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1. 发明授权

US5166318A Polypeptide having thrombin inhibiting activity 失效
标题翻译：具有硫蛋白抑制活性的多肽
公开(公告)号：US5166318A
公开(公告)日：1992-11-24
申请号：US531403
申请日：1990-06-04
申请人： Yoshio Furutani , Masaru Honjo , Akira Nakayama , Koichi Kawamura , Kazunori Ando , Michiko Hori , Keiko Fukazawa
发明人： Yoshio Furutani , Masaru Honjo , Akira Nakayama , Koichi Kawamura , Kazunori Ando , Michiko Hori , Keiko Fukazawa
IPC分类号： C12N15/09 , A61K38/00 , A61K38/55 , A61P7/02 , C07K1/20 , C07K14/00 , C07K14/435 , C07K14/81 , C07K14/815 , C12N1/21 , C12N9/54 , C12N15/15 , C12P21/02 , C12R1/125 , F02B1/04
CPC分类号： C12N9/54 , C07K14/815 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/036 , C07K2319/33 , F02B1/04
摘要： Modified HV1-type hirudinin which valine at the N-terminal end of the HV1-type hirudin and aspartic acid at the 5th residue of the N-terminal end were replaced with alanine and glutamic acid, respectively. A secretion plasmid into which a DNA sequence coding for a precursor with an addition of a secretion signal of neutral protease of Bacillus amyloliquefaciens at the N-terminal end of this modified HV1-type hirudin is integrated is introduced into bacteria of the genus Bacillus and the precursor is expressed intracellularly. The modified HV1-type hirudin can be efficiently secreted extracellularly while maintaining its high thrombin inhibiting activity.

2. 发明授权

US5084383A Bacillus subtilis strain whose extracellular protease activities are reduced, method for obtaining the strain and method for secreting proteins by using the strain 失效
标题翻译：减少细胞外蛋白酶活性的BACILLUS SUBTILIS菌株，获得菌株的方法和使用菌株分泌蛋白质的方法
公开(公告)号：US5084383A
公开(公告)日：1992-01-28
申请号：US553356
申请日：1990-07-18
申请人： Yoshio Furutani , Masaru Honjo , Akira Nakayama , Koichi Kawamura , Hiroaki Shimada , Izumi Mita , Akiko Akaoka
发明人： Yoshio Furutani , Masaru Honjo , Akira Nakayama , Koichi Kawamura , Hiroaki Shimada , Izumi Mita , Akiko Akaoka
IPC分类号： C12N1/20 , C07K14/32 , C07K14/61 , C12N1/21 , C12N9/54 , C12N15/09 , C12N15/67 , C12N15/75 , C12P21/00 , C12P21/02 , C12R1/07 , C12R1/125
CPC分类号： C12N15/75 , C07K14/32 , C07K14/61 , C12N15/67
摘要： Residual extracellular protease activities of a Bacillus subtilis strain can be further reduced by introducing a gene for the stimulation of extracellular protease levels into the genomic DNA of the strain.The resultant strain whose extracellular protease activities are further reduced is transformed with a recombinant plasmid for secretion of a desired protein and the desired protein can be efficiently produced and accumulated in the culture medium in a large amount. The accumulated desired protein can be easily recovered from the culture medium.For example, the accumulation level of human growth hormone secreted by a B. subtilis MT-430 strain carrying recombinant DNA phGH427 for the expression and secretion of human growth hormone can be increased five to tenfold as a result of the above treatment for reduction of the residual extracellular protease activities of the extracellular protease-activity-deficient strain.
摘要翻译：通过将用于刺激细胞外蛋白酶水平的基因引入菌株的基因组DNA，可以进一步降低枯草芽孢杆菌菌株的残留细胞外蛋白酶活性。细胞外蛋白酶活性进一步降低的所得菌株用用于分泌所需蛋白质的重组质粒转化，并且所需蛋白质可以有效地产生并大量积累在培养基中。可以容易地从培养基中回收积累的所需蛋白质。例如，由于上述用于还原的人类生长激素的表达和分泌，由携带重组DNA phGH427的枯草芽孢杆菌MT-430菌株分泌的人生长激素用于人生长激素的表达和分泌的累积水平可增加5至10倍细胞外蛋白酶活性缺陷型菌株的残留细胞外蛋白酶活性。

