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1. 发明授权

US07208267B2 Compositions and methods relating to breast specific genes and proteins 失效
标题翻译：与乳腺特异性基因和蛋白质有关的组成和方法
公开(公告)号：US07208267B2
公开(公告)日：2007-04-24
申请号：US09989890
申请日：2001-11-21
申请人： Susana Salceda , Roberto Macina , Herve E. Recipon , Jason Pluta , Yongming Sun , Chenghua Liu
发明人： Susana Salceda , Roberto Macina , Herve E. Recipon , Jason Pluta , Yongming Sun , Chenghua Liu
IPC分类号： C12Q1/68 , C12N15/00 , C12N5/00 , C12N15/11 , C12N15/12 , C12P21/02 , A61K31/711 , A61K31/713
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , A61K2039/505 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast tissue, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性乳腺细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗乳腺组织中的乳腺癌和非癌性疾病状态，鉴定乳腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程乳腺组织的生产。

2. 发明申请

US20050014710A1 Compositions and methods relating to prostate specific genes and proteins 审中-公开
标题翻译：与前列腺特异性基因和蛋白质有关的组成和方法
公开(公告)号：US20050014710A1
公开(公告)日：2005-01-20
申请号：US10487556
申请日：2002-08-29
申请人： Yongming Sun , Chenghua Liu , Sei-Yu Chen
发明人： Yongming Sun , Chenghua Liu , Sei-Yu Chen
IPC分类号： A61K38/00 , A61K48/00 , C07H21/04 , C07K14/47 , C07K14/705 , C12N15/12 , C12Q1/68 , C12Q1/6886 , G01N33/574
CPC分类号： C07K14/4748 , A61K38/00 , A61K48/00 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , G01N33/57434
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic prostate cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating prostate cancer and non-cancerous disease states in prostate, identifying prostate tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered prostate tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤前列腺细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗前列腺中的前列腺癌和非癌性疾病状态，鉴定前列腺组织，监测和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程前列腺组织的生产。

3. 发明申请

US20060199180A1 Compositions and methods relating to ovarian specific genes and proteins 失效
标题翻译：与卵巢特异性基因和蛋白质有关的组成和方法
公开(公告)号：US20060199180A1
公开(公告)日：2006-09-07
申请号：US10523834
申请日：2003-08-06
申请人： Roberto Macina , Susana Salceda , Chenghua Liu , Yongming Sun , Leah Turner
发明人： Roberto Macina , Susana Salceda , Chenghua Liu , Yongming Sun , Leah Turner
IPC分类号： C12Q1/68
CPC分类号： C07K14/82 , A61K38/00 , A61K39/00 , C07K14/47
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic ovarian cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and noncancerous disease states in ovarian, identifying ovarian tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovarian tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性卵巢细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括在卵巢中识别，诊断，监测，分期，成像和治疗卵巢癌和非癌性疾病状态，鉴定卵巢组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程化卵巢组织的生产。

4. 发明申请

US20060051759A1 Compositions and methods relating to breast specific genes and proteins 审中-公开
标题翻译：与乳腺特异性基因和蛋白质有关的组成和方法
公开(公告)号：US20060051759A1
公开(公告)日：2006-03-09
申请号：US10517696
申请日：2003-06-16
申请人： Susana Salceda , Roberto Macina , Leah Turner , Yongming Sun , Chenghua Liu
发明人： Susana Salceda , Roberto Macina , Leah Turner , Yongming Sun , Chenghua Liu
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6886 , A61K38/00 , A61K39/00 , C07K14/4748 , C12Q2600/112
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性乳腺细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括鉴定诊断，监测，分期，成像和治疗乳腺癌和非癌性疾病状态，识别乳腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程乳腺组织的生产。

5. 发明申请

US20050123551A1 Compositions and methods relating to endometrial specific genes and proteins 审中-公开
标题翻译：与子宫内膜特异性基因和蛋白质有关的组成和方法
公开(公告)号：US20050123551A1
公开(公告)日：2005-06-09
申请号：US10499353
申请日：2002-12-20
申请人： Yongming Sun , Chenghua Liu
发明人： Yongming Sun , Chenghua Liu
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P15/00 , A61P35/00 , C07H21/04 , C07K14/47 , C07K14/82 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/00 , C12Q1/68 , G01N33/566 , G01N33/574
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic endometrial cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating endometrial cancer and non-cancerous disease states in endometrial, identifying endometrial tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered endometrial tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性子宫内膜细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗子宫内膜中的子宫内膜癌和非癌性疾病状态，鉴定子宫内膜组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的产生，以及用于治疗和研究的工程子宫内膜组织的产生。

