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1. 发明申请

US20110238395A1 METHOD FOR GENERATING MODEL FOR PREOPERATIVE SIMULATION 有权
标题翻译：用于生成预测模拟的模型的方法
公开(公告)号：US20110238395A1
公开(公告)日：2011-09-29
申请号：US12998797
申请日：2009-11-30
申请人： Yoshinobu Kubota , Kazuhide Makiyama , Manabu Nagasaka , Kentaro Takanami , Masato Ogata
发明人： Yoshinobu Kubota , Kazuhide Makiyama , Manabu Nagasaka , Kentaro Takanami , Masato Ogata
IPC分类号： G06G7/60
CPC分类号： G06T17/20 , A61B2034/105 , G06F19/00 , G06F19/3481 , G06T15/08 , G06T19/20 , G06T2210/41 , G06T2219/2021 , G16H50/50
摘要： The invention is directed to the provision of a method for generating a model for a preoperative simulation, wherein the method includes: a first step of constructing volume data for necessary organs by acquiring geometrical information from a medical image; a second step of manipulating the volume data to reposition and reorient an operator-designated organ to achieve a position and orientation appropriate for a surgical operation; a third step of generating a blood-vessel model, depicting a blood vessel to be joined to the designated organ, so as to match the position and orientation of the designated organ; a fourth step of generating volume data by forming a fat model of prescribed thickness around a prescribed organ contained in the earlier constructed volume data, after the blood-vessel model has been joined to the designated organ; a fifth step of thereafter meshing the organ represented by the generated volume data; a sixth step of manipulating a template model of a prescribed shape by using a template, and arranging the template model around the generated blood-vessel model; and a seventh step of generating a line-segment model based on the thus arranged template model.
摘要翻译：本发明旨在提供一种用于产生用于术前模拟的模型的方法，其中所述方法包括：第一步骤，通过从医学图像获取几何信息来构建所需器官的体积数据; 操纵体积数据以重新定位和重新定向操作者指定的器官以实现适合外科手术的位置和取向的第二步骤; 产生血管模型的第三步骤，描绘要连接到指定器官的血管，以便与指定器官的位置和方向相匹配; 在血管模型已经结合到指定的器官之后，通过在早期构建的体积数据中包含的规定的器官周围形成规定厚度的脂肪模型来生成体数据的第四步骤; 其后，将生成的体数据表示的脏器啮合的第五步骤; 通过使用模板来操作规定形状的模板模型的第六步骤，以及围绕生成的血管模型布置模板模型; 以及基于由此布置的模板模型生成线段模型的第七步骤。

2. 发明授权

US08681152B2 Method for generating model for preoperative simulation 有权
标题翻译：用于生成术前模拟模型的方法
公开(公告)号：US08681152B2
公开(公告)日：2014-03-25
申请号：US12998797
申请日：2009-11-30
申请人： Yoshinobu Kubota , Kazuhide Makiyama , Manabu Nagasaka , Kentaro Takanami , Masato Ogata
发明人： Yoshinobu Kubota , Kazuhide Makiyama , Manabu Nagasaka , Kentaro Takanami , Masato Ogata
IPC分类号： G06T17/00 , G06G7/58 , G06K9/00
CPC分类号： G06T17/20 , A61B2034/105 , G06F19/00 , G06F19/3481 , G06T15/08 , G06T19/20 , G06T2210/41 , G06T2219/2021 , G16H50/50
摘要： The invention is directed to the provision of a method for generating a model for a preoperative simulation, wherein the method includes: a first step of constructing volume data for necessary organs by acquiring geometrical information from a medical image; a second step of manipulating the volume data to reposition and reorient an operator-designated organ to achieve a position and orientation appropriate for a surgical operation; a third step of generating a blood-vessel model, depicting a blood vessel to be joined to the designated organ, so as to match the position and orientation of the designated organ; a fourth step of generating volume data by forming a fat model of prescribed thickness around a prescribed organ contained in the earlier constructed volume data, after the blood-vessel model has been joined to the designated organ; a fifth step of thereafter meshing the organ represented by the generated volume data; a sixth step of manipulating a template model of a prescribed shape by using a template, and arranging the template model around the generated blood-vessel model; and a seventh step of generating a line-segment model based on the thus arranged template model.
摘要翻译：本发明旨在提供一种用于产生用于术前模拟的模型的方法，其中所述方法包括：第一步骤，通过从医学图像获取几何信息来构建所需器官的体积数据; 操纵体积数据以重新定位和重新定向操作者指定的器官以实现适合外科手术的位置和取向的第二步骤; 产生血管模型的第三步骤，描绘要连接到指定器官的血管，以便与指定器官的位置和方向相匹配; 在血管模型已经结合到指定的器官之后，通过在早期构建的体积数据中包含的规定的器官周围形成规定厚度的脂肪模型来生成体数据的第四步骤; 其后，将生成的体数据表示的脏器啮合的第五步骤; 通过使用模板来操作规定形状的模板模型的第六步骤，以及围绕生成的血管模型布置模板模型; 以及基于由此布置的模板模型生成线段模型的第七步骤。

