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1. 发明申请

US20090246186A1 AGENT FOR IMPROVING NERVOUS SYSTEM CELL FUNCTIONS 审中-公开
标题翻译：改善神经系统细胞功能的代理
公开(公告)号：US20090246186A1
公开(公告)日：2009-10-01
申请号：US12295258
申请日：2007-03-29
申请人： Yoshiyuki Shinagawa , Hideyuki Kishida , Taizo Kawabe , Hirokazu Sakamoto , Hiroshi Kubo , Kazunori Hosoe
发明人： Yoshiyuki Shinagawa , Hideyuki Kishida , Taizo Kawabe , Hirokazu Sakamoto , Hiroshi Kubo , Kazunori Hosoe
IPC分类号： A61K31/122 , A61P25/00
CPC分类号： A61K31/09 , A61K31/122
摘要： The present invention aims to activate neural cells in brain, and further provide a useful composition having an action to protect intracerebral neural cells from external and internal stresses.An agent for improving a neural cell function containing reduced coenzyme Q as an active ingredient, more specifically, an agent for activating neural cells and an agent for protecting neural cells, is useful, and can be used for the improvement or prophylaxis of central neurological diseases or neuropathy symptoms derived from or associated with a neurodegenerative disease, promotion of cognitive function or improvement of learning and memory disorders.
摘要翻译：本发明旨在激活脑中的神经细胞，并进一步提供一种有用的组合物，其具有保护脑内神经细胞免受外部和内部应激的作用。用于改善包含还原型辅酶Q作为活性成分的神经细胞功能的药剂，更具体地，用于激活神经细胞的药剂和用于保护神经细胞的药剂是有用的，并且可用于改善或预防中枢神经系统疾病或由神经退行性疾病引起或与之相关的神经病症状，促进认知功能或改善学习和记忆障碍。

2. 发明申请

US20080145411A1 COMPOSITION OF HIGH ABSORBABILITY FOR ORAL ADMINISTRATION COMPRISING OXIDIZED COENZYME Q10 审中-公开
标题翻译：含有氧化聚苯乙烯的口服药物Q10的高可吸收性组合物Q10
公开(公告)号：US20080145411A1
公开(公告)日：2008-06-19
申请号：US11867347
申请日：2007-10-04
申请人： Yoshiyuki Shinagawa , Taizo Kawabe , Hideyuki Kishida , Kazunori Hosoe
发明人： Yoshiyuki Shinagawa , Taizo Kawabe , Hideyuki Kishida , Kazunori Hosoe
IPC分类号： A61K9/00 , A61K38/43 , A61K9/48 , A61K31/122
CPC分类号： A61K31/122 , A23K20/10 , A23K20/111 , A23K20/158 , A23K50/40 , A23L29/06 , A23L29/10 , A23L33/10 , A23L33/17 , A61K9/4858
摘要： The present invention provides a method of increasing the absorbability of oxidized coenzyme Q10 by preparing the oxidized coenzyme Q10 as a composition in the presence of a lysolecithin and an oil and fat. The composition of the present invention comprising oxidized coenzyme Q10, a lysolecithin and an oil and fat, wherein the weight ratio of the lysolecithin to the oxidized coenzyme Q10 is not less than 0.7, shows superior absorption of oxidized coenzyme Q10 and can be utilized for food, food with nutrient function, food for specified health uses, nutritional supplement, nutritional product, animal drug, beverage, feed, pet food, cosmetics, pharmaceutical product, therapeutic drug, preventive drug and the like.
摘要翻译：本发明提供了通过在溶血卵磷脂和油脂中存在下制备氧化型辅酶Q 10作为组合物来提高氧化型辅酶Q 10的吸收性的方法。包含氧化型辅酶Q 10，溶血卵磷脂和油脂的本发明组合物，其中溶血卵磷脂与氧化型辅酶Q 10重量比不小于超过0.7，表现出优异的氧化型辅酶Q 10的吸收，可用于食品，具有营养功能的食物，特定健康用途的食物，营养补充剂，营养产品，动物药物，饮料，饲料，宠物食品，化妆品，医药产品，治疗药物，预防药物等。

