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1. 发明授权

US08221967B2 Method for quantification of peptide and protein 有权
标题翻译：肽和蛋白质定量方法
公开(公告)号：US08221967B2
公开(公告)日：2012-07-17
申请号：US12521632
申请日：2007-12-27
申请人： Yoshikazu Morita , Aiko Ono , Atsushi Serizawa , Hiroshi Kawakami
发明人： Yoshikazu Morita , Aiko Ono , Atsushi Serizawa , Hiroshi Kawakami
IPC分类号： C12Q1/00
CPC分类号： G01N33/6848 , G01N30/7233 , G01N2030/8831
摘要： A determination method quantifies a specific protein or peptide contained in a trace amount with high accuracy and in a simple manner without the need of using any expensive reagent. A protein or peptide of interest can be quantified by LC/MS/MS by using, as an internal standard, a protein or peptide including an amino acid sequence having the reshuffling the binding order of amino acid residues in the amino acid sequence for the protein or peptide of interest.
摘要翻译：测定方法以高精度和简单的方式量化痕量含有的特定蛋白质或肽，而不需要使用任何昂贵的试剂。通过使用作为内标的蛋白质或肽，可以通过LC / MS / MS来定量蛋白质或肽，所述蛋白质或肽包含具有重排洗涤蛋白质的氨基酸序列中的氨基酸残基的结合顺序的氨基酸序列或感兴趣的肽。

2. 发明申请

US20110039287A1 METHOD FOR QUANTIFICATION OF PEPTIDE AND PROTEIN 有权
标题翻译：肽和蛋白质的定量方法
公开(公告)号：US20110039287A1
公开(公告)日：2011-02-17
申请号：US12521632
申请日：2007-12-27
申请人： Yoshikazu Morita , Aiko Ono , Atsushi Serizawa , Hiroshi Kawakami
发明人： Yoshikazu Morita , Aiko Ono , Atsushi Serizawa , Hiroshi Kawakami
IPC分类号： C12Q1/44 , C12Q1/28 , B01D59/44
CPC分类号： G01N33/6848 , G01N30/7233 , G01N2030/8831
摘要： A determination method quantifies a specific protein or peptide contained in a trace amount with high accuracy and in a simple manner without the need of using any expensive reagent. A protein or peptide of interest can be quantified by LC/MS/MS by using, as an internal standard, a protein or peptide including an amino acid sequence having the reshuffling the binding order of amino acid residues in the amino acid sequence for the protein or peptide of interest.
摘要翻译：测定方法以高精度和简单的方式量化痕量含有的特定蛋白质或肽，而不需要使用任何昂贵的试剂。通过使用作为内标的蛋白质或肽，可以通过LC / MS / MS来定量蛋白质或肽，所述蛋白质或肽包含具有重排洗涤蛋白质的氨基酸序列中的氨基酸残基的结合顺序的氨基酸序列或感兴趣的肽。

3. 发明申请

US20100099848A1 RANKL PRODUCTION INHIBITOR 审中-公开
标题翻译： RANKL生产抑制剂
公开(公告)号：US20100099848A1
公开(公告)日：2010-04-22
申请号：US12529660
申请日：2008-02-29
申请人： Aiko Ono , Atsushi Serizawa , Yoshikazu Morita , Hiroshi Kawakami
发明人： Aiko Ono , Atsushi Serizawa , Yoshikazu Morita , Hiroshi Kawakami
IPC分类号： C07K14/00
CPC分类号： A61K38/018 , A23K20/147 , A23L33/19 , A23V2002/00 , A23V2200/306 , A23V2200/324 , A23V2250/5424
摘要： The production of RANKL may be inhibited by orally ingesting a milk-derived basic protein. Thus, a RANKL production inhibitor containing a milk-derived basic protein fraction as an active ingredient; a therapeutic agent for a metabolic bone disease and a therapeutic agent for an immune disease each containing the RANKL production inhibitor; and a food/beverage and a feed each containing a specified amount of the RANKL production inhibitor and being characterized by inhibiting the production of RANKL have a remarkable effect of inhibiting the production of RANKL, can be ingested on a daily basis, and exhibit high safety even when being ingested over a long period.
摘要翻译：通过口服摄取乳源性碱性蛋白质可以抑制RANKL的产生。因此，含有乳衍生的碱性蛋白质级分作为活性成分的RANKL产生抑制剂; 每种含有RANKL产生抑制剂的代谢骨疾病治疗剂和免疫疾病治疗剂; 并且每种含有特定量的RANKL产生抑制剂的食品/饮料和饲料，其特征在于抑制RANKL的产生具有显着的抑制RANKL产生的作用，可以每天摄取并显示高安全性即使长时间摄入也是如此。

