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1. 发明授权

US06312950B1 Apparatus and method for isolating and recovering cells 有权
标题翻译：用于分离和回收细胞的装置和方法
公开(公告)号：US06312950B1
公开(公告)日：2001-11-06
申请号：US09395740
申请日：1999-09-14
申请人： Yoshitaka Ohmura , Miyuki Shimizu , Tadashi Sameshima
发明人： Yoshitaka Ohmura , Miyuki Shimizu , Tadashi Sameshima
IPC分类号： C12N500
CPC分类号： B01D69/12 , A61M1/0218 , A61M1/0236 , A61M1/3633 , A61M1/3643 , A61M1/3644 , A61M2202/0439 , A61M2205/7554 , B01D61/14 , B01D69/02 , A61M2202/005
摘要： There is proposed an apparatus for isolating and recovering an objective cell, which comprises, a filtering device having a filtering member which is capable of setting a porosity thereof to two or more different porosity, a first line for feeding a priming liquid to the filtering device, a second line for feeding a liquid to be treated containing the cell aimed to isolate to the filtering device, and a third line provided with a storage container for storing the priming liquid that has been passed through the filtering device, wherein the priming liquid stored in the storage container is employed for washing the filtering device. There is also proposed a method for isolating and recovering an objective cell using the aforementioned apparatus.
摘要翻译：提出了一种用于分离和回收目标单元的装置，其包括：过滤装置，其具有能够将其孔隙率设定为两个或多个不同孔隙率的过滤构件，用于将起动液体供给到过滤装置的第一管线用于供给待处理的液体的第二管线，其中所述待处理液体旨在与所述过滤装置隔离;以及第三管线，设置有用于储存已经通过所述过滤装置的引发液体的储存容器，其中所述引发液体存储在储存容器中用于洗涤过滤装置。还提出了使用上述装置分离和回收目标单元的方法。

2. 发明授权

US6139757A Method of separating cells from blood using a filter having a changeable porosity 失效
标题翻译：使用具有可变孔隙率的过滤器从血液中分离细胞的方法
公开(公告)号：US6139757A
公开(公告)日：2000-10-31
申请号：US999529
申请日：1997-03-28
申请人： Yoshitaka Ohmura , Noboru Taguchi , Tadashi Sameshima
发明人： Yoshitaka Ohmura , Noboru Taguchi , Tadashi Sameshima
IPC分类号： A61M1/00 , A61M1/34 , B01D29/01 , B01D61/18 , B01D63/08 , B01D69/02 , B01D69/12 , C12M3/06 , G01N1/10 , B01D25/26
CPC分类号： B01D69/12 , B01D61/18 , B01D69/02 , G01N33/491
摘要： A method of separating cells from blood by using a filter apparatus having first and second ports and a filter member therebetween having a changeable porosity. The filter member includes a stack of porous polymer sheets that preferably has a gradient of a physical or chemical characteristic in the direction of stacking. This can include a gradient in porosity, hydrophilicity or zeta potential. In a first step, blood is filtered through the apparatus when the filter member is set to a compressive state having a first porosity capable of capturing the objective cells. In a later step, the filter member is then set to a non-compressive state having a second porosity, higher than the first, for recovering the objective cells. The change in porosity results from the enlargement or reduction of the diameter of the pores of the filter member. The method can also include washing the filter member when the member is set to a porosity that is higher than the first porosity but lower than the second porosity.
摘要翻译：通过使用具有第一和第二端口的过滤装置和其间具有可变孔隙率的过滤器构件从血液中分离细胞的方法。过滤构件包括一堆多孔聚合物片，其优选地具有在堆叠方向上的物理或化学特性的梯度。这可以包括孔隙度，亲水性或ζ电位的梯度。在第一步骤中，当过滤构件被设置为具有能够捕获目标单元的第一孔隙的压缩状态时，通过设备过滤血液。在随后的步骤中，然后将过滤器构件设置为具有高于第一孔隙率的第二孔隙率的非压缩状态，用于回收目标单元。孔隙度的变化是由于过滤构件的孔的直径的扩大或减小。该方法还可以包括当将构件设定为高于第一孔隙度但低于第二孔隙率的孔隙率时，洗涤过滤构件。

