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1. 发明授权

US07695911B2 Genetic polymorphisms associated with Alzheimer's Disease, methods of detection and uses thereof 有权
标题翻译：与阿尔茨海默病相关的遗传多态性，检测方法及其应用
公开(公告)号：US07695911B2
公开(公告)日：2010-04-13
申请号：US11586427
申请日：2006-10-24
申请人： Yonghong Li , Andrew Grupe
发明人： Yonghong Li , Andrew Grupe
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with Alzheimer's Disease. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
摘要翻译：本发明基于与阿尔茨海默病相关的遗传多态性的发现。特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法用于检测的试剂。

2. 发明申请

US20080051318A1 Genetic polymorphisms associated with Alzheimer's disease, methods of detection and uses thereof 有权
标题翻译：与阿尔茨海默病相关的遗传多态性，检测方法及其应用
公开(公告)号：US20080051318A1
公开(公告)日：2008-02-28
申请号：US11827992
申请日：2007-07-13
申请人： Yonghong Li , Andrew Grupe
发明人： Yonghong Li , Andrew Grupe
IPC分类号： A61K31/70 , A01K67/00 , A61P25/28 , C07H21/04 , C07K16/00 , C12N15/00 , C12N5/00 , C12Q1/68 , G01N33/50 , G01N33/53
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/6896 , G01N2800/2821
摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with Alzheimer's Disease. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
摘要翻译：本发明基于与阿尔茨海默病相关的遗传多态性的发现。特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法用于检测的试剂。

3. 发明授权

US07651840B2 Genetic polymorphisms associated with Alzheimer's disease, methods of detection and uses thereof 有权
标题翻译：与阿尔茨海默病相关的遗传多态性，检测方法及其应用
公开(公告)号：US07651840B2
公开(公告)日：2010-01-26
申请号：US11827992
申请日：2007-07-13
申请人： Yonghong Li , Andrew Grupe
发明人： Yonghong Li , Andrew Grupe
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/6896 , G01N2800/2821
摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with Alzheimer's Disease. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
摘要翻译：本发明基于与阿尔茨海默病相关的遗传多态性的发现。特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法用于检测的试剂。

4. 发明申请

US20080286796A1 Genetic polymorphisms associated with neurodegenerative diseases, methods of detection and uses thereof 有权
标题翻译：与神经变性疾病相关的遗传多态性，检测方法及其应用
公开(公告)号：US20080286796A1
公开(公告)日：2008-11-20
申请号：US12151163
申请日：2008-05-01
申请人： Andrew Grupe , Yonghong Li
发明人： Andrew Grupe , Yonghong Li
IPC分类号： C12Q1/68 , G01N33/566
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172
摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
摘要翻译：本发明基于与神经变性疾病，特别是阿尔茨海默病和帕金森病相关的遗传多态性的发现。特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法用于检测的试剂。

5. 发明授权

US07816083B2 Genetic polymorphisms associated with neurodegenerative diseases, methods of detection and uses thereof 有权
标题翻译：与神经变性疾病相关的遗传多态性，检测方法及其应用
公开(公告)号：US07816083B2
公开(公告)日：2010-10-19
申请号：US12151163
申请日：2008-05-01
申请人： Andrew Grupe , Yonghong Li
发明人： Andrew Grupe , Yonghong Li
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172
摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
摘要翻译：本发明基于与神经变性疾病，特别是阿尔茨海默病和帕金森病相关的遗传多态性的发现。特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法用于检测的试剂。

6. 发明申请

US20070254289A1 Genetic polymorphisms associated with Alzheimer's Disease, methods of detection and uses thereof 有权
标题翻译：与阿尔茨海默病相关的遗传多态性，检测方法及其应用
公开(公告)号：US20070254289A1
公开(公告)日：2007-11-01
申请号：US11586427
申请日：2006-10-24
申请人： Yonghong Li , Andrew Grupe
发明人： Yonghong Li , Andrew Grupe
IPC分类号： G01N33/53 , C07H21/04 , C07K16/18 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with Alzheimer's Disease. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
摘要翻译：本发明基于与阿尔茨海默病相关的遗传多态性的发现。特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法用于检测的试剂。

7. 发明授权

US06479490B2 3-indolyl-4-phenyl-1H-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3&bgr; 失效
标题翻译： 3-吲哚基-4-苯基-1H-吡咯-2,5-二酮衍生物作为糖原合酶激酶-3β的抑制剂
公开(公告)号：US06479490B2
公开(公告)日：2002-11-12
申请号：US09916706
申请日：2001-07-27
申请人： Leyi Gong , Andrew Grupe , Gary Allen Peltz
发明人： Leyi Gong , Andrew Grupe , Gary Allen Peltz
IPC分类号： A61K31535
CPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14
摘要： This invention relates to inhibitors of glycogen synthase kinase-3&bgr;, methods of treating diseases characterized by an excess of Th2 cytokines, and to 3-indolyl-4-phenyl-1H-pyrrole-2,5-dione derivatives of Formula (I): that are inhibitors of glycogen synthase kinase -3&bgr;, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
摘要翻译：本发明涉及糖原合成酶激酶-3β的抑制剂，治疗以过量的Th2细胞因子为特征的疾病的方法，以及式（I）的3-吲哚基-4-苯基-1H-吡咯-2,5-二酮衍生物：即糖原合酶激酶-3β的抑制剂，含有它们的药物组合物，其使用方法和制备这些化合物的方法。

