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1. 发明授权

US06702850B1 Multi-coated drug-eluting stent for antithrombosis and antirestenosis 失效
标题翻译：用于抗血栓形成和抗再狭窄的多层药物洗脱支架
公开(公告)号：US06702850B1
公开(公告)日：2004-03-09
申请号：US10262432
申请日：2002-09-30
申请人： Youngro Byun , Jung Han Yoon
发明人： Youngro Byun , Jung Han Yoon
IPC分类号： A61F206
CPC分类号： A61L31/10 , A61L31/16 , A61L33/0029 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2420/08
摘要： A stent having a multi-layered coating adhered to its surface which can prevent restenosis and thrombosis at the implant site. The stent coating is comprised of two layers. The first layer is a polymeric coating with one or more biologically active agent(s) dispersed therein. The second layer is comprised of a hydrophobic heparinized polymer that inhibits blood coagulation and provides a hydrophilic surface for reducing the friction between stent and lesion site. In preferred embodiments of the invention, the multi-layered stent is effective in deterring restenosis and thrombosis at the implant site. In these same preferred embodiments, the multi-layered stent is capable of reducing the burst release of the biologically active agents from the first layer and sustaining a release of an effective amount of these agents for a relatively extended period of time. Methods of applying the multi-layered coating to the stent surface are also part of this invention.
摘要翻译：具有粘附到其表面上的多层涂层的支架，其能够防止植入部位的再狭窄和血栓形成。支架涂层由两层组成。第一层是其中分散有一种或多种生物活性剂的聚合物涂层。第二层由抑制血液凝固的疏水性肝素化聚合物组成，并提供亲水性表面以减少支架和病变部位之间的摩擦。在本发明的优选实施方案中，多层支架有效地阻止了植入部位的再狭窄和血栓形成。在这些相同的优选实施方案中，多层支架能够减少生物活性剂从第一层的爆发释放并且在相对延长的时间段内维持有效量的这些试剂的释放。将多层涂层施加到支架表面的方法也是本发明的一部分。

2. 发明授权

US07638158B2 Drug release from antithrombogenic multi-layer coated stent 失效
标题翻译：抗凝血多层涂层支架药物释放
公开(公告)号：US07638158B2
公开(公告)日：2009-12-29
申请号：US10797629
申请日：2004-03-09
申请人： Youngro Byun , Jung Han Yoon
发明人： Youngro Byun , Jung Han Yoon
IPC分类号： A61L33/10 , A61L33/12 , A61L2/06
CPC分类号： A61L31/10 , A61L31/16 , A61L33/0029 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2420/08
摘要： A stent having a multi-layered coating adhered to its surface which can prevent restenosis and thrombosis at the implant site. The stent coating is comprised of two layers. The first layer is a polymeric coating with one or more biologically active agent(s) dispersed therein. The second layer is comprised of a hydrophobic heparinized polymer that inhibits blood coagulation and provides a hydrophilic surface for reducing the friction between stent and lesion site. In preferred embodiments of the invention, the multi-layered stent is effective in deterring restenosis and thrombosis at the implant site. In these same preferred embodiments, the multi-layered stent is capable of reducing the burst release of the biologically active agents from the first layer and sustaining a release of an effective amount of these agents for a relatively extended period of time. Methods of applying the multi-layered coating to the stent surface are also part of this invention.
摘要翻译：具有粘附到其表面上的多层涂层的支架，其能够防止植入部位的再狭窄和血栓形成。支架涂层由两层组成。第一层是其中分散有一种或多种生物活性剂的聚合物涂层。第二层由抑制血液凝固的疏水性肝素化聚合物组成，并提供亲水性表面以减少支架和病变部位之间的摩擦。在本发明的优选实施方案中，多层支架有效地阻止了植入部位的再狭窄和血栓形成。在这些相同的优选实施方案中，多层支架能够减少生物活性剂从第一层的爆发释放并且在相对延长的时间段内维持有效量的这些试剂的释放。将多层涂层施加到支架表面的方法也是本发明的一部分。

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