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1. 发明授权

US07947451B2 Genetic polymorphisms associated with psoriasis, methods of detection and uses thereof 有权
标题翻译：与牛皮癣相关的遗传多态性，检测方法及其用途
公开(公告)号：US07947451B2
公开(公告)日：2011-05-24
申请号：US12325832
申请日：2008-12-01
申请人： Yonghong Li , Ann Begovich , Monica Chang , Michele Cargill , Steven Schrodi
发明人： Yonghong Li , Ann Begovich , Monica Chang , Michele Cargill , Steven Schrodi
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/6881 , G01N33/6893 , G01N2500/04 , G01N2800/065 , G01N2800/205 , G01N2800/50
摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with psoriasis and related pathologies. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, including groups of nucleic acid molecules that may be used as a signature marker set, such as a haplotype, a diplotype, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
摘要翻译：本发明基于与牛皮癣和相关病理学相关的遗传多态性的发现。具体地，本发明涉及含有多态性的核酸分子，包括可用作签名标记组的核酸分子的基团，例如单倍型，外来型，由该核酸分子编码的变体蛋白，用于检测多态性核酸分子和蛋白质，以及使用核酸和蛋白质的方法以及使用试剂进行检测的方法。

2. 发明授权

US07816083B2 Genetic polymorphisms associated with neurodegenerative diseases, methods of detection and uses thereof 有权
标题翻译：与神经变性疾病相关的遗传多态性，检测方法及其应用
公开(公告)号：US07816083B2
公开(公告)日：2010-10-19
申请号：US12151163
申请日：2008-05-01
申请人： Andrew Grupe , Yonghong Li
发明人： Andrew Grupe , Yonghong Li
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172
摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
摘要翻译：本发明基于与神经变性疾病，特别是阿尔茨海默病和帕金森病相关的遗传多态性的发现。特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法用于检测的试剂。

3. 发明申请

US20070254289A1 Genetic polymorphisms associated with Alzheimer's Disease, methods of detection and uses thereof 有权
标题翻译：与阿尔茨海默病相关的遗传多态性，检测方法及其应用
公开(公告)号：US20070254289A1
公开(公告)日：2007-11-01
申请号：US11586427
申请日：2006-10-24
申请人： Yonghong Li , Andrew Grupe
发明人： Yonghong Li , Andrew Grupe
IPC分类号： G01N33/53 , C07H21/04 , C07K16/18 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with Alzheimer's Disease. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
摘要翻译：本发明基于与阿尔茨海默病相关的遗传多态性的发现。特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法用于检测的试剂。

4. 发明申请

US20090130682A1 GENETIC POLYMORPHISMS ASSOCIATED WITH LIVER FIBROSIS, METHODS OF DETECTION AND USES THEREOF 有权
标题翻译：与肝纤维化相关的遗传多态性，检测方法及其用途
公开(公告)号：US20090130682A1
公开(公告)日：2009-05-21
申请号：US12264501
申请日：2008-11-04
申请人： Yonghong Li , Hongjin Huang
发明人： Yonghong Li , Hongjin Huang
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with liver fibrosis and related pathologies. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, including groups of nucleic acid molecules that may be used as a signature marker set, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
摘要翻译：本发明基于与肝纤维化和相关病理学相关的遗传多态性的发现。具体地，本发明涉及含有多态性的核酸分子，包括可用作标记标记组的核酸分子组，由该核酸分子编码的变体蛋白，用于检测多态型核酸分子和蛋白质的试剂，以及使用核酸和蛋白质的方法以及使用试剂进行检测的方法。

5. 发明申请

US20080051318A1 Genetic polymorphisms associated with Alzheimer's disease, methods of detection and uses thereof 有权
标题翻译：与阿尔茨海默病相关的遗传多态性，检测方法及其应用
公开(公告)号：US20080051318A1
公开(公告)日：2008-02-28
申请号：US11827992
申请日：2007-07-13
申请人： Yonghong Li , Andrew Grupe
发明人： Yonghong Li , Andrew Grupe
IPC分类号： A61K31/70 , A01K67/00 , A61P25/28 , C07H21/04 , C07K16/00 , C12N15/00 , C12N5/00 , C12Q1/68 , G01N33/50 , G01N33/53
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/6896 , G01N2800/2821
摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with Alzheimer's Disease. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
摘要翻译：本发明基于与阿尔茨海默病相关的遗传多态性的发现。特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法用于检测的试剂。

6. 发明申请

US20080286796A1 Genetic polymorphisms associated with neurodegenerative diseases, methods of detection and uses thereof 有权
标题翻译：与神经变性疾病相关的遗传多态性，检测方法及其应用
公开(公告)号：US20080286796A1
公开(公告)日：2008-11-20
申请号：US12151163
申请日：2008-05-01
申请人： Andrew Grupe , Yonghong Li
发明人： Andrew Grupe , Yonghong Li
IPC分类号： C12Q1/68 , G01N33/566
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172
摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
摘要翻译：本发明基于与神经变性疾病，特别是阿尔茨海默病和帕金森病相关的遗传多态性的发现。特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法用于检测的试剂。

