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1. 发明授权

US3941770A Method for purifying 3',5'-cyclic-adenylic acid or 3',5'-cyclic-deoxyadenylic acid 失效
标题翻译：纯化3 {40,5 {40-环 - 腺苷酸或3 {40,5 {40-环 - 脱氧腺苷酸
公开(公告)号：US3941770A
公开(公告)日：1976-03-02
申请号：US422566
申请日：1973-12-06
申请人： Jiro Ishiyama , Tamotsu Yokotsuka , Motohiko Kato , Nobuyuki Yamaji , Fumihiko Yoshida
发明人： Jiro Ishiyama , Tamotsu Yokotsuka , Motohiko Kato , Nobuyuki Yamaji , Fumihiko Yoshida
IPC分类号： C07H19/213 , C07H19/20 , C12P19/32
CPC分类号： C07H19/20
摘要： 3' ,5'-Cyclic-adenylic acid or 3' ,5'-cyclic-deoxadenylic acid can be obtained in a high purity and a high yield by adding a water-soluble organic solvent such as methyl alcohol, ethyl alcohol, n-propyl alcohol, isopropyl alcohol, tert-butyl alcohol, acetone, N,N'-dimethylformamide, dioxane, tetrahydrafuran, ethyleneglycolmonomethylether and the like singly or in combination to an aqueous solution containing as impurities one or more kinds of nucleotides other than 3' ,5'-cyclicadenylic acid and 3' ,5'-cyclic-deoxyadenylic acid, nucleosides, nucleobases, colored substances, proteins and the like in addition to 3' ,5'-cyclic-adenylic acid or 3', 5'-cyclic-deoxyadenylic acid.The said 3' ,5'-cyclic-adenylic acid or 3' ,5'-cyclic-deoxyadenylic acid are useful and valuable as a biochemical reagent.
摘要翻译： 3'，5'-环 - 腺苷酸或3'，5'-环脱羰腺苷酸可以通过加入水溶性有机溶剂如甲醇，乙醇，正己酸，丙醇，异丙醇，叔丁醇，丙酮，N，N'-二甲基甲酰胺，二恶烷，四氢呋喃，乙二醇单甲醚等单独或组合成含有作为杂质的一种或多种以外的3'以外的核苷酸的水溶液，除了3'，5'-环腺苷酸或3'，5'-环 - 腺苷酸，3'，5'-环腺苷酸和3'，5'-环脱氧腺苷酸，核苷，核碱基，着色物质，蛋白质等，脱氧腺苷酸。

2. 发明授权

US4028184A Process for producing 3',5'-cyclic adenylic acid 失效
标题翻译：制备3 {40,5 {40-环腺苷酸
公开(公告)号：US4028184A
公开(公告)日：1977-06-07
申请号：US673067
申请日：1976-04-02
申请人： Jiro Ishiyama , Motohiko Kato , Fumihiko Yoshida , Tamotsu Yokotsuka
发明人： Jiro Ishiyama , Motohiko Kato , Fumihiko Yoshida , Tamotsu Yokotsuka
IPC分类号： C12P19/32 , C12D13/06
CPC分类号： C12P19/32 , Y10S435/803 , Y10S435/822 , Y10S435/83 , Y10S435/843
摘要： A process for producing 3',5'-cyclic adenylic acid in a high yield at a lower price by culturing a strain belonging to the genus selected from the group consisting of Corynebacterium, Arthrobacter and Microbacterium such as, for example, Corynebacterium murisepticum No. 7-10 (ATCC 21977), Arthrobacter 11-211 (ATCC 21978) Microbacterium No. 205-CM7 (ATCC 21979), Microbacterium No. 205-CM-XA3 (ATCC 21980), or Microbacterium No. 205-MP-197 (ATCC 21976) in a medium containing nutrient sources such as, carbon sources, nitrogen sources, inorganic salts and the like but containing no precursors and having a pH of 5-9 at a temperature of 20.degree.-40.degree. C under aerobic condition. The obtained 3',5'-cyclic adenylic acid is well-known for its participation in various biochemical reactions in vivo and for its active role as a mediator to various hormones. It has therefore always been highly evaluated biochemical reagent.
摘要翻译：通过培养属于选自棒状杆菌属，节杆菌属和微杆菌属的菌株，例如例如鼠尾草杆菌（Corynebacterium murisepticum No.），以较低的价格生产3'，5'-环腺嘌呤酸的方法，以较低的价格生产。 7-10（ATCC 21977），节节杆菌11-211（ATCC 21978）细菌杆菌205-CM7（ATCC 21979），细菌细菌编号205-CM-XA3（ATCC 21980）或微杆菌205-MP-197（ ATCC 21976）在含有营养源如碳源，氮源，无机盐等的培养基中，但不含前体，在需氧条件下，在20℃-40℃下pH为5-9。获得的3'，5'-环腺苷酸因其在体内参与各种生物化学反应以及作为各种激素介导物的活性而众所周知。因此，它一直被高度评价生化试剂。

