structure, such as a carina. The distance information may provide an indication as to whether or not the tracheal tube is properly placed within the trachea. The optical techniques may include backscattered intensity measurements.
摘要翻译：根据各种实施例，气管插管可以采用光学感测技术来确定插入的管和解剖结构之间的距离，例如小孔。距离信息可以提供关于气管管是否适当地放置在气管内的指示。光学技术可以包括后向散射强度测量。

8. 发明授权

US08712492B2 Photon density wave based determination of physiological blood parameters 失效
标题翻译：光子密度波测定生理血液参数
公开(公告)号：US08712492B2
公开(公告)日：2014-04-29
申请号：US13149606
申请日：2011-05-31
申请人： Daniel Lisogurski , Doug P. Miller , Friso Schlottau , Youzhi Li , Andy S. Lin , Edward M. McKenna
发明人： Daniel Lisogurski , Doug P. Miller , Friso Schlottau , Youzhi Li , Andy S. Lin , Edward M. McKenna
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B5/02028 , A61B5/024
摘要： A system for measuring a physiological parameter of blood in a patient is presented. The system includes a transmission module configured to emit a plurality of photon density waves into tissue of the patient from a plurality of modulated light sources. The system also includes a receiver module configured to detect characteristics of the plurality of photon density waves. The system also includes a processing module configured to identify characteristics of a pulsatile perturbation of the tissue based on the characteristics of the plurality of photon density waves, and identify a value of the physiological parameter based on at least the characteristics of the pulsatile perturbation of the tissue and the characteristics of the plurality of photon density waves.
摘要翻译：提出了一种用于测量患者血液生理参数的系统。该系统包括被配置为从多个调制光源向患者的组织发射多个光子密度波的传输模块。该系统还包括被配置为检测多个光子密度波的特性的接收器模块。该系统还包括处理模块，该处理模块被配置为基于多个光子密度波的特性来识别组织的脉动扰动的特性，并且至少基于脉冲扰动的特征来识别生理参数的值组织和多个光子密度波的特性。

9. 发明授权

US08391943B2 Multi-wavelength photon density wave system using an optical switch 有权
标题翻译：使用光开关的多波长光子密度波系统
公开(公告)号：US08391943B2
公开(公告)日：2013-03-05
申请号：US12751264
申请日：2010-03-31
申请人： Youzhi Li , Andy S. Lin , Edward M. McKenna
发明人： Youzhi Li , Andy S. Lin , Edward M. McKenna
IPC分类号： A61B5/00 , A61B6/00
CPC分类号： A61B5/14551 , A61B5/02416 , A61B5/1455 , A61B2562/0242 , A61B2562/223 , G01N21/3151 , G01N21/49
摘要： Multi-wavelength photon density wave (PDW) medical systems, methods, and devices are provided. In one embodiment, a multi-wavelength system may include a sensor, a sensor cable, and a patient monitor. The sensor may have an emitter and a detector configured to pass a multi-wavelength PDW input signal into a patient and receive a resulting multi-wavelength PDW output signal. The sensor cable may couple to the sensor and include two optical cables for transmitting and receiving the multi-wavelength PDW signals. The patient monitor may couple to the sensor cable and generate several single-wavelength PDW input signals by modulating a plurality of light sources. The monitor may include an optical switch configured to time-division multiplex the several single-wavelength PDW wave input signals by selecting one of the single-wavelength PDW signals at one time to produce a multi-wavelength PDW signal which is output from the monitor to the sensor via the sensor cable.
摘要翻译：提供了多波长光子密度波（PDW）医疗系统，方法和设备。在一个实施例中，多波长系统可以包括传感器，传感器电缆和患者监护仪。传感器可以具有发射器和检测器，其被配置为将多波长PDW输入信号传递到患者体内并且接收所得到的多波长PDW输出信号。传感器电缆可以耦合到传感器并且包括用于发射和接收多波长PDW信号的两条光缆。患者监视器可以耦合到传感器电缆并且通过调制多个光源来生成多个单波长PDW输入信号。监视器可以包括配置成通过一次选择一个单波长PDW信号来对多个单波长PDW波输入信号进行时分复用以产生从监视器输出的多波长PDW信号的光开关传感器通过传感器电缆。

10. 发明申请

US20120310058A1 PHOTON DENSITY WAVE BASED DETERMINATION OF PHYSIOLOGICAL BLOOD PARAMETERS 失效
标题翻译：基于光子密度波的生物学参数的确定
公开(公告)号：US20120310058A1
公开(公告)日：2012-12-06
申请号：US13149606
申请日：2011-05-31
申请人： Daniel Lisogurski , Doug P. Miller , Friso Schlottau , Youzhi Li , Andy S. Lin , Edward M. McKenna
发明人： Daniel Lisogurski , Doug P. Miller , Friso Schlottau , Youzhi Li , Andy S. Lin , Edward M. McKenna
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B5/02028 , A61B5/024
摘要： A system for measuring a physiological parameter of blood in a patient is presented. The system includes a transmission module configured to emit a plurality of photon density waves into tissue of the patient from a plurality of modulated light sources. The system also includes a receiver module configured to detect characteristics of the plurality of photon density waves. The system also includes a processing module configured to identify characteristics of a pulsatile perturbation of the tissue based on the characteristics of the plurality of photon density waves, and identify a value of the physiological parameter based on at least the characteristics of the pulsatile perturbation of the tissue and the characteristics of the plurality of photon density waves.
摘要翻译：提出了一种用于测量患者血液生理参数的系统。该系统包括被配置为从多个调制光源向患者的组织发射多个光子密度波的传输模块。该系统还包括被配置为检测多个光子密度波的特性的接收器模块。该系统还包括处理模块，该处理模块被配置为基于多个光子密度波的特性来识别组织的脉动扰动的特性，并且至少基于脉冲扰动的特征来识别生理参数的值组织和多个光子密度波的特性。

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