3. 发明授权

US09214095B2 Surgical simulation model generating method, surgical simulation method, and surgical simulator 有权
标题翻译：手术模拟生成方法，手术模拟方法和手术模拟器
公开(公告)号：US09214095B2
公开(公告)日：2015-12-15
申请号：US13376697
申请日：2010-06-04
申请人： Yoshinobu Kubota , Kazuhide Makiyama , Takaaki Kikukawa , Manabu Nagasaka , Hideo Sakamoto , Masato Ogata
发明人： Yoshinobu Kubota , Kazuhide Makiyama , Takaaki Kikukawa , Manabu Nagasaka , Hideo Sakamoto , Masato Ogata
IPC分类号： G09B23/28 , G06T17/20 , A61B19/00
CPC分类号： G06T7/204 , A61B2034/105 , G06F19/00 , G06K9/52 , G06K9/6201 , G06T7/0014 , G06T7/248 , G06T7/74 , G06T13/80 , G06T17/20 , G06T2207/30004 , G09B23/285
摘要： A surgical simulation model generating method includes: a first process in which a computing unit acquires geometrical information of an organ from a medical image stored in a storage unit, including an image of the organ, and generates volume data for the organ; a second process in which, after the first process, the computing unit forms nodal points by meshing the organ represented by the generated volume data; a third process in which the computing unit generates a simulated membrane that covers the organ represented by the volume data meshed in the second process; and a fourth process in which the computing unit generates a simulated organ by drawing an imaginary line so as to extend from each nodal point formed on a surface of the organ represented by the volume data meshed in the second process in a direction that intersects the simulated membrane and thereby forming a membrane nodal point at a point where the imaginary line intersects the simulated membrane generated in the third process, and by arranging on each imaginary line an imaginary inter-membrane spring that connects between the nodal point formed on the surface of the organ and the membrane nodal point, while also arranging an in-plane spring that connects between adjacent membrane nodal points on the simulated membrane.
摘要翻译：手术模拟模型生成方法包括：第一处理，其中计算单元从存储在存储单元中的医学图像获取器官的几何信息，包括器官的图像，并且生成器官的体积数据; 第二处理，其中，在第一处理之后，计算单元通过对由生成的卷数据表示的器官进行啮合而形成节点; 第三处理，其中所述计算单元生成覆盖由在所述第二处理中筛选的所述体数据表示的所述器官的模拟膜; 以及第四处理，其中所述计算单元通过绘制假想线来生成模拟器官，以从形成在所述器官的表面上的所述器官的表面延伸，所述节点由所述第二处理中的网格化的体数据表示在与所述模拟膜，从而在假想线与第三工艺中产生的模拟膜相交的点形成膜节点，并且通过在每个假想线上布置假想的膜间弹簧，其连接在形成在该表面上的节点之间器官和膜节点，同时还布置连接在模拟膜上的相邻膜节点之间的平面内弹簧。

