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1. 发明申请

US20060181097A1 Microfabricated mechanically actuated microtool and methods 失效
标题翻译：微型机械致动微型工具和方法
公开(公告)号：US20060181097A1
公开(公告)日：2006-08-17
申请号：US11271450
申请日：2005-11-11
申请人： Yoonsu Choi , Mark Allen , James Ross , Stephen DeWeerth
发明人： Yoonsu Choi , Mark Allen , James Ross , Stephen DeWeerth
IPC分类号： B66C1/00
CPC分类号： C25D1/00 , B25J7/00 , B81C99/002 , Y10S294/902
摘要： Apparatus and processes are disclosed that provide a microfabricated microtool having a mechanically actuated manipulating mechanism. The microtool comprises a tweezer having flexible arms, and an actuating mechanism. A biological, electrical, or mechanical component is grasped, cut, sensed, or measured by the flexible arms. The actuating mechanism requires no electric power and is achieved by the reciprocating motion of a smooth, rigid microstructure applied against the flexible arms of the microtool. In certain implementations, actuator motion is controlled distally by a tethered cable. A process is also disclosed for producing a microtool, and in particular, by micropatterning. Photolithography may be used to form micro-molds that pattern the microtool or components of the microtool. In certain implementations, the tweezer and actuating mechanism are produced fully assembled. In other implementations, the tweezer and actuating mechanism are produced separately and assembled together.
摘要翻译：公开了提供具有机械致动的操纵机构的微加工微型工具的装置和方法。微型工具包括具有柔性臂的镊子和致动机构。通过柔性臂来抓住，切割，感测或测量生物，电或机械部件。致动机构不需要电力，并且通过向微型工具的柔性臂施加的光滑的刚性微结构的往复运动来实现。在某些实施方案中，致动器运动由系留电缆远程控制。还公开了一种用于生产微型工具，特别是通过微图案化的方法。可以使用光刻法来形成对微型工具或微型工具的组件进行图案化的微型模具。在某些实施方案中，镊子和致动机构被完全组装。在其他实施方式中，镊子和致动机构分开制造并组装在一起。

2. 发明申请

US20070178579A1 Circuits and methods for artifact elimination 有权
标题翻译：电路和消除方法
公开(公告)号：US20070178579A1
公开(公告)日：2007-08-02
申请号：US11511794
申请日：2006-08-29
申请人： James Ross , Edgar Brown , Richard Blum , Stephen DeWeerth
发明人： James Ross , Edgar Brown , Richard Blum , Stephen DeWeerth
IPC分类号： C12M1/36 , C12M1/00 , C12Q1/00 , C12M1/38 , A61B5/05
CPC分类号： G01N37/00 , A61B5/04 , A61B5/04001 , A61B5/7217 , A61N1/3605 , A61N1/3704 , G01N33/4836
摘要： Disclosed are apparatus and methods that provide the ability to electrical stimulate a physical system, and actively eliminate interference with signal acquisition (artifacts) that arises from the stimulation. The technique implemented in the circuits and methods for eliminating interference connects a discharge path to a physical interface to the system to remove charge that is built-up during stimulation. By placing the discharge path in a feedback loop that includes a recording preamplifier and AC-coupling circuitry, the physical interface is brought back to its pre-stimulation offset voltage. The disclosed apparatus and methods may be used with piezoelectric transducers, ultrasound devices, optical diodes, and polarizable and non-polarizable electrodes. The disclosed apparatus can be employed in implantable devices, in vitro or in vivo setups with vertebrate and invertebrate neural tissue, muscle fibers, pancreatic islet cells, osteoblasts, osteoclasts, bacteria, algae, fungi, protists, and plants.
摘要翻译：公开了提供电刺激物理系统的能力的装置和方法，并且主动地消除由刺激产生的信号采集（伪影）的干扰。在电路中实现的技术和消除干扰的方法将放电路径连接到系统的物理接口，以去除在刺激期间积累的电荷。通过将放电路径放置在包括记录前置放大器和AC耦合电路的反馈回路中，物理接口被带回其预刺激偏移电压。所公开的装置和方法可以与压电换能器，超声波装置，光二极管以及可极化和不可极化的电极一起使用。所公开的装置可用于可植入装置，体外或体内用脊椎动物和无脊椎动物神经组织，肌肉纤维，胰岛细胞，成骨细胞，破骨细胞，细菌，藻类，真菌，原生生物和植物的装置。

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