4. 发明申请

US20060228345A1 Osteogenesis promoter 审中-公开
标题翻译：成骨启动子
公开(公告)号：US20060228345A1
公开(公告)日：2006-10-12
申请号：US10566711
申请日：2004-08-13
申请人： Mutsumi Motouri , Hiroaki Matsuyama , Yoshikazu Morita , Atsushi Serizawa , Hiroshi Kawakami
发明人： Mutsumi Motouri , Hiroaki Matsuyama , Yoshikazu Morita , Atsushi Serizawa , Hiroshi Kawakami
IPC分类号： A61K38/44 , A61K47/00
CPC分类号： C12Y111/01007 , A23K20/189 , A23L33/19 , A23V2002/00 , A61K38/44 , A23V2250/5425 , A23V2200/306
摘要： It is intended to provide an osteogenesis promoter capable of promoting osteogenesis by promoting the differentiation of osteoblasts, and foods, drinks, drugs or feeds for promoting osteogenesis. Namely, an osteogenesis promoter capable of promoting osteogenesis by promoting the differentiation of osteoblasts which comprises, as the active ingredient, lactoperoxidase and/or a digestion product obtained by digesting lactoperoxidase with a protease such as trypsin; and foods, drinks, drugs or feeds for promoting osteogenesis containing lactoperoxidase and/or its digestion product.
摘要翻译：旨在通过促进成骨细胞和用于促进成骨的食物，饮料，药物或饲料的分化来提供能够促进成骨的骨形成促进剂。即，通过促进成骨细胞的分化来促进成骨的成骨促进剂，其包含作为活性成分的乳过氧化物酶和/或通过用蛋白酶如胰蛋白酶消化乳过氧化物酶获得的消化产物; 以及用于促进含有过氧化物酶和/或其消化产物的成骨的食物，饮料，药物或饲料。

5. 发明申请

US20080206226A1 AGENT FOR PROMOTING OSTEOGENESIS AND/OR INHIBITING BONE RESORPTION 审中-公开
标题翻译：促进骨质疏松和/或抑制骨质疏松症的药剂
公开(公告)号：US20080206226A1
公开(公告)日：2008-08-28
申请号：US12102552
申请日：2008-04-14
申请人： Yoshikazu Morita , Atsushi Serizawa , Hiroaki Matsuyama , Mutsumi Motouri , Hiroshi Kawakami
发明人： Yoshikazu Morita , Atsushi Serizawa , Hiroaki Matsuyama , Mutsumi Motouri , Hiroshi Kawakami
IPC分类号： A61K38/48 , A61P19/08
CPC分类号： A61K38/1729 , A23K20/147 , A23K20/189 , A23L33/17 , A61K38/1725
摘要： Provided is a novel agent for promoting osteogenesis and/or inhibiting bone resorption, which: can be directly taken from daily meals by mouth for long periods without any trouble in taste; directly impart a promoting effect on osteogenesis and an inhibiting effect on bone resorption to the bone; and can be expected to have therapeutic effects for preventing or ameliorating/treating various bone diseases. The above agent includes, as an active ingredient, any one or more of β2-microglobulin, histone, complement component 3, monocyte chemotactic protein 1, lysozyme, ribonuclease, prothrombin, cytochrome P-450, plasminogen, transferrin, thrombin, plasmin, complement component 4, and β defensin, and enzymatic digestion products thereof. Those substances have a remarkable inhibiting effect on bone resorption by osteoclasts and/or a promoting effect on osteogenesis via promotion of the proliferation and differentiation of osteoblasts.
摘要翻译：本发明提供一种用于促进成骨和/或抑制骨吸收的新型药剂，其可以直接从日常饮食中口服长时间，没有任何麻烦的味道; 直接对骨骼发生促进作用，对骨吸收骨骼具有抑制作用; 并且可以预期具有预防或改善/治疗各种骨疾病的治疗效果。作为活性成分，上述试剂包含β2 - 亚微球蛋白，组蛋白，补体成分3，单核细胞趋化蛋白1，溶菌酶，核糖核酸酶，凝血酶原，细胞色素P-450，纤溶酶原中的任何一种或多种，转铁蛋白，凝血酶，纤溶酶，补体成分4和β防御素及其酶消化产物。这些物质通过促进成骨细胞的增殖和分化对破骨细胞的骨吸收和/或对成骨的促进作用具有显着的抑制作用。