3. 发明授权

US4393083A Method for producing grape must and wine 失效
标题翻译：生产葡萄酒和葡萄酒的方法
公开(公告)号：US4393083A
公开(公告)日：1983-07-12
申请号：US276497
申请日：1981-06-23
申请人： Masazumi Watanabe , Mikio Uehara , Yoshimi Shimazu , Jiro Ishiyama , Motohiko Kato
发明人： Masazumi Watanabe , Mikio Uehara , Yoshimi Shimazu , Jiro Ishiyama , Motohiko Kato
IPC分类号： C12G1/02 , C12P7/20
CPC分类号： C12G1/02
摘要： A glycerol-enriched artificially botrytized grape must is obtained by adding cyclic-3',5'-adenylic acid or cyclic-3',5'-adenylic acid derivatives to a grape must and contacting the must aerobically with the mycelia of Botrytis cineria to increase the glycerol content of the must. A noble botrytized wine is obtained by adding a wine yeast to the above artificially botrytized grape must and subjecting the must to fermentation and subsequent aging.
摘要翻译：通过向葡萄必须加入环状3'，5'-腺苷酸或环状-3'，5'-腺苷酸衍生物，并且必须与Botrytis cineria的菌丝体有机接触才能获得富含甘油的人造葡萄糖，增加必需的甘油含量。通过将葡萄酒酵母加入到上述人造葡萄葡萄中并经过发酵和随后的老化获得高贵的葡萄酒。

4. 发明授权

US4751293A Process for preparation of N.sup.6 -substituted 3',5'-cyclic adenosine monophosphate and salt thereof 失效
标题翻译：制备N6-取代的3'，5'-环腺苷一磷酸及其盐的方法
公开(公告)号：US4751293A
公开(公告)日：1988-06-14
申请号：US727062
申请日：1985-04-25
申请人： Shigehiro Kataoka , Ayako Nasu , Nobuyuki Yamaji , Motohiko Kato
发明人： Shigehiro Kataoka , Ayako Nasu , Nobuyuki Yamaji , Motohiko Kato
IPC分类号： C07H19/213 , C07H1/00 , C07H19/20 , C07H15/12 , C07H17/00
CPC分类号： C07H19/20
摘要： A method for the preparation of an N.sup.6 -substituted 3',5'-cyclic adenosine monophosphate or a salt thereof represented by the general formula ##STR1## wherein R.sub.1 represents a straight chain or branched chain alkyl group of 1 to 13 carbon atoms or an aromatic group and B.sym. represents a hydrogen ion or an alkali metal ion, which comprises allowing a 3',5'-cyclic adenosine monophosphate or a salt thereof represented by the general formula ##STR2## wherein A.sym. represents a hydrogen ion, alkali metal ion, organic ammonium ion, or ammonium ion, to react with an aldehyde represented by the general formulaR.sub.1 CHO (III)wherein R.sub.1 is as defined above, under the conditions such that pH is 7.0 or below, the temperature is -10.degree. to 120.degree. C., and the molar ratio of the compound (II) to the compound (III) is 1:1-40, and reducing the resulting compound with a metal hydride or nascent hydrogen.
摘要翻译：一种制备由通式（I）表示的N6-取代的3'，5'-环腺苷一磷酸或其盐的方法，其中R 1表示1至13个碳的直链或支链烷基原子或芳基，B（+）表示氢离子或碱金属离子，其包括使通式（II）表示的3'，5'-环腺苷一磷酸或其盐，其中A （+）表示氢离子，碱金属离子，有机铵离子或铵离子，在通式R 1 CHO（III）表示的醛中，其中R 1如上定义，在pH为7.0或温度为-10℃〜120℃，化合物（II）与化合物（III）的摩尔比为1:1-40，用金属氢化物或新生氢还原所得化合物。

