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1. 发明授权

US5932759A Process for producing substituted amines and a method for purifying synthetic intermediates therefor 失效
标题翻译：制备取代胺的方法及其合成中间体的纯化方法
公开(公告)号：US5932759A
公开(公告)日：1999-08-03
申请号：US800149
申请日：1997-02-13
申请人： Yoshio Motoyama , Naoshi Nagai , Takeshi Ishitoku , Noriaki Kihara
发明人： Yoshio Motoyama , Naoshi Nagai , Takeshi Ishitoku , Noriaki Kihara
IPC分类号： C07C239/20 , C07C261/00
CPC分类号： C07C239/20
摘要： The present invention relates to a process for producing a substituted amine represented by the general formula (IV):R.sup.2 NHOR.sup.3 (IV)(wherein R.sup.2 represents a hydrogen atom, a hydrocarbon group or a heteroatom-containing hydrocarbon group, and R.sup.3 represents a hydrocarbon group or a heteroatom-containing hydrocarbon group), which comprises the steps of:(b) reacting a hydroxamic acid represented by the general formula (II):R.sup.1 CONHOH (II)(wherein R.sup.1 represents a hydrogen atom or a hydrocarbon group) in the presence of a base with a reaction reagent capable of introducing a hydrocarbon or a heteroatom-containing hydrocarbon group to an oxygen atom and/or a nitrogen atom to form a substituted hydroxamic acid represented by the general formula (III): ##STR1## (wherein R.sup.1, R.sup.2 and R.sup.3 possess the same meanings as defined above),(c) hydrolyzing said substituted hydroxamic acid (III) in the presence of a base or an acid to produce a substituted amine represented by the general formula (IV):R.sup.2 NHOR.sup.3 (IV)(wherein R.sup.2 and R.sup.3 possess the same meanings as defined above). The present further relates to a method for purifying a synthetic intermediate for said substituted amine.
摘要翻译：本发明涉及由通式（IV）表示的取代胺的制备方法：R2NHOR3（IV）（其中R2表示氢原子，烃基或含杂原子的烃基，R3表示烃基或含杂原子的烃基），其包括以下步骤：（b）使通式（II）表示的异羟肟酸：R 1 CONHOH（II）（其中R 1表示氢原子或烃基）的具有能够将烃或含杂原子的烃基引入氧原子和/或氮原子的反应试剂形成由通式（III）表示的取代的异羟肟酸的反应试剂：其中R1，R2和 R3具有与上述相同的含义），（c）在碱或酸的存在下水解所述取代的异羟肟酸（III）以产生由通式（IV）表示的取代胺：R2NHOR3（IV）（其中 R 2和R3具有与上述相同的含义）。本发明还涉及纯化所述取代胺的合成中间体的方法。

2. 发明授权

US4973703A Process for purification of N-cyano-N'-methyl-N"-(2-((5-methyl-1Himidazol-4-yl)methylthio)ethyl)guan idine 失效
标题翻译：纯化N-氰基-N'-甲基-N“ - （2 - （（5-甲基-1H-咪唑-4-基）甲硫基）乙基）胍的方法
公开(公告)号：US4973703A
公开(公告)日：1990-11-27
申请号：US267379
申请日：1988-11-04
申请人： Junichi Imuta , Noriaki Kihara , Takeshi Ishitoku
发明人： Junichi Imuta , Noriaki Kihara , Takeshi Ishitoku
IPC分类号： C07D233/54 , C07D233/64
CPC分类号： C07D233/64
摘要： A process for the purification of N-cyano-N'-methyl-N"-[2-{(5-methyl-1H-imidazol-4-yl)methylthio}-ethyl]guanidine, which comprises bringing a crude product of N-cyano-N'-methyl-N"-[2-{(5-methyl-1H-imidazol-4-yl)-methylthio}ethyl]guanidine into contact with activated carbon in water in the presence of an organic acid.

