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1. 发明授权

US06656971B2 Trisubstituted carbocyclic cyclophilin binding compounds and their use 失效
公开(公告)号：US06656971B2
公开(公告)日：2003-12-02
申请号：US10057203
申请日：2002-01-25
申请人： Yong-Qian Wu , Sergei Belyakov , Gregory S. Hamilton , David Limburg , Joseph P. Steiner , Mark Vaal , Ling Wei , Douglas Wilkinson
发明人： Yong-Qian Wu , Sergei Belyakov , Gregory S. Hamilton , David Limburg , Joseph P. Steiner , Mark Vaal , Ling Wei , Douglas Wilkinson
IPC分类号： A61K31166
CPC分类号： C07D209/48 , A61K31/325 , C07C233/29 , C07C233/66 , C07C233/75 , C07C233/76 , C07C235/42 , C07C235/56 , C07C243/38 , C07C255/54 , C07C275/42 , C07C311/46 , C07C311/48 , C07C335/18 , C07C335/36 , C07C337/06 , C07C2602/10 , C07D213/56 , C07D213/74 , C07D231/12 , C07D233/56 , C07D249/08 , C07D295/135 , Y02A50/409 , Y02A50/411 , Y02A50/421 , Y02A50/422 , Y02A50/423
摘要： The present invention relates to novel, non-peptidic small organic compounds having an affinity for cyclophilin (CyP)-type immunophilin proteins, and to pharmaceutical compositions comprising one or more of the said compounds. The invention further relates to the uses of these compounds and compositions for binding CyP-type proteins, inhibiting their peptidyl-prolyl isomerase activity, and for research, development, and therapeutic applications in a variety of medical disorders.

2. 发明授权

US06677376B1 Non-peptidic cyclophilin binding compounds and their use 失效
标题翻译：非肽亲环蛋白结合化合物及其用途
公开(公告)号：US06677376B1
公开(公告)日：2004-01-13
申请号：US09656898
申请日：2000-09-07
申请人： Gregory S. Hamilton , Joseph P. Steiner , Mark J. Vaal , Chi Choi , Ling Wei
发明人： Gregory S. Hamilton , Joseph P. Steiner , Mark J. Vaal , Chi Choi , Ling Wei
IPC分类号： A61K3118
CPC分类号： C07C275/28 , A61K31/17 , C07C275/30 , C07C275/40 , C07C275/42 , C07C311/21 , C07C323/62 , C07C2601/14
摘要： The invention relates to non-peptidic compounds that possess bioactive properties, such as the ability to protect neuronal cells from otherwise lethal treatments or the ability to promote the growth or regeneration of neuronal cells. In part, the invention provides compounds that interact with or bind to a cyclophilin and compounds that have activity towards neuronal cells. Methods for using the compounds, such as administering them to cells or animals or using them to treat neurodegenerative conditions, are specifically included.
摘要翻译：本发明涉及具有生物活性的非肽类化合物，例如保护神经细胞免受其他致死性治疗或促进神经元细胞生长或再生的能力。部分地，本发明提供了与亲环蛋白相互作用或结合的化合物和对神经元细胞具有活性的化合物。具体包括使用化合物的方法，例如将其施用于细胞或动物或用于治疗神经变性病症。