5. 发明授权

US4458067A Process for producing N.sup.6,O.sup.2' -diacyladenosine-3',5'-cyclic phosphoric ester alkali metal salts 失效
标题翻译：制备N6，O2'-二酰基腺苷-3'，5'-环磷酸酯碱金属盐的方法
公开(公告)号：US4458067A
公开(公告)日：1984-07-03
申请号：US336612
申请日：1981-12-30
申请人： Nobuyuki Yamaji , Kyoko Tahara , Motohiko Kato
发明人： Nobuyuki Yamaji , Kyoko Tahara , Motohiko Kato
IPC分类号： C07H19/213 , C07H15/20 , C07H15/12 , C07H17/00
CPC分类号： C07H15/20
摘要： An N.sup.6,O.sup.2' -diacyladenosine-3',5'-cyclic phosphoric ester alkali metal salt can be obtained with ease and in a high yield by reacting an adenosine-3',5'-cyclic phosphoric ester alkali metal salt with a carboxylic anhydride having 4 or less carbon atoms at a temperature of 70.degree. C. or above.
摘要翻译：通过使腺苷-3'，5'-环磷酸酯碱金属盐与羧酸反应，可以容易且高产率地获得N6，O 2'-二酰基腺苷-3'，5'-环磷酸酯碱金属盐在70℃以上的温度下具有4个以下碳原子的酸酐。

6. 发明授权

US5246922A N.sup.6,N.sup.6 -disubstituted-cyclic adenosine-3',5'-monophosphates and pharmacutical compositions 失效
标题翻译： N6，N6-二取代 - 环腺苷-3'，5'-单磷酸酯和药物组合物
公开(公告)号：US5246922A
公开(公告)日：1993-09-21
申请号：US571188
申请日：1990-08-23
申请人： Shigehiro Kataoka , Nobuyuki Yamaji , Motohiko Kato , Shoichi Imai
发明人： Shigehiro Kataoka , Nobuyuki Yamaji , Motohiko Kato , Shoichi Imai
IPC分类号： C07H19/213 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61P9/04 , C07H19/20
CPC分类号： C07H19/20 , Y02P20/55
摘要： The present invention relates to a N.sup.6,N.sup.6 -disubstituted-cyclic adenosine-3',5'-monophosphate represented by the formula ##STR1## wherein R represents a linear alkyl group having 3 or more carbon atoms or a branched alkyl group having 4 or more carbon atoms, an aralkyl group or an alkenyl group; A.sup..sym. represents a hydrogen ion, an alkali metal ion, an alkaline earth metal ion, an ammonium ion or an organoammonium ion, or a salt thereof, and a cardiac composition comprising it as an effective component, and further includes a process for preparing a compound represented by the formula ##STR2## wherein R.sub.1 represents an alkyl group, an aralkyl group or an alkenyl group and A.sup..sym. has the same meanings as defined above, or a salt thereof, characterized in that a 2'-O-protected-cyclic adenosine-3',5'-monophosphate represented by the formula ##STR3## wherein Y represents a protecting group and A.sup..sym. has the same meanings as defined above, or a salt thereof is reacted with an organic halide represented by the formulaR.sub.1 X (III) wherein X represents a halogen atom and R.sub.1 has the same meanings as defined above, and the protecting group is then removed.
摘要翻译：本发明涉及由式（I）表示的N6，N6-二取代环腺苷-3'，5'-单磷酸酯，其中R表示具有3个或更多个碳原子的直链烷基或支链烷基具有4个或更多个碳原子，芳烷基或烯基; A（+）表示氢离子，碱金属离子，碱土金属离子，铵离子或有机铵离子或其盐，以及包含其作为有效成分的心脏组合物，还包括制备由式（I'）表示的化合物，其中R 1表示烷基，芳烷基或烯基，A（+）具有与上述相同的含义或其盐，其特征在于，或其盐，其中Y表示保护基，A（+）与上述相同的含义，由式（II）表示的2'-O-保护环腺苷-3'，5'-单磷酸与式R1X（III）表示的有机卤化物反应，其中X表示卤素原子，R 1具有与上述相同的含义，然后除去保护基。

