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    • 3. 发明授权
    • Arylpiperidinol and arylpiperidine derivatives and drugs containing the same
    • 芳基哌啶醇和芳基哌啶衍生物和含有相同的药物
    • US06455549B1
    • 2002-09-24
    • US09043563
    • 1998-03-20
    • Hirokazu AnnouraKyoko NakanishiShigeki Tamura
    • Hirokazu AnnouraKyoko NakanishiShigeki Tamura
    • A61K31445
    • C07D211/44C07D211/12C07D211/14C07D211/18C07D211/52C07D211/70
    • A pharmaceutical composition, especially a pharmaceutical composition for the alleviation or treatment of symptoms due to ischemic diseases and symptoms derived from seizures, epilepsy, and migraine, and a Ca2+ overload suppressant, containing an arylpiperidinol or arylpiperidine derivative having the formula (I): wherein, R is H, an optionally substituted phenyl, an optionally substituted phenoxy, or an optionally substituted benzoyl, A is a connecting bond, a cycloalkylene, or an alkenylene optionally substituted with a lower alkyl, B is an alkylene optionally substituted with OH or an alkoxy or —NHCO(CH2)n— where n is an integer of 1 to 5, E is a connecting bond, O, or a methylene, X is OH or H provided that when E is O or a methylene, X is not H, and Y and Z are independently H, a halogen, an alkoxy, or an alkyl optionally substituted with a halogen.
    • 一种药物组合物,特别是用于缓解或治疗由于缺血性疾病引起的症状和由癫痫发作,癫痫和偏头痛引起的症状的药物组合物和含有具有式(I)的芳基哌啶醇或芳基哌啶衍生物的Ca2 +过量抑制剂:其中 R是H,任意取代的苯基,任意取代的苯氧基或任选取代的苯甲酰基,A是任选被低级烷基取代的连接键,亚环烷基或亚烯基,B是任选被OH取代的亚烷基或 烷氧基或-NHCO(CH 2)n - ,其中n为1至5的整数,E为连接键,O或亚甲基,X为OH或H,条件是当E为O或亚甲基时,X不为H ,Y和Z独立地为H,卤素,烷氧基或任选被卤素取代的烷基。
    • 4. 发明授权
    • Method of integrally attaching hollow member to cast product by casting
and apparatus therefor
    • 通过铸造将中空构件一体地安装到铸造产品上的方法及其装置
    • US5957190A
    • 1999-09-28
    • US922341
    • 1997-09-03
    • Hisaya MorishitaAkira SekiShigeki TamuraMitsuru Inui
    • Hisaya MorishitaAkira SekiShigeki TamuraMitsuru Inui
    • B22D17/22B22D19/00
    • B22D19/0072
    • In a method of integrally attaching a hollow member to a cast product by casting so that the hollow member communicates with a hollow interior of the cast product, a closure member is fitted into an open end of the hollow member so that the open end of the hollow member is closed by the closure member. The closure member projects from a core for forming the hollow interior of the cast product in a direction different from a direction in which the core is drawn out of the cast product. A molten metal is poured into a casting mold after the casting mold has been clamped. The closure member is moved inside the core after solidification of the molten metal so that the closure member is released from the fitting in the hollow member. The core is drawn out of the solidified metal subsequently to the moving step of the closure member.