3. 发明授权

US08236802B2 PARP inhibitor compounds, compositions and methods of use 有权
标题翻译： PARP抑制剂化合物，组合物和使用方法
公开(公告)号：US08236802B2
公开(公告)日：2012-08-07
申请号：US12244399
申请日：2008-10-02
申请人： Weizheng Xu , Greg Delahanty , Ling Wei , Jie Zhang
发明人： Weizheng Xu , Greg Delahanty , Ling Wei , Jie Zhang
IPC分类号： A01N43/58 , A61K31/50 , C07D491/00
CPC分类号： A61K31/519 , A61K31/53 , C07D487/06 , C07D519/00
摘要： The present invention relates to tetraaza phenalen-3-one compounds which inhibit poly (ADP-ribose) polymerase (PARP) and are useful in the chemosensitization of cancer therapeutics. The induction of peripheral neuropathy is a common side-effect of many of the conventional and newer chemotherapies. The present invention further provides means to reliably prevent or cure chemotherapy-induced neuropathy. The invention also relates to the use of the disclosed PARP inhibitor compounds in enhancing the efficacy of chemotherapeutic agents such as temozolomide. The invention also relates to the use of the disclosed PARP inhibitor compounds to radiosensitize tumor cells to ionizing radiation. The invention also relates to the use of the disclosed PARP inhibitor compounds for treatment of cancers with DNA repair defects.
摘要翻译：本发明涉及抑制聚（ADP-核糖）聚合酶（PARP）并可用于癌症治疗剂的化学敏化的四氮芥苯并三氮唑-3-酮化合物。周围神经病变的诱导是许多常规和较新的化学疗法的常见副作用。本发明还提供了可靠地预防或治愈化疗诱发的神经病变的方法。本发明还涉及所公开的PARP抑制剂化合物在增强化疗剂如替莫唑胺的功效中的用途。本发明还涉及所公开的PARP抑制剂化合物对肿瘤细胞对电离辐射进行放射增敏的用途。本发明还涉及所公开的PARP抑制剂化合物用于治疗具有DNA修复缺陷的癌症的用途。

4. 发明申请

US20130011365A1 PARP INHIBITOR COMPOUNDS, COMPOSITIONS AND METHODS OF USE 有权
标题翻译： PARP抑制剂化合物，组合物和使用方法
公开(公告)号：US20130011365A1
公开(公告)日：2013-01-10
申请号：US13527158
申请日：2012-06-19
申请人： Weizheng XU , Greg Delahanty , Ling Wei , Jie Zhang
发明人： Weizheng XU , Greg Delahanty , Ling Wei , Jie Zhang
IPC分类号： A61K31/519 , A61K33/24 , A61K31/7008 , A61K38/21 , A61K31/7036 , A61K31/7048 , A61K31/664 , A61P35/00 , A61P35/02 , A61K38/14 , A61K31/704 , A61K38/20
CPC分类号： A61K31/519 , A61K31/53 , C07D487/06 , C07D519/00
摘要： The present invention relates to tetraaza phenalen-3-one compounds which inhibit poly (ADP-ribose) polymerase (PARP) and are useful in the chemosensitization of cancer therapeutics. The induction of peripheral neuropathy is a common side-effect of many of the conventional and newer chemotherapies. The present invention further provides means to reliably prevent or cure chemotherapy-induced neuropathy. The invention also relates to the use of the disclosed PARP inhibitor compounds in enhancing the efficacy of chemotherapeutic agents such as temozolomide. The invention also relates to the use of the disclosed PARP inhibitor compounds to radio sensitize tumor cells to ionizing radiation. The invention also relates to the use of the disclosed PARP inhibitor compounds for treatment of cancers with DNA repair defects.
摘要翻译：本发明涉及抑制聚（ADP-核糖）聚合酶（PARP）并可用于癌症治疗剂的化学敏化的四氮芥苯并三氮唑-3-酮化合物。周围神经病变的诱导是许多常规和较新的化学疗法的常见副作用。本发明还提供了可靠地预防或治愈化疗诱发的神经病变的方法。本发明还涉及所公开的PARP抑制剂化合物在增强化疗剂如替莫唑胺的功效中的用途。本发明还涉及所公开的PARP抑制剂化合物对肿瘤细胞对电离辐射的敏感性的应用。本发明还涉及所公开的PARP抑制剂化合物用于治疗具有DNA修复缺陷的癌症的用途。