3. 发明授权

US5015574A DNA sequence involved in gene expression and protein secretion, expression-secretion vector including the DNA sequence and the method of producing proteins by using the expression-secretion vector 失效
标题翻译：涉及基因表达和蛋白质分泌的DNA序列，包括DNA序列的表达分泌载体和通过使用表达分泌载体产生蛋白质的方法
公开(公告)号：US5015574A
公开(公告)日：1991-05-14
申请号：US932587
申请日：1986-11-20
申请人： Yoshio Furutani , Akira Nakayama , Masaru Honjo , Hiroaki Shimada , Kouichi Kawamura , Izumi Mita , Akiko Akaoka
发明人： Yoshio Furutani , Akira Nakayama , Masaru Honjo , Hiroaki Shimada , Kouichi Kawamura , Izumi Mita , Akiko Akaoka
IPC分类号： C12N15/09 , C07H21/04 , C07K14/565 , C07K14/61 , C12N1/21 , C12N9/28 , C12N9/54 , C12N15/00 , C12N15/67 , C12N15/75 , C12P21/02 , C12R1/07
CPC分类号： C12N9/2417 , C07K14/565 , C07K14/61 , C12N15/67 , C12N15/75 , C12N9/54
摘要： A expression-secretion vector is constructed by using a DNA sequence comprising a DNA fragment obtained by subjecting a DNA sequence consisting of a region involved in the expression of a gene coding for an extracellular enzyme of a bacterium of the genus Bacillus and a region involved in the secretion of the enzyme thus expressed to a deletion in the region involved in the secretion which can enhance the extracellular production of a protein dependent on the DNA fragment. By transforming a host bacterium with a recombinant DNA molecule formed by inserting a DNA fragment comprising a gene coding for a desired protein into the expression-secretion vector and then culturing the transformed host, the extracellular production of the desired protein in a large amount can be accomplished.
摘要翻译：通过使用包含DNA片段的DNA序列构建表达分泌载体，所述DNA序列通过使由编码芽孢杆菌属的细菌的细胞外基因的基因的表达所涉及的区域和涉及的区域因此分泌的酶在涉及分泌的区域中被表达为可以增强依赖于DNA片段的蛋白质的细胞外产生的缺失。通过将包含编码所需蛋白质的基因的DNA片段插入表达分泌载体并随后培养转化的宿主而形成的重组DNA分子转化宿主细菌，可以大量的所需蛋白质的细胞外产生完成了

4. 发明授权

US5496713A Process for producing 20 kD human growth hormone 失效
标题翻译：生产20 kD人生长激素的方法
公开(公告)号：US5496713A
公开(公告)日：1996-03-05
申请号：US117809
申请日：1993-09-09
申请人： Masaru Honjo , Setsuo Yoshino , Akira Nakayama , Naokazu Naito
发明人： Masaru Honjo , Setsuo Yoshino , Akira Nakayama , Naokazu Naito
IPC分类号： C07K14/61 , C12N1/21 , C12N15/24 , C12N15/62 , C12N15/70 , C12P21/06 , A61K38/27
CPC分类号： C12N15/70 , C07K14/61 , C12N15/625 , C07K2319/00 , C07K2319/02
摘要： A human growth hormone having a molecular weight of 20,000 daltons can be effectively secreted and produced in the periplasm of Escherichia coli by constructing a human growth hormone secretion plasmid comprising a vector DNA replicable in E. coli and a DNA fragment including a promoter, a ribosome binding site, a secretion signal coding region, which are all those of the neutral protease gene of B. amyloliquefaciens and a gene encoding 20 kD hGH placed just downstream from the secretion signal coding region; introducing the said plasmid into E. coli; and culturing the resultant transformed cells.
摘要翻译：通过构建包含可在大肠杆菌中可复制的载体DNA的人生长激素分泌质粒和包含启动子，核糖体的DNA片段，可以有效地分泌分子量为20,000道尔顿的人生长激素，并在大肠杆菌的周质中产生结合位点，分泌信号编码区，其均是解淀粉芽孢杆菌的中性蛋白酶基因的所有位点和编码分布信号编码区正下游的20kD hGH的基因; 将所述质粒导入大肠杆菌; 并培养所得转化细胞。