6. 发明申请

US20060286084A1 Agent for promoting osteogenesis and/or inhibiting bone resorption 审中-公开
标题翻译：用于促进成骨和/或抑制骨吸收的药剂
公开(公告)号：US20060286084A1
公开(公告)日：2006-12-21
申请号：US10573776
申请日：2004-09-30
申请人： Yoshikazu Morita , Atsushi Serizawa , Hiroaki Matsuyama , Mutsumi Motouri , Hiroshi Kawakami
发明人： Yoshikazu Morita , Atsushi Serizawa , Hiroaki Matsuyama , Mutsumi Motouri , Hiroshi Kawakami
IPC分类号： A61K38/54 , A61K38/48
CPC分类号： A61K38/1729 , A23K20/147 , A23K20/189 , A23L33/17 , A61K38/1725
摘要： Provided is a novel agent for promoting osteogenesis and/or inhibiting bone resorption, which: can be directly taken from daily meals by mouth for long periods without any trouble in taste; directly impart a promoting effect on osteogenesis and an inhibiting effect on bone resorption to the bone; and can be expected to have therapeutic effects for preventing or ameliorating/treating various bone diseases. The above agent includes, as an active ingredient, any one or more of β2-microglobulin, histone, complement component 3, monocyte chemotactic protein 1, lysozyme, ribonuclease, prothrombin, cytochrome P-450, plasminogen, transferrin, thrombin, plasmin, complement component 4, and β defensin, and enzymatic digestion products thereof. Those substances have a remarkable inhibiting effect on bone resorption by osteoclasts and/or a promoting effect on osteogenesis via promotion of the proliferation and differentiation of osteoblasts.
摘要翻译：本发明提供一种用于促进成骨和/或抑制骨吸收的新型药剂，其可以直接从日常饮食中口服长时间，没有任何麻烦的味道; 直接对骨骼发生促进作用，对骨吸收骨骼具有抑制作用; 并且可以预期具有预防或改善/治疗各种骨疾病的治疗效果。作为活性成分，上述试剂包含β2 - 亚微球蛋白，组蛋白，补体成分3，单核细胞趋化蛋白1，溶菌酶，核糖核酸酶，凝血酶原，细胞色素P-450，纤溶酶原中的任何一种或多种，转铁蛋白，凝血酶，纤溶酶，补体成分4和β防御素及其酶消化产物。这些物质通过促进成骨细胞的增殖和分化对破骨细胞的骨吸收和/或对成骨的促进作用具有显着的抑制作用。

7. 发明授权

US08647619B2 Osteogenesis promoter 有权
标题翻译：成骨启动子
公开(公告)号：US08647619B2
公开(公告)日：2014-02-11
申请号：US12573413
申请日：2009-10-05
申请人： Mutsumi Motouri , Hiroaki Matsuyama , Yoshikazu Morita , Atsushi Serizawa , Hiroshi Kawakami
发明人： Mutsumi Motouri , Hiroaki Matsuyama , Yoshikazu Morita , Atsushi Serizawa , Hiroshi Kawakami
IPC分类号： A61K38/43
CPC分类号： C12Y111/01007 , A23K20/189 , A23K50/10 , A23K50/40 , A23L33/19 , A23V2002/00 , A61K38/44 , A23V2250/5425 , A23V2200/306
摘要： It is intended to provide an osteogenesis promoter capable of promoting osteogenesis by promoting the differentiation of osteoblasts, and foods, drinks, drugs or feeds for promoting osteogenesis. Namely, an osteogenesis promoter capable of promoting osteogenesis by promoting the differentiation of osteoblasts which comprises, as the active ingredient, lactoperoxidase and/or a digestion product obtained by digesting lactoperoxidase with a protease such as trypsin; and foods, drinks, drugs or feeds for promoting osteogenesis containing lactoperoxidase and/or its digestion product.
摘要翻译：旨在通过促进成骨细胞和用于促进成骨的食物，饮料，药物或饲料的分化来提供能够促进成骨的骨形成促进剂。即，通过促进成骨细胞的分化来促进成骨的成骨促进剂，其包含作为活性成分的乳过氧化物酶和/或通过用蛋白酶如胰蛋白酶消化乳过氧化物酶获得的消化产物; 以及用于促进含有过氧化物酶和/或其消化产物的成骨的食物，饮料，药物或饲料。