    • 在通过铸造将中空构件整体地附接到铸造产品的方法中,使得中空构件与铸造产品的中空内部连通,将封闭构件装配到中空构件的开口端中,使得开口端 中空构件被封闭构件封闭。 封闭构件从用于形成铸造产品的中空内部的芯部沿与芯从铸造产品中拉出的方向不同的方向突出。 在铸模被夹紧后,将熔融金属倒入铸模中。 在熔融金属凝固之后,封闭构件在芯内移动,使得封闭构件从中空构件中的配件释放。 随后在封闭构件的移动步骤之后,将芯体从固化的金属中拉出。
    • 5. 发明授权
    • Arylpiperidinol and arylpiperidine derivatives and pharmaceuticals containing the same
    • 芳基哌啶醇和芳基哌啶衍生物和含有它们的药物
    • US07498344B2
    • 2009-03-03
    • US10799681
    • 2004-03-15
    • Hirokazu AnnouraKyoko NakanishiShigeki Tamura
    • Hirokazu AnnouraKyoko NakanishiShigeki Tamura
    • A61K31/4465C07D211/22C07D211/40
    • C07D211/44C07D211/12C07D211/14C07D211/18C07D211/52C07D211/70
    • A pharmaceutical composition, especially a pharmaceutical composition for the alleviation or treatment of symptoms due to ischemic diseases and symptoms derived from seizures, epilepsy, and migraine, and a Ca2+ overload suppressant, containing an arylpiperidinol or arylpiperidine derivative having the formula (I): wherein, R is H, an optionally substituted phenyl, an optionally substituted phenoxy, or an optionally substituted benzoyl, A is a connecting bond, a cycloalkylene, or an alkenylene optionally substituted with a lower alkyl, B is an alkylene optionally substituted with OH or an alkoxy or —NHCO(CH2)n— where n is an integer of 1 to 5, E is a connecting bond, O, or a methylene, X is OH or H provided that when E is O or a methylene, X is not H, and Y and Z are independently H, a halogen, an alkoxy, or an alkyl optionally substituted with a halogen.
    • 一种药物组合物,特别是用于缓解或治疗由于缺血性疾病引起的症状和由癫痫发作,癫痫和偏头痛引起的症状的药物组合物和含有具有式(I)的芳基哌啶醇或芳基哌啶衍生物的Ca2 +过量抑制剂:其中 R是H,任意取代的苯基,任意取代的苯氧基或任选取代的苯甲酰基,A是任选被低级烷基取代的连接键,亚环烷基或亚烯基,B是任选被OH取代的亚烷基或 烷氧基或-NHCO(CH 2)n - ,其中n为1至5的整数,E为连接键,O或亚甲基,X为OH或H,条件是当E为O或亚甲基时,X不为H ,Y和Z独立地为H,卤素,烷氧基或任选被卤素取代的烷基。
    • 7. 发明申请
    • Method and apparatus for manufacturing spark plug
    • 制造火花塞的方法和装置
    • US20050039332A1
    • 2005-02-24
    • US10921295
    • 2004-08-19
    • Syushi OdaShigeki Tamura
    • Syushi OdaShigeki Tamura
    • H01T13/20H01T21/02H01R9/00B23P19/00H05K3/00
    • H01T21/02Y10T29/49151Y10T29/49218Y10T29/5195Y10T29/53204
    • A spark plug is provided, for a provisional bending process for manufacturing the spark plug, as a work in a condition where an earth electrode is straight and substantially in parallel with an axial line of a center electrode. In the provisional bending process, two searchers individually facing the tip of the center electrode with the tip located therebetween are arranged, positions of the searchers in a first direction perpendicular to the axial line being adjusted for every spark plug. Then a bending punch is driven to press a second end-surface of the other end of the earth electrode down to the searchers so that the earth electrode is provisionally bent at a substantially perpendicular angle to the axial line, the second end-surface being opposite to the first end-surface. Preferably, before the provisional bending process, positioning the work and correcting the position and tilt of the work are performed.