3. 发明申请

US20070293572A1 Anti-Fatigue Composition 审中-公开
标题翻译：抗疲劳成分
公开(公告)号：US20070293572A1
公开(公告)日：2007-12-20
申请号：US11596059
申请日：2005-05-09
申请人： Hideyuki Kishida , Taizo Kawabe , Kazunori Hosoe , Kenji Fujii
发明人： Hideyuki Kishida , Taizo Kawabe , Kazunori Hosoe , Kenji Fujii
IPC分类号： A61K31/05 , A61K31/205 , A61P25/26
CPC分类号： A61K31/205 , A23L33/10 , A23V2002/00 , A61K31/09 , A61K31/122 , A61K45/06 , A61K2300/00 , A23V2200/31 , A23V2250/314 , A23V2250/0612
摘要： Fatigue is significantly involved in the lifestyle of people today. Although many anti-fatigue products are on market, those with definite and reliable effects are still few. Under such circumstances, the inventors of the present invention have conducted studies aiming at providing a composition which exhibits a distinctive anti-fatigue effect, and consequently accomplished the present invention. The present invention provides an anti-fatigue composition containing reduced coenzyme Q and a carnitine derivative. By administering the anti-fatigue composition of the present invention to a mammal, anti-fatigue effects can be synergistically seen even at doses which are not effective when the components are individually used. According to the present invention, an anti-fatigue composition having a reliable effect can be provided.
摘要翻译：疲劳显着地涉及到今天人们的生活方式。虽然许多抗疲劳产品在市场上，但具有确定和可靠影响的产品仍然很少。在这种情况下，本发明的发明人进行了旨在提供具有显着抗疲劳效果的组合物的研究，从而完成了本发明。本发明提供含有还原型辅酶Q和肉碱衍生物的抗疲劳组合物。通过将本发明的抗疲劳组合物施用于哺乳动物，即使在单独使用组分时没有效果的剂量，也可以协同地看到抗疲劳作用。根据本发明，可以提供具有可靠效果的抗疲劳组合物。

4. 发明申请

US20090226408A1 ANTI-FATIGUE COMPOSITION 审中-公开
标题翻译：抗疲劳组合物
公开(公告)号：US20090226408A1
公开(公告)日：2009-09-10
申请号：US11993743
申请日：2006-06-21
申请人： Hideyuki Kishida , Taizo Kawabe , Kazunori Hosoe
发明人： Hideyuki Kishida , Taizo Kawabe , Kazunori Hosoe
IPC分类号： A61K38/44 , A61K31/122 , A61K31/385 , A61K38/45 , A61P43/00
CPC分类号： A61K45/06 , A61K31/09 , A61K31/122 , A61K31/19 , A61K31/385 , A61K2300/00
摘要： A method of preventing or treating fatigue in a subject mammal comprises administering an effective amount of a composition comprising (a) reduced coenzyme Q represented by the following formula (1): wherein n is an integer of 1 to 12, and (b) lipoic acid or a derivative thereof, to the mammal.
摘要翻译：预防或治疗受试者哺乳动物疲劳的方法包括施用有效量的组合物，其包含（a）由下式（1）表示的还原型辅酶Q：其中n为1至12的整数，和（b）硫辛酸酸或其衍生物。

5. 发明授权

US07754205B2 Composition for transmucosal administration containing conenzyme Q as the active ingredient 有权
标题翻译：用于经粘膜给药的组合物，其含有辅酶Q作为活性成分
公开(公告)号：US07754205B2
公开(公告)日：2010-07-13
申请号：US10476208
申请日：2002-05-08
申请人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
发明人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
IPC分类号： A61K38/43
CPC分类号： A61K31/122 , A23L33/10 , A23V2002/00 , A61K9/0031 , A61K9/0048 , A61K9/02 , A61K31/047 , A61K31/09 , Y10S514/882 , A61K2300/00 , A23V2250/314
摘要： The present invention relates to the supply of coenzyme Q which is highly useful in maintaining human health, and provides a method and preparations whereby coenzyme Q can be efficiently supplied to patients having difficulties in oral administration, aged having swallowing difficulties and patients with diseases caused by topical disorders. It is found that the coenzyme Q concentration in the blood or topical mucosae can be elevated by using a composition for transmucosal administration containing oxidized coenzyme Q and/or reduced coenzyme Q as the active ingredient, wherein the total content of the oxidized coenzyme Q and the reduced coenzyme Q amounts to 0.0001 to 99% by weight of the whole composition.
摘要翻译：本发明涉及能够维持人体健康的辅酶Q的供给，提供可以将辅酶Q有效地供给口服给药困难的患者，患有吞咽困难的老年患者以及由局部疾病。通过使用含有氧化型辅酶Q和/或还原型辅酶Q作为活性成分的经粘膜给药用组合物，可以提高血液或局部粘膜中的辅酶Q浓度，其中氧化型辅酶Q和还原型辅酶Q占整个组合物的0.0001-99重量％。

6. 发明申请

US20060165672A1 Fatigue reducing agent 有权
公开(公告)号：US20060165672A1
公开(公告)日：2006-07-27
申请号：US10541020
申请日：2004-01-19
申请人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
发明人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
IPC分类号： A61K38/43 , A01N31/14
CPC分类号： A61K31/09 , A61K31/122
摘要： To maintain physical fitness and health of middle-aged and older persons living in the threshold of the aging society, the present invention provides a fatigue reducing agent which is highly effective for preventing and reducing fatigue, wherein the agent is made of a composition of substances that are very safe so that long-term administration is possible. A composition containing reduced coenzyme Q was found to be effective for preventing and reducing fatigue, including muscle fatigue. Since the fatigue reducing effect of the composition of the present invention is seen not only in young rats but also more pronounced in aged rats, the present invention can provide the fatigue reducing agent which is very useful, especially, for middle-aged and older persons as well as for young people.