7. 发明授权

US09176467B2 Printer cartridge having a retractable mechanism 有权
标题翻译：具有可缩回机构的打印机墨盒
公开(公告)号：US09176467B2
公开(公告)日：2015-11-03
申请号：US13548981
申请日：2012-07-13
申请人： Weidong Gu , Geming Ding , Yonghong Li , Zhiyong Li , Jianxin Cao , Xiong Li , Xiaobing Liu
发明人： Weidong Gu , Geming Ding , Yonghong Li , Zhiyong Li , Jianxin Cao , Xiong Li , Xiaobing Liu
IPC分类号： G03G21/00 , G03G21/18
CPC分类号： G03G21/1857 , G03G21/186
摘要： The invention relates to a process cartridge, which comprises a process cartridge housing, a photosensitive member, a driving force receiving opening, a retractable mechanism and a control mechanism, wherein the photosensitive member is arranged inside the process cartridge housing; the driving force receiving opening is connected with the photosensitive member and provides a driving force for the photosensitive member; the retractable mechanism allows the driving force receiving opening to extend or retract in the axial direction of the photosensitive member; and the control mechanism controls the extension and retraction of the retractable mechanism.
摘要翻译：本发明涉及一种处理盒，其包括处理盒壳体，感光构件，驱动力接收开口，可伸缩机构和控制机构，其中感光构件布置在处理盒壳体内; 驱动力接收开口与感光构件连接，并为感光构件提供驱动力; 可伸缩机构允许驱动力接收开口在感光构件的轴向方向上延伸或缩回; 并且控制机构控制伸缩机构的伸缩。

8. 发明授权

US07855515B2 High-voltage high-power constant current LED driver device 失效
标题翻译：高压大功率恒流LED驱动器
公开(公告)号：US07855515B2
公开(公告)日：2010-12-21
申请号：US12178746
申请日：2008-07-24
申请人： Chaogang Huang , Yonghong Li
发明人： Chaogang Huang , Yonghong Li
IPC分类号： H05B41/00
CPC分类号： H05B33/0818
摘要： A high-voltage high-power constant current LED driver device, can drive LED cluster, comprises switch tube, current sensing resistor Rcs and inductor L, particularly, comprises a low voltage control circuit that detects the voltage drop on the said current sensing resistor Rcs to produce a control signal transmitting to the control terminal of the switch tube; the said current sensing resistor Rcs connects with inductor L in series and is positioned between the output terminal of switch tube and the current output terminal of the current driving device in series connection; the input terminal of the said switch tube is connected to a DC voltage source; and also comprises a diode D3 which the cathode is connected to the output terminal of the said switch tube and anti cathode is grounding. The device of the invention has the advantages of constant current, simple driving circuit and low cost under the high-voltage high-power application.
摘要翻译：一种高压大功率恒流LED驱动器件，可驱动LED集群，包括开关管，电流检测电阻器Rcs和电感器L，特别是包括一个低电压控制电路，用于检测电流检测电阻器Rcs上的电压降以产生传送到开关管的控制端的控制信号; 所述电流感测电阻器Rcs串联连接电感器L，并且位于开关管的输出端子与串联连接的电流驱动装置的电流输出端子之间; 所述开关管的输入端连接到直流电压源; 并且还包括二极管D3，阴极连接到所述开关管的输出端子，反电极接地。本发明的装置具有电流恒流，驱动电路简单，低电压大功率低成本的优点。

9. 发明授权

US07695911B2 Genetic polymorphisms associated with Alzheimer's Disease, methods of detection and uses thereof 有权
标题翻译：与阿尔茨海默病相关的遗传多态性，检测方法及其应用
公开(公告)号：US07695911B2
公开(公告)日：2010-04-13
申请号：US11586427
申请日：2006-10-24
申请人： Yonghong Li , Andrew Grupe
发明人： Yonghong Li , Andrew Grupe
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with Alzheimer's Disease. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
摘要翻译：本发明基于与阿尔茨海默病相关的遗传多态性的发现。特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法用于检测的试剂。

10. 发明授权

US08039212B2 Genetic polymorphisms associated with liver fibrosis, methods of detection and uses thereof 有权
标题翻译：与肝纤维化相关的遗传多态性，检测方法及其应用
公开(公告)号：US08039212B2
公开(公告)日：2011-10-18
申请号：US12264501
申请日：2008-11-04
申请人： Yonghong Li , Hongjin Huang
发明人： Yonghong Li , Hongjin Huang
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with liver fibrosis and related pathologies. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, including groups of nucleic acid molecules that may be used as a signature marker set, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
摘要翻译：本发明基于与肝纤维化和相关病理学相关的遗传多态性的发现。具体地，本发明涉及含有多态性的核酸分子，包括可用作标记标记组的核酸分子组，由该核酸分子编码的变体蛋白，用于检测多态型核酸分子和蛋白质的试剂，以及使用核酸和蛋白质的方法以及使用试剂进行检测的方法。

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