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1. 发明授权

US06641542B2 Method and apparatus to detect and treat sleep respiratory events 有权
公开(公告)号：US06641542B2
公开(公告)日：2003-11-04
申请号：US10133009
申请日：2002-04-26
申请人： Yong Kyun Cho , Luc R. Mongeon , Mark K. Erickson , H. Toby Markowitz
发明人： Yong Kyun Cho , Luc R. Mongeon , Mark K. Erickson , H. Toby Markowitz
IPC分类号： A61B508
CPC分类号： A61B5/08 , A61B5/0205 , A61B5/4818 , A61N1/3601
摘要： The present invention provides a method and apparatus for detecting and treating sleep respiratory events that includes a plurality of sensors gathering physiological data related to sleep respiratory events. A processor extracts an average cycle length and a frequency of at least one of Cheyne-Stokes respiration and periodic breathing based upon the physiological data, and determines whether therapy is required based on the average cycle length and the frequency.

2. 发明授权

US07160252B2 Method and apparatus for detecting respiratory disturbances 有权
标题翻译：用于检测呼吸障碍的方法和装置
公开(公告)号：US07160252B2
公开(公告)日：2007-01-09
申请号：US10419467
申请日：2003-04-21
申请人： Yong K. Cho , Steven L. Ning , Luc R. Mongeon , Scott W. Davie , Todd J. Sheldon , Mark K. Erickson , H. Toby Markowitz
发明人： Yong K. Cho , Steven L. Ning , Luc R. Mongeon , Scott W. Davie , Todd J. Sheldon , Mark K. Erickson , H. Toby Markowitz
IPC分类号： A61B5/02 , A61B5/05 , A61B5/00
CPC分类号： A61B5/145 , A61B5/0205 , A61B5/029 , A61B5/0809 , A61B5/0816 , A61B5/091 , A61B5/4818 , A61M2016/0021 , A61M2230/04 , A61M2230/205 , A61M2230/60 , A61M2230/63 , A61M2230/65 , G06F19/00
摘要： A system and method for monitoring respiration including sensing a signal that varies with respiration, deriving a respiration parameter, applying criteria for detecting a respiration disturbance and determining one or more respiratory disturbance metrics. The system preferably includes an implantable sensor with an associated implantable medical device such that chronic respiration monitoring is possible. The implantable medical device may execute methods for detecting and measuring respiratory disturbances or may store data to be transferred to an external device for detecting and measuring respiratory disturbances. Respiratory disturbance detection may trigger a responsive action such as physiological data storage, a change in therapy delivery, or a clinician warning. Assessment of cardiac function may be made based on metrics of respiratory disturbances or a measure of circulatory delay time following detection of a respiratory disturbance.
摘要翻译：一种用于监测呼吸的系统和方法，包括感测随呼吸变化的信号，导出呼吸参数，应用用于检测呼吸障碍的标准和确定一个或多个呼吸障碍度量。该系统优选地包括具有相关联的可植入医疗装置的可植入传感器，使得可以进行慢性呼吸监测。可植入医疗装置可以执行用于检测和测量呼吸障碍的方法，或者可以将要传送到外部设备的数据存储以检测和测量呼吸障碍。呼吸道干扰检测可能会触发响应动作，如生理数据存储，治疗传递的变化或临床医生的警告。心脏功能的评估可以基于呼吸紊乱的度量或检测到呼吸障碍之后的循环延迟时间的量度进行。