5. 发明授权

US08586854B2 Thermoelectric conversion element 有权
标题翻译：热电转换元件
公开(公告)号：US08586854B2
公开(公告)日：2013-11-19
申请号：US13059107
申请日：2009-08-17
申请人： Kenji Higashi , Yuji Hori , Yoshikazu Tanaka , Yoji Yamada , Kaoru Kishigui , Akira Nakayama
发明人： Kenji Higashi , Yuji Hori , Yoshikazu Tanaka , Yoji Yamada , Kaoru Kishigui , Akira Nakayama
IPC分类号： H01L35/32 , H01L35/30 , H01L35/00
CPC分类号： H01L35/32 , H01L35/00
摘要： A thermoelectric conversion element is configured to have two types of conductors with different Seebeck coefficients physically connected alternately with an electrode via one or more electrical resistance layers formed by electrical resistor having electrical resistance rate of 1×10−3 Ωcm or more. This arrangement enables charges to be generated by the difference of temperature in both ends of the element and to be densely stored in the electrical resistance layers formed by electrical resistor. Moreover, it is thought that thermal energy equivalent to the difference of temperature is input into the electrical resistance layers and that electromotive force increases as a result of an increase of output voltage.
摘要翻译：热电转换元件被配置为具有两种类型的导体，其中不同的塞贝克系数通过一个或多个由电阻率为1×10 -3Ω或更大的电阻形成的电阻层与电极交替物理连接。这种布置使得能够通过元件的两端的温度差产生电荷并且密集地存储在由电阻器形成的电阻层中。此外，认为与温差相当的热能被输入到电阻层中，并且由于输出电压的增加，电动势增加。

6. 发明授权

US08508453B2 Display panel driving apparatus 有权
标题翻译：显示面板驱动装置
公开(公告)号：US08508453B2
公开(公告)日：2013-08-13
申请号：US12533133
申请日：2009-07-31
申请人： Akira Nakayama
发明人： Akira Nakayama
IPC分类号： G09G3/36
CPC分类号： G09G3/3688 , G09G3/3614 , G09G2330/06
摘要： The present disclosure provides a display panel driving apparatus for driving a display panel including a plurality of display cells, in accordance with an inputted image signal, including, a first latch section that successively reads and holds a pixel data piece for each pixel based on the inputted image signal, a second latch section that successively reads and outputs pixel data pieces every Q pieces (Q is an integer equal to or larger than 2) with a predetermined time difference therebetween in accordance with a load signal, a drive potential generating section that generates a drive potential to drive each of the display cells based on the outputted pixel data pieces, and an output gate section that applies the drive potentials to the respective display cells of the display panel, simultaneously after an elapse of a predetermined time period from a timing of supplying the load signal.
摘要翻译：本公开提供了一种显示面板驱动装置，用于根据输入的图像信号来驱动包括多个显示单元的显示面板，所述显示面板驱动装置包括：第一锁存部，其基于所述第一锁存部连续读取并保持每个像素的像素数据输入图像信号;第二锁存部，其根据负载信号以其间的预定时间差，每Q个（Q为2以上的整数）依次读取并输出像素数据;驱动电位生成部，根据输出的像素数据产生驱动电位以驱动每个显示单元;以及输出栅极部分，其在从预定时间段经过一段时间之后同时将显示面板的各显示单元施加驱动电位提供负载信号的时间。

