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    • 3. 发明授权
    • Process for producing 3',5'-cyclic adenylic acid
    • 制备3 {40,5 {40-环腺苷酸
    • US4028184A
    • 1977-06-07
    • US673067
    • 1976-04-02
    • Jiro IshiyamaMotohiko KatoFumihiko YoshidaTamotsu Yokotsuka
    • Jiro IshiyamaMotohiko KatoFumihiko YoshidaTamotsu Yokotsuka
    • C12P19/32C12D13/06
    • C12P19/32Y10S435/803Y10S435/822Y10S435/83Y10S435/843
    • A process for producing 3',5'-cyclic adenylic acid in a high yield at a lower price by culturing a strain belonging to the genus selected from the group consisting of Corynebacterium, Arthrobacter and Microbacterium such as, for example, Corynebacterium murisepticum No. 7-10 (ATCC 21977), Arthrobacter 11-211 (ATCC 21978) Microbacterium No. 205-CM7 (ATCC 21979), Microbacterium No. 205-CM-XA3 (ATCC 21980), or Microbacterium No. 205-MP-197 (ATCC 21976) in a medium containing nutrient sources such as, carbon sources, nitrogen sources, inorganic salts and the like but containing no precursors and having a pH of 5-9 at a temperature of 20.degree.-40.degree. C under aerobic condition. The obtained 3',5'-cyclic adenylic acid is well-known for its participation in various biochemical reactions in vivo and for its active role as a mediator to various hormones. It has therefore always been highly evaluated biochemical reagent.
    • 通过培养属于选自棒状杆菌属,节杆菌属和微杆菌属的菌株,例如例如鼠尾草杆菌(Corynebacterium murisepticum No.),以较低的价格生产3',5'-环腺嘌呤酸的方法,以较低的价格生产。 7-10(ATCC 21977),节节杆菌11-211(ATCC 21978)细菌杆菌205-CM7(ATCC 21979),细菌细菌编号205-CM-XA3(ATCC 21980)或微杆菌205-MP-197( ATCC 21976)在含有营养源如碳源,氮源,无机盐等的培养基中,但不含前体,在需氧条件下,在20℃-40℃下pH为5-9。 获得的3',5'-环腺苷酸因其在体内参与各种生物化学反应以及作为各种激素介导物的活性而众所周知。 因此,它一直被高度评价生化试剂。