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1. 发明申请

US20110213288A1 Device And Method For Transfecting Cells For Therapeutic Uses 审中-公开
标题翻译：用于转染细胞用于治疗用途的装置和方法
公开(公告)号：US20110213288A1
公开(公告)日：2011-09-01
申请号：US12884084
申请日：2010-09-16
申请人： Yoonsu Choi , Lawrence J.N. Cooper , Dean A. Lee , Sibani Lisa Biswal , Robert Raphael , Thomas C. Killian
发明人： Yoonsu Choi , Lawrence J.N. Cooper , Dean A. Lee , Sibani Lisa Biswal , Robert Raphael , Thomas C. Killian
IPC分类号： A61M1/36 , C12M1/42 , C12N13/00
CPC分类号： C12M23/16 , C12M35/02 , C12N15/87
摘要： This invention generally relates to devices and methods for ex vivo or in vivo transfection of living cells using electroporation, in particular high throughput microfluidic electroporation, and to therapeutic uses of the transfected cells.
摘要翻译：本发明一般涉及使用电穿孔，特别是高通量微流控电穿孔活体或体内转染活细胞的装置和方法，以及转染细胞的治疗用途。

2. 发明授权

US07461882B2 Microfabricated mechanically actuated microtool and methods 失效
标题翻译：微型机械致动微型工具和方法
公开(公告)号：US07461882B2
公开(公告)日：2008-12-09
申请号：US11271450
申请日：2005-11-11
申请人： Yoonsu Choi , Mark G. Allen , James Ross , Stephen P. DeWeerth
发明人： Yoonsu Choi , Mark G. Allen , James Ross , Stephen P. DeWeerth
IPC分类号： B25J15/12 , B25J7/00
CPC分类号： C25D1/00 , B25J7/00 , B81C99/002 , Y10S294/902
摘要： Apparatus and processes are disclosed that provide a microfabricated microtool having a mechanically actuated manipulating mechanism. The microtool comprises a tweezer having flexible arms, and an actuating mechanism. A biological, electrical, or mechanical component is grasped, cut, sensed, or measured by the flexible arms. The actuating mechanism requires no electric power and is achieved by the reciprocating motion of a smooth, rigid microstructure applied against the flexible arms of the microtool. In certain implementations, actuator motion is controlled distally by a tethered cable. A process is also disclosed for producing a microtool, and in particular, by micropatterning. Photolithography may be used to form micro-molds that pattern the microtool or components of the microtool. In certain implementations, the tweezer and actuating mechanism are produced fully assembled. In other implementations, the tweezer and actuating mechanism are produced separately and assembled together.
摘要翻译：公开了提供具有机械致动的操纵机构的微加工微型工具的装置和方法。微型工具包括具有柔性臂的镊子和致动机构。通过柔性臂来抓住，切割，感测或测量生物，电或机械部件。致动机构不需要电力，并且通过向微型工具的柔性臂施加的光滑的刚性微结构的往复运动来实现。在某些实施方案中，致动器运动由系留电缆远程控制。还公开了一种用于生产微型工具，特别是通过微图案化的方法。可以使用光刻法来形成对微型工具或微型工具的组件进行图案化的微型模具。在某些实施方案中，镊子和致动机构被完全组装。在其他实施方式中，镊子和致动机构分开制造并组装在一起。