7. 发明授权

US07015252B2 Compositions for lessening oxidative stress 有权
标题翻译：用于减轻氧化应激的组合物
公开(公告)号：US07015252B2
公开(公告)日：2006-03-21
申请号：US10492164
申请日：2002-10-15
申请人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
发明人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
IPC分类号： A61K31/12
CPC分类号： A61K31/085 , A61K31/122
摘要： The present invention provides an antioxidative composition with high safety, which is capable of lessening oxidative stress due to active oxygen species, free radicals, or the like in vivo, thereby preventing the occurrence or worsening of a disease. It was confirmed that by using a composition containing oxidized coenzyme Q and/or reduced coenzyme Q, the amount of urinary 8-hydroxydeoxyquanosine can be decreased in normal or diabetic animals. Also, in histopathological research of the spleens of diabetic rats, it was confirmed that spleen tissue denaturation caused by oxidative stress can be prevented. It was thus found that oxidative stress in vivo can be lessened. According to the present invention, oxidative stress in vivo can be lessened by using a composition containing coenzyme Q as an active ingredient.
摘要翻译：本发明提供了具有高安全性的抗氧化组合物，其能够在体内减少由活性氧，自由基等引起的氧化应激，从而防止疾病的发生或恶化。确认通过使用含有氧化型辅酶Q和/或还原型辅酶Q的组合物，在正常或糖尿病动物中尿8-羟基脱氧奎诺糖的量可以降低。此外，在糖尿病大鼠脾脏的组织病理学研究中，证实可以预防由氧化应激引起的脾脏组织变性。因此发现体内的氧化应激可以减轻。根据本发明，通过使用含有辅酶Q作为有效成分的组合物，可以减轻体内的氧化应激。

8. 发明申请

US20050070610A1 Dermal compositions containing coenzyme q as the active ingredient 审中-公开
标题翻译：含有辅酶q作为活性成分的皮肤组合物
公开(公告)号：US20050070610A1
公开(公告)日：2005-03-31
申请号：US10275882
申请日：2001-05-09
申请人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
发明人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
IPC分类号： A61K8/34 , A61K8/35 , A61K8/86 , A61K9/00 , A61K9/06 , A61K9/107 , A61K31/05 , A61K31/075 , A61K31/12 , A61K31/122 , A61K47/10 , A61L15/44 , A61P17/00 , A61P17/02 , A61P17/04 , A61P17/06 , A61P17/08 , A61P37/08 , A61Q19/00 , A61Q19/10
CPC分类号： A61Q19/00 , A61K8/347 , A61K8/355 , A61K8/86 , A61K9/0014 , A61K9/06 , A61K31/05 , A61K31/122 , A61K47/10 , A61K2800/70 , A61L15/44 , A61L2300/216 , A61Q19/10
摘要： The present invention provides a composition for dermal application which comprises, as an active ingredient, an oxidized coenzyme Q represented by the formula (1): in which n represents an integer of 1 to 12, and/or a reduced coenzyme Q represented by the formula (2): in which n represents an integer of 1 to 12, the total content of the oxidized coenzyme Q and reduced coenzyme Q being 0.01 to 99% by weight relative to the whole amount of the composition. The present invention also provides a therapeutic composition for skin diseases, a cosmetic composition, a skin health care composition and a bath salt composition, each comprising the above composition for dermal application. The present invention is further provides a method for the treatment of skin diseases which comprises applying, to a patient suffering from a skin disease, the above-mentioned therapeutic composition for skin diseases, or a method for the treatment of skin diseases which comprises applying, to a patient suffering from a skin disease, the above therapeutic agent for skin diseases other than the oxidized coenzyme Q represented by the formula (1) and other than the reduced coenzyme Q represented by the formula (2) in parallel with a therapeutic composition for skin diseases.
摘要翻译：本发明提供了一种用于真皮应用的组合物，其包含作为活性成分的由式（1）表示的氧化型辅酶Q：其中n表示1〜12的整数，和/或由下式表示的还原型辅酶Q 式（2）：其中n表示1〜12的整数，相对于组合物的总量，氧化型辅酶Q和还原型辅酶Q的总含量为0.01〜99重量％。本发明还提供了一种皮肤病的治疗组合物，化妆品组合物，皮肤保健组合物和浴盐组合物，每种组合物包含上述用于真皮应用的组合物。本发明还提供了一种治疗皮肤病的方法，其包括向患有皮肤病的患者应用上述皮肤病治疗组合物或皮肤病治疗方法，对于患有皮肤病的患者，除了由式（1）表示的氧化型辅酶Q以外，除了式（2）所示的还原型辅酶Q以外，还可以使用与上述治疗组合物平行的上述皮肤病治疗剂，皮肤病。

