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1. 发明授权

US09284560B2 Application of highly conserved domain sequences from viral genome as template to design therapeutic sliRNAs 有权
标题翻译：将来自病毒基因组的高度保守的结构域序列应用于模板以设计治疗性的SliRNA
公开(公告)号：US09284560B2
公开(公告)日：2016-03-15
申请号：US13388979
申请日：2011-09-19
申请人： York YuanYuan Zhu , Li Chen , Tiejun Li , Yixiang Lu , YunCheng Sun , Jinkang Wang
发明人： York YuanYuan Zhu , Li Chen , Tiejun Li , Yixiang Lu , YunCheng Sun , Jinkang Wang
IPC分类号： A61K31/70 , C07H21/02 , C07H21/04 , C12N15/113 , A61K31/713 , C12N15/115
CPC分类号： C12N15/115 , A61K31/713 , C12N2310/13 , C12N2310/16 , Y02A50/465
摘要： This invention relates to the application of the highly conserved sequences of viral genome, especially from a highly conserved domain of enteroviral genome as templates to design target small ligand RNAs (sliRNAs). The resulting sliRNAs are therapeutically active ingredients in the treatment of the related diseases caused by pathological angiogenesis.
摘要翻译：本发明涉及病毒基因组的高度保守序列的应用，特别是来自肠道病毒基因组的高度保守结构域作为模板来设计靶小配体RNA（sliRNA）。所得的sliRNA是治疗由病理性血管发生引起的相关疾病的治疗活性成分。

2. 发明授权

US09080174B2 HBV treatment 有权
标题翻译： HBV治疗
公开(公告)号：US09080174B2
公开(公告)日：2015-07-14
申请号：US13882124
申请日：2011-10-27
申请人： Michael Wayne Graham , Peter French , York YuanYuan Zhu , Yixiang Lu , TieJun Li , Yuncheng Sun , XiaoJun Tang , Li Shan
发明人： Michael Wayne Graham , Peter French , York YuanYuan Zhu , Yixiang Lu , TieJun Li , Yuncheng Sun , XiaoJun Tang , Li Shan
IPC分类号： C07H21/04 , C12N15/113
CPC分类号： C12N15/1131 , C12N2310/14 , C12N2310/531
摘要： RNA interference (RNAi) agents and the use of the RNAi agents for treating hepatitis B infection in individuals, as well as pharmaceutical compositions containing the RNAi agents are provided. The RNAi agents, or constructs for expressing them are utilized to inhibit expression of at least one Hepatitis B virus (HBV) gene, wherein each agent comprises an effector sequence complementary to or substantially complementary to a predicted sequence transcribed from a target region. In some embodiments of the present invention, the agents have more than one effector sequence; wherein the multiple effectors may target the same region of an HBV gene, different (possibly overlapping) regions of the same gene and/or different HBV genes.
摘要翻译：提供RNA干扰（RNAi）试剂和使用RNAi试剂治疗个体中的乙型肝炎感染，以及含有RNAi试剂的药物组合物。用于表达它们的RNAi剂或构建体用于抑制至少一种乙型肝炎病毒（HBV）基因的表达，其中每种试剂包含与从靶区转录的预测序列互补或基本上互补的效应序列。在本发明的一些实施方案中，所述试剂具有多于一个效应序列; 其中所述多个效应子可以靶向相同基因和/或不同HBV基因的HBV基因的相同区域，不同（可能重叠的）区域。

3. 发明授权

US08217163B2 Application of highly conserved domain sequences from viral genome as template to design therapeutic slirnas 有权
标题翻译：将来自病毒基因组的高度保守的结构域序列应用于模板，设计治疗性疾病
公开(公告)号：US08217163B2
公开(公告)日：2012-07-10
申请号：US12886446
申请日：2010-09-20
申请人： York Yuan Yuan Zhu , Li Chen , TieJun Li , YiXiang Lu , YunCheng Sun , Jinkang Wang
发明人： York Yuan Yuan Zhu , Li Chen , TieJun Li , YiXiang Lu , YunCheng Sun , Jinkang Wang
IPC分类号： C07H21/02 , C07H21/04 , C12Q1/68 , A61K31/70
CPC分类号： C12N15/115 , A61K31/713 , C12N2310/13 , C12N2310/16 , Y02A50/465
摘要： This invention relates to the application of the highly conserved sequences of viral genome, especially from a highly conserved domain of enteroviral genome as templates to design target small ligand RNAs (sliRNAs). The resulting sliRNAs are therapeutically active ingredients in the treatment of the related diseases caused by pathological angiogenesis.
摘要翻译：本发明涉及病毒基因组的高度保守序列的应用，特别是来自肠道病毒基因组的高度保守结构域作为模板来设计靶小配体RNA（sliRNA）。所得的sliRNA是治疗由病理性血管发生引起的相关疾病的治疗活性成分。

