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    • 10. 发明授权
    • Titania fine-particle composite and compositions containing the titania fine-particle composite
    • 二氧化钛微粒复合材料和含有二氧化钛微粒复合材料的组合物
    • US08945520B2
    • 2015-02-03
    • US12989145
    • 2009-04-28
    • Eiji Takahashi
    • Eiji Takahashi
    • A61K8/29A61Q17/04C09C1/36A61K8/11A61K8/362A61K8/39A61K8/81B82Y30/00A61Q1/02
    • A61K8/8147A61K8/0241A61K8/11A61K8/29A61K8/345A61K8/362A61K8/39A61K8/8164A61K2800/412A61Q1/02A61Q17/04B82Y30/00C01P2002/82C01P2004/64C01P2006/22C09C1/3661C09C1/3669C09C1/3676C09C1/3692
    • Provided are a novel titania fine-particle composite which has high transparency, high stability, and high ultraviolet-absorbing power and excellent redispersibility, and skin-care external preparations which contain the titania fine-particle composite and exert high ultraviolet protective effect. The titania fine-particle composite can be produced by adding one or more selected from among carboxylic acids and carboxylic acid derivatives represented by general formula (1), and polymers containing the carboxylic acids or carboxylic acid derivatives as a constituent monomer to an aqueous acid dispersion of titania fine particles, and neutralizing the resulting dispersion with an alkali to form a titania fine-particle composite composed of titania fine particles functioning as cores and the carboxylic monomer or polymer deposited on the surface of the cores. In the titania fine-particle composite, titania fine particles functioning as cores have a high degree of crystallization and the intermolecular interaction between titania fine particles and the carboxylic monomer or polymer is strong. Therefore, the titania fine-particle composite can be uniformly dispersed in a dispersion medium to attain high transparency and high stability. Further, skin-care external preparations which exert high ultraviolet protective effect can be produced by adding the titania fine-particle composite.
    • 提供了具有高透明度,高稳定性,高紫外线吸收力和优异的再分散性的新型二氧化钛微粒复合体,以及含有二氧化钛微粒复合体并具有高紫外线保护作用的护肤外用剂。 二氧化钛微粒复合体可以通过将选自由通式(1)表示的羧酸和羧酸衍生物中的一种或多种,​​以及含有羧酸或羧酸衍生物作为构成单体的聚合物加入到酸性分散体 的二氧化钛细颗粒,并用碱中和所得分散体以形成由作为核心的二氧化钛细颗粒和沉积在芯的表面上的羧基单体或聚合物组成的二氧化钛微粒复合体。 在二氧化钛微粒复合体中,作为芯的二氧化钛微粒具有高结晶度,二氧化钛微粒与羧酸单体或聚合物之间的分子间相互作用强。 因此,可以将二氧化钛微粒复合体均匀地分散在分散介质中,以获得高透明性和高稳定性。 此外,通过添加二氧化钛微粒复合体可以制造出具有高紫外线保护作用的护肤外用制剂。