7. 发明授权

US08294653B2 Display panel driving voltage output circuit 有权
标题翻译：显示面板驱动电压输出电路
公开(公告)号：US08294653B2
公开(公告)日：2012-10-23
申请号：US12618806
申请日：2009-11-16
申请人： Akira Nakayama
发明人： Akira Nakayama
IPC分类号： G09G5/00
CPC分类号： G09G3/3688 , G09G3/3614
摘要： A driving voltage output circuit for a matrix display panel includes high-side voltage followers and low-side voltage followers. Each voltage follower includes a differential input stage, a control stage, and an output stage. The differential input stage receives non-inverting and inverting inputs and produces first and second potentials. The control stage generates third and fourth potentials from the first and second potentials. The output stage includes three transistors connected respectively to the high-side power supply, the low-side power supply, and an intermediate reference potential, and connected in common to an output terminal. Two of the three transistors are of identical channel type and are controlled by the first and fourth potentials. The third transistor is of the opposite conductive type and is controlled by the third potential.
摘要翻译：用于矩阵显示面板的驱动电压输出电路包括高边电压跟随器和低侧电压跟随器。每个电压跟随器包括差分输入级，控制级和输出级。差分输入级接收非反相和反相输入并产生第一和第二电位。控制级从第一和第二电位产生第三和第四电位。输出级包括分别连接到高侧电源，低侧电源和中间参考电位的三个晶体管，并且共同连接到输出端子。三个晶体管中的两个具有相同的沟道类型并由第一和第四电位控制。第三晶体管具有相反的导电类型并由第三电位控制。

8. 发明授权

US07532912B2 Mobile radio device having movable pointer on display screen 失效
标题翻译：移动无线电设备在显示屏幕上具有可移动指针
公开(公告)号：US07532912B2
公开(公告)日：2009-05-12
申请号：US10396325
申请日：2003-03-26
申请人： Akira Nakayama
发明人： Akira Nakayama
IPC分类号： H04M1/00 , H04B1/38
CPC分类号： G06F3/016 , G06F3/04892 , G06F2203/014 , H04M1/72583
摘要： A mobile radio device improves its operability with a simple configuration and facilitates the pointing operation of a pointer displayed on a screen to a desired area. First apparatus displays a first area, a second area, and a pointer on a screen. The second area is partitioned by a boundary and located outside the first area. The pointer is movable on the screen according to a user's operation. Second apparatus acquires position information of the pointer on the screen. Third apparatus sets positional information of the first area and the second area. Fourth apparatus notifies with vibration, sound, and/or light the user a fact that the pointer is moved on the screen across the boundary between the first area and the second area based on the position information of the pointer acquired by the second apparatus and the positional information of the first area and the second area set by the third apparatus.
摘要翻译：移动无线电设备通过简单的配置提高其可操作性，并且便于将显示在屏幕上的指针指向操作到期望的区域。第一装置在屏幕上显示第一区域，第二区域和指针。第二区域由边界划分，位于第一区域外。指针可以根据用户的操作在屏幕上移动。第二装置在屏幕上获取指针的位置信息。第三装置设置第一区域和第二区域的位置信息。第四装置基于由第二装置获取的指示器的位置信息，通过振动，声音和/或点亮用户指示器在屏幕上跨越第一区域和第二区域之间的边界移动的事实，由第三装置设定的第一区域和第二区域的位置信息。