3. 发明授权

US5072007A Process for preparing polyalkyl-2-alkoxy-7-hydroxychroman derivatives 失效
标题翻译：制备聚烷基-2-羟基-7-羟基喹啉衍生物的方法
公开(公告)号：US5072007A
公开(公告)日：1991-12-10
申请号：US547132
申请日：1990-07-03
申请人： Daisuke Fukuoka , Takeshi Ishitoku , Katsuya Takahashi , Takashi Tashiro , Junichi Imuta , Hiroaki Tan , Masaharu Ishiguro , Noriaki Kihara , Teruaki Mukaiyama
发明人： Daisuke Fukuoka , Takeshi Ishitoku , Katsuya Takahashi , Takashi Tashiro , Junichi Imuta , Hiroaki Tan , Masaharu Ishiguro , Noriaki Kihara , Teruaki Mukaiyama
IPC分类号： C07D311/20
CPC分类号： C07D311/20
摘要： Process for preparing polyalkyl-2-alkoxy-7-hydroxychroman derivative of the general formula (V): ##STR1## wherein R.sup.1 denotes lower primary alkyl, R.sup.2 denotes hydrogen or lower primary alkyl and R.sup.3 denotes loweralkyl, by reacting resorcin with either an aliphatic ketone of the general formula (I): ##STR2## wherein R.sup.1 and R.sup.2 are as defined above, and an alcohol of the formula (II):R.sup.3 OH (II)wherein R.sup.3 is as defined above, in the presence of an acid catalyst, or an aliphatic ketone acetal of the general formula (III): ##STR3## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined above, in the presence of an acid catalyst.

4. 发明授权

US5037977A Method for production of dimeric alkaloids 失效
标题翻译：二聚生物碱的生产方法
公开(公告)号：US5037977A
公开(公告)日：1991-08-06
申请号：US390903
申请日：1989-08-08
申请人： Hiroaki Tan , Naoya Sakamoto , Eiichiro Hata , Takeshi Ishitoku , Noriaki Kihara
发明人： Hiroaki Tan , Naoya Sakamoto , Eiichiro Hata , Takeshi Ishitoku , Noriaki Kihara
IPC分类号： C07D519/04
CPC分类号： C07D519/04
摘要： This invention concerns a method for the production of dimeric alkaloids, characterized by reacting of catharanthine with vindoline in the presence of Fe.sup.3+ and (1) removing or inactivating the Fe.sup.3+ and allowing the reaction product to react with a reducing agent or (2) allowing presence of oxygen and a dicarboxylic acid or a derivative thereof in the reaction system and allowing the reaction product to react with a hydride source.In accordance with this invention, such dimeric alkaloid as vinblastine, leurosidin, and 3',4'-anhydrovinblastine which are useful as antineoplastic drugs can be produced in high yields.

5. 发明授权

US4814500A Cyanoguanidine derivative and process for preparation thereof 失效
标题翻译：氰基胍衍生物及其制备方法
公开(公告)号：US4814500A
公开(公告)日：1989-03-21
申请号：US91850
申请日：1987-09-01
申请人： Noriaki Kihara , Teruaki Mukaiyama , Takeshi Ishitoku , Katsuya Takahashi
发明人： Noriaki Kihara , Teruaki Mukaiyama , Takeshi Ishitoku , Katsuya Takahashi
IPC分类号： C07C319/18 , C07C319/20 , C07C323/44 , C07C129/08
CPC分类号： C07C323/44
摘要： A novel cyanoguanidine derivative represented by the following general formula (I): ##STR1## wherein X stands for a hydrogen atom, a chlorine atom or a bromine atom, and R stands for a lower alkyl group, is an effective precursor for the synthesis of N-cyano-N'-methyl-N"-(2-(5-methyl-4-imidazolylmethylthio(ethyl)-guanidine (Cimetidine) which has an action of controlling secretion of gastric acid and is valuable as an agent for the remedy of a gastric ulcer.This cyanoguanidine derivative is prepared by reacting a methylvinylketone derivative with a mercaptoguanidine derivative or by reacting an amidinoketone derivative with a halogenating agent.