4. 发明申请

US20120081367A1 SURGICAL SIMULATION MODEL GENERATING METHOD, SURGICAL SIMULATION METHOD, AND SURGICAL SIMULATOR 有权
标题翻译：外科模拟模型生成方法，手术模拟方法和手术模拟器
公开(公告)号：US20120081367A1
公开(公告)日：2012-04-05
申请号：US13376697
申请日：2010-06-04
申请人： Yoshinobu Kubota , Kazuhide Makiyama , Takaaki Kikukawa , Manabu Nagasaka , Hideo Sakamoto , Masato Ogata
发明人： Yoshinobu Kubota , Kazuhide Makiyama , Takaaki Kikukawa , Manabu Nagasaka , Hideo Sakamoto , Masato Ogata
IPC分类号： G06T15/00
CPC分类号： G06T7/204 , A61B2034/105 , G06F19/00 , G06K9/52 , G06K9/6201 , G06T7/0014 , G06T7/248 , G06T7/74 , G06T13/80 , G06T17/20 , G06T2207/30004 , G09B23/285
摘要： A surgical simulation model generating method includes: a first process in which a computing unit acquires geometrical information of an organ from a medical image stored in a storage unit, including an image of the organ, and generates volume data for the organ; a second process in which, after the first process, the computing unit forms nodal points by meshing the organ represented by the generated volume data; a third process in which the computing unit generates a simulated membrane that covers the organ represented by the volume data meshed in the second process; and a fourth process in which the computing unit generates a simulated organ by drawing an imaginary line so as to extend from each nodal point formed on a surface of the organ represented by the volume data meshed in the second process in a direction that intersects the simulated membrane and thereby forming a membrane nodal point at a point where the imaginary line intersects the simulated membrane generated in the third process, and by arranging on each imaginary line an imaginary inter-membrane spring that connects between the nodal point formed on the surface of the organ and the membrane nodal point, while also arranging an in-plane spring that connects between adjacent membrane nodal points on the simulated membrane.
摘要翻译：手术模拟模型生成方法包括：第一处理，其中计算单元从存储在存储单元中的医学图像获取器官的几何信息，包括器官的图像，并且生成器官的体积数据; 第二处理，其中，在第一处理之后，计算单元通过对由生成的卷数据表示的器官进行啮合而形成节点; 第三处理，其中所述计算单元生成覆盖由在所述第二处理中筛选的所述体数据表示的所述器官的模拟膜; 以及第四处理，其中所述计算单元通过绘制假想线来生成模拟器官，以从形成在所述器官的表面上的所述器官的表面延伸，所述节点由所述第二处理中的网格化的体数据表示在与所述模拟膜，从而在假想线与第三工艺中产生的模拟膜相交的点形成膜节点，并且通过在每个假想线上布置假想的膜间弹簧，其连接在形成在该表面上的节点之间器官和膜节点，同时还布置连接在模拟膜上的相邻膜节点之间的平面内弹簧。

5. 发明授权

US08532359B2 Biodata model preparation method and apparatus, data structure of biodata model and data storage device of biodata model, and load dispersion method and apparatus of 3D data model 有权
标题翻译：生物数据模型制备方法和装置，生物数据模型的生物数据模型和数据存储装置的数据结构，以及3D数据模型的负载分散方法和装置
公开(公告)号：US08532359B2
公开(公告)日：2013-09-10
申请号：US13003607
申请日：2009-07-10
申请人： Kentaro Takanami , Manabu Nagasaka , Hideo Sakamoto , Masato Ogata , Hideo Yokota , Hiroyuki Shimai
发明人： Kentaro Takanami , Manabu Nagasaka , Hideo Sakamoto , Masato Ogata , Hideo Yokota , Hiroyuki Shimai
IPC分类号： G06K9/00 , A61B6/00
CPC分类号： G06T7/11 , G01R33/4812 , G06F19/00 , G06T7/155 , G06T17/20 , G06T2200/08 , G06T2207/10081 , G06T2207/10088 , G06T2207/30004 , G09B23/30
摘要： Medical image data is utilized, physical values are assigned to body parts based on image information, and the target organs are separated from the image data to prepare a 3D biodata model to thereby realize a data model unique to a patient, having an internal structure, and enabling dynamic simulation of a live body. The same target part of a body is captured by CT and MRI to obtain medical images. Sets of pairs of CT images and MRI images are set, a plurality of features showing the same locations are selected and set from the sets of CT images and MRI images, a conversion coefficient between the CT images and MRI images is obtained, and this conversion coefficient is used to rearrange the MRI images by projection transforms and linear interpolation, combine them with the contours of the CT images, and correct their positions in the contours. Further, the images are used to prepare a 3D data model.
摘要翻译：利用医学图像数据，基于图像信息将物理值分配给身体部位，并且将目标器官与图像数据分离以制备3D生物数据模型，从而实现具有内部结构的患者独有的数据模型，并实现对活体的动态模拟。通过CT和MRI捕获身体的相同目标部分以获得医学图像。设置CT图像和MRI图像对，从CT图像和MRI图像组中选择并设置显示相同位置的多个特征，获得CT图像和MRI图像之间的转换系数，并且该转换系数用于通过投影变换和线性插值重新排列MRI图像，将其与CT图像的轮廓组合，并校正其在轮廓中的位置。此外，图像用于准备3D数据模型。