    • 作为用于制造火花塞的临时弯曲加工的火花塞作为在接地电极是直的并且基本上与中心电极的轴线平行的状态下的工作。 在临时弯曲过程中,布置了两个分别面向中心电极的尖端的搜索器,其顶端位于它们之间,针对每个火花塞调整搜索器沿与轴线垂直的第一方向的位置。 然后驱动弯曲冲头将地电极的另一端的第二端面向下压到搜索器,使得接地电极以与轴线大致垂直的角度临时弯曲,第二端表面相对 到第一个端面。 优选地,在临时弯曲处理之前,执行定位工件并校正工件的位置和倾斜。
    • 8. 发明授权
    • Arylpiperidinopropanol and arylpiperazinopropanol derivatives and pharmaceuticals containing the same
    • 芳基哌啶丙醇和芳基哌嗪丙醇衍生物和含有它们的药物
    • US06407099B1
    • 2002-06-18
    • US09331712
    • 1999-06-25
    • Hirokazu AnnouraKyoko NakanishiShigeki Tamura
    • Hirokazu AnnouraKyoko NakanishiShigeki Tamura
    • A61K31495
    • C07D295/088C07C217/84C07C271/28C07D211/22C07D211/52C07D295/13Y02P20/55
    • A compound having the formula (I) or its salt, hydrate, hydrate salt or solvate: wherein R1 to R4 independently represent H, halogen, OH, alkoxy, optionally substituted alkyl, aryl, or aralkyl group, R5 represents H, optionally substituted alkyl, aryl, or aralkyl group, E1 represents O, S, or —NR6, where R6 represents H, an optionally substituted alkyl, aryl, or aralkyl group, E2 represents O, S, or —NR7, where R7 represents H, an optionally substituted alkyl, aryl, or aralkyl group, A represents CH, C(OH), or N, X represents H, halogen, alkoxy, or an optionally substituted alkyl group, and Q represents an optionally substituted phenyl group, phenoxy, phenylmethyl, or cycloalkyloxy group, where when E1 represents O or S, E2 does not represent O or S, which has an action of suppressing the cytotoxic Ca2+ overload and lipid peroxidation and effective for pharmaceutical preparation for the alleviation and treatment of symptoms due to ischemic diseases, etc.
    • 具有式(I)的化合物或其盐,水合物,水合物盐或溶剂合物:其中R 1至R 4独立地表示H,卤素,OH,烷氧基,任选取代的烷基,芳基或芳烷基,R 5表示H,任选取代的烷基 ,芳基或芳烷基,E1表示O,S或-NR6,其中R6表示H,任选取代的烷基,芳基或芳烷基,E2表示O,S或-NR7,其中R7表示H, 取代的烷基,芳基或芳烷基,A表示CH,C(OH)或N,X表示H,卤素,烷氧基或任选取代的烷基,Q表示任选取代的苯基,苯氧基,苯甲基或 环状烷氧基,当E1表示O或S时,E2不表示O或S,其具有抑制细胞毒性Ca 2+过载和脂质过氧化的作用,并且有效用于缓解和治疗由于缺血性疾病引起的症状的药物制剂等 。
    • 10. 发明授权
    • Heavy article inversion device
    • 重物反转装置
    • US07985044B2
    • 2011-07-26
    • US12373665
    • 2007-07-17
    • Shigeki Tamura
    • Shigeki Tamura
    • B21B39/24B65G47/22
    • B65G7/08B65G47/252
    • A heavy article inversion device is provided, in which the inverting operations may be performed in a short time by reducing the size of the heavy article inversion device comprising a pair of inversion boards that may be revolved about a common rotary shaft supported in the center of a base between the horizontal state and the angles of revolution of less than 180 degrees from the horizontal state, and a pair of cam plates each fixed to the corresponding one of the pair of inversion boards and having its proximal end side rotatably fixed to the common rotary shaft, in which each one of the pair of cam plates has a curved lower outer circumferential surface extending from the proximal end side toward the radial outside end and which may be engaged by the rod of each respective one of the pair of linear drive mechanisms when the rod is being moved out of and moved back into the corresponding cylinder of the respective liner drive mechanism, thereby causing the respective cam plate to be rotated about the common rotary shaft. In accordance with the present invention, the direction in which the rod of each one of pair of the linear drive mechanisms may be moved out of or moved back into the cylinder occurs from the obliquely downward direction toward the direction of the common rotary shaft.
    • 提供了一种重物倒置装置,其中可以在短时间内通过减小重物反转装置的尺寸来进行翻转操作,该重物反转装置包括一对反转板,该反转板可围绕支撑在 在水平状态和旋转角度之间的水平状态的角度小于180度的基部和一对凸轮板,每个凸轮板固定到一对倒置板中的相应一个,并且其近端侧可旋转地固定到共同的 所述一对凸轮板中的每一个具有从所述近端侧向所述径向外端延伸的弯曲的下外周面,并且所述旋转轴可与所述一对线性驱动机构 当杆被移出并移回到相应的衬套驱动机构的相应的缸中时,从而使相应的凸轮板为 围绕公共旋转轴旋转。 根据本发明,一对直线驱动机构中的每一个的杆的方向可以从向公共旋转轴的方向的倾斜向下方向移动或移回到气缸中。