3. 发明授权

US07524292B2 Method and apparatus for detecting respiratory disturbances 有权
标题翻译：用于检测呼吸障碍的方法和装置
公开(公告)号：US07524292B2
公开(公告)日：2009-04-28
申请号：US11565092
申请日：2006-11-30
申请人： Yong K. Cho , Steven L. Ning , Luc R. Mongeon , Scott W. Davie , Todd J. Sheldon , Mark K. Erickson , H. Toby Markowitz
发明人： Yong K. Cho , Steven L. Ning , Luc R. Mongeon , Scott W. Davie , Todd J. Sheldon , Mark K. Erickson , H. Toby Markowitz
IPC分类号： A61B5/08 , A61B5/02 , A61B5/00 , A61B5/103 , A61B5/05
CPC分类号： A61B5/0809 , A61B5/0205 , A61B5/0215 , A61B5/0402 , A61B5/1459 , A61B5/4818 , G06F19/00
摘要： A system and method for monitoring respiration including sensing a signal that varies with respiration, deriving a respiration parameter, applying criteria for detecting a respiration disturbance and determining one or more respiratory disturbance metrics. The system preferably includes an implantable sensor with an associated implantable medical device such that chronic respiration monitoring is possible. The implantable medical device may execute methods for detecting and measuring respiratory disturbances or may store data to be transferred to an external device for detecting and measuring respiratory disturbances. Respiratory disturbance detection may trigger a responsive action such as physiological data storage, a change in therapy delivery, or a clinician warning. Assessment of cardiac function may be made based on metrics of respiratory disturbances or a measure of circulatory delay time following detection of a respiratory disturbance.
摘要翻译：一种用于监测呼吸的系统和方法，包括感测随呼吸变化的信号，导出呼吸参数，应用用于检测呼吸障碍的标准和确定一个或多个呼吸障碍度量。该系统优选地包括具有相关联的可植入医疗装置的可植入传感器，使得可以进行慢性呼吸监测。可植入医疗装置可以执行用于检测和测量呼吸障碍的方法，或者可以将要传送到外部设备的数据存储以检测和测量呼吸障碍。呼吸道干扰检测可能会触发响应动作，如生理数据存储，治疗传递的变化或临床医生的警告。心脏功能的评估可以基于呼吸紊乱的度量或检测到呼吸障碍之后的循环延迟时间的量度进行。

4. 发明授权

US07123965B2 Method and apparatus for injection of external data within an implantable medical device 有权
公开(公告)号：US07123965B2
公开(公告)日：2006-10-17
申请号：US10137171
申请日：2002-04-30
申请人： Catherine R. Condie , Gerald A. Portzline , Yong Kyun Cho , John S. Brandstetter , Luc R. Mongeon , Lucy M. Nichols , Steve R Hornberger
发明人： Catherine R. Condie , Gerald A. Portzline , Yong Kyun Cho , John S. Brandstetter , Luc R. Mongeon , Lucy M. Nichols , Steve R Hornberger
IPC分类号： A61N1/365
CPC分类号： A61N1/37252 , A61N1/36514 , A61N1/37264 , G06F19/00
摘要： A method and an apparatus for performing implementing external data into an implantable medical device. A first stress test is performed using an external sensor. External data resulting from the initial stress test is acquired. An external data injection process is performed. The external data injection process includes providing the external data to the implantable medical device. A second stress test is performed, the second stress test being substantially similar to the first stress test. Internal data resulting from the second stress test is acquired. Internal data resulting from the second stress test along with the external data resulting from the first stress test, are processed.

5. 发明授权

US07206635B2 Method and apparatus for modifying delivery of a therapy in response to onset of sleep 有权
标题翻译：响应睡眠发作改变治疗递送的方法和装置
公开(公告)号：US07206635B2
公开(公告)日：2007-04-17
申请号：US10736370
申请日：2003-12-15
申请人： Yong Kyun Cho , Donald N. Jensen , Luc R. Mongeon
发明人： Yong Kyun Cho , Donald N. Jensen , Luc R. Mongeon
IPC分类号： A61F1/365
CPC分类号： A61N1/36521 , A61N1/36542 , A61N1/3702
摘要： A method and apparatus for providing a therapy to the patient that includes a therapy component configured to provide the therapy to the patient, sensing circuitry sensing a parameter of the patient, and a microprocessor coupled to the therapy component and the sensing circuitry to determine onset of a first state of the patient in response to the sensed physiologic parameter, and to determine whether the onset of the first state is detected for a predetermined time period.
摘要翻译：一种用于向患者提供治疗的方法和装置，包括治疗组件，其被配置为向患者提供治疗，感测电路感测患者的参数，以及耦合到治疗组件和感测电路的微处理器，以确定响应于感测到的生理参数的患者的第一状态，并且确定在预定时间段内是否检测到第一状态的开始。

6. 发明授权

US07031772B2 Method and apparatus for rate responsive adjustments in an implantable medical device 有权
公开(公告)号：US07031772B2
公开(公告)日：2006-04-18
申请号：US10134560
申请日：2002-04-29
申请人： Catherine R. Condie , John D. Wahlstrand , Gerald A. Portzline , Yong Kyun Cho , John S. Brandstetter , Luc R. Mongeon
发明人： Catherine R. Condie , John D. Wahlstrand , Gerald A. Portzline , Yong Kyun Cho , John S. Brandstetter , Luc R. Mongeon
IPC分类号： A61N1/365
CPC分类号： A61N1/36542 , A61N1/36521 , G06F19/00 , G06F19/3456 , G16H40/63
摘要： A method and an apparatus for performing rate responsive control in an implantable medical device using a scaling factor. Sensor data is acquired using a sensor operatively coupled with the implantable medical device. At least one setpoint for controlling a rate of therapy is generated, the setpoint being based upon the sensor data. A scaling factor adjustment process is performed for scaling the internal sensor data to correlate the sensor data to the setpoint. The rate of therapy is adjusted based upon the scaling factor adjustment.

