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1. 发明授权

US6077408A Biosensor and method of manufacturing the same 失效
标题翻译：生物传感器及其制造方法
公开(公告)号：US6077408A
公开(公告)日：2000-06-20
申请号：US002368
申请日：1998-01-02
申请人： Yoshiko Miyamoto , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
发明人： Yoshiko Miyamoto , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01N27/327 , C12Q1/00 , C12Q1/26 , G01N27/26
CPC分类号： C12Q1/001 , C12Q1/26
摘要： Disclosed is a biosensor facilitating high accuracy quantification of a specific component in a sample solution with no adverse influence of solid substances. The biosensor comprises an electrically insulating base plate, an electrode system comprising a working electrode and a counter electrode formed on the base plate, a reaction layer containing at least one enzyme disposed on the electrode system, and an anionic filter formed on the reaction layer for inhibiting permeation of solid components.
摘要翻译：公开了一种促进样品溶液中特定组分的高精度定量的生物传感器，其不受固体物质的不利影响。生物传感器包括电绝缘基板，包括在基板上形成的工作电极和对电极的电极系统，包含设置在电极系统上的至少一个酶的反应层和形成在反应层上的阴离子过滤器抑制固体组分的渗透。

2. 发明授权

US06258254B1 Biosensor 失效
标题翻译：生物传感器
公开(公告)号：US06258254B1
公开(公告)日：2001-07-10
申请号：US09122628
申请日：1998-07-27
申请人： Yoshiko Miyamoto , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
发明人： Yoshiko Miyamoto , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01F164
CPC分类号： C12Q1/004
摘要： A method using a biosensor is disclosed which facilitates high accuracy quantitation of a substrate by best eliminating adverse effects of red blood cell existing in blood together with the substrate. The biosensor comprises an electrode system including a working electrode and a counter electrode formed on an electrically insulating base plate, and a reaction layer containing at least an oxidoreductase and an electron acceptor, wherein the electron acceptor is a sodium salt.
摘要翻译：公开了一种使用生物传感器的方法，其通过最好地消除血液中存在于血液中的红细胞与基质一起的不良影响，促进了基质的高精度定量。生物传感器包括电极系统，其包括在电绝缘基板上形成的工作电极和对电极，以及至少包含氧化还原酶和电子受体的反应层，其中电子受体是钠盐。

3. 发明授权

US5958199A Biosensor 失效
标题翻译：生物传感器
公开(公告)号：US5958199A
公开(公告)日：1999-09-28
申请号：US815760
申请日：1997-03-12
申请人： Yoshiko Miyamoto , Toshihiko Yoshioka , Shiro Nankai
发明人： Yoshiko Miyamoto , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01N27/327 , C12Q1/00 , G01N27/26
CPC分类号： C12Q1/001 , Y10S435/817
摘要： Disclosed is a high performance biosensor free from the effect of any components existing in a sample solution other than a substrate. The biosensor comprises an electrically insulating base plate, an electrode system including a working electrode and a counter electrode provided on the base plate, and a reaction layer containing a hydrophilic polymer, an enzyme and an electron acceptor located over the electrode system. The reaction layer contains an excess amount of hydrophilic polymer in a range of 150 to 1,000% by weight of the enzyme.
摘要翻译：本发明公开了一种高效能的生物传感器，不受基片以外的样品溶液中存在的任何成分的影响。生物传感器包括电绝缘基板，包括设置在基板上的工作电极和对电极的电极系统，以及包含位于电极系统上的亲水性聚合物，酶和电子受体的反应层。反应层含有过量的亲水性聚合物，其量为该酶的150-1000重量％。

4. 发明授权

US06547954B2 Biosensor and method for quantitating biochemical substrate using the same 有权
标题翻译：生物传感器和使用其生物化学底物的定量方法
公开(公告)号：US06547954B2
公开(公告)日：2003-04-15
申请号：US09232320
申请日：1999-01-18
申请人： Shin Ikeda , Tomohiro Yamamoto , Toshihiko Yoshioka , Shiro Nankai , Shigeki Joko , Junko Iwata
发明人： Shin Ikeda , Tomohiro Yamamoto , Toshihiko Yoshioka , Shiro Nankai , Shigeki Joko , Junko Iwata
IPC分类号： G01N27327
CPC分类号： C12Q1/004 , Y10S435/817
摘要： A biosensor includes: an insulating substrate; an electrode system formed on the insulating substrate which has a working electrode and a counter electrode; and a reaction layer formed on the insulating substrate which contains an oxidoreductase and an electron acceptor. The electron acceptor is ferricinium ion derived from ferrocene electrolyte.
摘要翻译：生物传感器包括：绝缘基板; 形成在具有工作电极和对电极的绝缘基板上的电极系统; 以及形成在包含氧化还原酶和电子受体的绝缘基板上的反应层。电子受体是衍生自二茂铁电解质的三价铁离子。