9. 发明申请

US20090057808A1 SEMICONDUCTOR DEVICE, SEMICONDUCTOR ELEMENT, AND SUBSTRATE 有权
标题翻译：半导体器件，半导体元件和衬底
公开(公告)号：US20090057808A1
公开(公告)日：2009-03-05
申请号：US12046535
申请日：2008-03-12
申请人： Akira Nakayama
发明人： Akira Nakayama
IPC分类号： H01L23/58
CPC分类号： H01L23/50 , G09G3/20 , G09G2300/0426 , H01L23/5386 , H01L23/64 , H01L2924/0002 , H01L2924/3011 , H01L2924/00
摘要： A semiconductor device, a semiconductor element, and a substrate are provided, which allow the semiconductor element to be provided with a reduced size when combined. The semiconductor device of the invention has a rectangular semiconductor element mounted on a substrate formed with an external input terminal, an external output terminal, and a plurality of wiring patterns connected to each of the external input terminal and the external output terminal. The semiconductor element includes a grayscale voltage generating unit for generating a plurality of grayscale voltages by dividing a reference voltage, a plurality of electrodes for the reference voltage formed in the neighborhood of the grayscale voltage generating unit; and an internal wiring for connecting the grayscale voltage generating unit and the reference voltage electrodes. The substrate includes a wiring pattern for the reference voltage for connecting the external input terminal and the reference voltage electrodes.
摘要翻译：提供半导体器件，半导体元件和衬底，其使得当组合时可以使半导体元件具有减小的尺寸。本发明的半导体器件具有安装在形成有外部输入端子，外部输出端子和连接到外部输入端子和外部输出端子的多个布线图案的基板上的矩形半导体元件。半导体元件包括：灰度级电压产生单元，用于通过划分参考电压产生多个灰度电压;多个电极，用于在灰度级电压产生单元附近形成的参考电压; 以及用于连接灰度级电压产生单元和参考电压电极的内部布线。衬底包括用于连接外部输入端子和参考电压电极的参考电压的布线图案。

10. 发明授权

US07201082B2 Automobile pedal supporting structure 有权
标题翻译：汽车踏板支撑结构
公开(公告)号：US07201082B2
公开(公告)日：2007-04-10
申请号：US10669684
申请日：2003-09-25
申请人： Hideto Yamada , Yasunori Sasaki , Kiyonobu Takahashi , Akira Nakayama
发明人： Hideto Yamada , Yasunori Sasaki , Kiyonobu Takahashi , Akira Nakayama
IPC分类号： G05G1/14 , B60K28/10
CPC分类号： G05G1/30 , Y10T74/20528 , Y10T74/20888
摘要： The automobile pedal supporting structure includes a first bracket 5, the front end of the first bracket 5 being fixed on a dash panel 1, and the rear end of the first bracket 5 being fixed on a vehicle-side member 8 which is more rigid than the dash panel 1 so that the first bracket 5 can be removed from the vehicle-side member 8, and a second bracket 6, the front-end lower part of the second bracket 6 being pivotally attached to the first bracket 5 so that the second bracket 6 can swing, the rear-end upper part of the second bracket 6 being fixed on the vehicle-side member 8 so that the second bracket 6 can be removed from the vehicle-side member 8, and an operation pedal 4 being pivotally attached to the second bracket 6 so that the operation pedal 4 can swing, in which the first bracket 5 and the second bracket 6 are placed to substantially overlap each other, the rear-end upper part of the second bracket 6 are fixed together with the first bracket 5 on the vehicle-side member 8, and a turn promoting member 12 is provided, which is connected from the vehicle-side member 8 through the rear-end outside of the first bracket 5 to the upper part of the second bracket 6 and promotes a turn of the second bracket 6 toward the vehicle-lower side by a backward movement of the first bracket 5 toward the vehicle-rear side.
摘要翻译：汽车踏板支撑结构包括第一支架5，第一支架5的前端固定在仪表板1上，第一支架5的后端固定在车辆侧部件8上，该车辆侧部件8的刚性比仪表板1，使得第一支架5能够从车辆侧部件8移除;第二支架6将第二支架6的前端下部可枢转地安装在第一支架5上，支架6可以摆动，第二支架6的后端上部固定在车辆侧部件8上，从而第二支架6能够从车辆侧部件8移除，并且操作踏板4可枢转地附接到第二支架6，使得操作踏板4摆动，第一支架5和第二支架6放置在第二托架6和第二支架6之间，第二支架6的后端上部与第一托架车身侧的支架5 如图8所示，并且设置有转向促进构件12，其从车辆侧构件8经由第一支架5的后端向后连接到第二支架6的上部，并且促进第二支架6的转动通过第一支架5向车辆后侧的向后移动而朝向车辆下侧。

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