专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07638158B2 Drug release from antithrombogenic multi-layer coated stent 失效
标题翻译：抗凝血多层涂层支架药物释放
公开(公告)号：US07638158B2
公开(公告)日：2009-12-29
申请号：US10797629
申请日：2004-03-09
申请人： Youngro Byun , Jung Han Yoon
发明人： Youngro Byun , Jung Han Yoon
IPC分类号： A61L33/10 , A61L33/12 , A61L2/06
CPC分类号： A61L31/10 , A61L31/16 , A61L33/0029 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2420/08
摘要： A stent having a multi-layered coating adhered to its surface which can prevent restenosis and thrombosis at the implant site. The stent coating is comprised of two layers. The first layer is a polymeric coating with one or more biologically active agent(s) dispersed therein. The second layer is comprised of a hydrophobic heparinized polymer that inhibits blood coagulation and provides a hydrophilic surface for reducing the friction between stent and lesion site. In preferred embodiments of the invention, the multi-layered stent is effective in deterring restenosis and thrombosis at the implant site. In these same preferred embodiments, the multi-layered stent is capable of reducing the burst release of the biologically active agents from the first layer and sustaining a release of an effective amount of these agents for a relatively extended period of time. Methods of applying the multi-layered coating to the stent surface are also part of this invention.
摘要翻译：具有粘附到其表面上的多层涂层的支架，其能够防止植入部位的再狭窄和血栓形成。支架涂层由两层组成。第一层是其中分散有一种或多种生物活性剂的聚合物涂层。第二层由抑制血液凝固的疏水性肝素化聚合物组成，并提供亲水性表面以减少支架和病变部位之间的摩擦。在本发明的优选实施方案中，多层支架有效地阻止了植入部位的再狭窄和血栓形成。在这些相同的优选实施方案中，多层支架能够减少生物活性剂从第一层的爆发释放并且在相对延长的时间段内维持有效量的这些试剂的释放。将多层涂层施加到支架表面的方法也是本发明的一部分。

2. 发明授权

US06875227B2 Metal stent for insertion in coronary artery 有权
标题翻译：金属支架插入冠状动脉
公开(公告)号：US06875227B2
公开(公告)日：2005-04-05
申请号：US10276376
申请日：2001-05-21
申请人： Jung-Han Yoon
发明人： Jung-Han Yoon
IPC分类号： A61L27/00 , A61F2/00 , A61F2/06 , A61F2/84 , A61F2/90
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91533 , A61F2002/91558 , A61F2002/91575 , A61F2230/0013 , A61F2250/0068
摘要： The object of this invention is to provide a metal stent used for insertion into a coronary artery to treat a patient suffering from angina pectoris or myocardial infarction due to a coronary artery disease. This stent consists of a plurality of primary stent units (1), each having a zigzag shape rounded at its bent portions and being expandable in a circumferential direction. The primary stent units (1) are assembled into a single cylindrical structure of the stent such that each two primary stent units (1) are integrated into one secondary stent unit by a first strut (2′) or (2″) connecting each projected bent portion of each of the two primary stent units (1) to an associated bent portion of the other. Each two secondary stent units are integrated into a desired stent by a plurality of hook-shaped second struts (3) connecting the projected bent portions of the two secondary stent units to each other.
摘要翻译：本发明的目的是提供一种用于插入冠状动脉以治疗由于冠状动脉疾病引起的心绞痛或心肌梗塞的患者的金属支架。该支架由多个主支架单元（1）组成，每个主支架单元（1）在其弯曲部分具有圆形的Z字形，并且可在圆周方向上扩展。将主支架单元（1）组装成支架的单个圆柱形结构，使得每两个主支架单元（1）通过连接每个支架单元（1）的第一支柱（2'）或（2“）整合到一个辅助支架单元中两个主支架单元（1）中的每一个的突出弯曲部分彼此相关联的弯曲部分。通过将两个辅助支架单元的突出的弯曲部彼此连接的多个钩状的第二支柱（3）将每个二次支架单元集成到所需的支架中。

3. 发明授权

US06702850B1 Multi-coated drug-eluting stent for antithrombosis and antirestenosis 失效
标题翻译：用于抗血栓形成和抗再狭窄的多层药物洗脱支架
公开(公告)号：US06702850B1
公开(公告)日：2004-03-09
申请号：US10262432
申请日：2002-09-30
申请人： Youngro Byun , Jung Han Yoon
发明人： Youngro Byun , Jung Han Yoon
IPC分类号： A61F206
CPC分类号： A61L31/10 , A61L31/16 , A61L33/0029 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2420/08
摘要： A stent having a multi-layered coating adhered to its surface which can prevent restenosis and thrombosis at the implant site. The stent coating is comprised of two layers. The first layer is a polymeric coating with one or more biologically active agent(s) dispersed therein. The second layer is comprised of a hydrophobic heparinized polymer that inhibits blood coagulation and provides a hydrophilic surface for reducing the friction between stent and lesion site. In preferred embodiments of the invention, the multi-layered stent is effective in deterring restenosis and thrombosis at the implant site. In these same preferred embodiments, the multi-layered stent is capable of reducing the burst release of the biologically active agents from the first layer and sustaining a release of an effective amount of these agents for a relatively extended period of time. Methods of applying the multi-layered coating to the stent surface are also part of this invention.
摘要翻译：具有粘附到其表面上的多层涂层的支架，其能够防止植入部位的再狭窄和血栓形成。支架涂层由两层组成。第一层是其中分散有一种或多种生物活性剂的聚合物涂层。第二层由抑制血液凝固的疏水性肝素化聚合物组成，并提供亲水性表面以减少支架和病变部位之间的摩擦。在本发明的优选实施方案中，多层支架有效地阻止了植入部位的再狭窄和血栓形成。在这些相同的优选实施方案中，多层支架能够减少生物活性剂从第一层的爆发释放并且在相对延长的时间段内维持有效量的这些试剂的释放。将多层涂层施加到支架表面的方法也是本发明的一部分。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式