8. 发明授权

US08207131B2 Peptide 有权
标题翻译：肽
公开(公告)号：US08207131B2
公开(公告)日：2012-06-26
申请号：US12298190
申请日：2007-04-25
申请人： Yukiko Kunieda , Satoshi Higurashi , Mutsumi Motouri , Hiroaki Matsuyama , Atsushi Serizawa , Hiroshi Kawakami
发明人： Yukiko Kunieda , Satoshi Higurashi , Mutsumi Motouri , Hiroaki Matsuyama , Atsushi Serizawa , Hiroshi Kawakami
IPC分类号： A61K38/08 , A61K38/06 , A61K38/07 , A61K38/04 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00
CPC分类号： C07K5/1024 , A21D2/26 , A21D2/268 , A23C9/1544 , A23C19/082 , A23C19/086 , A23K20/147 , A23K50/40 , A23L2/02 , A23L2/52 , A23L33/18 , A61K38/00 , C07K7/06
摘要： The present invention relates to a peptide that is derived from a milk protein and has an antioxidative effect, an antioxidant that includes the peptide as an active ingredient, and an antioxidative food, drink, or feed that includes the peptide. The present invention also relates to a peptide that is derived from a milk protein and has an adiponectin production promotion effect, an adiponectin production promoter that includes the peptide as an active ingredient, and an adiponectin production promotion food, drink, or feed that includes the peptide. The present invention further relates to a blood adiponectin level increase promotion and/or decrease inhibition agent that includes a component contained in cheese as an active ingredient, and a blood adiponectin level increase promotion and/or decrease inhibition food or drink that includes a component contained in cheese. The present invention to the peptide that consists of an amino acid sequence shown by His-Pro-Ile-Lys-His-Gln-Gly-Leu-Pro-Gln (1), His-Pro-Ile-Lys (2) or His-Gln-Gly-Leu-Pro-Gln (3), and has an antioxidative effect.
摘要翻译：本发明涉及一种衍生自乳蛋白并具有抗氧化作用的肽，包含该肽作为活性成分的抗氧化剂和包含该肽的抗氧化食品，饮料或饲料。本发明还涉及一种衍生自乳蛋白质并具有脂联素生产促进作用的肽，包含该肽作为活性成分的脂联素生产促进剂，以及含有所述脂联素生产促进食品，饮料或饲料肽。本发明还涉及包含酪乳中含有的成分作为活性成分的血液脂联素含量增加促进和/或减少抑制剂，并且血液脂联素水平升高促进和/或减少抑制食品或饮料，其包含含有在奶酪里本发明涉及由His-Pro-Ile-Lys-His-Gln-Gly-Leu-Pro-Gln（1），His-Pro-Ile-Lys（2）或His -Gln-Gly-Leu-Pro-Gln（3），具有抗氧化作用。

9. 发明申请

US20100075909A1 PEPTIDE 有权
标题翻译：肽
公开(公告)号：US20100075909A1
公开(公告)日：2010-03-25
申请号：US12298190
申请日：2007-04-25
申请人： Yukiko Kunieda , Satoshi Higurashi , Mutsumi Motouri , Hiroki Matsuyama , Atsushi Serizawa , Hiroshi Kawakami
发明人： Yukiko Kunieda , Satoshi Higurashi , Mutsumi Motouri , Hiroki Matsuyama , Atsushi Serizawa , Hiroshi Kawakami
IPC分类号： A61K38/08 , C07K7/06 , C07K5/10 , A61K38/07 , A61P3/00
CPC分类号： C07K5/1024 , A21D2/26 , A21D2/268 , A23C9/1544 , A23C19/082 , A23C19/086 , A23K20/147 , A23K50/40 , A23L2/02 , A23L2/52 , A23L33/18 , A61K38/00 , C07K7/06
摘要： The present invention relates to a peptide that is derived from a milk protein and has an antioxidative effect, an antioxidant that includes the peptide as an active ingredient, and an antioxidative food, drink, or feed that includes the peptide. The present invention also relates to a peptide that is derived from a milk protein and has an adiponectin production promotion effect, an adiponectin production promoter that includes the peptide as an active ingredient, and an adiponectin production promotion food, drink, or feed that includes the peptide. The present invention further relates to a blood adiponectin level increase promotion and/or decrease inhibition agent that includes a component contained in cheese as an active ingredient, and a blood adiponectin level increase promotion and/or decrease inhibition food or drink that includes a component contained in cheese. The present invention to the peptide that consists of an amino acid sequence shown by His-Pro-Ile-Lys-His-Gln-Gly-Leu-Pro-Gln (1), His-Pro-Ile-Lys (2) or His-Gln-Gly-Leu-Pro-Gln (3), and has an antioxidative effect.
摘要翻译：本发明涉及一种衍生自乳蛋白并具有抗氧化作用的肽，包含该肽作为活性成分的抗氧化剂和包含该肽的抗氧化食品，饮料或饲料。本发明还涉及一种衍生自乳蛋白质并具有脂联素生产促进作用的肽，包含该肽作为活性成分的脂联素生产促进剂，以及包含该蛋白质的脂联素生产促进食品，饮料或饲料肽。本发明还涉及包含酪乳中含有的成分作为活性成分的血液脂联素含量增加促进和/或减少抑制剂，并且血液脂联素水平升高促进和/或减少抑制食品或饮料，其包含含有在奶酪里本发明涉及由His-Pro-Ile-Lys-His-Gln-Gly-Leu-Pro-Gln（1），His-Pro-Ile-Lys（2）或His -Gln-Gly-Leu-Pro-Gln（3），具有抗氧化作用。