4. 发明申请

US20120071542A1 Application of Highly Conserved Domain Sequences From Viral Genome As Template To Design Therapeutic Slirnas 有权
标题翻译：应用病毒基因组的高保守域序列作为设计治疗性Slirnas的模板
公开(公告)号：US20120071542A1
公开(公告)日：2012-03-22
申请号：US12886446
申请日：2010-09-20
申请人： York YuanYuan Zhu , Li Chen , TieJun Li , YiXiang Lu , YunCheng Sun , Jinkang Wang
发明人： York YuanYuan Zhu , Li Chen , TieJun Li , YiXiang Lu , YunCheng Sun , Jinkang Wang
IPC分类号： A61K31/713 , A61P27/02 , A61P35/00 , C07H21/02 , C12Q1/68
CPC分类号： C12N15/115 , A61K31/713 , C12N2310/13 , C12N2310/16 , Y02A50/465
摘要： This invention relates to the application of the highly conserved sequences of viral genome, especially from a highly conserved domain of enteroviral genome as templates to design target small ligand RNAs (sliRNAs). The resulting sliRNAs are therapeutically active ingredients in the treatment of the related diseases caused by pathological angiogenesis.
摘要翻译：本发明涉及病毒基因组的高度保守序列的应用，特别是来自肠道病毒基因组的高度保守结构域作为模板来设计靶小配体RNA（sliRNA）。所得的sliRNA是治疗由病理性血管发生引起的相关疾病的治疗活性成分。

5. 发明授权

US09115167B2 Multi-targets interfering RNA molecules and their applications 有权
标题翻译：多靶点干扰RNA分子及其应用
公开(公告)号：US09115167B2
公开(公告)日：2015-08-25
申请号：US13415600
申请日：2012-03-08
申请人： York YuanYuan Zhu , TieJun Li
发明人： York YuanYuan Zhu , TieJun Li
IPC分类号： C07H21/02 , A61K31/7088
CPC分类号： C12N15/1135 , A61K31/7088 , C07H21/02 , C12N15/113 , C12N2310/111 , C12N2310/14 , C12N2310/3519 , C12N2310/52 , C12N2310/53 , C12N2310/531
摘要： This invention relates to interfering RNA (iRNA) molecules and their applications, especially multi-targets iRNA molecules and their applications. The said multi-targets iRNA molecules comprised of a sense strand annealed onto at least one antisense strand, each strand is at least 30 nucleotides in length, the sense or antisense strand has at least two segments, which can target at least two RNAs of different genes, or can target at least two portions of an RNA, and wherein the iRNA does not induce an interferon-response when transfected into a cell. The iRNA molecule can interfere with the translation procedure post-transcription, and the target gene is inhibited or blocked, the iRNA does not induce an interferon-response in vivo. The RNA molecules are the active ingredient in preparation of the drug which can regulate one or many genes function.
摘要翻译：本发明涉及干扰RNA（iRNA）分子及其应用，特别是多靶标iRNA分子及其应用。所述多靶iRNA分子由在至少一条反义链上退火的有义链组成，每条链长度至少为30个核苷酸，正义或反义链具有至少两个片段，其可靶向至少两个不同的RNA 基因，或可靶向RNA的至少两部分，并且其中iRNA在转染入细胞时不诱导干扰素反应。 iRNA分子可以干扰转录后的翻译过程，靶基因被抑制或阻断，iRNA在体内不诱导干扰素反应。 RNA分子是可以调节一种或多种基因功能的药物的制备中的活性成分。

6. 发明申请

US20150027910A1 Protective jewelry display device 审中-公开
标题翻译：防护饰品显示装置
公开(公告)号：US20150027910A1
公开(公告)日：2015-01-29
申请号：US14065885
申请日：2013-10-29
申请人： Tiejun LI
发明人： Tiejun LI
IPC分类号： A45C11/16
CPC分类号： A45C11/16 , A45C2200/10
摘要： A protective display device comprising a hollow transparent tube; an article for sale or display placed inside the tube; two covers respectively closing openings at both ends of the tube; a disposable blocking material closing and locking connecting portions between each end of the tubes and each of the two covers; at least one observation window passing through walls of the tube to facilitate measurement and observation of the article for sale or display.
摘要翻译：一种保护性显示装置，包括中空透明管; 出售或放置在管内的物品; 两个盖分别在管的两端封闭开口; 一次性阻塞材料封闭和锁定管的每个端部和两个盖中的每一个之间的连接部分; 至少一个观察窗通过管的壁，以便于用于销售或展示的物品的测量和观察。