6. 发明申请

US20110150312A1 BIODATA MODEL PREPARATION METHOD AND APPARATUS, DATA STRUCTURE OF BIODATA MODEL AND DATA STORAGE DEVICE OF BIODATA MODEL, AND LOAD DISPERSION METHOD AND APPARATUS OF 3D DATA MODEL 有权
标题翻译： BIODATA模型制备方法和设备，BIODATA模型的数据结构和BIODATA模型的数据存储设备，以及负载分散方法和3D数据模型的设备
公开(公告)号：US20110150312A1
公开(公告)日：2011-06-23
申请号：US13003607
申请日：2009-07-10
申请人： Kentaro Takanami , Manabu Nagasaka , Hideo Sakamoto , Masato Ogata , Hideo Yokoto , Hiroyuki Shimai
发明人： Kentaro Takanami , Manabu Nagasaka , Hideo Sakamoto , Masato Ogata , Hideo Yokoto , Hiroyuki Shimai
IPC分类号： G06K9/00
CPC分类号： G06T7/11 , G01R33/4812 , G06F19/00 , G06T7/155 , G06T17/20 , G06T2200/08 , G06T2207/10081 , G06T2207/10088 , G06T2207/30004 , G09B23/30
摘要： Medical image data is utilized, physical values are assigned to body parts based on image information, and the target organs are separated from the image data to prepare a 3D biodata model to thereby realize a data model unique to a patient, having an internal structure, and enabling dynamic simulation of a live body. The same target part of a body is captured by CT and MRI to obtain medical images. Sets of pairs of CT images and MRI images are set, a plurality of features showing the same locations are selected and set from the sets of CT images and MRI images, a conversion coefficient between the CT images and MRI images is obtained, and this conversion coefficient is used to rearrange the MRI images by projection transforms and linear interpolation, combine them with the contours of the CT images, and correct their positions in the contours. Further, the images are used to prepare a 3D data model.
摘要翻译：利用医学图像数据，基于图像信息将物理值分配给身体部位，并且将目标器官与图像数据分离以制备3D生物数据模型，从而实现具有内部结构的患者独有的数据模型，并实现对活体的动态模拟。通过CT和MRI捕获身体的相同目标部分以获得医学图像。设置CT图像和MRI图像对，从CT图像和MRI图像组中选择并设置显示相同位置的多个特征，获得CT图像和MRI图像之间的转换系数，并且该转换系数用于通过投影变换和线性插值重新排列MRI图像，将其与CT图像的轮廓组合，并校正其在轮廓中的位置。此外，图像用于准备3D数据模型。

7. 发明授权

US06956585B2 Image composing system and a method thereof 有权
标题翻译：图像合成系统及其方法
公开(公告)号：US06956585B2
公开(公告)日：2005-10-18
申请号：US10291854
申请日：2002-11-08
申请人： Shigeru Muraki , Masato Ogata
发明人： Shigeru Muraki , Masato Ogata
IPC分类号： G06T3/00 , G06T1/20 , G06T5/50 , G06T15/40 , G09G5/00 , G09G5/377
CPC分类号： G06T1/20
摘要： The present invention provides an image composing apparatus that can composite images at high speed and in which the apparatus configuration can be easily expanded as the number of images to be composed increases.Sub-images generated by node computers are synchronized each other by a synchronizing section. Then, each pair of synchronized sub-image data is composed into a single sub-image in a first-layer image composing section, comprising a plurality of image composing circuits each for composing two sub-images, and the resulting sub-images are composed iteratively through a second-layer image composing section, a third-layer image composing section, and so on, that have the same configuration as the first-layer image composing section.
摘要翻译：本发明提供一种图像合成装置，其可以高速合成图像，并且随着要组合的图像的数量增加，装置配置可以容易地扩展。由节点计算机生成的子图像由同步部分彼此同步。然后，将每对同步子图像数据构成为第一层图像合成部中的单个子图像，包括构成两个子图像的多个图像合成电路，并且生成的子图像被构成迭代地通过具有与第一层图像合成部分相同的配置的第二层图像合成部分，第三层图像合成部分等。