7. 发明授权

US06731984B2 Method for providing a therapy to a patient involving modifying the therapy after detecting an onset of sleep in the patient, and implantable medical device embodying same 有权
标题翻译：用于在检测到患者的睡眠发作之后对涉及修改治疗的患者提供治疗的方法以及体内相同的可植入医疗装置
公开(公告)号：US06731984B2
公开(公告)日：2004-05-04
申请号：US09876528
申请日：2001-06-07
申请人： Yong Kyun Cho , Donald N. Jensen , Luc R. Mongeon
发明人： Yong Kyun Cho , Donald N. Jensen , Luc R. Mongeon
IPC分类号： A61N1365
CPC分类号： A61N1/36521 , A61N1/36542
摘要： An implantable medical device system is described including an implantable medical device for implantation in a patient. One embodiment of the implantable medical device includes a therapy component for providing a therapy to the patient, a minute ventilation (MV) sensing circuit producing MV values indicative of a MV of the patient at time intervals, and computational circuitry. The computational circuitry receives a number of the MV values over a period of time, calculates a statistical parameter (e.g., a mean) of the MV values, and calculates a deviation of the MV values from the statistical parameter (e.g., a standard deviation of the MV values). The computational circuitry detects an onset of sleep in the patient when the deviation of the MV values from the statistical parameter is less than a predetermined MV threshold value, and signals the therapy component to modify the therapy when the onset of sleep is detected in the patient. A method is disclosed for providing therapy to a patient, including detecting an onset of sleep in the patient, and modifying the therapy following the detecting the onset of sleep in the patient.
摘要翻译：描述了一种植入式医疗装置系统，其包括用于植入患者体内的可植入医疗装置。可植入医疗装置的一个实施例包括用于向患者提供治疗的治疗部件，以及以计算电路产生指示患者的MV的MV值的分钟通气（MV）感测电路。计算电路在一段时间内接收多个MV值，计算MV值的统计参数（例如，平均值），并计算MV值与统计参数的偏差（例如，标准偏差 MV值）。当MV值与统计参数的偏差小于预定的MV阈值时，计算电路检测患者的睡眠开始，并且当在患者中检测到睡眠发作时发出信号，以修改治疗组件。公开了一种用于向患者提供治疗的方法，包括检测患者的睡眠发作，以及在检测到患者的睡眠发作之后修改治疗。

8. 发明授权

US6091988A Apparatus for treating atrial tachyarrhythmias with synchronized shocks 失效
标题翻译：用同步冲击治疗房性快速性心律失常的装置
公开(公告)号：US6091988A
公开(公告)日：2000-07-18
申请号：US70690
申请日：1998-04-30
申请人： Eduardo N. Warman , Michael R. S. Hill , David K. L. Peterson , Rahul Mehra , Luc R. Mongeon
发明人： Eduardo N. Warman , Michael R. S. Hill , David K. L. Peterson , Rahul Mehra , Luc R. Mongeon
IPC分类号： A61N1/362 , A61N1/39
CPC分类号： A61N1/3956 , A61N1/3622 , A61N1/3987
摘要： An implantable anti-tachyarrhythmia device which delivers atrial cardioversion or defibrillation pulses heart in response to detection of atrial tachyarrhythmias. The pulses are synchronized to atrial and ventricular events in such a fashion as to assure they occur outside of the vulnerable periods associated with both chambers. The device is provided with a pulse synchronizer which defines a first synchronization interval initiated following a sensed atrial event and a second synchronization interval initiated responsive to a sensed ventricular event and a pulse triggerer which triggers delivery of a cardioversion or defibrillation pulse responsive to the first and second synchronization intervals simultaneously being underway. In particular, the pulse triggerer may be responsive to initiation of the first synchronization interval during the second synchronization interval. In addition, the synchronizer may also define minimum time intervals following ventricular events and the triggerer may additionally be responsive to expiration of a defined minimum time interval following a ventricular event preceding the sensed ventricular event which initiated the second synchronization interval currently underway.
摘要翻译：一种可植入的抗快速性心律失常装置，其响应于心房快速性心律失常的检测而传送心房心脏复律或除颤脉冲心脏。这些脉冲以这样的方式与心房和心室事件同步，以确保它们发生在与两个腔室相关联的脆弱周期之外。该装置设置有脉冲同步器，该脉冲同步器限定在感测的心房事件之后启动的第一同步间隔和响应于感测到的心室事件而发起的第二同步间隔和脉冲触发器，其响应于第一和第二同步间隔触发心脏复律或除颤脉冲的传递第二同步间隔同时进行。特别地，脉冲触发器可以响应于在第二同步间隔期间启动第一同步间隔。此外，同步器还可以定义心室事件之后的最小时间间隔，并且触发器可以另外响应于起始于当前正在进行的第二同步区间的感测的心室事件之前的心室事件之后的限定的最小时间间隔的到期。