7. 发明授权

US07746571B2 Large-field unit-magnification projection optical system 有权
标题翻译：大场单位放大投影光学系统
公开(公告)号：US07746571B2
公开(公告)日：2010-06-29
申请号：US12302824
申请日：2006-12-04
申请人： Tiejun Li , Ling Huang , Jun Wei
发明人： Tiejun Li , Ling Huang , Jun Wei
IPC分类号： G02B9/60 , G02B17/00
CPC分类号： G02B17/08 , G02B13/26 , G03F7/70225 , G03F7/70791
摘要： The present invention discloses a large-field unit-magnification projection optical system. The optical system includes an optical axis, a spherical concave reflection mirror; a lens group with positive refracting power arranged adjacent the mirror with an air space therebetween. The lens group includes a first plano-convex lens, a negative meniscus lens adjacent the plano-convex lens, a positive lens adjacent the negative meniscus lens, a negative double-convex lens spaced apart far from the positive lens, and a second plano-convex lens. The optical system further includes a pair of prisms each having respective first and second surface. The second surfaces are arranged adjacent the flat surface of the plano-convex lens element on opposite sides of the optical axis and the first surfaces are arranged adjacent object planes and image planes, respectively. Each lens in the lens group and the pair of prisms provide chromatic aberration correction in a spectral region that contains at least g, h and i-line wavelengths. In this projection optical system, the object plane is parallel to the image plane.
摘要翻译：本发明公开了一种大视场单位放大投影光学系统。光学系统包括光轴，球面凹面反射镜; 具有正反射功率的透镜组，其布置在反射镜附近，其间具有空气空间。透镜组包括第一平凸透镜，与平凸透镜相邻的负弯月透镜，邻近负弯月透镜的正透镜，与正透镜间隔开的负双凸透镜，以及第二平凸透镜，凸透镜光学系统还包括一对棱镜，每个棱镜具有相应的第一和第二表面。第二面与光轴的相对侧的平凸透镜元件的平面相邻配置，第一面与物平面和像面分别配置。透镜组中的每个透镜和一对棱镜在包含至少g，h和i线波长的光谱区域中提供色差校正。在该投影光学系统中，物平面与图像平面平行。

8. 发明授权

US08343921B2 Method for treating myocardial ischemia 有权
标题翻译：治疗心肌缺血的方法
公开(公告)号：US08343921B2
公开(公告)日：2013-01-01
申请号：US13355873
申请日：2012-01-23
申请人： Yaocheng Rui , Tiejun Li , Pengyuan Yang , Yuefan Zhang
发明人： Yaocheng Rui , Tiejun Li , Pengyuan Yang , Yuefan Zhang
IPC分类号： A61P9/10 , A61K38/08 , C07K7/06
CPC分类号： A61K38/08
摘要： Use of polypeptide micromolecule MLIF in preparing medicine for preventing and treating myocardial ischmia, where amino acid sequence of the polypeptide micromolecule MLIF is Met-Gln-Cys-Asn-Ser (SEQ ID NO:1).
摘要翻译：多肽小分子MLIF在制备用于预防和治疗心肌异位症的药物中的应用，其中多肽小分子MLIF的氨基酸序列是Met-Gln-Cys-Asn-Ser（SEQ ID NO：1）。

9. 发明申请

US20120122786A1 Use of Polypeptide Micromolecule MLIF in Preparing Medicine for Preventing and Treating Myocardial Ischemia 有权
标题翻译：多肽微分子MLIF在制备药物中用于预防和治疗心肌缺血的应用
公开(公告)号：US20120122786A1
公开(公告)日：2012-05-17
申请号：US13355873
申请日：2012-01-23
申请人： Yaocheng Rui , Tiejun Li , Pengyuan Yang , Yuefan Zhang
发明人： Yaocheng Rui , Tiejun Li , Pengyuan Yang , Yuefan Zhang
IPC分类号： A61K38/08 , A61P9/10 , C07K7/06
CPC分类号： A61K38/08
摘要： Use of polypeptide micromolecule MLIF in preparing medicine for preventing and treating myocardial ischmia, where amino acid sequence of the polypeptide micromolecule MLIF is Met-Gln-Cys-Asn-Ser (SEQ ID NO:1).
摘要翻译：多肽小分子MLIF在制备用于预防和治疗心肌异位症的药物中的应用，其中多肽小分子MLIF的氨基酸序列是Met-Gln-Cys-Asn-Ser（SEQ ID NO：1）。

10. 发明申请

US20210386096A1 FEED ADDITIVE TO PROMOTE THE GROWTH OF SOWS AND PIGLETS AND APPLICATION THEREOF 有权
公开(公告)号：US20210386096A1
公开(公告)日：2021-12-16
申请号：US17347485
申请日：2021-06-14
申请人： LIUQIN HE , TIEJUN LI , YANZHONG FENG , WENJIE TANG , YULONG YIN , JIANZHONG LI , SHENGPING WANG , XINGGUO HE
发明人： LIUQIN HE , TIEJUN LI , YANZHONG FENG , WENJIE TANG , YULONG YIN , JIANZHONG LI , SHENGPING WANG , XINGGUO HE
IPC分类号： A23K20/142 , A23K10/30 , A23K50/30
摘要： The present invention provides feed additive to promote the growth of sows and piglets, which comprises serine, astragalus and ginseng leaves. The feed additive preferably contains: 50-60 wt % of the serine, 20-25 wt % of the astragalus, 20-25 wt % of the ginseng leaves and the balance of rice bran meal as a carrier. The invention also provides applications of the above-mentioned feed additive in promoting the growth of sows and piglets, that is, before feeding, make the serine content in the diet reach 0.69 wt % and incorporate it into the diet of gestational sows, and/or make the serine content in the diet reach 0.82 wt % and incorporate it into the diet of lactating sows.

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