6. 发明申请

US20050084899A1 Compositions and methods relating to breast specific genes and proteins 审中-公开
公开(公告)号：US20050084899A1
公开(公告)日：2005-04-21
申请号：US11005609
申请日：2004-12-06
申请人： Susana Salceda , Roberto Macina , Herve Recipon , Robert Cafferkey , Yongming Sun , Chenghua Liu , Leah Turner
发明人： Susana Salceda , Roberto Macina , Herve Recipon , Robert Cafferkey , Yongming Sun , Chenghua Liu , Leah Turner
IPC分类号： C07K14/47 , C12N1/21 , C12N15/12 , C12Q1/68 , C12Q1/6886 , G01N33/574 , C07H21/04 , C07K14/72
CPC分类号： G01N33/57415 , A61K2039/505 , C07K14/47 , C12Q1/6886 , C12Q2600/158
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast tissue, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.

7. 发明申请

US20050208546A1 Compositions and methods relating to colon secific genes and proteins 失效
标题翻译：与结肠分泌基因和蛋白质有关的组成和方法
公开(公告)号：US20050208546A1
公开(公告)日：2005-09-22
申请号：US11042241
申请日：2005-01-25
申请人： Yongming Sun , Herve Recipon , Malavika Ghosh , Chenghua Liu
发明人： Yongming Sun , Herve Recipon , Malavika Ghosh , Chenghua Liu
IPC分类号： G01N33/53 , A61K38/00 , A61K39/00 , A61K39/395 , A61K48/00 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , G01N33/566 , A61K38/17 , C07H21/04 , C07K14/82 , G01N33/574
CPC分类号： C07K14/47 , A61K38/00 , A61K2039/505 , A61K2039/53
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic colon cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating colon cancer and non-cancerous disease states in colon tissue, identifying colon tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered colon tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性结肠细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括鉴定，诊断，监测，分期，成像和治疗结肠组织中的结肠癌和非癌性疾病状态，鉴定结肠组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程结肠组织的生产。

8. 发明申请

US20050208062A1 Compositions and methods relating to hepatic specific genes and proteins 审中-公开
标题翻译：与肝脏特异性基因和蛋白质有关的组成和方法
公开(公告)号：US20050208062A1
公开(公告)日：2005-09-22
申请号：US10499065
申请日：2002-12-20
申请人： Yongming Sun , Chenghua Liu
发明人： Yongming Sun , Chenghua Liu
IPC分类号： A61K38/00 , A61K39/00 , C07H21/04 , C07K14/47 , C07K14/705 , C12N1/21 , C12N15/12 , C12Q1/68 , G01N33/574
CPC分类号： C07K14/4748 , A61K38/00 , C12Q1/6886 , C12Q2600/158 , G01N33/57438
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic hepatic cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating hepatic cancer and non-cancerous disease states in hepatic, identifying hepatic tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered hepatic tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性肝细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗肝脏中的肝癌和非癌性疾病状态，鉴定肝组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程化肝组织的生产。

9. 发明申请

US20050148008A1 Compositions and methods relating to ovarian specific genes and proteins 审中-公开
标题翻译：与卵巢特异性基因和蛋白质有关的组成和方法
公开(公告)号：US20050148008A1
公开(公告)日：2005-07-07
申请号：US11057516
申请日：2005-02-14
申请人： Susana Salceda , Roberto Macina , Ping Hu , Herve Recipon , Kalpana Karra , Robert Cafferkey , Yongming Sun , Chenghua Liu
发明人： Susana Salceda , Roberto Macina , Ping Hu , Herve Recipon , Kalpana Karra , Robert Cafferkey , Yongming Sun , Chenghua Liu
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , C12Q1/68 , A61K48/00 , C07H21/04 , C07K14/72 , C07K16/30
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic ovary cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and non-cancerous disease states in ovary tissue, identifying ovary tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovary tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性卵巢细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗卵巢组织中的卵巢癌和非癌性疾病状态，鉴定卵巢组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程化卵巢组织的生产。

10. 发明申请

US20050048559A1 Compositions and methods relating to breast specific genes and proteins 审中-公开
标题翻译：与乳腺特异性基因和蛋白质有关的组成和方法
公开(公告)号：US20050048559A1
公开(公告)日：2005-03-03
申请号：US10958863
申请日：2004-10-05
申请人： Susana Salceda , Roberto Macina , Herve Recipon , Robert Cafferkey , Yongming Sun , Chenghua Liu
发明人： Susana Salceda , Roberto Macina , Herve Recipon , Robert Cafferkey , Yongming Sun , Chenghua Liu
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , G01N33/574 , C12Q1/68 , C07H21/04
CPC分类号： C07K14/47 , A61K38/00 , G01N33/57415
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast tissue, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性乳腺细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗乳腺组织中的乳腺癌和非癌性疾病状态，鉴定乳腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程乳腺组织的生产。

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