5. 发明授权

US08189958B2 Method of fast image reconstruction 有权
标题翻译：快速图像重建方法
公开(公告)号：US08189958B2
公开(公告)日：2012-05-29
申请号：US12538006
申请日：2009-08-07
申请人： Guogua Shi , Xiqi Li , Ling Wei , Yudong Zhang
发明人： Guogua Shi , Xiqi Li , Ling Wei , Yudong Zhang
IPC分类号： G06K9/36 , G06K9/32
CPC分类号： G01B9/02091 , A61B5/0066 , A61B5/7257 , G01B9/02044 , G01B9/02083 , G01N21/4795
摘要： The present invention provides a method of fast image construction. The wavelength information is extracted in advance based on characteristics of a Fourier domain Optical Coherent Tomography (OCT) system, to obtain a vector of wavelengths which are in a uniform distribution in a wave number space, and thus to obtain a virtual position coefficient of this wavelength vector at a CCD, from which a weight matrix is calculated based on a transfer function for a discrete Fourier transform with zero-padding interpolation. In operation of the system, the interpolation is carried out based on the weight matrix and collected data, or is carried out based on the weight matrix which has been truncated by being subject to windowing and the collected data, to obtain interpolated data satisfying requirements. The method according to the present invention is simple and easy to implement, by which, it is possible to improve the precision and speed of the Fourier domain OCT data process, and thus to improve the capacity of real-time image reconstruction of the Fourier domain OCT system.
摘要翻译：本发明提供一种快速构图方法。基于傅立叶域光学相干层析成像（OCT）系统的特性预先提取波长信息，以获得在波数空间中处于均匀分布的波长矢量，从而获得该波长信息的虚拟位置系数基于用于具有零填充插值的离散傅立叶变换的传递函数来计算加权矩阵。在系统的操作中，基于权重矩阵和收集的数据进行内插，或者基于通过加窗截取的权重矩阵和收集的数据来执行内插，以获得满足要求的内插数据。根据本发明的方法简单易于实现，通过该方法，可以提高傅立叶域OCT数据处理的精度和速度，从而提高傅立叶域的实时图像重建能力 OCT系统。

6. 发明授权

US08894989B2 PARP inhibitor compounds, compositions and methods of use 有权
标题翻译： PARP抑制剂化合物，组合物和使用方法
公开(公告)号：US08894989B2
公开(公告)日：2014-11-25
申请号：US13527158
申请日：2012-06-19
申请人： Weizheng Xu , Greg Delahanty , Ling Wei , Jie Zhang
发明人： Weizheng Xu , Greg Delahanty , Ling Wei , Jie Zhang
IPC分类号： A61K45/00 , A01N43/58 , C07D491/00
CPC分类号： A61K31/519 , A61K31/53 , C07D487/06 , C07D519/00
摘要： The present invention relates to tetraaza phenalen-3-one compounds which inhibit poly(ADP-ribose) polymerase (PARP) and are useful in the chemosensitization of cancer therapeutics. The induction of peripheral neuropathy is a common side-effect of many of the conventional and newer chemotherapies. The present invention further provides means to reliably prevent or cure chemotherapy-induced neuropathy. The invention also relates to the use of the disclosed PARP inhibitor compounds in enhancing the efficacy of chemotherapeutic agents such as temozolomide. The invention also relates to the use of the disclosed PARP inhibitor compounds to radiosensitize tumor cells to ionizing radiation. The invention also relates to the use of the disclosed PARP inhibitor compounds for treatment of cancers with DNA repair defects.
摘要翻译：本发明涉及抑制聚（ADP-核糖）聚合酶（PARP）并可用于癌症治疗剂的化学敏化的四氮芥苯并三氮唑-3-酮化合物。周围神经病变的诱导是许多常规和较新的化学疗法的常见副作用。本发明还提供了可靠地预防或治愈化疗诱发的神经病变的方法。本发明还涉及所公开的PARP抑制剂化合物在增强化疗剂如替莫唑胺的功效中的用途。本发明还涉及所公开的PARP抑制剂化合物对肿瘤细胞对电离辐射进行放射增敏的用途。本发明还涉及所公开的PARP抑制剂化合物用于治疗具有DNA修复缺陷的癌症的用途。