5. 发明授权

US06340428B1 Device and method for determining the concentration of a substrate 有权
标题翻译：用于确定底物浓度的装置和方法
公开(公告)号：US06340428B1
公开(公告)日：2002-01-22
申请号：US09424715
申请日：1999-11-29
申请人： Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
发明人： Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01N2726
CPC分类号： C12Q1/004
摘要： A method for determining the concentration of a substrate in a sample solution using an electrode system comprising a working electrode, a counter electrode, and a reaction layer which contains at least an oxidoreductase and an electron mediator and is formed on the electrode system to electrochemically measure a reduced amount of the electron mediator resulting from enzyme reaction in the reaction layer, wherein a third electrode is formed as an interfering substance detecting electrode. A current flowing between the counter electrode and the third electrode is measured which is taken as a positive error. Subsequently, voltage application between the counter electrode and the third electrode is released and a voltage for oxidizing the reduced form electron mediator is applied between the working electrode and the counter electrode to measure a current flowing between the two electrodes.
摘要翻译：一种使用包括工作电极，对电极和至少包含氧化还原酶和电子介体的反应层的电极系统来确定样品溶液中的衬底的浓度的方法，并且形成在电极系统上以电化学测量在反应层中由酶反应产生的电子介体的量减少，其中形成第三电极作为干扰物质检测电极。测量在对电极和第三电极之间流动的电流，其被认为是正误差。随后，释放对电极和第三电极之间的电压施加，并且在工作电极和对电极之间施加用于氧化还原形式的电子介体的电压，以测量在两个电极之间流动的电流。

6. 发明授权

US06212417B1 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US06212417B1
公开(公告)日：2001-04-03
申请号：US09379128
申请日：1999-08-20
申请人： Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
发明人： Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： A61B505
CPC分类号： G01N27/3272
摘要： A highly reliable biosensor is provided which is reduced in influences of any interfering substance or preexisting oxygen in a sample solution. The biosensor comprises an electrode system including a working electrode, a counter electrode and a third electrode also usable as an interfering substance detecting electrode, a reagent layer containing at least an oxidoreductase and an electron mediator, and an electrically insulating base plate for supporting the electrode system and the reagent layer, wherein the third electrode is arranged at an opposing position to that of at least one of the working electrode and the counter electrode and the reagent layer is arranged at a predetermined position apart from the third electrode.
摘要翻译：提供了高度可靠的生物传感器，其减少了样品溶液中任何干扰物质或预先存在的氧气的影响。生物传感器包括电极系统，其包括工作电极，对电极和也可用作干扰物质检测电极的第三电极，至少含有氧化还原酶和电子介体的试剂层，以及用于支撑电极的电绝缘基板系统和试剂层，其中第三电极布置在与工作电极和对电极中的至少一个相对的位置，并且试剂层布置在与第三电极隔开的预定位置处。

7. 发明授权

US6104940A Electrode probe and body fluid examination equipment including the same 有权
标题翻译：电极探针和体液检查设备包括相同
公开(公告)号：US6104940A
公开(公告)日：2000-08-15
申请号：US326350
申请日：1999-06-04
申请人： Motokazu Watanabe , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
发明人： Motokazu Watanabe , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01N27/30 , A61B5/00 , A61B5/145 , A61B5/1486 , A61B5/15 , A61B5/157 , A61B5/05
CPC分类号： A61B5/1486 , A61B5/6848
摘要： Disclosed is an electrode probe and a body fluid examination equipment enabling examination of a trace amount of body fluid. The electrode probe comprises an insulating needle member, a working electrode lead disposed in the needle member, a working electrode whose lead is protruding outside from the needle member, a counter electrode disposed on the surface of the needle member, a lead connected to the counter electrode, and a reagent layer disposed in contact with or in the vicinity of the working and counter electrodes of the electrode system. When a trace amount of body fluid leaking on the skin surface is brought into contact with the reagent layer, the reagent layer dissolves which results in electron transfer whereby information about the concentration of analyte in the body fluid can be obtained from the electrode system.
摘要翻译：公开了能够检测微量体液的电极探针和体液检查装置。电极探针包括绝缘针构件，设置在针构件中的工作电极引线，其引线从针构件向外突出的工作电极，设置在针构件表面上的对电极，连接到计数器的引线电极和设置成与电极系统的工作电极和对电极接触或附近的试剂层。当皮肤表面泄漏的微量体液与试剂层接触时，试剂层溶解，导致电子转移，从而可以从电极系统获得关于体液中分析物浓度的信息。

