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1. 发明授权

US07208267B2 Compositions and methods relating to breast specific genes and proteins 失效
标题翻译：与乳腺特异性基因和蛋白质有关的组成和方法
公开(公告)号：US07208267B2
公开(公告)日：2007-04-24
申请号：US09989890
申请日：2001-11-21
申请人： Susana Salceda , Roberto Macina , Herve E. Recipon , Jason Pluta , Yongming Sun , Chenghua Liu
发明人： Susana Salceda , Roberto Macina , Herve E. Recipon , Jason Pluta , Yongming Sun , Chenghua Liu
IPC分类号： C12Q1/68 , C12N15/00 , C12N5/00 , C12N15/11 , C12N15/12 , C12P21/02 , A61K31/711 , A61K31/713
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , A61K2039/505 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast tissue, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性乳腺细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗乳腺组织中的乳腺癌和非癌性疾病状态，鉴定乳腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程乳腺组织的生产。

2. 发明授权

US06855517B2 Compositions and methods relating to breast specific genes and proteins 失效
公开(公告)号：US06855517B2
公开(公告)日：2005-02-15
申请号：US10001887
申请日：2001-11-20
申请人： Susana Salceda , Roberto A. Macina , Herve E. Recipon , Robert Cafferkey , Yongming Sun , Chenghua Liu
发明人： Susana Salceda , Roberto A. Macina , Herve E. Recipon , Robert Cafferkey , Yongming Sun , Chenghua Liu
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , G01N33/574 , C12Q1/68 , C07H21/04
CPC分类号： C07K14/47 , A61K38/00 , G01N33/57415
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast tissue, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.

3. 发明授权

US06846650B2 Compositions and methods relating to lung specific genes and proteins 失效
标题翻译：与肺特异性基因和蛋白质有关的组成和方法
公开(公告)号：US06846650B2
公开(公告)日：2005-01-25
申请号：US10002344
申请日：2001-10-25
申请人： Herve E. Recipon , Yongming Sun , Sei-Yu Chen , Chenghua Liu , Leah R. Turner
发明人： Herve E. Recipon , Yongming Sun , Sei-Yu Chen , Chenghua Liu , Leah R. Turner
IPC分类号： G01N33/53 , A61K38/00 , A61K39/00 , A61K39/395 , A61K48/00 , A61P11/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/566 , G01N33/574 , C07H21/04
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic lung cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating lung cancer and non-cancerous disease states in lung, identifying lung tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered lung tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性肺细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗肺中的肺癌和非癌性疾病状态，识别肺组织，监测和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程化肺组织的生产。

4. 发明申请

US20080267863A1 Method of Diagnosing, Monitoring, Staging, Imaging and Treating Colon Cancer 审中-公开
标题翻译：诊断，监测，分期，成像和治疗结肠癌的方法
公开(公告)号：US20080267863A1
公开(公告)日：2008-10-30
申请号：US12136444
申请日：2008-06-10
申请人： Roberto A. Macina , Sei-Yu Chen , Jason Pluta , Yongming Sun , Herve E. Recipon
发明人： Roberto A. Macina , Sei-Yu Chen , Jason Pluta , Yongming Sun , Herve E. Recipon
IPC分类号： A61K51/10 , C07H21/04 , C07K14/705 , C12Q1/68 , A61P35/04 , A61K39/00 , C07K16/18 , A61K39/395
CPC分类号： G01N33/57419 , A61K49/0008 , C12Q1/6886 , C12Q2600/136
摘要： The present invention provides new methods for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating colon cancer.
摘要翻译：本发明提供了检测，诊断，监测，分期，预后，成像和治疗结肠癌的新方法。

5. 发明授权

US07361475B2 Compositions and methods relating to colon specific genes and proteins 失效
标题翻译：与结肠特异性基因和蛋白质有关的组成和方法
公开(公告)号：US07361475B2
公开(公告)日：2008-04-22
申请号：US11042241
申请日：2005-01-25
申请人： Yongming Sun , Herve E. Recipon , Malavika G. Ghosh , Chenghua Liu
发明人： Yongming Sun , Herve E. Recipon , Malavika G. Ghosh , Chenghua Liu
IPC分类号： G01N33/53 , C07K16/00 , A61K39/395
CPC分类号： C07K14/47 , A61K38/00 , A61K2039/505 , A61K2039/53
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic colon cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating colon cancer and non-cancerous disease states in colon tissue, identifying colon tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered colon tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性结肠细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括鉴定，诊断，监测，分期，成像和治疗结肠组织中的结肠癌和非癌性疾病状态，鉴定结肠组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程结肠组织的生产。

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