9. 发明授权

US5836976A Cardioversion energy reduction system 失效
标题翻译：心律转换能量减少系统
公开(公告)号：US5836976A
公开(公告)日：1998-11-17
申请号：US846747
申请日：1997-04-30
申请人： Xiaoyi Min , Li Wang , Rahul Mehra , Paul J. DeGroot , Walter H. Olson , Luc R. Mongeon , Michael R. S. Hill
发明人： Xiaoyi Min , Li Wang , Rahul Mehra , Paul J. DeGroot , Walter H. Olson , Luc R. Mongeon , Michael R. S. Hill
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61N1/3925 , A61N1/3987
摘要： In an implantable pacemaker/cardioverter/defibrillator, a system for correlating the delivery of a cardioversion therapy to an optimum point or phase of the respiratory cycle of the patient to effect delivery of the therapy when the impedance between the cardioversion electrodes is minimized. In a first application for use with cardioversion electrodes located substantially in contact with the heart chamber, the optimum point or phase is at the end of inspiration. In a second application for use with at least one cardioversion electrode located remotely from the heart chamber, the optimum point or phase is at end expiration or beginning of inspiration. The cardioversion therapy is delivered in synchrony with a ventricular sense event, if present. If the optimum point or phase of the respiratory cycle cannot be determined during a therapy time, a pre-shock may be delivered to elicit a respiration cycle through a stimulated contraction of the diaphragm.
摘要翻译：在植入式心脏起搏器/心律转复除颤器中，用于将心脏复律治疗的输送与患者呼吸周期的最佳点或阶段相关联的系统，以在心脏复律电极之间的阻抗最小化时实现治疗的传递。在与基本上与心脏腔室接触的心脏复律电极一起使用的第一个应用中，最佳点或阶段在吸气结束时。在与远离心脏室的位置的至少一个心脏复律电极一起使用的第二个应用中，最佳点或阶段是结束期满或开始吸气。复发疗法与心室感觉事件（如果存在）同步传递。如果在治疗时间内不能确定呼吸周期的最佳点或相位，则可以传送预休克以通过振膜的刺激收缩引起呼吸循环。

10. 发明授权

US5713924A Defibrillation threshold reduction system 失效
标题翻译：除颤门限降低系统
公开(公告)号：US5713924A
公开(公告)日：1998-02-03
申请号：US495251
申请日：1995-06-27
申请人： Xiaoyi Min , Luc R. Mongeon , Michael R. S. Hill
发明人： Xiaoyi Min , Luc R. Mongeon , Michael R. S. Hill
IPC分类号： A61N1/39
CPC分类号： A61N1/3962 , A61N1/395
摘要： A method an apparatus for treating fibrillation, particularly atrial fibrillation. In response to detection of fibrillation, a high frequency, low energy pulse burst is delivered via pacing electrodes, accompanied by a high energy pulse delivered via defibrillation electrodes. The low energy pulse burst is preferably delivered to an area of the heart which exhibits relatively lower current density during delivery of the high energy pulse.
摘要翻译：一种用于治疗纤维性颤动，特别是心房颤动的装置的方法。响应于原纤维的检测，通过起搏电极输送高频，低能脉冲脉冲，伴随着通过除颤电极传送的高能量脉冲。低能量脉冲脉冲优选地被传送到在高能量脉冲传送期间呈现相对较低的电流密度的心脏区域。

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