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1. 发明授权

US08217163B2 Application of highly conserved domain sequences from viral genome as template to design therapeutic slirnas 有权
标题翻译：将来自病毒基因组的高度保守的结构域序列应用于模板，设计治疗性疾病
公开(公告)号：US08217163B2
公开(公告)日：2012-07-10
申请号：US12886446
申请日：2010-09-20
申请人： York Yuan Yuan Zhu , Li Chen , TieJun Li , YiXiang Lu , YunCheng Sun , Jinkang Wang
发明人： York Yuan Yuan Zhu , Li Chen , TieJun Li , YiXiang Lu , YunCheng Sun , Jinkang Wang
IPC分类号： C07H21/02 , C07H21/04 , C12Q1/68 , A61K31/70
CPC分类号： C12N15/115 , A61K31/713 , C12N2310/13 , C12N2310/16 , Y02A50/465
摘要： This invention relates to the application of the highly conserved sequences of viral genome, especially from a highly conserved domain of enteroviral genome as templates to design target small ligand RNAs (sliRNAs). The resulting sliRNAs are therapeutically active ingredients in the treatment of the related diseases caused by pathological angiogenesis.
摘要翻译：本发明涉及病毒基因组的高度保守序列的应用，特别是来自肠道病毒基因组的高度保守结构域作为模板来设计靶小配体RNA（sliRNA）。所得的sliRNA是治疗由病理性血管发生引起的相关疾病的治疗活性成分。

2. 发明申请

US20120071542A1 Application of Highly Conserved Domain Sequences From Viral Genome As Template To Design Therapeutic Slirnas 有权
标题翻译：应用病毒基因组的高保守域序列作为设计治疗性Slirnas的模板
公开(公告)号：US20120071542A1
公开(公告)日：2012-03-22
申请号：US12886446
申请日：2010-09-20
申请人： York YuanYuan Zhu , Li Chen , TieJun Li , YiXiang Lu , YunCheng Sun , Jinkang Wang
发明人： York YuanYuan Zhu , Li Chen , TieJun Li , YiXiang Lu , YunCheng Sun , Jinkang Wang
IPC分类号： A61K31/713 , A61P27/02 , A61P35/00 , C07H21/02 , C12Q1/68
CPC分类号： C12N15/115 , A61K31/713 , C12N2310/13 , C12N2310/16 , Y02A50/465
摘要： This invention relates to the application of the highly conserved sequences of viral genome, especially from a highly conserved domain of enteroviral genome as templates to design target small ligand RNAs (sliRNAs). The resulting sliRNAs are therapeutically active ingredients in the treatment of the related diseases caused by pathological angiogenesis.
摘要翻译：本发明涉及病毒基因组的高度保守序列的应用，特别是来自肠道病毒基因组的高度保守结构域作为模板来设计靶小配体RNA（sliRNA）。所得的sliRNA是治疗由病理性血管发生引起的相关疾病的治疗活性成分。

3. 发明授权

US09080174B2 HBV treatment 有权
标题翻译： HBV治疗
公开(公告)号：US09080174B2
公开(公告)日：2015-07-14
申请号：US13882124
申请日：2011-10-27
申请人： Michael Wayne Graham , Peter French , York YuanYuan Zhu , Yixiang Lu , TieJun Li , Yuncheng Sun , XiaoJun Tang , Li Shan
发明人： Michael Wayne Graham , Peter French , York YuanYuan Zhu , Yixiang Lu , TieJun Li , Yuncheng Sun , XiaoJun Tang , Li Shan
IPC分类号： C07H21/04 , C12N15/113
CPC分类号： C12N15/1131 , C12N2310/14 , C12N2310/531
摘要： RNA interference (RNAi) agents and the use of the RNAi agents for treating hepatitis B infection in individuals, as well as pharmaceutical compositions containing the RNAi agents are provided. The RNAi agents, or constructs for expressing them are utilized to inhibit expression of at least one Hepatitis B virus (HBV) gene, wherein each agent comprises an effector sequence complementary to or substantially complementary to a predicted sequence transcribed from a target region. In some embodiments of the present invention, the agents have more than one effector sequence; wherein the multiple effectors may target the same region of an HBV gene, different (possibly overlapping) regions of the same gene and/or different HBV genes.
摘要翻译：提供RNA干扰（RNAi）试剂和使用RNAi试剂治疗个体中的乙型肝炎感染，以及含有RNAi试剂的药物组合物。用于表达它们的RNAi剂或构建体用于抑制至少一种乙型肝炎病毒（HBV）基因的表达，其中每种试剂包含与从靶区转录的预测序列互补或基本上互补的效应序列。在本发明的一些实施方案中，所述试剂具有多于一个效应序列; 其中所述多个效应子可以靶向相同基因和/或不同HBV基因的HBV基因的相同区域，不同（可能重叠的）区域。