8. 发明授权

US5922188A Biosensor and method for quantitating biochemical substrate using the same 失效
公开(公告)号：US5922188A
公开(公告)日：1999-07-13
申请号：US812602
申请日：1997-03-07
申请人： Shin Ikeda , Tomohiro Yamamoto , Toshihiko Yoshioka , Shiro Nankai , Shigeki Joko , Junko Iwata
发明人： Shin Ikeda , Tomohiro Yamamoto , Toshihiko Yoshioka , Shiro Nankai , Shigeki Joko , Junko Iwata
IPC分类号： C12Q1/00 , G01N27/26
CPC分类号： C12Q1/004 , Y10S435/817
摘要： A biosensor includes: an insulating substrate; an electrode system formed on the insulating substrate which has a working electrode and a counter electrode; and a reaction layer formed on the insulating substrate which contains an oxidoreductase and an electron acceptor. The electron acceptor is ferricinium ion derived from ferrocene electrolyte.

9. 发明授权

US5582697A Biosensor, and a method and a device for quantifying a substrate in a sample liquid using the same 失效
标题翻译：生物传感器，以及使用其进行样品液体中的基板的定量的方法和装置
公开(公告)号：US5582697A
公开(公告)日：1996-12-10
申请号：US425820
申请日：1995-04-20
申请人： Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai , Haruhiro Tsutsumi , Hideyuki Baba , Yoshinobu Tokuno , Syoji Miyazaki
发明人： Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai , Haruhiro Tsutsumi , Hideyuki Baba , Yoshinobu Tokuno , Syoji Miyazaki
IPC分类号： C12Q1/00 , G01N27/26
CPC分类号： C12Q1/005 , C12Q1/001 , Y10S435/817
摘要： The biosensor of this invention can quantify a substrate in a sample liquid by electrochemically measuring the amount of an electron acceptor that has been reduced by electrons generated in a reaction between the substrate and an oxidoreductase. The biosensor has an electrically insulating substrate and an electrode system formed on the substrate including a working electrode, a counter electrode and a third electrode used for detecting a liquid junction. The third electrode can be used merely for detecting a liquid junction, or can be used as both a reference electrode and a liquid junction detecting electrode.
摘要翻译：本发明的生物传感器可以通过电化学测量由底物和氧化还原酶之间的反应中产生的电子而减少的电子受体的量来量化样品液体中的底物。生物传感器具有电绝缘基板和形成在基板上的电极系统，该基板包括工作电极，对电极和用于检测液体接合点的第三电极。第三电极可以仅用于检测液体接点，也可以用作参考电极和液体接点检测电极。

10. 发明申请

US20050072670A1 Biosensor 审中-公开
标题翻译：生物传感器
公开(公告)号：US20050072670A1
公开(公告)日：2005-04-07
申请号：US10478283
申请日：2002-12-27
申请人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
发明人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： C12Q1/00 , C12Q1/60 , G01N27/403 , G01N33/487 , G01N33/49 , G01N27/26
CPC分类号： C12Q1/001 , C12Q1/006 , C12Q1/60 , G01N27/3272
摘要： In order to provide a biosensor with high accuracy and excellent response where plasma obtained by filtration of blood rapidly arrives at an electrode system, in a biosensor comprising: an insulating base plate; an electrode system having a working electrode and a counter electrode which are provided on the base plate; a reaction layer including at least oxidoreductase and an electron mediator; a sample solution supply pathway which includes the electrode system and the reaction layer and has an inlet and an air aperture; a sample solution supply part for introducing a sample solution, which is in position apart from the sample solution supply pathway; and a first filter which is disposed between the sample solution supply pathway and the sample solution supply part for filtering the sample solution, where the filtrate filtered with the first filter is supplied into the sample solution supply pathway due to capillary action, the direction in which the sample solution passes through the first filter and the direction in which the filtrate passes through the sample solution supply pathway are made cross at right angles.
摘要翻译：为了提供具有高精度和优异响应的生物传感器，其中通过过滤血液获得的血液迅速到达电极系统，在生物传感器中包括：绝缘基板; 具有设置在基板上的工作电极和对置电极的电极系统; 至少包含氧化还原酶和电子介体的反应层; 包括电极系统和反应层并具有入口和空气孔的样品溶液供应路径; 用于引入样品溶液的样品溶液供应部件，其处于离样品溶液供给路径的位置; 以及第一过滤器，其设置在样品溶液供给路径和样品溶液供给部之间，用于过滤样品溶液，其中用第一过滤器过滤的滤液由于毛细作用而被供给到样品溶液供给通道中，其中样品溶液通过第一过滤器，滤液通过样品溶液供应通道的方向被成直角交叉。

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