8. 发明授权

US5082927A Selectively cytotoxic IL-4-PE40 fusion protein 失效
标题翻译：选择性细胞毒性IL-4-PE40融合蛋白
公开(公告)号：US5082927A
公开(公告)日：1992-01-21
申请号：US351448
申请日：1989-05-12
申请人： Ira Pastan , David FitzGerald , Masato Ogata
发明人： Ira Pastan , David FitzGerald , Masato Ogata
IPC分类号： A61K38/00 , A61K39/00 , A61K47/48 , C07K14/21 , C07K14/495 , C07K14/55 , C07K16/28
CPC分类号： C07K14/495 , A61K47/48369 , A61K47/48484 , C07K14/21 , C07K14/55 , C07K16/2866 , C07K16/2896 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/55 , C07K2319/75 , Y10S530/82 , Y10S530/825
摘要： The present invention provides a chimeric protein IL4-PE40 which selectively kills IL4 receptor bearing cells. A mutant form of the protein is also provided.
摘要翻译：本发明提供了选择性地杀死携带IL4受体的细胞的嵌合蛋白IL4-PE40。还提供了蛋白质的突变体形式。

9. 发明申请

US20060007245A1 Image composing system and a method thereof 审中-公开
公开(公告)号：US20060007245A1
公开(公告)日：2006-01-12
申请号：US11223369
申请日：2005-09-09
申请人： Shigeru Muraki , Masato Ogata
发明人： Shigeru Muraki , Masato Ogata
IPC分类号： G09G5/00
CPC分类号： G06T1/20
摘要： The present invention provides an image composing apparatus that can composite images at high speed and in which the apparatus configuration can be easily expanded as the number of images to be composed increases. Sub-images generated by node computers are synchronized each other by a synchronizing section. Then, each pair of synchronized sub-image data is composed into a single sub-image in a first-layer image composing section, comprising a plurality of image composing circuits each for composing two sub-images, and the resulting sub-images are composed iteratively through a second-layer image composing section, a third-layer image composing section, and so on, that have the same configuration as the first-layer image composing section.

10. 发明授权

US06313841B1 Parallel volume rendering system with a resampling module for parallel and perspective projections 失效
标题翻译：具有用于并行和透视投影的重采样模块的并行体绘制系统
公开(公告)号：US06313841B1
公开(公告)日：2001-11-06
申请号：US09059155
申请日：1998-04-13
申请人： Masato Ogata , TakaHide Ohkami , Hugh C. Lauer
发明人： Masato Ogata , TakaHide Ohkami , Hugh C. Lauer
IPC分类号： G06T1700
CPC分类号： G06T15/10
摘要： A volume rendering system re-samples voxels read from a voxel memory to generate samples along perspective rays cast from a center of projection using a level of detail value. Color computations are performed with the samples to produce pixels for a baseplane image. The level of detail is computed, at each plane of samples perpendicular to a principal viewing axis, from the current sample position and the distance between the center of projection and the baseplane; the principal viewing axis is the coordinate axis in a rendered volume most parallel with a viewing vector. The level of detail provides a measure of the distance between two neighboring perspective rays at each plane and is used to determine the number of voxels and weights for these voxels required to compute a single sample at each plane. Multi-resolution datasets prepared for different levels of details are used to simplify the resampling operation by limiting the number of voxels required to compute a single sample.
摘要翻译：体绘制系统重新对从体元记忆读取的体素进行重新采样，以使用一定程度的细节值从投影中心投射的透视光线生成样本。使用样本执行颜色计算，以生成基板图像的像素。在垂直于主观察轴的样本的每个平面处，从当前采样位置和投影中心与基板之间的距离计算细节水平; 主观察轴是与观看向量最平行的渲染卷中的坐标轴。细节水平提供了每个平面上两个相邻透视射线之间的距离的度量，并且用于确定在每个平面处计算单个样本所需的这些体素的体素数和权重。用于不同级别细节的多分辨率数据集用于通过限制计算单个样本所需的体素数来简化重采样操作。

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