10. 发明授权

US06649590B2 Method of producing fractions containing a high concentration of milk basic cystatin and decomposition products thereof 有权
$Method of producing fractions containing a high concentration of milk basic cystatin and decomposition products thereof$
标题翻译：制备含有高浓度的乳碱性半胱氨酸蛋白酶抑制剂及其分解产物的级分的方法
公开(公告)号：US06649590B2
公开(公告)日：2003-11-18
申请号：US09876267
申请日：2001-06-06
申请人： Yukihiro Takada , Atsushi Serizawa , Yasuhiro Matsuoka , Yasuhiro Toba , Hiroshi Kawakami
发明人： Yukihiro Takada , Atsushi Serizawa , Yasuhiro Matsuoka , Yasuhiro Toba , Hiroshi Kawakami
IPC分类号： A61K3800
CPC分类号： A61K35/20 , A21D2/263 , A21D13/80 , A23C9/1307 , A23C19/082 , A23J1/20 , A23J3/08 , A23J3/343 , A23K20/147 , A23K20/174 , A23K20/22 , A23L33/19
摘要： A milk basic protein fraction is heated if necessary, the resulting precipitate is removed to recover the resulting supernatant, alcohol is added to this supernatant, a fraction containing a high concentration of milk basic cystatin is recovered by removing the resulting precipitate and brought into contact with a carrier containing a sulfuric acid group, such as heparin, to recover a fraction which is not adsorbed onto the carrier, and this fraction is then treated with an ultrafiltration membrane having an cut-off molecular weight of 10-50 kDa to recover the permeate to produce a fraction containing a high concentration of milk basic cystatin. Alternatively, a milk-derived basic protein composition is brought into contact with an anion exchange resin to recover a fraction which is not adsorbed onto the resin, after which this fraction is brought into contact with a cation exchange resin to recover the target fraction by eluting a fraction which is adsorbed onto the resin with an eluent to produce a fraction containing a high concentration of milk basic cystatin. Further, a decomposition product of the fraction containing a high concentration of milk basic cystatin is produced by decomposing this fraction containing a high concentration of milk basic cystatin with protease.
摘要翻译：如果需要，加热牛奶碱性蛋白质级分，除去所得沉淀物以回收所得上清液，向该上清液中加入醇，通过除去所得沉淀物并与之接触，回收含有高浓度的乳碱性半胱氨酸蛋白酶的级分含有硫酸基的载体如肝素，以回收未吸附到载体上的级分，然后用截留分子量为10-50kDa的超滤膜处理该级分以回收渗透物以产生含有高浓度的牛奶碱性半胱氨酸蛋白酶的部分。或者，将乳衍生的碱性蛋白质组合物与阴离子交换树脂接触以回收未吸附到树脂上的级分，之后使该级分与阳离子交换树脂接触，以通过洗脱来回收目标级分用洗脱液吸附到树脂上的一部分，以产生含有高浓度的乳碱性半胱氨酸蛋白酶的部分。此外，含有高浓度的乳碱性半胱氨酸蛋白酶抑制剂的级分的分解产物是通过将含有高浓度的乳碱性半胱氨酸蛋白酶的部分用蛋白酶分解而产生的。

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