9. 发明申请

US20110070213A1 DERMAL COMPOSITIONS CONTAINING COENZYME Q AS THE ACTIVE INGREDIENT 审中-公开
标题翻译：含有COENZYME Q的组合物作为活性成分
公开(公告)号：US20110070213A1
公开(公告)日：2011-03-24
申请号：US12954356
申请日：2010-11-24
申请人： Kenji FUJII , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
发明人： Kenji FUJII , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
IPC分类号： A61K31/09 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/08
CPC分类号： A61Q19/00 , A61K8/347 , A61K8/355 , A61K8/86 , A61K9/0014 , A61K9/06 , A61K31/05 , A61K31/122 , A61K47/10 , A61K2800/70 , A61L15/44 , A61L2300/216 , A61Q19/10
摘要： The present invention provides a composition for dermal application which comprises, as an active ingredient, an oxidized coenzyme Q represented by the formula (1): in which n represents an integer of 1 to 12, and/or a reduced coenzyme Q represented by the formula (2): in which n represents an integer of 1 to 12, the total content of the oxidized coenzyme Q and reduced coenzyme Q being 0.01 to 99% by weight relative to the whole amount of the composition. The present invention also provides a therapeutic composition for skin diseases, a cosmetic composition, a skin health care composition and a bath salt composition, each comprising the above composition for dermal application.The present invention is further provides a method for the treatment of skin diseases which comprises applying, to a patient suffering from a skin disease, the above-mentioned therapeutic composition for skin diseases, or a method for the treatment of skin diseases which comprises applying, to a patient suffering from a skin disease, the above therapeutic agent for skin diseases other than the oxidized coenzyme Q represented by the formula (1) and other than the reduced coenzyme Q represented by the formula (2) in parallel with a therapeutic composition for skin diseases.
摘要翻译：本发明提供了一种用于真皮应用的组合物，其包含作为活性成分的由式（1）表示的氧化型辅酶Q：其中n表示1〜12的整数，和/或由下式表示的还原型辅酶Q 式（2）：其中n表示1〜12的整数，相对于组合物的总量，氧化型辅酶Q和还原型辅酶Q的总含量为0.01〜99重量％。本发明还提供了一种皮肤病的治疗组合物，化妆品组合物，皮肤保健组合物和浴盐组合物，每种组合物包含上述用于真皮应用的组合物。本发明还提供了一种治疗皮肤病的方法，其包括向患有皮肤病的患者应用上述皮肤病治疗组合物或皮肤病治疗方法，对于患有皮肤病的患者，除了由式（1）表示的氧化型辅酶Q以外，除了式（2）所示的还原型辅酶Q以外，还可以使用与上述治疗组合物平行的上述皮肤病治疗剂，皮肤病。

10. 发明申请

US20090087420A1 STABLE SOLUTION OF REDUCED COENZYME Q 审中-公开
标题翻译：降低COENZYME的稳定解决方案Q
公开(公告)号：US20090087420A1
公开(公告)日：2009-04-02
申请号：US12328293
申请日：2008-12-04
申请人： Kenji FUJII , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
发明人： Kenji FUJII , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
IPC分类号： A61K31/122 , A61K8/35 , A61P43/00 , A61Q90/00 , A23L3/34 , C05F11/00
CPC分类号： C07C50/28 , A23D9/007 , A23K20/10 , A23K20/111 , A23K20/158 , A61K8/14 , A61K8/347 , A61K8/355 , A61K9/127 , A61K2800/52 , A61Q5/00 , A61Q19/00 , C07C41/46 , C07C43/23
摘要： The present invention provides a composition of a practically usable solution capable of stably maintaining, against oxidation, reduced coenzyme Q, which has not been employed in practice so far because of being liable to undergo oxidation and hydrophobic, a method of preparing the solution and a method of storing the solution. A solution of reduced coenzyme Q which can be stored at a low temperature or room temperature over a long time can be prepared by coating reduced coenzyme Q with liposome made of refined soybean lecithin, etc, and solubilizing, or solubilizing or emulsifying reduced coenzyme Q by using a surfactant at a low temperature.
摘要翻译：本发明提供一种能够稳定地维持抗氧化还原型辅酶Q的组合物，该辅酶Q由于易于发生氧化和疏水而迄今尚未用于实践中，制备溶液的方法和存储解决方法。可以在低温或室温下长时间储存的还原型辅酶Q的溶液可以通过用由精制大豆卵磷脂等制成的脂质体涂布还原型辅酶Q，并通过将增溶或乳化还原型辅酶Q 在低温下使用表面活性剂。

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