7. 发明授权

US4902677A Treatment of heart failure of mammals with N.sup.6 -substituted cyclic adenosine monophosphates 失效
标题翻译：用N6-取代的环状腺苷单磷酸酯治疗哺乳动物的心力衰竭
公开(公告)号：US4902677A
公开(公告)日：1990-02-20
申请号：US159747
申请日：1988-02-24
申请人： Shoichi Imai , Shigehiro Kataoka , Junko Isono , Nobuyuki Yamaji , Motohiko Kato
发明人： Shoichi Imai , Shigehiro Kataoka , Junko Isono , Nobuyuki Yamaji , Motohiko Kato
IPC分类号： C07H19/213 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61P9/04 , C07H19/20
CPC分类号： C07H19/20
摘要： A composition for use in the treatment of heart failure of mammals which comprises, as its active ingredient, an N.sup.6 -substututed-adenosine-3',5'-cyclic phosphate represented by the following general formula (I) or a physiologically acceptable salt thereof: ##STR1## wherein R represents alkyl or aralkyl group and a pharmaceutically acceptable carrier, as well as a method for treating heart failure of mammals which comprises administering said composition.
摘要翻译：一种用于治疗哺乳动物心力衰竭的组合物，其包含作为其活性成分的由以下通式（I）表示的N 6 - 亚基 - 腺苷-3'，5'-环磷酸酯或其生理学上可接受的盐：其中R表示烷基或芳烷基和药学上可接受的载体，以及用于治疗哺乳动物心力衰竭的方法，其包括施用所述组合物。

8. 发明授权

US4401808A Adenosine cyclic 3',5'-phosphate triesters and the acid addition salts thereof, and process for production thereof 失效
标题翻译：腺苷环3'，5'-磷酸三酯及其酸加成盐及其生产方法
公开(公告)号：US4401808A
公开(公告)日：1983-08-30
申请号：US317282
申请日：1981-11-02
申请人： Nobuyuki Yamaji , Motohiko Kato
发明人： Nobuyuki Yamaji , Motohiko Kato
IPC分类号： C07H19/213 , C07H19/20 , C07H19/00
CPC分类号： C07H19/20
摘要： Triesters of adenosine cyclic 3',5'-phosphoric acid having cardiotonic, diuretic and anti-tumor activities represented by the following formula ##STR1## wherein R represents a linear or branched alkyl group having 5 to 15 carbon atoms, and the acid addition salts thereof; and a process for production thereof.
摘要翻译：具有由下式表示的强心，利尿和抗肿瘤活性的腺苷环状3'，5'-磷酸的转化体，其中R表示碳原子数为5〜15的直链或支链烷基，酸加成盐的; 及其制造方法。