6. 发明申请

US20120155524A1 PULSE SIGNAL RECEIVING APPARATUS AND TRANSMISSION SYSTEM 有权
标题翻译：脉冲信号接收装置和传输系统
公开(公告)号：US20120155524A1
公开(公告)日：2012-06-21
申请号：US13313887
申请日：2011-12-07
申请人： Yoshio YOSHIDA , Noriaki Kihara
发明人： Yoshio YOSHIDA , Noriaki Kihara
IPC分类号： H03K7/08 , H04B17/00 , H03K9/08
CPC分类号： H04L25/4902 , H01L2924/0002 , H04L25/03834 , H01L2924/00
摘要： A pulse signal receiving apparatus may include a reception unit that receives a pulse signal modulated by a double-edge modulation scheme, a measurement unit that measures an edge interval of the pulse signal, which has been received by the reception unit, a detection unit that detects a deviation of the edge interval, which has been measured by the measurement unit, for a pulse-width reference value indicating a reference value of a width of the pulse signal, a correction unit that corrects the edge interval, which is to be measured next by the measurement unit, by using the deviation, which has been detected by the detection unit, and a decoding unit that decodes the pulse signal, of which the edge interval has been corrected by the correction unit, so as to output a digital signal.
摘要翻译：脉冲信号接收装置可以包括接收由双边缘调制方式调制的脉冲信号的接收单元，测量单元，其测量由接收单元接收的脉冲信号的边缘间隔;检测单元，检测由测量单元测量的边缘间隔的偏差，对于指示脉冲信号的宽度的参考值的脉冲宽度参考值，修正要测量的边缘间隔的校正单元接下来由测量单元通过使用由检测单元检测到的偏差和解码单元，其解码由校正单元校正了边缘间隔的脉冲信号，以便输出数字信号。

7. 发明申请

US20110062943A1 TIMING DETECTION DEVICE 有权
标题翻译：时序检测装置
公开(公告)号：US20110062943A1
公开(公告)日：2011-03-17
申请号：US12882727
申请日：2010-09-15
申请人： Noriaki Kihara , Shunsuke Hayashi , Kenji Habaguchi , Takayuki Ooshima
发明人： Noriaki Kihara , Shunsuke Hayashi , Kenji Habaguchi , Takayuki Ooshima
IPC分类号： G01R23/02
CPC分类号： H04L7/033 , H03K5/01 , H03K5/1252 , H04L7/0087 , H04L25/063
摘要： A timing detection device includes a draw back amount acquiring unit and a detecting unit. The draw back amount acquiring unit is configured to acquire a draw back amount of a received signal with respect to a peak value of the signal. The detecting unit is configured to detect the timing at which the draw back amount acquired by the draw back amount acquiring unit has exceeded a constant value as the timing at which a value of the signal is switched.
摘要翻译：定时检测装置包括抽取量获取单元和检测单元。拉出量获取单元被配置为相对于该信号的峰值获取接收信号的回退量。检测单元被配置为检测由缩回量获取单元获取的回退量已超过常数值的定时，作为切换信号值的定时。

8. 发明申请

US20070289690A1 Method for manufacturing a ceramic stack 审中-公开
标题翻译：制造陶瓷叠层的方法
公开(公告)号：US20070289690A1
公开(公告)日：2007-12-20
申请号：US11808977
申请日：2007-06-14
申请人： Eturo Yasuda , Noriaki Kihara , Hirokatsu Mukai , Daisuke Makino
发明人： Eturo Yasuda , Noriaki Kihara , Hirokatsu Mukai , Daisuke Makino
IPC分类号： C03B29/00
CPC分类号： B32B18/00 , C04B35/632 , C04B35/64 , C04B35/645 , C04B2235/9607 , C04B2235/9615 , C04B2237/343
摘要： A method for manufacturing a ceramic stack is provided, which can suppress distortion, separation, cracking and the like that may be caused in plural types of ceramic sheets after being stacked and baked for integration. The method includes a step of obtaining a relation between volume rates of organic materials contained in the ceramic sheets and baking shrinkages of the sheets, resulting from baking the sheets at a predetermined temperature, a step of selecting a volume rate of organic materials for each of the ceramic sheets based on the relation obtained at the previous step, so that all the sheets may have substantially the same baking shrinkage as desired, a step of forming the plural types of ceramic sheets based on the volume rate selected at the previous step, and a step of stacking and baking for integration the plural types of ceramic sheets to fabricate a ceramic stack.
摘要翻译：提供了一种制造陶瓷堆叠的方法，其可以抑制在堆叠和烘烤一体化之后可能在多种类型的陶瓷片中引起的变形，分离，开裂等。该方法包括获得陶瓷片中所含的有机材料的体积率与片材的烘烤收缩率之间的关系的步骤，其是在预定温度下对片材进行烘烤而得到的步骤，选择有机材料的体积比为基于上述步骤获得的关系，使得所有的片材可以具有基本上相同的烘烤收缩率，基于在前一步骤选择的体积率形成多种陶瓷片材的步骤，以及堆叠和烘烤用于整合多种类型的陶瓷片以制造陶瓷叠层的步骤。

