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1. 发明授权

US07698117B2 System and method for predicting chromosomal regions that control phenotypic traits 失效
标题翻译：用于预测控制表型性状的染色体区域的系统和方法
公开(公告)号：US07698117B2
公开(公告)日：2010-04-13
申请号：US10015167
申请日：2001-12-11
申请人： Jonathan A. Usuka , Andrew Grupe , Gary Allen Peltz
发明人： Jonathan A. Usuka , Andrew Grupe , Gary Allen Peltz
IPC分类号： G06G7/48 , G06G7/58 , G01N33/48 , G01N31/00
CPC分类号： G06F19/18 , C12Q1/6876
摘要： A method of associating a phenotype with one or more candidate chromosomal regions in a genome of an organism includes the step of deriving a phenotypic data structure that represents differences in phenotypes between different strains of the organism. Further, a genotypic data structure is established. The genotypic data structure corresponds to a locus selected from a plurality of loci in the genome of the organism. The genotypic data structure represents variations of at least one component of the locus between different strains of the organism. The phenotypic data structure is compared to the genotypic data structure to form a correlation value. The process of establishing a genotypic data structure and comparing it to the phenotypic data structure is repeated for each locus in the plurality of loci, thereby identifying one or more genotypic data structures that form a high correlation value relative to all other compared genotypic data structures. The loci that correspond to the one or more genotypic data structures having a high correlation value represent the one or more candidate chromosomal regions.
摘要翻译：将表型与生物体基因组中的一个或多个候选染色体区域相关联的方法包括产生表示生物体不同菌株之间的表型差异的表型数据结构的步骤。此外，建立了基因型数据结构。基因型数据结构对应于选自生物体基因组中多个基因座的位点。基因型数据结构表示生物体的不同菌株之间的轨迹的至少一个成分的变化。将表型数据结构与基因型数据结构进行比较，形成相关值。针对多个基因座中的每个基因座重复建立基因型数据结构并将其与表型数据结构进行比较的过程，从而鉴定相对于所有其他比较的基因型数据结构形成高相关值的一个或多个基因型数据结构。对应于具有高相关值的一个或多个基因型数据结构的基因座表示一个或多个候选染色体区域。

2. 发明授权

US07647188B2 Systems and methods for processing nucleic acid chromatograms 失效
标题翻译：用于处理核酸色谱图的系统和方法
公开(公告)号：US07647188B2
公开(公告)日：2010-01-12
申请号：US10942538
申请日：2004-09-15
申请人： Guochun Liao , Jonathan A. Usuka , Gary Allen Peltz
发明人： Guochun Liao , Jonathan A. Usuka , Gary Allen Peltz
IPC分类号： G06F19/00
CPC分类号： G06F19/22
摘要： Computer systems, computer program products and methods for processing an input nucleic acid chromatogram having a plurality of substantially simultaneous traces. Each trace in the plurality of traces has a plurality of datapoints. Each respective datapoint in each of the plurality of datapoints represents a signal amplitude at a position in the trace corresponding to the respective datapoint. A first peak is identified in a first trace that is substantially overlapping a second peak in a second trace in the plurality of traces. The first peak is outputted to a first output homozygous representation and the second peak is outputted to a second output homozygous representation. The first output homozygous representation is a first homozygous sequence representation or a first homozygous nucleic acid chromatogram corresponding to the input nucleic acid chromatogram. The second output homozygous representation is a second homozygous sequence representation or second homozygous nucleic acid chromatogram of the input nucleic acid chromatogram.
摘要翻译：计算机系统，计算机程序产品和用于处理具有多个基本上同时的踪迹的输入核酸色谱图的方法。多个迹线中的每个迹线具有多个数据点。多个数据点中的每一个中的每个相应数据点表示对应于相应数据点的轨迹位置处的信号振幅。在第一迹线中识别出第一峰值，其基本上与多个迹线中的第二迹线中的第二峰值重叠。将第一峰值输出到第一输出纯合表示，并将第二峰值输出到第二输出纯合表示。第一个输出纯合表达是对应于输入核酸色谱图的第一个纯合序列表示或第一个纯合的核酸色谱图。第二个输出纯合表达是输入核酸色谱图的第二个纯合序列表示或第二个纯合的核酸色谱图。

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