3. 发明授权

US4725355A Body fluid purification medium and apparatus 失效
标题翻译：体液净化介质及仪器
公开(公告)号：US4725355A
公开(公告)日：1988-02-16
申请号：US762293
申请日：1985-08-05
申请人： Yuichi Yamamoto , Tadashi Sameshima
发明人： Yuichi Yamamoto , Tadashi Sameshima
IPC分类号： B01J20/24 , A61M1/36 , B01J20/22 , B01D27/02
CPC分类号： A61M1/3679
摘要： A body fluid purification medium comprises a support, and an adsorbent including at least one sulfa drug and fixed on a surface of said insoluble support for adsorbing and removing a pathogenic substance in a body fluid. The medium can be provided in a body fluid flow path provided in a container between body fluid inlet and outlet ports.
摘要翻译：体液净化介质包括载体和包含至少一种磺胺药物的吸附剂，并固定在所述不溶性载体的表面上，用于吸附和除去体液中的致病物质。介质可以设置在设置在体液入口和出口之间的容器中的体液流动路径中。

4. 发明授权

US4705628A Immunoglobulin adsorbent and adsorption apparatus 失效
标题翻译：免疫球蛋白吸附剂和吸附装置
公开(公告)号：US4705628A
公开(公告)日：1987-11-10
申请号：US849068
申请日：1986-04-07
申请人： Yuichi Yamamoto , Tadashi Sameshima
发明人： Yuichi Yamamoto , Tadashi Sameshima
IPC分类号： B01J20/26 , A61M1/36 , B01J20/10 , B01J20/281 , B01J20/32 , G01N33/543 , G01N33/552 , G01N33/564 , B01D15/00
CPC分类号： B01J20/3263 , A61M1/3679 , G01N33/54353 , G01N33/552 , G01N33/564 , A61M2202/0417
摘要： For the treatment of various diseases including autoimmune diseases such as myathenia gravis, articular rhematism, lupus erythematosus, etc., immunity-related diseases such as glumerulonephritis, bronchial asthma, polyneuritis, etc., organ transplantation such as transplanted kidney rejection, AOB incompatibility bone marrow transplantation, etc., tumor, hypertension, and hepatic insufficiency, immunoglobulin adsorbents comprising a hydroxyl-containing water-insoluble carrier to which a diamine compound having the general formula:NH.sub.2 (CH.sub.2).sub.n NH.sub.2wherein n is an integer having a value of 3 to 9 is attached through a silane coupling agent or a derivative thereof, to which diamine a heterocyclic compound is attached through a difunctional reagent, are useful as they can selectively and efficiently adsorb specific proteins such as immunoglobulins and immune complexes which are pathogenic substances in the diseases, exhibit minimized non-specific adsorption, and are safe and easy to sterilize.
摘要翻译：用于治疗诸如重症肌无力，关节性血症，红斑狼疮等自身免疫性疾病的各种疾病，免疫相关疾病如脑性脑炎，支气管哮喘，多发性神经炎等，器官移植如移植肾排斥反应，AOB不相容性骨骨髓移植等，肿瘤，高血压和肝功能不全，包含含羟基的水不溶性载体的免疫球蛋白吸附剂，其中具有通式：NH 2（CH 2）n NH 2的二胺化合物，其中n是具有值3的整数至9通过硅烷偶联剂或其衍生物通过双官能试剂连接到杂环化合物上的二胺是有用的，因为它们可以选择性地和有效地吸附特异性蛋白质，例如免疫球蛋白和作为病原体的免疫复合物疾病，展示最小化非特异性吸附，并且是安全和容易灭菌。

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