8. 发明授权

US07698117B2 System and method for predicting chromosomal regions that control phenotypic traits 失效
标题翻译：用于预测控制表型性状的染色体区域的系统和方法
公开(公告)号：US07698117B2
公开(公告)日：2010-04-13
申请号：US10015167
申请日：2001-12-11
申请人： Jonathan A. Usuka , Andrew Grupe , Gary Allen Peltz
发明人： Jonathan A. Usuka , Andrew Grupe , Gary Allen Peltz
IPC分类号： G06G7/48 , G06G7/58 , G01N33/48 , G01N31/00
CPC分类号： G06F19/18 , C12Q1/6876
摘要： A method of associating a phenotype with one or more candidate chromosomal regions in a genome of an organism includes the step of deriving a phenotypic data structure that represents differences in phenotypes between different strains of the organism. Further, a genotypic data structure is established. The genotypic data structure corresponds to a locus selected from a plurality of loci in the genome of the organism. The genotypic data structure represents variations of at least one component of the locus between different strains of the organism. The phenotypic data structure is compared to the genotypic data structure to form a correlation value. The process of establishing a genotypic data structure and comparing it to the phenotypic data structure is repeated for each locus in the plurality of loci, thereby identifying one or more genotypic data structures that form a high correlation value relative to all other compared genotypic data structures. The loci that correspond to the one or more genotypic data structures having a high correlation value represent the one or more candidate chromosomal regions.
摘要翻译：将表型与生物体基因组中的一个或多个候选染色体区域相关联的方法包括产生表示生物体不同菌株之间的表型差异的表型数据结构的步骤。此外，建立了基因型数据结构。基因型数据结构对应于选自生物体基因组中多个基因座的位点。基因型数据结构表示生物体的不同菌株之间的轨迹的至少一个成分的变化。将表型数据结构与基因型数据结构进行比较，形成相关值。针对多个基因座中的每个基因座重复建立基因型数据结构并将其与表型数据结构进行比较的过程，从而鉴定相对于所有其他比较的基因型数据结构形成高相关值的一个或多个基因型数据结构。对应于具有高相关值的一个或多个基因型数据结构的基因座表示一个或多个候选染色体区域。

9. 发明申请

US20050096258A1 Methods and compositions for treating gastrointestinal tract mucin production associated disease conditions 审中-公开
标题翻译：用于治疗胃肠道粘蛋白生成相关疾病状况的方法和组合物
公开(公告)号：US20050096258A1
公开(公告)日：2005-05-05
申请号：US10967463
申请日：2004-10-18
申请人： Andrew Grupe , David Szymkowski
发明人： Andrew Grupe , David Szymkowski
IPC分类号： A61K31/44 , A61K38/17 , A61K39/00 , A61K39/38 , G01N33/68
CPC分类号： G01N33/6872
摘要： The invention provides a method of treatment for an animal having a disease state associated with a mucus secretion disorder with a chloride channel modulator. The invention further provides for a method of screening for therapeutic compounds using the chloride channel. Also provided is a transgenic animal having a disrupted chloride gene, and a method of diagnosing a disease state associated with a mucus secretion disorder.
摘要翻译：本发明提供了一种使用氯化物通道调节剂治疗具有与粘液分泌紊乱相关的疾病状态的动物的方法。本发明还提供了使用氯化物通道筛选治疗化合物的方法。还提供了具有破坏的氯化物基因的转基因动物，以及诊断与粘液分泌病症相关的疾病状态的方法。

10. 发明授权

US5968508A Antagonists to insulin receptor tyrosine kinase inhibitor 失效
标题翻译：胰岛素受体酪氨酸激酶抑制剂的拮抗剂
公开(公告)号：US5968508A
公开(公告)日：1999-10-19
申请号：US504169
申请日：1995-07-19
申请人： Ira D. Goldfine , Andrew Grupe , Betty A. Maddux , Steven Spencer , Timothy A. Stewart , Denise M. Harrison
发明人： Ira D. Goldfine , Andrew Grupe , Betty A. Maddux , Steven Spencer , Timothy A. Stewart , Denise M. Harrison
IPC分类号： G01N33/53 , A61P3/10 , C07K16/40 , G01N33/566 , G01N33/573 , G01N33/577 , G01N33/74 , A61K39/395 , C07K16/00
CPC分类号： G01N33/74 , C07K16/40 , G01N33/573 , A61K2039/505 , G01N2333/62 , G01N2333/72 , G01N2333/9121
摘要： A method of diagnosing insulin resistance and related disorders is provided. Additionally, methods of treating mammals with insulin resistance and related disorders is provided. The methods employ antagonists to an insulin receptor tyrosine kinase inhibitor protein.
摘要翻译：提供了诊断胰岛素抵抗和相关疾病的方法。此外，提供了治疗具有胰岛素抵抗和相关疾病的哺乳动物的方法。该方法使用胰岛素受体酪氨酸激酶抑制蛋白的拮抗剂。

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