3. 发明申请

US20080284187A1 MICROFABRICATED MECHANICALLY ACTUATED MICROTOOL AND METHODS 审中-公开
标题翻译：微生物机械致动微生物和方法
公开(公告)号：US20080284187A1
公开(公告)日：2008-11-20
申请号：US11851579
申请日：2007-09-07
申请人： Yoonsu Choi , Mark G. Allen , James Ross , Stephen P. DeWeerth
发明人： Yoonsu Choi , Mark G. Allen , James Ross , Stephen P. DeWeerth
IPC分类号： B66C1/00
CPC分类号： C25D1/00 , B25J7/00 , B81C99/002 , Y10S294/902
摘要： Apparatus and processes are disclosed that provide a microfabricated microtool having a mechanically actuated manipulating mechanism. The microtool comprises a tweezer having flexible arms, and an actuating mechanism. A biological, electrical, or mechanical component is grasped, cut, sensed, or measured by the flexible arms. The actuating mechanism requires no electric power and is achieved by the reciprocating motion of a smooth, rigid microstructure applied against the flexible arms of the microtool. In certain implementations, actuator motion is controlled distally by a tethered cable. A process is also disclosed for producing a microtool, and in particular, by micropatterning. Photolithography may be used to form micro-molds that pattern the microtool or components of the microtool. In certain implementations, the tweezer and actuating mechanism are produced fully assembled. In other implementations, the tweezer and actuating mechanism are produced separately and assembled together.
摘要翻译：公开了提供具有机械致动的操纵机构的微加工微型工具的装置和方法。微型工具包括具有柔性臂的镊子和致动机构。通过柔性臂来抓住，切割，感测或测量生物，电或机械部件。致动机构不需要电力，并且通过向微型工具的柔性臂施加的光滑的刚性微结构的往复运动来实现。在某些实施方案中，致动器运动由系留电缆远程控制。还公开了一种用于生产微型工具，特别是通过微图案化的方法。可以使用光刻法来形成对微型工具或微型工具的组件进行图案化的微型模具。在某些实施方案中，镊子和致动机构被完全组装。在其他实施方式中，镊子和致动机构分开制造并组装在一起。

4. 发明申请

US20070179599A1 Vascular protective device 审中-公开
标题翻译：血管保护装置
公开(公告)号：US20070179599A1
公开(公告)日：2007-08-02
申请号：US11699586
申请日：2007-01-25
申请人： William G. Brodbeck , Yoonsu Choi , Vernon H. Merritt , Jasmine D. Patel , Udayan Patel , Michael J. Wiggins
发明人： William G. Brodbeck , Yoonsu Choi , Vernon H. Merritt , Jasmine D. Patel , Udayan Patel , Michael J. Wiggins
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/89 , A61F2/915 , A61F2002/072 , A61F2002/075 , A61F2250/0067
摘要： A medical device to protect and/or heal a diseased and/or injured area in the body passageway.
摘要翻译：用于保护和/或治疗身体通道中的患病和/或受伤区域的医疗装置。

5. 发明申请

US20060181097A1 Microfabricated mechanically actuated microtool and methods 失效
标题翻译：微型机械致动微型工具和方法
公开(公告)号：US20060181097A1
公开(公告)日：2006-08-17
申请号：US11271450
申请日：2005-11-11
申请人： Yoonsu Choi , Mark Allen , James Ross , Stephen DeWeerth
发明人： Yoonsu Choi , Mark Allen , James Ross , Stephen DeWeerth
IPC分类号： B66C1/00
CPC分类号： C25D1/00 , B25J7/00 , B81C99/002 , Y10S294/902
摘要： Apparatus and processes are disclosed that provide a microfabricated microtool having a mechanically actuated manipulating mechanism. The microtool comprises a tweezer having flexible arms, and an actuating mechanism. A biological, electrical, or mechanical component is grasped, cut, sensed, or measured by the flexible arms. The actuating mechanism requires no electric power and is achieved by the reciprocating motion of a smooth, rigid microstructure applied against the flexible arms of the microtool. In certain implementations, actuator motion is controlled distally by a tethered cable. A process is also disclosed for producing a microtool, and in particular, by micropatterning. Photolithography may be used to form micro-molds that pattern the microtool or components of the microtool. In certain implementations, the tweezer and actuating mechanism are produced fully assembled. In other implementations, the tweezer and actuating mechanism are produced separately and assembled together.
摘要翻译：公开了提供具有机械致动的操纵机构的微加工微型工具的装置和方法。微型工具包括具有柔性臂的镊子和致动机构。通过柔性臂来抓住，切割，感测或测量生物，电或机械部件。致动机构不需要电力，并且通过向微型工具的柔性臂施加的光滑的刚性微结构的往复运动来实现。在某些实施方案中，致动器运动由系留电缆远程控制。还公开了一种用于生产微型工具，特别是通过微图案化的方法。可以使用光刻法来形成对微型工具或微型工具的组件进行图案化的微型模具。在某些实施方案中，镊子和致动机构被完全组装。在其他实施方式中，镊子和致动机构分开制造并组装在一起。

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