7. 发明申请

US20100054626A1 METHOD OF FAST IMAGE RECONSTRUCTION 有权
标题翻译：快速图像重建方法
公开(公告)号：US20100054626A1
公开(公告)日：2010-03-04
申请号：US12538006
申请日：2009-08-07
申请人： Guohua Shi , Xiqi Li , Ling Wei , Yudong Zhang
发明人： Guohua Shi , Xiqi Li , Ling Wei , Yudong Zhang
IPC分类号： G06K9/36
CPC分类号： G01B9/02091 , A61B5/0066 , A61B5/7257 , G01B9/02044 , G01B9/02083 , G01N21/4795
摘要： The present invention provides a method of fast image construction. The wavelength information is extracted in advance based on characteristics of a Fourier domain Optical Coherent Tomography (OCT) system, to obtain a vector of wavelengths which are in a uniform distribution in a wave number space, and thus to obtain a virtual position coefficient of this wavelength vector at a CCD, from which a weight matrix is calculated based on a transfer function for a discrete Fourier transform with zero-padding interpolation. In operation of the system, the interpolation is carried out based on the weight matrix and collected data, or is carried out based on the weight matrix which has been truncated by being subject to windowing and the collected data, to obtain interpolated data satisfying requirements. The method according to the present invention is simple and easy to implement, by which, it is possible to improve the precision and speed of the Fourier domain OCT data process, and thus to improve the capacity of real-time image reconstruction of the Fourier domain OCT system.
摘要翻译：本发明提供一种快速构图方法。基于傅立叶域光学相干层析成像（OCT）系统的特性预先提取波长信息，以获得在波数空间中处于均匀分布的波长矢量，从而获得该波长信息的虚拟位置系数基于用于具有零填充插值的离散傅立叶变换的传递函数来计算加权矩阵。在系统运行中，基于权重矩阵和收集的数据进行内插，或者基于通过加窗截取的权重矩阵和收集的数据来执行内插，以获得满足要求的内插数据。根据本发明的方法简单易于实现，通过该方法，可以提高傅立叶域OCT数据处理的精度和速度，从而提高傅立叶域的实时图像重建能力 OCT系统。

8. 发明申请

US20090098084A1 PARP INHIBITOR COMPOUNDS, COMPOSITIONS AND METHODS OF USE 有权
标题翻译： PARP抑制剂化合物，组合物和使用方法
公开(公告)号：US20090098084A1
公开(公告)日：2009-04-16
申请号：US12244399
申请日：2008-10-02
申请人： Weizheng Xu , Greg Delahanty , Ling Wei , Jie Zhang
发明人： Weizheng Xu , Greg Delahanty , Ling Wei , Jie Zhang
IPC分类号： A61K31/519 , C07D487/06 , A61P35/00 , A61K31/704 , A61K38/21 , A61K38/20 , A61K33/24 , A61K31/551
CPC分类号： A61K31/519 , A61K31/53 , C07D487/06 , C07D519/00
摘要： The present invention relates to tetraaza phenalen-3-one compounds which inhibit poly (ADP-ribose) polymerase (PARP) and are useful in the chemosensitization of cancer therapeutics. The induction of peripheral neuropathy is a common side-effect of many of the conventional and newer chemotherapies. The present invention further provides means to reliably prevent or cure chemotherapy-induced neuropathy. The invention also relates to the use of the disclosed PARP inhibitor compounds in enhancing the efficacy of chemotherapeutic agents such as temozolomide. The invention also relates to the use of the disclosed PARP inhibitor compounds to radiosensitize tumor cells to ionizing radiation. The invention also relates to the use of the disclosed PARP inhibitor compounds for treatment of cancers with DNA repair defects.
摘要翻译：本发明涉及抑制聚（ADP-核糖）聚合酶（PARP）并可用于癌症治疗剂的化学敏化的四氮芥苯并三氮唑-3-酮化合物。周围神经病变的诱导是许多常规和较新的化学疗法的常见副作用。本发明还提供了可靠地预防或治愈化疗诱发的神经病变的方法。本发明还涉及所公开的PARP抑制剂化合物在增强化疗剂如替莫唑胺的功效中的用途。本发明还涉及所公开的PARP抑制剂化合物对肿瘤细胞对电离辐射进行放射增敏的用途。本发明还涉及所公开的PARP抑制剂化合物用于治疗具有DNA修复缺陷的癌症的用途。

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