9. 发明授权

US4886910A Cyanoguanidine derivative and process for preparation thereof 失效
公开(公告)号：US4886910A
公开(公告)日：1989-12-12
申请号：US156658
申请日：1988-02-17
申请人： Hiroaki Tan , Koji Kato , Junichi Imuta , Noriaki Kihara
发明人： Hiroaki Tan , Koji Kato , Junichi Imuta , Noriaki Kihara
IPC分类号： C07C319/20 , C07C67/00 , C07C313/00 , C07C323/44 , C07D233/54 , C07D233/64
CPC分类号： C07D233/64 , C07C323/44
摘要： The present invention provides a cyanoguanidine derivtive which is a precursor for the synthesis of N-cyano-N'-methyl-N"-[2-{(5-methyl-1H-imidazol-4-yl)methylothio}ethyl]-guanidine (Cimetidine) or its relted compound, which has an action of controlling secretion of acid in the stomach based on the histamine H.sub.2 receptor antagonism and is valuable as a drug for treating gastric ulcer. This cyanoguanidine derivative is prepared by reacting a haloketone derivative with an ammonium salt and a lower fatty acid salt or by reacting other cyanoguanidine derivative with an ammonium salt.

10. 发明授权

US07819996B2 Method of manufacturing ceramic sheet and method of manufacturing gas sensing element 有权
标题翻译：制造陶瓷片的方法和制造气体传感元件的方法
公开(公告)号：US07819996B2
公开(公告)日：2010-10-26
申请号：US11976735
申请日：2007-10-26
申请人： Eturo Yasuda , Noriaki Kihara , Daisuke Makino , Makoto Shirai , Hirokatsu Mukai , Takumi Ushikubo
发明人： Eturo Yasuda , Noriaki Kihara , Daisuke Makino , Makoto Shirai , Hirokatsu Mukai , Takumi Ushikubo
IPC分类号： C03B29/00 , A61F13/15 , B29C65/00 , C04B38/00
CPC分类号： C04B38/0074 , B32B18/00 , C04B35/111 , C04B35/46 , C04B35/486 , C04B35/6264 , C04B35/632 , C04B35/6342 , C04B2235/3217 , C04B2235/5445 , C04B2235/5472 , C04B2235/6025 , C04B2235/604 , C04B2235/77 , C04B2237/343 , C04B2237/348 , C04B2237/62 , C04B2237/86 , C04B35/00
摘要： Methods of manufacturing a ceramic sheet and a gas sensing element are disclosed. At least ceramic powder, a binder and a plasticizer are blended and mixed in slurry. The slurry is formed into unfired green sheets, on which paste is printed. Each of the unfired green sheets has porosity greater than 5%. In the manufacturing methods, the unfired green sheets are pressurized with a pressure of 10 MPa at a temperature above 60° C., after which the paste is printed on surfaces of the unfired green sheets. In the method of manufacturing the gas sensing element, a shielding layer, a porous diffusion resistance layer and the unfired green sheets for a sensing layer, a reference gas airspace forming layer and a heating layer are stacked to form a stacked ceramic body, whish is fired to obtain the gas sensing element.
摘要翻译：公开了制造陶瓷片和气体感测元件的方法。将至少陶瓷粉末，粘合剂和增塑剂混合并在浆料中混合。将浆料形成未印刷的生片，印刷糊状物。每个未生坯的生片具有大于5％的孔隙率。在制造方法中，将未烧成的生片在10℃以上的压力下在60℃以上的压力下进行加压，然后将糊状物印刷在未烧成的生片的表面上。在制造气体感测元件的方法中，层叠有屏蔽层，多孔扩散电阻层和用于感测层的未烧成的生片，参考气体空间形成层和加热层，以形成堆叠的陶瓷体，燃烧以获得气体感测元件。

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