9. 发明授权

US4887758A Apparatus for connecting external leads 失效
标题翻译：用于连接外部引线的装置
公开(公告)号：US4887758A
公开(公告)日：1989-12-19
申请号：US302473
申请日：1989-01-26
申请人： Yasunobu Suzuki , Motohiko Kato , Akio Bando , Hisao Ishida , Akihiro Nishimura
发明人： Yasunobu Suzuki , Motohiko Kato , Akio Bando , Hisao Ishida , Akihiro Nishimura
IPC分类号： H01L21/60 , H01L21/00
CPC分类号： H01L21/67138 , H01L24/97 , H01L2224/50
摘要： An apparatus for connecting or bonding leads of solid-state devices to lead frames, etc. in which a solid-state device punched out of a film carrier by a punch is first picked up and held by a suction-adhesion head. A raising and lowering arm is then driven longitudinally and laterally so that the suction-adhesion head with the solid-state device thereon is moved to a position over a first bonding station. Then, the raising and lowering arm is lowered via a vertical driving mechanism, and the solid-state device held by the suction-adhesion head is pressed against a specified lead frame. A first bonding tool is lowered and simultaneously bonds the leads on two opposite sides of the solid-state device to the lead frame. Then, the first bonding tool is raised, and the suction-adhesion head is raised and moves back to a position over the punch. The lead frame to which two sides of the solid-state device have been thus bonded is fed, and at a second bonding position, the leads on the other two opposite sides of the solid-state device are bonded to the lead frame by a second bonding tool.
摘要翻译：用于将固态器件的引线连接或接合到引线框架等的装置，其中通过冲头从薄膜载体冲出的固态装置首先由吸附粘合头拾起并保持。然后将升降臂纵向和横向地驱动，使得其上具有固态装置的吸附粘合头移动到第一粘结台上方的位置。然后，升降臂通过垂直驱动机构降低，由吸附粘合头保持的固态装置压靠指定的引线框架。第一接合工具被降低并且同时将固态器件的两个相对侧上的引线键合到引线框架。然后，第一接合工具被升高，并且吸附粘合头被升高并且移回到冲头上方的位置。馈送固态器件的两侧的引线框架，并且在第二接合位置，固态器件的另外两个相对侧上的引线被连接到引线框架上粘接工具。

10. 发明授权

US06449516B1 Bonding method and apparatus 有权
标题翻译：粘合方法和装置
公开(公告)号：US06449516B1
公开(公告)日：2002-09-10
申请号：US09401155
申请日：1999-07-01
申请人： Ryuichi Kyomasu , Motohiko Kato
发明人： Ryuichi Kyomasu , Motohiko Kato
IPC分类号： G05B1918
CPC分类号： H01L24/78 , B23K20/004 , B23K2101/40 , B23Q15/22 , G05B2219/37555 , G05B2219/50299 , G06T7/70 , G06T2207/30141 , H01L2224/78301 , H01L2924/00014 , H01L2924/01004 , H01L2924/01005 , H01L2924/01033 , H01L2924/01039 , H01L2924/01061 , H01L2924/01082 , H01L2224/48 , H01L2224/45099 , H01L2224/05599
摘要： In a bonding method and apparatus, a position-detecting camera is moved to a point above reference marks, and the positional relationship between the reference marks and the optical axis of the position-detecting camera is measured by the position-detecting camera, a bonding tool is moved to a point above the reference marks in accordance with an amount of offset stored in memory beforehand, the positional relationships between the reference marks and the tool are measured by an offset-correcting camera, and an accurate amount of offset is determined by correcting the mount of offset stored in memory beforehand based upon such a measurement result.
摘要翻译：在接合方法和装置中，将位置检测摄像机移动到参考标记之上的位置，并且通过位置检测摄像机测量位置检测摄像机的参考标记和光轴之间的位置关系，预先根据存储在存储器中的偏移量将工具移动到参考标记之上的点，通过偏移校正照相机测量参考标记和工具之间的位置关系，并且通过以下方式确定精确的偏移量：基于这样的测量结果预先校正存储在存储器中的偏移量的位置。

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