4. 发明授权

US09115167B2 Multi-targets interfering RNA molecules and their applications 有权
标题翻译：多靶点干扰RNA分子及其应用
公开(公告)号：US09115167B2
公开(公告)日：2015-08-25
申请号：US13415600
申请日：2012-03-08
申请人： York YuanYuan Zhu , TieJun Li
发明人： York YuanYuan Zhu , TieJun Li
IPC分类号： C07H21/02 , A61K31/7088
CPC分类号： C12N15/1135 , A61K31/7088 , C07H21/02 , C12N15/113 , C12N2310/111 , C12N2310/14 , C12N2310/3519 , C12N2310/52 , C12N2310/53 , C12N2310/531
摘要： This invention relates to interfering RNA (iRNA) molecules and their applications, especially multi-targets iRNA molecules and their applications. The said multi-targets iRNA molecules comprised of a sense strand annealed onto at least one antisense strand, each strand is at least 30 nucleotides in length, the sense or antisense strand has at least two segments, which can target at least two RNAs of different genes, or can target at least two portions of an RNA, and wherein the iRNA does not induce an interferon-response when transfected into a cell. The iRNA molecule can interfere with the translation procedure post-transcription, and the target gene is inhibited or blocked, the iRNA does not induce an interferon-response in vivo. The RNA molecules are the active ingredient in preparation of the drug which can regulate one or many genes function.
摘要翻译：本发明涉及干扰RNA（iRNA）分子及其应用，特别是多靶标iRNA分子及其应用。所述多靶iRNA分子由在至少一条反义链上退火的有义链组成，每条链长度至少为30个核苷酸，正义或反义链具有至少两个片段，其可靶向至少两个不同的RNA 基因，或可靶向RNA的至少两部分，并且其中iRNA在转染入细胞时不诱导干扰素反应。 iRNA分子可以干扰转录后的翻译过程，靶基因被抑制或阻断，iRNA在体内不诱导干扰素反应。 RNA分子是可以调节一种或多种基因功能的药物的制备中的活性成分。

5. 发明申请

US20120232126A1 MULTI-TARGETS INTERFERING RNA MOLECULES AND THEIR APPLICATIONS 有权
标题翻译：多靶点干扰RNA分子及其应用
公开(公告)号：US20120232126A1
公开(公告)日：2012-09-13
申请号：US13415600
申请日：2012-03-08
申请人： York YuanYuan Zhu , TieJun Li
发明人： York YuanYuan Zhu , TieJun Li
IPC分类号： A61K31/7088 , A61P31/12 , A61P35/00 , C07H21/02
CPC分类号： C12N15/1135 , A61K31/7088 , C07H21/02 , C12N15/113 , C12N2310/111 , C12N2310/14 , C12N2310/3519 , C12N2310/52 , C12N2310/53 , C12N2310/531
摘要： This invention relates to interfering RNA (iRNA) molecules and their applications, especially multi-targets iRNA molecules and their applications. The said multi-targets iRNA molecules comprised of a sense strand annealed onto at least one antisense strand, each strand is at least 30 nucleotides in length, the sense or antisense strand has at least two segments, which can target at least two RNAs of different genes, or can target at least two portions of an RNA, and wherein the iRNA does not induce an interferon-response when transfected into a cell. The iRNA molecule can interfere with the translation procedure post-transcription, and the target gene is inhibited or blocked, the iRNA does not induce an interferon-response in vivo. The RNA molecules are the active ingredient in preparation of the drug which can regulate one or many genes function.
摘要翻译：本发明涉及干扰RNA（iRNA）分子及其应用，特别是多靶标iRNA分子及其应用。所述多靶iRNA分子由在至少一条反义链上退火的有义链组成，每条链的长度至少为30个核苷酸，正义或反义链具有至少两个片段，其可靶向至少两个不同的RNA 基因，或可靶向RNA的至少两部分，并且其中iRNA在转染入细胞时不诱导干扰素反应。 iRNA分子可以干扰转录后的翻译过程，靶基因被抑制或阻断，iRNA在体内不诱导干扰素反应。 RNA分子是可以调节一种或多种基因功能的药物的制备中的活性成分。

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